Spinal Cord Infections Treatment & Management
- Author: Andrew K Chang, MD; Chief Editor: Rick Kulkarni, MD more...
Prehospital Care
Because the course of this condition is measured in days and not in hours (some patients take several months to present to medical care), patients' arrival by Emergency Medical Services (EMS) transport is unlikely.
If presented with a patient who requires EMS transport, oxygen, analgesia, and a position of comfort are the only treatments needed in the prehospital arena.
In patients in whom meningismus is involved, antiemetics and gentle handling are indicated.
Emergency Department Care
Because this is such a rare entity, making the diagnosis in the ED is likely difficult. The emergency physician should consider the diagnosis when an infectious picture is present along with neurologic deficits originating at the spinal cord level.
Treatment goals include making an accurate diagnosis and starting antibiotics as early as possible.[4]
Determining the extent of the motor and sensory deficit and its levels is important to guide diagnostic modalities later. Examine the cervical, dorsal, and lumbar regions carefully looking for dermal sinuses, suggestive lesions, and signs of local infection.
Plain radiography of the involved spinal levels occasionally can offer a clue when abnormal.
A lumbar puncture always is considered in a patient with a septic picture with neurologic involvement; however, remember that besides cell count, protein, glucose, and bacteriologic studies, manometric maneuvers can establish the diagnosis of CSF block. Again, neuroimaging (especially MRI) of the spine has made CSF manometry largely obsolete for detecting spinal canal block. If a dermal sinus is found in the lumbar region, deferring the lumbar puncture until the absence of a tethered cord syndrome can be ascertained is prudent.
Start antibiotics as soon as the bacteriologic workup samples have been obtained. Concomitant risk factors determine the most optimal antibiotic coverage for each individual patient.
The use of steroids to treat spinal cord swelling should be made in consultation with neurosurgery.
For additional information, see Spinal Cord Abscess and Spinal Cord Tumors - Management of Intradural Intramedullary Neoplasms.
Consultations
The neurosurgeon should be involved early to guide the diagnostic flow toward surgery.
An infectious disease consultant can offer invaluable help regarding the best antimicrobial combination.
Consult a neuroradiologist to read the MRI with gadolinium study.
Chan CT, Gold WL. Intramedullary abscess of the spinal cord in the antibiotic era: clinical features, microbial etiologies, trends in pathogenesis, and outcomes. Clin Infect Dis. Sep 1998;27(3):619-26. [Medline].
Simon JK, Lazareff JA, Diament MJ, Kennedy WA. Intramedullary abscess of the spinal cord in children: a case report and review of the literature. Pediatr Infect Dis J. Feb 2003;22(2):186-92. [Medline].
Menezes AH, VanGilder JC. Spinal cord abscess. In: Wilkins RH, Rengachary SS. Neurosurgery. New York: McGraw-Hill; 1985:1969.
Al Barbarawi M, Khriesat W, Qudsieh S, Qudsieh H, Loai AA. Management of intramedullary spinal cord abscess: experience with four cases, pathophysiology and outcomes. Eur Spine J. May 2009;18(5):710-7. [Medline].
Bartels RH, Gonera EG, van der Spek JA, Thijssen HO, Mullaart RA, Gabreels FJ. Intramedullary spinal cord abscess. A case report. Spine. May 15 1995;20(10):1199-204. [Medline].
Benzil DL, Epstein MH, Knuckey NW. Intramedullary epidermoid associated with an intramedullary spinal abscess secondary to a dermal sinus. Neurosurgery. Jan 1992;30(1):118-21. [Medline].
Byrne RW, von Roenn KA, Whisler WW. Intramedullary abscess: a report of two cases and a review of the literature. Neurosurgery. Aug 1994;35(2):321-6; discussion 326. [Medline].
Cokca F, Meco O, Arasil E, Unlu A. An intramedullary dermoid cyst abscess due to Brucella abortus biotype 3 at T11-L2 spinal levels. Infection. Sep-Oct 1994;22(5):359-60. [Medline].
Darouiche RO. Spinal epidural abscess. N Engl J Med. Nov 9 2006;355(19):2012-20. [Medline].
David C, Brasme L, Peruzzi P, Bertault R, Vinsonneau M, Ingrand D. Intramedullary abscess of the spinal cord in a patient with a right-to-left shunt: case report. Clin Infect Dis. Jan 1997;24(1):89-90. [Medline].
Desai KI, Muzumdar DP, Goel A. Holocord intramedullary abscess: an unusual case with review of literature. Spinal Cord. Dec 1999;37(12):866-70. [Medline].
Dev R, Husain M, Gupta A, Gupta RK. MR of multiple intraspinal abscesses associated with congenital dermal sinus. AJNR Am J Neuroradiol. Apr 1997;18(4):742-3. [Medline].
DiTullio MV Jr. Intramedullary spinal abscess: a case report with a review of 53 previously described cases. Surg Neurol. Jun 1977;7(6):351-4. [Medline].
Hanci M, Sarioglu AC, Uzan M, Islak C, Kaynar MY, Oz B. Intramedullary tuberculous abscess: a case report. Spine. Mar 15 1996;21(6):766-9. [Medline].
Hardwidge C, Palsingh J, Williams B. Pyomyelia: an intramedullary spinal abscess complicating lumbar lipoma with spina bifida. Br J Neurosurg. 1993;7(4):419-22. [Medline].
Hart J. Case of encysted abscess in the centre of the spinal cord. Dublin Hosp Rep. 1830;5:522-524.
Hoil-Parra JA, Lazareff JA. [Lumbar dermal sinus as a cause of intramedullary and subdural abscess. Report of 2 cases]. Bol Med Hosp Infant Mex. May 1993;50(5):341-6. [Medline].
Hott JS, Horn E, Sonntag VK, Coons SW, Shetter A. Intramedullary histoplasmosis spinal cord abscess in a nonendemic region: case report and review of the literature. J Spinal Disord Tech. Apr 2003;16(2):212-5. [Medline].
Lahdou JB, Gilliard C, de Coene BD, Vandercam B, Deltombe T, Hanson P. [Streptococcus milleri subacute spinal cord abscess. Apropos of a case]. Neurochirurgie. 1996;42(2):100-4. [Medline].
Lindner A, Becker G, Warmuth-Metz M, Schalke BC, Bogdahn U, Toyka KV. Magnetic resonance image findings of spinal intramedullary abscess caused by Candida albicans: case report. Neurosurgery. Feb 1995;36(2):411-2. [Medline].
Manfredi M, Bozzao L, Frasconi F. Chronic intramedullary abscess of the spinal cord. Case report. J Neurosurg. Sep 1970;33(3):352-5. [Medline].
Martin RJ, Yuan HA. Neurosurgical care of spinal epidural, subdural, and intramedullary abscesses and arachnoiditis. Orthop Clin North Am. Jan 1996;27(1):125-36. [Medline].
Miranda Carus ME, Anciones B, Castro A, Lara M, Isla A. Intramedullary spinal cord abscess. J Neurol Neurosurg Psychiatry. Mar 1992;55(3):225-6. [Medline].
Rogg JM, Benzil DL, Haas RL, Knuckey NW. Intramedullary abscess, an unusual manifestation of a dermal sinus. AJNR Am J Neuroradiol. Nov-Dec 1993;14(6):1393-5. [Medline].
Tacconi L, Arulampalam T, Johnston FG, Thomas DG. Intramedullary spinal cord abscess: case report. Neurosurgery. Oct 1995;37(4):817-9. [Medline].
Vajramani GV, Nagmoti MB, Patil CS. Neurobrucellosis presenting as an intra-medullary spinal cord abscess. Ann Clin Microbiol Antimicrob. 2005;4:14. [Medline].
Weng TI, Shih FY, Chen WJ, Lin FY. Intramedullary abscess of the spinal cord. Am J Emerg Med. Mar 2001;19(2):177-8. [Medline].

