Delirium, Dementia, and Amnesia in Emergency Medicine Treatment & Management
- Author: Paul S Gerstein, MD; Chief Editor: Pamela L Dyne, MD more...
Prehospital Care
Prehospital care workers involved in the transport of an acutely confused, combative, or delirious patient must ensure the safety of the patient and staff.
Prior to transport, consider sedation with a benzodiazepine with or without an antipsychotic if unable to control a dangerous patient. Keep in mind that excess sedation may obscure the Mini-Mental Status Examination (MMSE) in the ED.
Use physical restraints if necessary for safe transport.
Provide supplemental oxygen.
Intubate when the airway is at risk or when the patient is comatose or has a poor gag reflex. Protect the cervical spine in the setting of trauma.
Emergency Department Care
ED physicians caring for the patient with agitation, confusion, delirium, combativeness, or obtundation must ensure the safety of both the patient and the staff while attending to issues of airway protection and immediate recognition and treatment of rapidly reversible problems (eg, hypoxia, hypoglycemia, narcotic overdose).
Provide supplemental oxygen unless oxygen saturation is above 93% on room air.
When carbon monoxide poisoning is suspected, ignore the oxygen saturation, obtain a carboxyhemoglobin level, and provide 100% oxygen.
In cases of airway compromise, coma, or poor gag reflex, the ED physician should have a low threshold for intubation. Use rapid sequence intubation (RSI), particularly in the settings of possible head trauma, elevated ICP, or a combative patient. RSI/intubation may be necessary to facilitate imaging studies.
Treat suspected overdose-induced delirium based on ingestion history and/or toxidromes. Such treatment may range from simple observation and supportive care, activated charcoal, lavage (rarely performed), sedation, specific antidotes to intubation/life support.
Behavioral control of a patient with delirium who is agitated and combative should be primarily medication-based with physical restraining kept at a minimum and for protection of both the patient and staff (see Medication).
Consultations
Specific cases may require consultation with neurosurgery, neurology, or internal medicine subspecialists (eg, infectious disease, endocrinology, nephrology, gastroenterology, toxicology, psychiatry).
In the setting of trauma or neurosurgical emergency, notify surgeons early in the workup. When available, a neurosurgeon should be consulted before using mannitol or high-dose steroid therapy.
The patient's private physician and/or family members are often the best sources of information regarding baseline functioning, prior medical history, and current medications.
Consult social services for home evaluation and placement issues for patients with dementia.
Han JH, Morandi A, Ely W, et al. Delirium in the nursing home patients seen in the emergency department. J Am Geriatr Soc. May 2009;57(5):889-94. [Medline].
Mitchell SL, Teno JM, Kiely DK, et al. The clinical course of advanced dementia. N Engl J Med. Oct 15 2009;361(16):1529-38. [Medline].
[Guideline] Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. Nov 1975;12(3):189-98. [Medline].
Fong TG, Jones RN, Rudolph JL, et al. Development and validation of a brief cognitive assessment tool: the sweet 16. Arch Intern Med. Mar 14 2011;171(5):432-7. [Medline].
Berli R, Hutter A, Waespe W, Bachli EB. Transient global amnesia - not so rare after all. Swiss Med Wkly. May 16 2009;139(19-20):288-92. [Medline].
Leong LB, Wei Jian KH, Vasu A, Seow E. Identifying risk factors for an abnormal computed tomographic scan of the head among patients with altered mental status in the Emergency Department. Eur J Emerg Med. Aug 2010;17(4):219-23. [Medline].
Blood Test Takes Step Toward Predicting Alzheimer's Risk. October 15, 2007. Science Daily. Available at http://www.sciencedaily.com/releases/2007/10/071014163700.htm.
Bennett DA, Whitmer RA. NSAID exposure and risk of Alzheimer disease: is timing everything?. Neurology. Jun 2 2009;72(22):1884-5. [Medline].
Breitner JC, Haneuse SJ, Walker R, et al. Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology. Jun 2 2009;72(22):1899-905. [Medline].
Filson S. 12th international conference on Alzheimer's disease. Part 1. 11-16 July 2009, Vienna, Austria. IDrugs. Sep 2009;12(9):535-6. [Medline].
American College of Emergency Physicians. Clinical policy for the initial approach to patients presenting with altered mental status. Ann Emerg Med. Feb 1999;33(2):251-81. [Medline].
American Psychiatric Association. Mental disorders due to a general medical condition. In: Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), Fourth Edition. Washington, DC: American Psychiatric Association; 1994:165-74.
American Psychiatric Association. Delirium, dementia, and amnestic and other cognitive disorders. In: Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), Fourth Edition. Washington, DC: American Psychiatric Association; 1994:123-63.
Bair BD. Frequently missed diagnosis in geriatric psychiatry. Psychiatr Clin North Am. Dec 1998;21(4):941-71, viii. [Medline].
Cassem EH. Behavioral and emotional disturbances. In: Wilson J, Braunwald E, Isselbacher KJ, eds. Harrison's Principles of Internal Medicine. 12th ed. New York, NY: McGraw-Hill; 1991:183-93.
de la Torre JC. Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics. Lancet Neurol. Mar 2004;3(3):184-90. [Medline].
Dziedzic L, Brady WJ, Lindsay R, Huff JS. The use of the mini-mental status examination in the ED evaluation of the elderly. Am J Emerg Med. Nov 1998;16(7):686-9. [Medline].
Esteban-Santillan C, Praditsuwan R, Ueda H, Geldmacher DS. Clock drawing test in very mild Alzheimer's disease. J Am Geriatr Soc. Oct 1998;46(10):1266-9. [Medline].
Geldmacher DS, Whitehouse PJ. Evaluation of dementia. N Engl J Med. Aug 1 1996;335(5):330-6. [Medline].
Hebert LE, Scherr PA, McCann JJ, et al. Is the risk of developing Alzheimer's disease greater for women than for men?. Am J Epidemiol. Jan 15 2001;153(2):132-6. [Medline].
Howarth DF, Heath JM, Snope FC. Beyond the Folstein: dementia in primary care. Prim Care. Jun 1999;26(2):299-314. [Medline].
Jick H, Zornberg GL, Jick SS, et al. Statins and the risk of dementia. Lancet. Nov 11 2000;356(9242):1627-31. [Medline].
Kumar. Pick disease. In: Robbins and Cotran: Pathologic Basis of Disease. 7th ed. 2005:1390.
Lagomasino I, Daly R, Stoudemire A. Medical assessment of patients presenting with psychiatric symptoms in the emergency setting. Psychiatr Clin North Am. Dec 1999;22(4):819-50, viii-ix. [Medline].
Locke WC. Thought and affective disorders. In: Rosen P, Barkin R, eds. Emergency Medicine: Concepts and Clinical Practice. 3rd ed. St Louis, Mo: Mosby; 1998:2074-6.
Luchsinger JA, Mayeux R. Dietary factors and Alzheimer's disease. Lancet Neurol. Oct 2004;3(10):579-87. [Medline].
McDowell I. Alzheimer's disease: insights from epidemiology. Aging (Milano). Jun 2001;13(3):143-62. [Medline].
Olson SC, Rund DA. Behavioral disorders: clinical features. In: Tintinalli JE, Krome RL, Ruiz E, eds. Emergency Medicine: A Comprehensive Study Guide. 3rd ed. New York, NY: McGraw-Hill; 1992:1068-9.
Palmer RM. Common clinical disorders in geriatric patients: intellectual failure. In: Dale DC, Federman DD, eds. Scientific American Medicine. New York, NY: Scientific American Inc; 1992.
Roses AD. Alzheimer's disease and the dementias. In: Dale DC, Federman DD, eds. Scientific American Medicine. New York, NY: Scientific American Inc; 1997.
Smith J. Organic brain syndrome. In: Rosen P, Barkin R, eds. Emergency Medicine: Concepts and Clinical Practice. 3rd ed. St Louis, Mo: Mosby; 1992:1766-86.
Sullivan SC, Richards KC. Predictors of circadian sleep-wake rhythm maintenance in elders with dementia. Aging Ment Health. Mar 2004;8(2):143-52. [Medline].
Tong DC, Grossman M. What causes transient global amnesia? New insights from DWI. Neurology. Jun 22 2004;62(12):2154-5. [Medline].
Yee B, Chang F. Altered mental status: is that good or bad. Resid Staff Physician. 1997;43(7):64-6.

