eMedicine Specialties > Emergency Medicine > Neurology

Complex Regional Pain Syndrome: Follow-up

Author: Steven J Parrillo, DO, FACOEP, FACEP, Associate Professor, Emergency Medicine, Jefferson Medical College and Philadelphia College of Osteopathic Medicine; Medical Director, Department of Emergency Medicine, Einstein Elkins Park; Chair, Emergency Management Committee, Albert Einstein Healthcare Network; Medical Director, Disaster Medicine and Management Masters Program, Philadelphia University
Contributor Information and Disclosures

Updated: Oct 26, 2009

Follow-up

Further Inpatient Care

Although not FDA approved in the United States, in some countries, patients with complex regional pain syndrome are hospitalized and placed on continuous intravenous infusions of medications such as lidocaine or ketamine. As a dissociative anesthetic, the latter is intended to "erase" the memory of dysfunctioning neurons. Results have been variable.

Further Outpatient Care

It is in the best interest of patients with complex regional pain syndrome (CRPS) to have a physician knowledgeable about this entity orchestrate all care. Appropriate referral is important.

Deterrence/Prevention

It has been well documented that those with complex regional pain syndrome who are diagnosed earliest do the best. Once the disease is well established, it probably cannot be reversed.

Complications

Once refractory to neural blockade, pain is probably lifelong and may be severe enough to be debilitating.

Prognosis

Prognosis of complex regional pain syndrome depends largely on timely diagnosis and use of early aggressive therapy.

Patient Education

Patients should be encouraged to seek out CRPS support groups.

Miscellaneous

Medicolegal Pitfalls

  • Because many clinicians are not aware of complex regional pain syndrome (CRPS), the possibility of misdiagnosis or late diagnosis with consequent poor outcome exists.
  • Individuals with CRPS/RSDS may depend on potent analgesia to control pain. Do not assume that they are illegitimate drug seekers.
 


More on Complex Regional Pain Syndrome

Overview: Complex Regional Pain Syndrome
Differential Diagnoses & Workup: Complex Regional Pain Syndrome
Treatment & Medication: Complex Regional Pain Syndrome
Follow-up: Complex Regional Pain Syndrome
References

References

  1. Schwartzman RJ. Reflex sympathetic dystrophy. Curr Opin Neurol Neurosurg. Aug 1993;6(4):531-6. [Medline].

  2. Campbell JN, Meyer RA, Raja SN. Is nociceptor activation by alpha-1 adrenoreceptors the culprit in sympathetically mediated pain?. Am Pain Soc J. 1992;1:3-11.

  3. [Guideline] Reflex Sympathetic Dystrophy Syndrome Association (RSDSA). Complex regional pain syndrome: treatment guidelines. Jun 2006;[Full Text].

  4. Maihofner C, Handwerker HO, Neundorfer B, Birklein F. Mechanical hyperalgesia in complex regional pain syndrome: a role for TNF-alpha?. Neurology. Jul 26 2005;65(2):311-3. [Medline].

  5. Blaes F, Schmitz K, Tschernatsch M, et al. Autoimmune etiology of complex regional pain syndrome (M. Sudeck). Neurology. Nov 9 2004;63(9):1734-6. [Medline].

  6. Oaklander AL, Fields HL. Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy?. Ann Neurol. Jun 2009;65(6):629-38. [Medline].

  7. de Mos M, Huygen FJ, Stricker BH, Dieleman JP, Sturkenboom MC. The association between ACE inhibitors and the complex regional pain syndrome: Suggestions for a neuro-inflammatory pathogenesis of CRPS. Pain. Apr 2009;142(3):218-24. [Medline].

  8. Schwartzman RJ, Erwin KL, Alexander GM. The natural history of complex regional pain syndrome. Clin J Pain. May 2009;25(4):273-80.

  9. Stanton-Hicks M. Complex regional pain syndrome. Anesthesiol Clin North America. Dec 2003;21(4):733-44. [Medline].

  10. Tong HC, Nelson VS. Recurrent and migratory reflex sympathetic dystrophy in children. Pediatr Rehabil. Apr-Jun 2000;4(2):87-9. [Medline].

  11. Kachko L, Efrat R, Ben Ami S, Mukamel M, Katz J. Complex regional pain syndromes in children and adolescents. Pediatr Int. Aug 2008;50(4):523-7. [Medline].

  12. Merskey H, Bogduk N, eds. International Association for the Study of Pain. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. IASP Press; 1996.

  13. Lankford LL. Reflex sympathetic dystrophy. In: Hunter JM, et al, eds. Rehabilitation of the Hand. Mosby-Year Book; 1990:763-86.

  14. van Hilten JJ, van de Beek WJ, Vein AA, van Dijk JG, Middelkoop HA. Clinical aspects of multifocal or generalized tonic dystonia in reflex sympathetic dystrophy. Neurology. Jun 26 2001;56(12):1762-5. [Medline].

  15. Schwartzman RJ. New treatments for reflex sympathetic dystrophy. N Engl J Med. Aug 31 2000;343(9):654-6. [Medline].

  16. Beerthuizen A, van 't Spijker A, Huygen FJ, Klein J, de Wit R. Is there an association between psychological factors and the Complex Regional Pain Syndrome type 1 (CRPS1) in adults? A systematic review. Pain. Sep 2009;145(1-2):52-9. [Medline].

  17. Peterlin BL, Rosso AL, Nair S, Young WB, Schwartzman RJ. Migraine may be a risk factor for the development of complex regional pain syndrome. Cephalalgia. Jul 9 2009;[Medline].

  18. Borsook D, Sava S. Pain: Do ACE inhibitors exacerbate complex regional pain syndrome?. Nat Rev Neurol. Jun 2009;5(6):306-8. [Medline].

  19. Maihofner C, Handwerker HO, Birklein F. Functional imaging of allodynia in complex regional pain syndrome. Neurology. Mar 14 2006;66(5):711-7. [Medline].

  20. Dadure C, Motais F, Ricard C, Raux O, Troncin R, Capdevila X. Continuous peripheral nerve blocks at home for treatment of recurrent complex regional pain syndrome I in children. Anesthesiology. Feb 2005;102(2):387-91. [Medline].

  21. Markman JD, Philip A. Interventional approaches to pain management. Anesthesiol Clin. Dec 2007;25(4):883-98, viii. [Medline].

  22. Kemler MA, Reulen JP, Barendse GA, van Kleef M, de Vet HC, van den Wildenberg FA. Impact of spinal cord stimulation on sensory characteristics in complex regional pain syndrome type I: a randomized trial. Anesthesiology. Jul 2001;95(1):72-80. [Medline].

  23. Oakley JC, Weiner RL. Spinal cord stimulation in complex regional pain syndrome: a prospective study of 19 patients at 2 centers. Neuromodulation. 1999;2:47-50.

  24. Kemler MA, Rijks CP, de Vet HC. Which patients with chronic reflex sympathetic dystrophy are most likely to benefit from physical therapy?. J Manipulative Physiol Ther. May 2001;24(4):272-8. [Medline].

  25. Cleary AG, Sills JA, Davidson JE, Cohen AM. Reflex sympathetic dystrophy. Rheumatology (Oxford). May 2001;40(5):590-1. [Medline].

  26. Kundu A, Berman B. Acupuncture for pediatric pain and symptom management. Pediatr Clin North Am. Dec 2007;54(6):885-9; x. [Medline].

  27. Reuben SS, Rosenthal EA, Steinberg RB, Faruqi S, Kilaru PA. Surgery on the affected upper extremity of patients with a history of complex regional pain syndrome: the use of intravenous regional anesthesia with clonidine. J Clin Anesth. Nov 2004;16(7):517-22. [Medline].

  28. Schwartzman RJ, Patel M, Grothusen JR, Alexander GM. Efficacy of 5-day continuous lidocaine infusion for the treatment of refractory complex regional pain syndrome. Pain Med. Mar 2009;10(2):401-12. [Medline].

  29. Everett A, Mclean B, Plunkett A, Buckenmaier C. A unique presentation of complex regional pain syndrome type I treated with a continuous sciatic peripheral nerve block and parenteral ketamine infusion: a case report. Pain Med. Sep 2009;10(6):1136-9. [Medline].

  30. Finch PM, Knudsen L, Drummond PD. Reduction of allodynia in patients with complex regional pain syndrome: A double-blind placebo-controlled trial of topical ketamine. Pain. Nov 2009;146(1-2):18-25. [Medline].

  31. Sigtermans MJ, van Hilten JJ, Bauer MC, Arbous MS, Marinus J, Sarton EY, et al. Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1. Pain. Oct 2009;145(3):304-11. [Medline].

  32. Collins S, Zuurmond WW, de Lange JJ, van Hilten BJ, Perez RS. Intravenous magnesium for complex regional pain syndrome type 1 (CRPS 1) patients: a pilot study. Pain Med. Jul-Aug 2009;10(5):930-40. [Medline].

  33. Hsu ES. Practical management of complex regional pain syndrome. Am J Ther. Mar-Apr 2009;16(2):147-54. [Medline].

  34. Karmarkar A, Lieberman I. Management of complex regional pain syndrome type II using lidoderm 5% patches. Br J Anaesth. Feb 2007;98(2):261-2. [Medline].

Further Reading

Keywords

complex regional pain syndrome symptoms, complex regional pain syndrome treatment, RSDSRSDreflex sympathetic dystrophy syndrome, causalgia, sympathetic maintained pain syndrome, complex regional pain syndrome, CRPS, CRPS I, CRPS II, peripheral nerve injury

Contributor Information and Disclosures

Author

Steven J Parrillo, DO, FACOEP, FACEP, Associate Professor, Emergency Medicine, Jefferson Medical College and Philadelphia College of Osteopathic Medicine; Medical Director, Department of Emergency Medicine, Einstein Elkins Park; Chair, Emergency Management Committee, Albert Einstein Healthcare Network; Medical Director, Disaster Medicine and Management Masters Program, Philadelphia University
Steven J Parrillo, DO, FACOEP, FACEP is a member of the following medical societies: American College of Emergency Physicians, American College of Osteopathic Emergency Physicians, American Osteopathic Association, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Medical Editor

Joseph A Salomone III, MD, EMS Medical Director, Kansas City, Missouri; Associate Professor and Staff Physician, Truman Medical Centers/UMKC School of Medicine
Joseph A Salomone III, MD is a member of the following medical societies: American Academy of Emergency Medicine, National Association of EMS Physicians, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

J Stephen Huff, MD, Associate Professor, Emergency Medicine and Neurology, Department of Emergency Medicine, University of Virginia Health Sciences Center
J Stephen Huff, MD is a member of the following medical societies: American Academy of Emergency Medicine, American Academy of Neurology, American College of Emergency Physicians, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

CME Editor

John D Halamka, MD, MS, Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center
John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Chief Editor

Robert E O'Connor, MD, MPH, Professor and Chair, Department of Emergency Medicine, University of Virginia Health System
Robert E O'Connor, MD, MPH is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American College of Physician Executives, American Heart Association, American Medical Association, Medical Society of Delaware, National Association of EMS Physicians, Society for Academic Emergency Medicine, and Wilderness Medical Society
Disclosure: Nothing to disclose.

 
 
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