eMedicine Specialties > Emergency Medicine > Ophthalmology

Chalazion: Differential Diagnoses & Workup

Author: Jane Lee Fansler, MD, Resident Physician, Stanford University/Kaiser Permanente Emergency Medicine Residency Program
Coauthor(s): Erik D Schraga, MD, Consulting Staff, Department of Emergency Medicine, Mills-Peninsula Emergency Medical Associates; Consulting Staff, Permanente Medical Group, Kaiser Permanente, Santa Clara Medical Center; Sally Santen, MD, Program Director, Assistant Professor, Department of Emergency Medicine, Vanderbilt University
Contributor Information and Disclosures

Updated: Apr 22, 2009

Differential Diagnoses

Basal Cell Carcinoma, Eyelid
Nasolacrimal Duct, Congenital Anomalies
Cellulitis, Orbital
Nasolacrimal Duct, Obstruction
Cellulitis, Preseptal
Neurofibromatosis-1
Contact Lens Complications
Ocular Manifestations of HIV
Dacryoadenitis
Papilloma, Eyelid
Dacryocystitis
Pigmented Lesions of the Eyelid
Dermatitis, Atopic
Psoriasis
Dermatitis, Contact
Sarcoidosis
Dermatochalasis
Sebaceous Gland Carcinoma
Dermoid, Orbital
Spider Bites
Hemangioma, Capillary
Squamous Cell Carcinoma, Conjunctival
Herpes Simplex
Squamous Cell Carcinoma, Eyelid
Herpes Zoster
Sturge-Weber Syndrome
Hordeolum
Trichiasis
Juvenile Xanthogranuloma
Tuberculosis
Lacrimal Gland Tumors
Tuberculosis
Leishmaniasis
Tumors, Orbital
Melanoma, Conjunctival
Xanthelasma
Molluscum Contagiosum

Other Problems to Be Considered

Blepharitis
Hyperimmunoglobulinemia E (hyper-IgE) syndrome
Meibomianitis
Meibomian cell carcinoma
Microcystic adnexal carcinoma
Plexiform neurofibroma
Sebaceous carcinoma
Squamous cell carcinoma
Staphylococcus aureus infection
Virus-induced infection

Workup

Laboratory Studies

  • The diagnosis of chalazion is usually a clinical one and often does not require further workup. The provider should be certain the eyelid lesion is a sterile inflammation that will resolve with limited intervention.
  • The provider must ensure that the patient has an adequate understanding of the typical progression of an uncomplicated chalazion: resolution within a few months. Recurrent symptoms, refractive errors, or persistent lesions should prompt the provider to further investigate the lesion.
  • Fine-needle aspiration cytology of chalazia with atypical clinical presentation provides a means of documenting the diagnosis and excluding malignancy but should be deferred to an eye specialist.
  • Viral and bacterial cultures can provide results to include or exclude an infectious etiology but tend to be low yield.
  • Visual acuity testing
  • Visual field testing

More on Chalazion

Overview: Chalazion
Differential Diagnoses & Workup: Chalazion
Treatment & Medication: Chalazion
Follow-up: Chalazion
Multimedia: Chalazion
References

References

  1. Lederman C, Miller M. Hordeola and chalazia. Pediatr Rev. Aug 1999;20(8):283-4. [Medline].

  2. Litoff D, Balin MW. Ocular infections and inflammation. In: Catalano RA, ed. Ocular Emergencies. WB Saunders; 1992:468-471.

  3. Santa Cruz CS, Culotta T, Cohen EJ, et al. Chalazion-induced hyperopia as a cause of decreased vision. Ophthalmic Surg Lasers. Aug 1997;28(8):683-4. [Medline].

  4. Berman JD. Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin Infect Dis. Apr 1997;24(4):684-703. [Medline].

  5. Aoki M, Kawana S. Bilateral chalazia of the lower eyelids associated with pulmonary tuberculosis. Acta Derm Venereol. 2002;82(5):386-7. [Medline].

  6. Khan JA, Doane JF, Grove AS Jr. Sebaceous and meibomian carcinomas of the eyelid. Recognition, diagnosis, and management. Ophthal Plast Reconstr Surg. 1991;7(1):61-6. [Medline].

  7. Goawalla A, Lee V. A prospective randomized treatment study comparing three treatment options for chalazia: triamcinolone acetonide injections, incision and curettage and treatment with hot compresses. Clin Experiment Ophthalmol. Nov 2007;35(8):706-12. [Medline].

  8. Ho SY, Lai JS. Subcutaneous steroid injection as treatment for chalazion: prospective case series. Hong Kong Med J. Feb 2002;8(1):18-20. [Medline].

  9. Hosal BM, Zilelioglu G. Ocular complication of intralesional corticosteroid injection of a chalazion. Eur J Ophthalmol. Nov-Dec 2003;13(9-10):798-9. [Medline].

  10. Brookes JL, Bentley C, Verma S, et al. Microcystic adnexal carcinoma masquerading as a chalazion. Br J Ophthalmol. Feb 1998;82(2):196-7. [Medline].

  11. Crama N, Toolens AM, van der Meer JW, et al. Giant chalazia in the hyperimmunoglobulinemia E (hyper-IgE) syndrome. Eur J Ophthalmol. May-Jun 2004;14(3):258-60. [Medline].

  12. De Silva DJ, Tumuluri K, Joshi N. Conjunctival squamous cell carcinoma: atypical presentation of HIV. Clin Experiment Ophthalmol. Aug 2005;33(4):419-20. [Medline].

  13. Destafeno JJ, Kodsi SR, Primack JD. Recurrent Staphylococcus aureus chalazia in hyperimmunoglobulinemia E (Job's) syndrome. Am J Ophthalmol. Dec 2004;138(6):1057-8. [Medline].

  14. Gershen HJ. Chalazion. In: Fraunfelder FT, et al, eds. Current Ocular Therapy, 4. WB Saunders; 1995:563-564.

  15. Koo L, Hatton MP, Rubin PA. "Pseudo-pseudochalazion": giant chalazion mimicking eyelid neoplasm. Ophthal Plast Reconstr Surg. Sep 2005;21(5):391-2. [Medline].

  16. Mansour AM, Chan CC, Crawford MA, et al. Virus-induced chalazion. Eye. Feb 2006;20(2):242-6. [Medline].

  17. Mueller JB, McStay CM. Ocular infection and inflammation. Emerg Med Clin North Am. Feb 2008;26(1):57-72, vi. [Medline].

  18. Mustafa TA, Oriafage IH. Three methods of treatment of chalazia in children. Saudi Med J. Nov 2001;22(11):968-72. [Medline].

  19. Ozdal PC, Codere F, Callejo S, et al. Accuracy of the clinical diagnosis of chalazion. Eye. Feb 2004;18(2):135-8. [Medline].

  20. Palva J, Pohjanpelto PE. Intralesional corticosteroid injection for the treatment of chalazia. Acta Ophthalmol (Copenh). Oct 1983;61(5):933-7. [Medline].

  21. Shields JA, Demirci H, Marr BP, et al. Sebaceous carcinoma of the eyelids: personal experience with 60 cases. Ophthalmology. Dec 2004;111(12):2151-7. [Medline].

  22. Smythe D, Hurwitz JJ, Tayfour F. The management of chalazion: a survey of Ontario ophthalmologists. Can J Ophthalmol. Aug 1990;25(5):252-5. [Medline].

Further Reading

Contributor Information and Disclosures

Author

Jane Lee Fansler, MD, Resident Physician, Stanford University/Kaiser Permanente Emergency Medicine Residency Program
Jane Lee Fansler, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Emergency Physicians, Emergency Medicine Residents Association, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Coauthor(s)

Erik D Schraga, MD, Consulting Staff, Department of Emergency Medicine, Mills-Peninsula Emergency Medical Associates; Consulting Staff, Permanente Medical Group, Kaiser Permanente, Santa Clara Medical Center
Disclosure: Nothing to disclose.

Sally Santen, MD, Program Director, Assistant Professor, Department of Emergency Medicine, Vanderbilt University
Sally Santen, MD is a member of the following medical societies: American College of Emergency Physicians and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Medical Editor

David FM Brown, MD, Assistant Professor, Department of Medicine, Division of Emergency Medicine, Harvard Medical School; Associate-Chief, Attending Physician, Department of Emergency Medicine, Massachusetts General Hospital
David FM Brown, MD is a member of the following medical societies: American College of Emergency Physicians and Society for Academic Emergency Medicine
Disclosure: Schering  Honoraria Speaking and teaching

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Douglas Lavenburg, MD, Clinical Professor, Department of Emergency Medicine, Christiana Care Health Systems
Douglas Lavenburg, MD is a member of the following medical societies: American Society of Cataract and Refractive Surgery
Disclosure: Nothing to disclose.

CME Editor

John D Halamka, MD, MS, Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center
John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Chief Editor

Barry E Brenner, MD, PhD, FACEP, Professor of Emergency Medicine, Professor of Internal Medicine, Program Director, Emergency Medicine, University Hospitals, Case Medical Center
Barry E Brenner, MD, PhD, FACEP is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, American College of Chest Physicians, American College of Emergency Physicians, American College of Physicians, American Heart Association, American Thoracic Society, Arkansas Medical Society, New York Academy of Medicine, New York Academy of Sciences, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

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