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Roseola Infantum in Emergency Medicine Follow-up

  • Author: Lisa S Lewis, MD; Chief Editor: Kirsten A Bechtel, MD  more...
 
Updated: Jan 15, 2015
 

Deterrence/Prevention

Because of the ubiquity of the virus, isolation of patients with HHV-6 infection is probably unnecessary.

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Complications

Complications of roseola infantum may include the following:

  • Meningitis
    • According to Yoshikawa and Asano, the presence of HHV-6 in cerebrospinal fluid has been demonstrated by polymerase chain reaction in 3 of 8 children with febrile seizures and in 3 of 3 children with encephalitis.[10]
    • CNS primary invasion and complications by HHV-6 appear to occur during the acute febrile portion of the illness.
  • Latency - Like other herpes viruses, HHV-6 and HHV-7 may persist in the salivary glands, peripheral blood, and brain.[11] HHV-6 may reactivate following organ or marrow transplant and may mimic graft versus host disease. It additionally may have a possible role in the development of temporal lobe epilepsy in immunocompromised patients,[12] as well as the flare and severity of drug-induced hypersensitivity syndromes.[13]
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Prognosis

See the list below:

  • The clinical course of roseola infantum is acute and benign, and complete recovery without sequelae is expected.
  • The skin eruption gradually fades and resolves without scarring.
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Patient Education

For excellent patient education resources, visit eMedicine's Children's Health Center. Also, see eMedicine's patient education article Skin Rashes in Children.

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Contributor Information and Disclosures
Author

Lisa S Lewis, MD Attending Physician, Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center

Lisa S Lewis, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Grace M Young, MD Associate Professor, Department of Pediatrics, University of Maryland Medical Center

Grace M Young, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Emergency Physicians

Disclosure: Nothing to disclose.

Chief Editor

Kirsten A Bechtel, MD Associate Professor of Pediatrics, Section of Pediatric Emergency Medicine, Yale University School of Medicine; Co-Director, Injury Free Coalition for Kids, Yale-New Haven Children's Hospital

Kirsten A Bechtel, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Additional Contributors

Garry Wilkes, MBBS, FACEM Director of Clinical Training (Simulation), Fiona Stanley Hospital; Clinical Associate Professor, University of Western Australia; Adjunct Associate Professor, Edith Cowan University, Western Australia

Disclosure: Nothing to disclose.

References
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Discrete rose-pink macules/maculopapules characteristic of roseola infantum.
 
 
 
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