Pediatric Headache in Emergency Medicine Workup
- Author: Kirsten A Bechtel, MD; Chief Editor: Richard G Bachur, MD more...
Laboratory Studies
- Migraine headache
- A thorough history and physical examination usually is all that is needed.
- Laboratory, radiologic, or encephalographic studies are not useful to confirm the diagnosis of migraine but may help exclude other etiologies of headache. For example, an EEG may be helpful to exclude seizures in children with acute confusional migraines.
- Tension headache
- A thorough history and physical examination is all that is needed to make the diagnosis of tension headache.
- With a suggestive history and normal physical examination findings, no additional tests are required.
- Head trauma and headache due to a significant intracranial hemorrhage: A consumptive coagulopathy, such as thrombocytopenia, and prolonged prothrombin and activated partial thromboplastin times, may be evident.
- Intracranial abscess: Lumbar puncture may reveal elevated opening pressure, leukocytosis, elevated protein level, and low glucose level.
- Benign intracranial hypertension: Lumbar puncture reveals elevated opening pressure without leukocytosis or abnormalities in glucose or protein concentration.
- Meningeal irritation
- In patients with meningitis, a lumbar puncture may show an elevated opening pressure, WBCs, low glucose level, high protein level (meningitis, encephalitis), and bacteria on Gram stain.
- In patients with a subarachnoid hemorrhage, a lumbar puncture demonstrates hemorrhagic CSF that does not clear during the collection of the first and last tubes. Opening pressure may also be elevated.
- Lumbar puncture is the most sensitive test in the diagnosis of subarachnoid hemorrhage.
- Check anticonvulsant levels in patients with a headache and a known history of epilepsy because adequate seizure control usually prevents the headache.
Imaging Studies
- Sinus headache
- The diagnosis of headache due to sinusitis is suggested by a history of persistent upper respiratory infection (URI) symptoms lasting longer than 10 days.
- Confirmation of the diagnosis may be made by means of sinus radiographs depicting air fluid levels in the sinuses. However, this test is not sensitive, and false-negative results are common.
- CT of the sinuses is more sensitive but is usually more expensive. Note that there is a high prevalence of mucoperiosteal thickening in the paranasal sinuses of children in general and serves to emphasize that when soft tissue changes of the sinuses are present, it does not necessarily indicate whether these changes are due to either bacterial infection or inflammation from other causes, such as viral infection, allergy, or chemical irritation. Thus, CT should not be used to make the diagnosis of sinusitis but should only be obtained in children in whom antibiotic therapy does not ameliorate symptoms or in whom sinus surgery is considered after failing appropriate antibiotic therapy for sinusitis.
- Head trauma
- Any abnormality on physical examination in children with head trauma and headache should prompt radiologic evaluation, such as CT, provided that the child has a protected airway and stable cardiovascular status.
- An MRI may not reveal accompanying skull fractures.
- Intracranial masses are most often diagnosed by means of CT (with contrast to enhance subtle lesions) or MRI.
- Benign intracranial hypertension (pseudotumor cerebri)
- CT findings may be normal or may show slit-like ventricles.
- CT is usually needed to exclude other causes of increased intracranial pressure, such as tumors.
- Meningeal irritation
- CT findings are positive in only about 90% of patients with subarachnoid hemorrhage. For this reason, a lumbar puncture should be performed despite unremarkable CT findings in patients thought to have a subarachnoid hemorrhage.
- CT is the best initial study to demonstrate intracranial hemorrhage from malignant HTN or vascular lesions.
- Epilepsy
- If the baseline neurologic examination changes, neuroimaging should be considered.
- If this is the patient's first seizure and it is coincident with a headache, neuroimaging (eg, CT, MRI) is warranted, despite normal baseline examination findings, to exclude the possibility of an intracranial mass.
Other Tests
- Electroencephalography (EEG) is useful to assess the status of an underlying seizure disorder associated with headache.
Lateef TM, Merikangas KR, He J, Kalaydjian A, Khoromi S, Knight E. Headache in a national sample of American children: prevalence and comorbidity. J Child Neurol. May 2009;24(5):536-43. [Medline].
Raieli V, Eliseo M, Pandolfi E, La Vecchia M, La Franca G, Puma D, et al. Recurrent and chronic headaches in children below 6 years of age. J Headache Pain. Jun 2005;6(3):135-42. [Medline].
[Best Evidence] Powers SW, Patton SR, Hommel KA, Hershey AD. Quality of life in childhood migraines: clinical impact and comparison to other chronic illnesses. Pediatrics. Jul 2003;112(1 Pt 1):e1-5. [Medline].
Abu-Arefeh I, Russell G. Prevalence of headache and migraine in schoolchildren. BMJ. Sep 24 1994;309(6957):765-9. [Medline].
Split W, Neuman W. Epidemiology of migraine among students from randomly selected secondary schools in Lodz. Headache. Jul-Aug 1999;39(7):494-501. [Medline].
Charles JA, Peterlin BL, Rapoport AM, Linder SL, Kabbouche MA, Sheftell FD. Favorable outcome of early treatment of new onset child and adolescent migraine-implications for disease modification. J Headache Pain. Aug 2009;10(4):227-33. [Medline].
Cuvellier JC, Mars A, Vallee L. The prevalence of premonitory symptoms in paediatric migraine: a questionnaire study in 103 children and adolescents. Cephalalgia. Nov 2009;29(11):1197-201. [Medline].
Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009;339:b3914. [Medline].
[Guideline] Lewis D, Ashwal S, Hershey A, Hirtz D, Yonker M, Silberstein S, et al. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology. Dec 28 2004;63(12):2215-24. [Medline]. [Full Text].
American Academy of Pediatrics. Clinical Practice Guideline: Management of sinusitis. Pediatrics. 2000;108(3):798-808.
Bechtel K. Acute mental status change due to acute confusional migraine. Pediatr Emerg Care. Apr 2004;20(4):238-41. [Medline].
Bille BS. Migraine in school children. A study of the incidence and short-term prognosis, and a clinical, psychological and electroencephalographic comparison between children with migraine and matched controls. Acta Paediatr Suppl. May 1962;136:1-151. [Medline].
Clement PA, Bluestone CD, Gordts F, et al. Management of rhinosinusitis in children. Int J Pediatr Otorhinolaryngol. Oct 5 1999;49 Suppl 1:S95-100. [Medline].
Fleisher DR, Matar M. The cyclic vomiting syndrome: a report of 71 cases and literature review. J Pediatr Gastroenterol Nutr. Nov 1993;17(4):361-9. [Medline].
Haslam R. Nelson's Textbook of Pediatrics. In: Behrman RE, Kleigman RM, Arvin AM, eds. Headaches-migraine. WB Saunders; 1996:1702-3.
Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. Cephalalgia. 1988;8 Suppl 7:1-96. [Medline].
Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia. 2004;24 Suppl 1:9-160. [Medline].
Hoffman G. Headache and facial pain. In: Tintinalli JE, ed. Emergency Medicine: A Comprehensive Study Guide. 4th ed. 1996:1008-14.
Kaniecki RG, Totten J. Cervicalgia in migraine: prevalence, clinical characteristics, and response to treatment. Cephalalgia. 2001;21:296.
Landy S. Migraine throughout the life cycle: treatment through the ages. Neurology. Mar 9 2004;62(5 Suppl 2):S2-8. [Medline].
Laurell K, Larsson B, Eeg-Olofsson O. Prevalence of headache in Swedish schoolchildren, with a focus on tension-type headache. Cephalalgia. May 2004;24(5):380-8. [Medline].
Lee LH, Levey EB. Formulary/special drug topics. In: Barone MB, ed. The Harriet Lane Handbook. Mosby Publishing Co; 1996:480-643.
Lewis DW. Headaches in children and adolescents. Curr Probl Pediatr Adolesc Health Care. Jul 2007;37(6):207-46. [Medline].
Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache. Jul-Aug 2001;41(7):646-57. [Medline].
Neinstein L, Milgrom E. Trauma-triggered migraine and acute confusional migraine. J Adolesc Health. Aug 2000;27(2):119-24. [Medline].
Olesen J, Larsen B, Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol. Apr 1981;9(4):344-52. [Medline].
Packer RJ, Berman PH. Emergency Medicine. Neurologic emergencies. In: Fleisher G, Ludwig S, et al, eds. Textbook of Pediatric. 1993:582-4.
Prensky A. Headache. Oski F, et al. Principles and Practice of Pediatrics. Neurology. 1990;1947-50.
Ramadan NM. Targeting therapy for migraine: what to treat?. Neurology. May 24 2005;64(10 Suppl 2):S4-8. [Medline].
Silberstein SD, Olesen J, Bousser MG, et al. The International Classification of Headache Disorders, 2nd Edition (ICHD-II)--revision of criteria for 8.2 Medication-overuse headache. Cephalalgia. Jun 2005;25(6):460-5. [Medline].
Stickler GB. Relationship between cyclic vomiting syndrome and migraine. Clin Pediatr (Phila). Jul-Aug 2005;44(6):505-8. [Medline].
Welch KM. Contemporary concepts of migraine pathogenesis. Neurology. Oct 28 2003;61(8 Suppl 4):S2-8. [Medline].
Wober-Bingol C, Wober C, Wagner-Ennsgraber C, et al. IHS criteria for migraine and tension-type headache in children and adolescents. Headache. Apr 1996;36(4):231-8. [Medline].
Zidverc-Trajkovic J, Pekmezovic T, Jovanovic Z, et al. Medication overuse headache: clinical features predicting treatment outcome at 1-year follow-up. Cephalalgia. Nov 2007;27(11):1219-25. [Medline].

