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Herpes Simplex in Emergency Medicine Clinical Presentation

  • Author: Rahul Sharma, MD, MBA, FACEP; Chief Editor: Steven C Dronen, MD, FAAEM  more...
Updated: Oct 27, 2015


The typical incubation period from exposure to development of symptoms is 4 days but can range from 1-26 days. Prodromal symptoms of local pain, tingling, itching, and burning often precede development of the rash. Constitutional symptoms of fever, fatigue, myalgias, and headache often accompany the primary herpes simplex virus (HSV) infection.

Herpetic lesions usually begin as clusters of small bumps, then blisters, followed by open sores or ulcers. Lesions coalesce and usually heal over several weeks.

Many times these classically described lesions in the genital area may not present in all patients and may be difficult to differentiate from other conditions such as syphilis and chancroid.

Local pain is a prominent and common complaint. Patients with genital herpes may also complain of pain in the groin area secondary to local adenopathy. Women often present with complaints of genital swelling, discharge, and dysuria.

Many primary infections are asymptomatic. Up to 80% of women with HSV-2 antibodies have no clinical history of infection. However, when primary infections are symptomatic, they are usually more severe than recurrent infections. Persons with asymptomatic genital HSV-2 infections still shed virus but less frequently than persons with symptomatic infections.[5]

Recurrent lesions are common.

  • Patients may give a history that includes the following:
    • Occupational exposure
      • Herpetic whitlow, found in health care workers (especially medical or dental)
      • Herpes gladiatorum on bodies of wrestlers
    • Previous history of herpetic diseases
    • Apparently undiagnosed episodes
  • Immune status
    • HIV
    • Malnourishment
    • Hematological malignancies
    • Bone marrow
    • Renal transplant
    • Cardiac transplant
  • Neurologic symptoms
    • Headache
    • Confusion
    • Fever
  • Lesions
    • Location varies
    • May be very painful
    • Tenesmus, itching with anal/perianal lesions
    • Dysuria with genital lesions
    • Sore throat with oral lesions
  • Constitutional symptoms (usually present with development of herpes lesions)
    • Anorexia
    • General malaise
    • Fever
    • Headache
    • Myalgias
  • Prodromal symptoms (present in advance of herpes lesions)
    • Burning
    • Itching
    • Tingling
    • Pain


Physical examination findings of HSV vary depending on location of the lesions.

General findings

  • Lesions usually are vesicular or ulcerative on an erythematous base, as shown in the image below.
    Cutaneous vesicles characteristic of herpes simple Cutaneous vesicles characteristic of herpes simples virus infection
  • Lesions coalesce and then heal over the next several weeks.
  • Tender bilateral lymphadenopathy occurs with genital lesions.

Skin infections (HSV-1 or HSV-2)

  • Herpetic whitlow or paronychia on the fingers of health care workers (not to be confused with abscess). This is usually is due to infection with HSV-1, but HSV-2 infections may be seen with digital-genital contact.
  • Herpes gladiatorum on the bodies of wrestlers and other sports that involve close physical contact. It has been estimated that in Division I National Collegiate Athletic Association (NCAA) wrestling, the incidence of herpes gladiatorum can be as high as 20-40%.

Oropharyngeal disease

  • Gingivostomatitis (herpes labialis on the lips, shown in the image below)
    Herpes labialis Herpes labialis
  • Submandibular lymphadenopathy
  • Fever

Genital herpes

  • Painful vesicular or ulcerative lesions may appear similar to chancroid or syphilis (vesicular lesions shown in the image below)
    Penile infection with herpes simplex virus type 2 Penile infection with herpes simplex virus type 2
  • Inguinal lymphadenopathy
  • Genital lesions, especially urethral lesions, may cause transient urinary retention in women


  • Dendritic keratitis found with slit lamp (dendritic ulcer shown in the image below)
    Herpes simplex virus dendritic ulcer with fluoresc Herpes simplex virus dendritic ulcer with fluorescein staining.
  • Corneal ulcers
  • Vesicles on eyelids


  • New psychiatric symptoms (indicative of encephalitis) - Confusion; seizures; meningeal signs (Recurrent lymphocytic meningitis [benign form of meningitis/encephalitis that may occur during primary HSV-2 infection])
  • Bell palsy (possible relationship with HSV-1)

Anal/perianal involvement

  • Discharge
  • Vesicles
  • Ulcerations
  • Inguinal adenopathy


HSV-1 is transmitted through direct contact with infected saliva or direct contact with contaminated utensils.

HSV-2 is usually acquired as an STD.

Maternal-fetal transmission-risk of transmission is greater in primary outbreak (30-50%) than with recurrent outbreaks (< 1%).[2]

Recurrent disease (reactivation) due to certain stimuli: fever, physical or emotional stress, ultraviolet light exposure, or axonal injury

Contributor Information and Disclosures

Rahul Sharma, MD, MBA, FACEP Medical Director and Associate Chief of Service, NYU Langone Medical Center, Tisch Hospital Emergency Department; Assistant Professor of Emergency Medicine, New York University School of Medicine

Rahul Sharma, MD, MBA, FACEP is a member of the following medical societies: American College of Emergency Physicians, American Association for Physician Leadership, Phi Beta Kappa, Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Eric L Weiss, MD, DTM&H Medical Director, Office of Service Continuity and Disaster Planning, Fellowship Director, Stanford University Medical Center Disaster Medicine Fellowship, Chairman, SUMC and LPCH Bioterrorism and Emergency Preparedness Task Force, Clinical Associate Professor, Department of Surgery (Emergency Medicine), Stanford University Medical Center

Eric L Weiss, MD, DTM&H is a member of the following medical societies: American College of Emergency Physicians, American College of Occupational and Environmental Medicine, American Medical Association, American Society of Tropical Medicine and Hygiene, Physicians for Social Responsibility, Southeastern Surgical Congress, Southern Oncology Association of Practices, Southern Clinical Neurological Society, Wilderness Medical Society

Disclosure: Nothing to disclose.

Chief Editor

Steven C Dronen, MD, FAAEM Chair, Department of Emergency Medicine, LeConte Medical Center

Steven C Dronen, MD, FAAEM is a member of the following medical societies: American Academy of Emergency Medicine, Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Additional Contributors

Lawrence C Brilliant, MD Clinical Assistant Professor, Department of Primary Care and Community Services, MCP Hahnemann University; Attending Physician, Department of Emergency Medicine, Doylestown Hospital

Lawrence C Brilliant, MD is a member of the following medical societies: American College of Emergency Physicians

Disclosure: Nothing to disclose.

Robin R Hemphill, MD, MPH Associate Professor, Director, Quality and Safety, Department of Emergency Medicine, Emory University School of Medicine

Robin R Hemphill, MD, MPH is a member of the following medical societies: American College of Emergency Physicians, Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

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Cutaneous vesicles characteristic of herpes simples virus infection
Herpes labialis
Penile infection with herpes simplex virus type 2
Tzanck smear showing a multinucleated giant cell
Herpes simplex virus dendritic ulcer with fluorescein staining.
Genital herpes infection
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