Hand-Foot-and-Mouth Disease in Emergency Medicine Differential Diagnoses
- Author: Pamela L Dyne, MD; Chief Editor: Russell W Steele, MD more...
A review by Nassef et al reported that atypical manifestations of hand-foot-and-mouth disease in children with atopic dermatitis may mimic herpetic superinfection. The authors further add that in a child presenting with nail changes, physicians should consider antecedent hand-foot-and-mouth disease in the differential diagnosis.
Pediatrics, Henoch-Schönlein Purpura
Suzuki Y, Taya K, Nakashima K, et al. Study on Risk Factors for Severe Hand-foot-and-mouth Disease. Pediatr Int. 2009 Aug 3. [Medline].
Wolff K, Johnson RA, Suurmond D. Viral infections of skin and mucosa. Fitzpatrick's Color Atlas & Synopsis of Clinical Dermatology. 5th ed. New York, NY: McGraw-Hill; 2005. 790-92.
Lott JP, Liu K, Landry ML, Nix WA, Oberste MS, Bolognia J, et al. Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection. J Am Acad Dermatol. 2013 Nov. 69(5):736-41. [Medline].
Nassef C, Ziemer C, Morrell DS. Hand-foot-and-mouth disease: a new look at a classic viral rash. Curr Opin Pediatr. 2015 Aug. 27 (4):486-91. [Medline].
Hopper SM, McCarthy M, Tancharoen C, Lee KJ, Davidson A, Babl FE. Topical Lidocaine to Improve Oral Intake in Children With Painful Infectious Mouth Ulcers: A Blinded, Randomized, Placebo-Controlled Trial. Ann Emerg Med. 2013 Nov 7. [Medline].
Chang LY, Tsao KC, Hsia SH, et al. Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan. JAMA. 2004 Jan 14. 291(2):222-7. [Medline].
Chen KT, Chang HL, Wang ST, Cheng YT, Yang JY. Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005. Pediatrics. 2007 Aug. 120(2):e244-52. [Medline].
Cherry JD. Enteroviruses: polioviruses, coxsackieviruses, echoviruses and enteroviruses. Textbook of Pediatric Infectious Diseases. 5th ed. 2005. 2007.
Cherry JD. Viral exanthems. Curr Probl Pediatr. 1983 Apr. 13(6):1-44. [Medline].
Davis H, Karasic R. Pediatric infectious disease. Atlas of Pediatric Physical Diagnosis. 3rd ed. 1997. 347-8.
Marks M. Viral and presumably viral syndromes. Pediatric Infectious Diseases for the Practitioner. 1985. 494-6.
Sasidharan CK, Sugathan P, Agarwal R, et al. Hand-foot-and-mouth disease in Calicut. Indian J Pediatr. 2005 Jan. 72(1):17-21. [Medline].
Wang CY, Li Lu F, Wu MH, et al. Fatal coxsackievirus A16 infection. Pediatr Infect Dis J. 2004 Mar. 23(3):275-6. [Medline].