Pediatric Pharyngitis Clinical Presentation

  • Author: Harold K Simon, MD, MBA; Chief Editor: Richard G Bachur, MD   more...
 
Updated: Apr 24, 2012
 

History

The clinical differentiation of the possible pathogens of pharyngitis often is difficult based on history or physical examination. In 1962, Feinstein et al wrote, "The only typical feature of streptococcal infections is their failure to show a single, consistent, typical feature."

  • History of exposure to known carriers
  • Fever
  • Sore throat
  • Headache
  • Abdominal pain
  • Anorexia
  • Chills
  • Malaise
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Physical

While no single or combination of physical findings is specific for distinguishing GABHS from viral etiologies, several items on physical examination are suggestive.

  • Enlarged tonsils
  • Pharyngeal erythema
  • Tonsillar exudates with necrotic crypts
  • Soft-palate petechiae
  • Tender cervical adenopathy
  • Fever
  • Scarlet fever rash (punctate erythematous macules and fine papules with reddened flexor creases and circumoral pallor), the so-called sandpaper rash
  • Conjunctivitis (more commonly with adenovirus infections)
  • Viral pharyngitis usually is associated with sneezing, rhinorrhea, and cough.
  • Mononucleosis typically is exudative with extensive false membranes.
  • Herpangina (usually coxsackievirus A) is associated with papulovesicular lesions.
  • Diphtheria, which is rare in developed countries, is associated with a thick gray membrane that is difficult to remove.
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Causes

  • Acute bacterial pharyngitis
    • Group A beta-hemolytic streptococci
    • N gonorrhoeae
    • C diphtheriae
    • H influenzae
    • Moraxella (Branhamella) catarrhalis
    • Group C and G streptococci (rare)
  • Acute viral pharyngitis
    • Rhinovirus
    • Adenovirus
    • Parainfluenza virus
    • Coxsackievirus
    • Coronavirus
    • Echovirus
    • Epstein-Barr virus (mononucleosis)
    • Cytomegalovirus
  • Chronic pharyngitis (usually noninfectious)
    • Irritation from postnasal discharge of chronic allergic rhinitis
    • Chemical irritation
    • Neoplasms and vasculitides
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Contributor Information and Disclosures
Author

Harold K Simon, MD, MBA  Professor of Pediatrics and Emergency Medicine, Associate Division Director of Pediatric Emergency Medicine, Director of Research, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Children's Healthcare of Atlanta at Egleston

Harold K Simon, MD, MBA is a member of the following medical societies: Ambulatory Pediatric Association, American Academy of Pediatrics, American Pediatric Society, and Sigma Xi

Disclosure: Nothing to disclose.

Specialty Editor Board

Garry Wilkes, MBBS, FACEM  Director of Emergency Medicine, Calvary Hospital, Canberra, ACT; Adjunct Associate Professor, Edith Cowan University, Western Australia

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Grace M Young, MD  Associate Professor, Department of Pediatrics, University of Maryland Medical Center

Grace M Young, MD is a member of the following medical societies: American Academy of Pediatrics and American College of Emergency Physicians

Disclosure: Nothing to disclose.

John D Halamka, MD, MS  Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center

John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Chief Editor

Richard G Bachur, MD  Associate Professor of Pediatrics, Harvard Medical School; Associate Chief and Fellowship Director, Attending Physician, Division of Emergency Medicine, Children's Hospital of Boston

Richard G Bachur, MD is a member of the following medical societies: American Academy of Pediatrics, Society for Academic Emergency Medicine, and Society for Pediatric Research

Disclosure: Nothing to disclose.

References
  1. Ayanruoh S, Waseem M, Quee F, Humphrey A, Reynolds T. Impact of rapid streptococcal test on antibiotic use in a pediatric emergency department. Pediatr Emerg Care. Nov 2009;25(11):748-50. [Medline].

  2. [Guideline] Michigan Quality Improvement Consortium. Acute pharyngitis in children. Southfield (MI): Michigan Quality Improvement Consortium; 2009 Jan.

  3. Altamimi S, Khalil A, Khalaiwi KA, Milner R, Pusic MV, Al Othman MA. Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children. Cochrane Database Syst Rev. Jan 21 2009;CD004872. [Medline].

  4. Bulloch B, Kabani A, Tenenbein M. Oral dexamethasone for the treatment of pain in children with acute pharyngitis: a randomized, double-blind, placebo-controlled trial. Ann Emerg Med. May 2003;41(5):601-8. [Medline].

  5. Wing A, Villa-Roel C, Yeh B, Eskin B, Buckingham J, Rowe B. Effectiveness of Corticosteroid Treatment in Acute Pharyngitis: A Systematic Review of the Literature. Acad Emerg Med. May 2010;17:473-483.

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  13. Marvez-Valls EG, Stuckey A, Ernst AA. A randomized clinical trial of oral versus intramuscular delivery of steroids in acute exudative pharyngitis. Acad Emerg Med. Jan 2002;9(1):9-14. [Medline].

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  15. Pichichero ME. Controversies in the treatment of streptococcal pharyngitis. Am Fam Physician. Dec 1990;42(6):1567-76. [Medline].

  16. Roosevelt GE, Kulkarni MS, Shulman ST. Critical evaluation of a CLIA-waived streptococcal antigen detection test in the emergency department. Ann Emerg Med. Apr 2001;37(4):377-81. [Medline].

  17. Snellman LW, Stang HJ, Stang JM. Duration of positive throat cultures for group A streptococci after initiation of antibiotic therapy. Pediatrics. Jun 1993;91(6):1166-70. [Medline].

  18. Van Cauwenberge PB, Vander Mijnsbrugge A. Pharyngitis: a survey of the microbiologic etiology. Pediatr Infect Dis J. Oct 1991;10(10 Suppl):S39-42. [Medline].

  19. Wannamaker LW, Rammelkamp CH, Denny FW, et al. Prophylaxis of acute rheumatic fever by treatment of the preceding streptococcal infection with various amounts of depot penicillin. Am J Med. Jun 1951;10(6):673-95. [Medline].

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