Updated: Jul 23, 2008
Background
Personality disorders are pervasive, persistent, inflexible, maladaptive patterns of behavior that deviate from expected cultural norms. The most common etiology is multifactorial; however, personality disorders may be secondary to biologic, developmental, or genetic abnormalities. Stressful situations may often result in decompensation, revealing a previously unrecognized personality disorder. Indeed, personality disorders are aggravated by stressors, external or self-induced.
A concept has emerged that personality may be expressed in terms of 5 basic dimensions: extraversion, agreeableness, conscientiousness, neuroticism, and openness to experience.1 This model is termed the 5-factor model, and it has developed a significant amount of acceptance among personality psychologists.
Pathophysiology
Abnormalities may be seen in the frontal, temporal, and parietal lobes. These abnormalities may be caused by perinatal injury, encephalitis, trauma, or genetics. Personality disorders are also seen with diminished monoamine oxidase (MAO) and serotonin levels. Relationships of anatomy, receptors, and neurotransmitters to personality disorders are purely speculative at this point.
Frequently, a history of psychiatric disorders is present. Developmental abnormalities secondary to abuse or incest may be present.
The 5-factor model has been used to describe the different accepted types of personality disorders. Most current research suggests that personality disorders may be differentiated by their interactions among the 5 dimensions rather than differences on any single dimension.
Frequency: Approximately 5-10% of the general population is affected.
Mortality/Morbidity: Risk of death is usually related to conditions or behaviors resulting from the disorder, such as suicide, substance abuse, or injuries from motor vehicle accidents and fighting.
Sex: Antisocial disorders occur more frequently in men than in women. Borderline, histrionic, and dependent disorders are present more commonly in women than in men.
Age: Personality disorders first become apparent in adolescence or early adulthood.
Personality disorders are grouped into 3 clusters. The odd or eccentric group is cluster A; the dramatic, emotional, and erratic group is cluster B; and the anxious and fearful group is cluster C.
Cluster A
Cluster B
Cluster C
| Anxiety | Toxicity, Amphetamine |
| Axis I disorder | Toxicity, Barbiturate |
| Cushing Syndrome | Toxicity, Cocaine |
| Hyperthyroidism, Thyroid Storm, and Graves
Disease | Toxicity, MDMA |
| Mood or anxiety disorder | Toxicity, Methamphetamine |
| Organic abnormality | Toxicity, Narcotics |
| Posttraumatic stress disorder | |
| Substance abuse | |
| Toxicity, Alcohols |
Consider an organic etiology first. Remain tough-minded but caring. Assist the patient in gaining control of behavior without increasing destructive impulses. Avoid the danger of countertransference. Medication is not advisable, unless an underlying mood disorder accompanies the personality disorder. Some empirical evidence suggests that psychotherapy is beneficial.
Cluster A
Cluster B
Cluster C
Medication is rarely necessary. Differentiating personality disorders from pure mood disorders is important. Patients with mood disorders will benefit from medication, particularly selective serotonin reuptake inhibitors. Patients with personality disorders and manifesting comorbid mood disorder require close medical supervision in terms of initiation and following of medication therapy.
Patients with personality disorders are prone to benzodiazepine abuse.
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Scully J. Personality disorders. In: National Medical Series for Independent Study Psychiatry. 1996:259-71.
personality disorder, behavioral disorder, borderline personality, obsessive-compulsive, psychopathy, psychopath, paranoia, paranoid, schizoid personality, schizoid, schizotypical personality, antisocial, character disorder, sociopathy, sociopath, psychopathy, hysteria, paranoid personality disorder, schizoid personality disorder, schizotypal personality disorder, antisocial personality disorder, borderline personality disorder, histrionic personality disorder, narcissistic personality disorder, avoidant personality disorder, dependentpersonality disorder, obsessive-compulsive personality disorder, OCD, Minnesota Multiphasic Personality Inventory, MMPI, psychiatric disorder, mood disorder, substance abuse, suicide, alcoholism, delusional disorder, schizophrenia, depression, obsessive-compulsive disorder, anxiety disorder, somatization disorder, posttraumatic stress disorder, bulimia, anorexia nervosa, social phobia
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