eMedicine Specialties > Emergency Medicine > Infectious Diseases

Salmonella Infection: Follow-up

Author: Michael D Owens, DO, FACEP, FAAEM, Clinical Faculty, Emergency Medicine Residency, Naval Medical Center Portsmouth; Consulting Staff, Department of Emergency Medicine, Chesapeake Emergency Physicians, Inc, Chesapeake Regional Medical Center
Coauthor(s): Dirk A Warren, MD, Emergency Medicine Resident, Naval Medical Center Portsmouth
Contributor Information and Disclosures

Updated: Apr 3, 2009

Follow-up

Further Outpatient Care

  • Follow-up treatment with the patient's primary care physician is highly recommended.
  • Worsening symptoms warrant a return visit to the ED.
  • Antibiotic treatment for a chronic carrier in coordination with the patient’s primary care physician may be indicated. Asymptomatic carriage occurs on average for about 5 weeks, with prolonged duration existing in children younger than 5 years.28

Deterrence/Prevention

  • Proper hygiene and food storage
  • Keep raw meat and poultry away from unprepared foods
  • Clean surfaces, utensils, and hands after contact with raw foods
  • Myrtle leaves oil has shown promise as an alternative disinfectant.29
  • Avoid eating raw or undercooked eggs
    • Salmonella can withstand temperatures as high as 194o F (90o C) for 50 minutes.10
  • Control of animal reservoir
  • Vaccine for enteric or typhoid fever
    • Current multidose oral vaccine (5 years) or single-dose parental vaccine (3 years) with an efficacy of 50-80%5
    • Trials underway for a single-dose oral vaccine13

Complications

Prognosis

  • Nontyphoid Salmonella is generally self-limiting.
    • Most patients are treated on an outpatient basis.
    • Extremes of age and an immunocompromised state increases morbidity and mortality.
  • Typhoid Salmonella generally requires treatment.
    • Mortality rate for treated cases is 2%, while complications occur in 30% of untreated cases.3
    • Morbidity and mortality increases with drug-resistant S typhi.12

Patient Education

  • Emphasize good hand-washing, thorough cleaning of cooking utensils, appropriate food preparation techniques, and adequate cooking temperature for killing the bacteria.

Miscellaneous

Medicolegal Pitfalls

  • Failure to aggressively manage patients who are immunocompromised, extremes of age, or have complicating factors such as sickle-cell disease or prosthetic grafts 
  • Failure to recognize an extraintestinal manifestation
  • Failure to query about recent travel to underdeveloped nations
  • Failure to ask about previous gastric surgery, use of antacids and H2 antagonists, or any predisposition toward reduced stomach acid production
  • Failure to consider alternative diagnoses - Perforated viscous and atypical presentation of appendicitis needs to be considered.
  • Failure to recognize that a sudden outbreak of Salmonella may be secondary to an intentional contamination31
 
Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous author, Robert A Barrali Jr, MD, to the development and writing of this article. We would like to acknowledge the assistance of Michelle Manfredi in researching this topic.



More on Salmonella Infection

Overview: Salmonella Infection
Differential Diagnoses & Workup: Salmonella Infection
Treatment & Medication: Salmonella Infection
Follow-up: Salmonella Infection
Multimedia: Salmonella Infection
References

References

  1. Coburn B, Grassl GA, Finlay BB. Salmonella, the host and disease: a brief review. Immunol Cell Biol. Feb-Mar 2007;85(2):112-8. [Medline].

  2. Grassl GA, Finlay BB. Pathogenesis of enteric Salmonella infections. Curr Opin Gastroenterol. Jan 2008;24(1):22-6. [Medline].

  3. Chambers HF. McPhee SJ, Papadakis MA, Tierney LM, eds. Current Medical Diagnosis & Treatment. 47th ed. McGraw-Hill Co; 2008:1250-1252.

  4. Centers for Disease Control and Prevention. Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food--10 states, 2007. MMWR Morb Mortal Wkly Rep. Apr 11 2008;57(14):366-70. [Medline].

  5. Linam WM, Gerber MA. Changing epidemiology and prevention of Salmonella infections. Pediatr Infect Dis J. Aug 2007;26(8):747-8. [Medline].

  6. Peques DA, Ohl M, Miller S. Mandell, Douglas, and Bennett's: Principles and Practice of Infectious Diseases. 6th ed. Elsevier; 2005:chap 220.

  7. Braden CR. Salmonella enterica serotype Enteritidis and eggs: a national epidemic in the United States. Clin Infect Dis. Aug 15 2006;43(4):512-7. [Medline].

  8. Jones TF, Ingram LA, Fullerton KE, et al. A case-control study of the epidemiology of sporadic Salmonella infection in infants. Pediatrics. Dec 2006;118(6):2380-7. [Medline].

  9. Centers for Disease Control and Prevention. Multistate outbreak of human Salmonella infections caused by contaminated dry dog food--United States, 2006-2007. MMWR Morb Mortal Wkly Rep. May 16 2008;57(19):521-4. [Medline].

  10. Centers for Disease Control and Prevention. Multistate outbreak of Salmonella infections associated with peanut butter and peanut butter-containing products--United States, 2008-2009. MMWR Morb Mortal Wkly Rep. Feb 6 2009;58(4):85-90. [Medline].

  11. Voetsch AC, Van Gilder TJ, Angulo FJ, et al. FoodNet estimate of the burden of illness caused by nontyphoidal Salmonella infections in the United States. Clin Infect Dis. Apr 15 2004;38 Suppl 3:S127-34. [Medline].

  12. Weinberger M, Keller N. Recent trends in the epidemiology of non-typhoid Salmonella and antimicrobial resistance: the Israeli experience and worldwide review. Curr Opin Infect Dis. Dec 2005;18(6):513-21. [Medline].

  13. Boyle EC, Bishop JL, Grassl GA, et al. Salmonella: from pathogenesis to therapeutics. J Bacteriol. Mar 2007;189(5):1489-95. [Medline].

  14. Sethuraman U, Kamat D. Management of child with fever after international travel. Clin Pediatr (Phila). Apr 2007;46(3):222-7. [Medline].

  15. Heymann DL. Control of Communicable Diseases Manual. 18th ed. American Public Health Association; 2004:469-473.

  16. Perera N, Geary C, Wiselka M, et al. Mixed Salmonella infection: case report and review of the literature. J Travel Med. Mar-Apr 2007;14(2):134-5. [Medline].

  17. Hatta M, Smits HL. Detection of Salmonella typhi by nested polymerase chain reaction in blood, urine, and stool samples. Am J Trop Med Hyg. Jan 2007;76(1):139-43. [Medline].

  18. Bottieau E, Clerinx J, Van den Enden E, et al. Fever after a stay in the tropics: diagnostic predictors of the leading tropical conditions. Medicine (Baltimore). Jan 2007;86(1):18-25. [Medline].

  19. Abubakar I, Irvine L, Aldus CF, et al. A systematic review of the clinical, public health and cost-effectiveness of rapid diagnostic tests for the detection and identification of bacterial intestinal pathogens in faeces and food. Health Technol Assess. Sep 2007;11(36):1-216. [Medline].

  20. Sirinavin S, Garner P. Antibiotics for treating salmonella gut infections. Cochrane Database Syst Rev. 2000;CD001167. [Medline].

  21. Wistrom J, Jertborn M, Ekwall E, et al. Empiric treatment of acute diarrheal disease with norfloxacin. A randomized, placebo-controlled study. Swedish Study Group. Ann Intern Med. Aug 1 1992;117(3):202-8. [Medline].

  22. Centers for Disease Control and Prevention. National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS): Human Isolates Final Report, 2004[Full Text].

  23. [Best Evidence] Thaver D, Zaidi AK, Critchley JA, Azmatullah A, Madni SA, Bhutta ZA. Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). Cochrane Database Syst Rev. Oct 8 2008;CD004530. [Medline].

  24. Parry CM, Threlfall EJ. Antimicrobial resistance in typhoidal and nontyphoidal salmonellae. Curr Opin Infect Dis. Oct 2008;21(5):531-8. [Medline].

  25. Grady R. Safety profile of quinolone antibiotics in the pediatric population. Pediatr Infect Dis J. Dec 2003;22(12):1128-32. [Medline].

  26. Threlfall EJ, de Pinna E, Day M, Lawrence J, Jones J. Alternatives to ciprofloxacin use for enteric Fever, United kingdom. Emerg Infect Dis. May 2008;14(5):860-1. [Medline].

  27. Molbak K. Human health consequences of antimicrobial drug-resistant Salmonella and other foodborne pathogens. Clin Infect Dis. Dec 1 2005;41(11):1613-20. [Medline].

  28. Buchwald DS, Blaser MJ. A review of human salmonellosis: II. Duration of excretion following infection with nontyphi Salmonella. Rev Infect Dis. May-Jun 1984;6(3):345-56. [Medline].

  29. Gunduz GT, Gonul SA, Karapinar M. Efficacy of myrtle oil against Salmonella Typhimurium on fresh produce. Int J Food Microbiol. Mar 31 2009;130(2):147-50. [Medline].

  30. Bhutta ZA. Current concepts in the diagnosis and treatment of typhoid fever. BMJ. Jul 8 2006;333(7558):78-82. [Medline].

  31. Torok TJ, Tauxe RV, Wise RP, et al. A large community outbreak of salmonellosis caused by intentional contamination of restaurant salad bars. JAMA. Aug 6 1997;278(5):389-95. [Medline].

  32. Amieva MR. Important bacterial gastrointestinal pathogens in children: a pathogenesis perspective. Pediatr Clin North Am. Jun 2005;52(3):749-77, vi. [Medline].

  33. Connor BA, Schwartz E. Typhoid and paratyphoid fever in travellers. Lancet Infect Dis. Oct 2005;5(10):623-8. [Medline].

  34. Hoffman SL, Punjabi NH, Kumala S, et al. Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone. N Engl J Med. Jan 12 1984;310(2):82-8. [Medline].

  35. Parry CM, Hien TT, Dougan G, et al. Typhoid fever. N Engl J Med. Nov 28 2002;347(22):1770-82. [Medline].

  36. Punjabi NH, Hoffman SL, Edman DC, et al. Treatment of severe typhoid fever in children with high dose dexamethasone. Pediatr Infect Dis J. Aug 1988;7(8):598-600. [Medline].

Further Reading

Keywords

Salmonella, salmonella infection, salmonella gastroenteritis, salmonellosis, typhi, typhoid fever, enteric fever, typhimurium, enteritidis, choleraesuis, Salmonella infection, severe diarrhea, food-borne illness

Contributor Information and Disclosures

Author

Michael D Owens, DO, FACEP, FAAEM, Clinical Faculty, Emergency Medicine Residency, Naval Medical Center Portsmouth; Consulting Staff, Department of Emergency Medicine, Chesapeake Emergency Physicians, Inc, Chesapeake Regional Medical Center
Michael D Owens, DO, FACEP, FAAEM is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, and American Osteopathic Association
Disclosure: Nothing to disclose.

Coauthor(s)

Dirk A Warren, MD, Emergency Medicine Resident, Naval Medical Center Portsmouth
Dirk A Warren, MD is a member of the following medical societies: American Academy of Family Physicians, American College of Emergency Physicians, and Society of United States Naval Flight Surgeons
Disclosure: Nothing to disclose.

Medical Editor

Mark Louden, MD, FACEP, Assistant Medical Director, Emergency Department, Duke Raleigh Hospital
Mark Louden, MD, FACEP is a member of the following medical societies: American Academy of Emergency Medicine and American College of Emergency Physicians
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Jeter (Jay) Pritchard Taylor III, MD, Compliance Officer, Attending Physician, Emergency Medicine Residency, Department of Emergency Medicine, Palmetto Health Richland, University of South Carolina; Medical Director, Department of Emergency Medicine, Palmetto Health Baptist
Jeter (Jay) Pritchard Taylor III, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

CME Editor

John D Halamka, MD, MS, Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center
John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Chief Editor

Jonathan Adler, MD, Attending Physician, Department of Emergency Medicine, Massachusetts General Hospital; Division of Emergency Medicine, Harvard Medical School
Jonathan Adler, MD is a member of the following medical societies: American Academy of Emergency Medicine and Society for Academic Emergency Medicine
Disclosure: eMedicine.com, Inc. Consulting fee Consulting

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.