Chronic Obstructive Pulmonary Disease and Emphysema in Emergency Medicine Clinical Presentation
- Author: Paul Kleinschmidt, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP more...
History
Patients with chronic obstructive pulmonary disease (COPD) present with a combination of signs and symptoms of chronic bronchitis, emphysema, and asthma. Symptoms include worsening dyspnea, progressive exercise intolerance, and alteration in mental status. In addition, some important clinical and historical differences can exist between the types of COPD.
- In the chronic bronchitis group, classic symptoms include the following:
- Productive cough, with progression over time to intermittent dyspnea
- Frequent and recurrent pulmonary infections
- Progressive cardiac/respiratory failure over time, with edema and weight gain
- In the emphysema group, the history is somewhat different and may include the following set of classic symptoms:
- A long history of progressive dyspnea with late onset of nonproductive cough
- Occasional mucopurulent relapses
- Eventual cachexia and respiratory failure
Physical
Depending on the type of chronic obstructive pulmonary disease (COPD), physical examination may vary.
- Chronic bronchitis (blue bloaters)
- Patients may be obese.
- Frequent cough and expectoration are typical.
- Use of accessory muscles of respiration is common.
- Coarse rhonchi and wheezing may be heard on auscultation.
- Patients may have signs of right heart failure (ie, cor pulmonale), such as edema and cyanosis.
- Because they share many of the same physical signs, COPD may be difficult to distinguish from congestive heart failure (CHF). One crude bedside test for distinguishing COPD from CHF is peak expiratory flow. If patients blow 150-200 mL or less, they are probably having a COPD exacerbation; higher flows indicate a probable CHF exacerbation.
- Emphysema (pink puffers)
- Patients may be very thin with a barrel chest.
- They typically have little or no cough or expectoration.
- Breathing may be assisted by pursed lips and use of accessory respiratory muscles; they may adopt the tripod sitting position.
- The chest may be hyperresonant, and wheezing may be heard; heart sounds are very distant.
- Overall appearance is more like classic COPD exacerbation.
Causes
In general, the vast majority of chronic obstructive pulmonary disease (COPD) cases are the direct result of tobacco abuse.[3] While other causes are known, such as alpha-1 antitrypsin deficiency, cystic fibrosis, air pollution, occupational exposure (eg, firefighters), and bronchiectasis, this is a disease process that is somewhat unique in its direct correlation to a human activity.
Hurst JR, Vestbo J, Anzueto A, Locantore N, Müllerova H, Tal-Singer R, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. Sep 16 2010;363(12):1128-38. [Medline].
Siddiqi A, Sethi S. Optimizing antibiotic selection in treating COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2008;3(1):31-44. [Medline].
[Guideline] Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Bethesda (MD): Global Initiative for Chronic Obstructive Lung Disease (GOLD). 2008;[Full Text].
[Best Evidence] Austin MA, Wills KE, Blizzard L, Walters EH, Wood-Baker R. Effect of high flow oxygen on mortality in chronic obstructive pulmonary disease patients in prehospital setting: randomised controlled trial. BMJ. Oct 18 2010;341:c5462. [Medline]. [Full Text].
Pierson DJ. Indications for mechanical ventilation in adults with acute respiratory failure. Respir Care. Mar 2002;47(3):249-62; discussion 262-5. [Medline].
Hanania NA, Donohue JF. Pharmacologic interventions in chronic obstructive pulmonary disease: bronchodilators. Proc Am Thorac Soc. Oct 1 2007;4(7):526-34. [Medline].
Barr RG, Rowe BH, Camargo CA Jr. Methyl-xanthines for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2001;(1):CD002168. [Medline].
Puhan MA, Vollenweider D, Latshang T, Steurer J, Steurer-Stey C. Exacerbations of chronic obstructive pulmonary disease: when are antibiotics indicated? A systematic review. Respir Res. 2007;8:30. [Medline].
Rothberg MB, Pekow PS, Lahti M, Brody O, Skiest DJ, Lindenauer PK. Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease. JAMA. May 26 2010;303(20):2035-42. [Medline].
Daniels JM, Snijders D, de Graaff CS, Vlaspolder F, Jansen HM, Boersma WG. Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. Jan 15 2010;181(2):150-7. [Medline].
Balter M, Weiss K. Treating acute exacerbations of chronic bronchitis and community-acquired pneumonia: how effective are respiratory fluoroquinolones?. Can Fam Physician. Oct 2006;52(10):1236-42. [Medline].
[Guideline] Balter MS, La Forge J, Low DE, Mandell L, Grossman RF. Canadian guidelines for the management of acute exacerbations of chronic bronchitis. Can Respir J. Jul-Aug 2003;10 Suppl B:3B-32B. [Medline].
Aaron SD, Vandemheen KL, Hebert P, Dales R, Stiell IG, Ahuja J, et al. Outpatient oral prednisone after emergency treatment of chronic obstructive pulmonary disease. N Engl J Med. Jun 26 2003;348(26):2618-25. [Medline].
Alter HJ, Koepsell TD, Hilty WM. Intravenous magnesium as an adjuvant in acute bronchospasm: a meta-analysis. Ann Emerg Med. Sep 2000;36(3):191-7. [Medline].
Baigorri F, Joseph D, Artigas A, Blanch L. Inhaled nitric oxide does not improve cardiac or pulmonary function in patients with an exacerbation of chronic obstructive pulmonary disease. Crit Care Med. Oct 1999;27(10):2153-8. [Medline].
Curtis JL, Freeman CM, Hogg JC. The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research. Proc Am Thorac Soc. Oct 1 2007;4(7):512-21. [Medline].
Cydulka RK, Emerman CL. Effects of combined treatment with glycopyrrolate and albuterol in acute exacerbation of chronic obstructive pulmonary disease. Ann Emerg Med. Apr 1995;25(4):470-3. [Medline].
Dailey RH. Chronic obstructive pulmonary disease. In: Rosen P, et al, eds. Emergency Medicine Concepts and Clinical Practice. 3rd ed. Mosby-Year Book Inc; 1992:1093-1111.
de Palo VA. Pulmonary disease: pneumonia, chronic obstructive pulmonary disease, asthma, and thromboembolic disease. J Am Podiatr Med Assoc. Mar-Apr 2004;94(2):157-67. [Medline].
Dewan NA, Daniels A, Zieman G, Kramer T. The National Outcomes Management Project: a benchmarking collaborative. J Behav Health Serv Res. Nov 2000;27(4):431-6. [Medline].
Faulkner MA, Hilleman DE. Pharmacologic treatment of chronic obstructive pulmonary disease: past, present, and future. Pharmacotherapy. Oct 2003;23(10):1300-15. [Medline].
Ferguson GT, Cherniack RM. Management of chronic obstructive pulmonary disease. N Engl J Med. Apr 8 1993;328(14):1017-22. [Medline].
FitzGerald JM, Shragge D, Haddon J, Jennings B, Lee J, Bai T, et al. A randomized, controlled trial of high dose, inhaled budesonide versus oral prednisone in patients discharged from the emergency department following an acute asthma exacerbation. Can Respir J. Jan-Feb 2000;7(1):61-7. [Medline].
Fromm RE Jr, Varon J. Acute exacerbations of obstructive lung disease. What to do when immediate care is crucial. Postgrad Med. Jun 1994;95(8):101-6. [Medline].
Greenfield RH. Pulmonary disease in the elderly. Lecture presented at the ACEP Scientific Assembly. 1994. [Medline].
Hirschmann JV. Do bacteria cause exacerbations of COPD?. Chest. Jul 2000;118(1):193-203. [Medline].
Hirshberg AJ, Dupper RL. Use of doxapram hydrochloride injection as an alternative to intubation to treat chronic obstructive pulmonary disease patients with hypercapnia. Ann Emerg Med. Oct 1994;24(4):701-3. [Medline].
Ingram RH. Harrison's Principles of Internal Medicine. In: Fauci AS, et al, eds. Chronic bronchitis, emphysema, and airway obstruction. McGraw-Hill Companies: 1991:1074-1082.
Jaber S, Fodil R, Carlucci A, Boussarsar M, Pigeot J, Lemaire F, et al. Noninvasive ventilation with helium-oxygen in acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. Apr 2000;161(4 Pt 1):1191-200. [Medline].
Kino RJ. The difficult COPD patient: Alternative therapy regimens. Lecture presented at the ACEP Scientific Assembly. 1996.
Korosec M, Novak RD, Myers E, Skowronski M, McFadden ER Jr. Salmeterol does not compromise the bronchodilator response to albuterol during acute episodes of asthma. Am J Med. Sep 1999;107(3):209-13. [Medline].
Lieberman D, Lieberman D, Ben-Yaakov M, Lazarovich Z, Hoffman S, Ohana B, et al. Infectious etiologies in acute exacerbation of COPD. Diagn Microbiol Infect Dis. Jul 2001;40(3):95-102. [Medline].
Maltais F, Ostinelli J, Bourbeau J, Tonnel AB, Jacquemet N, Haddon J, et al. Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial. Am J Respir Crit Care Med. Mar 1 2002;165(5):698-703. [Medline].
Peng CC, Aspinall SL, Good CB, Atwood CW Jr, Chang CC. Equal effectiveness of older traditional antibiotics and newer broad-spectrum antibiotics in treating patients with acute exacerbations of chronic bronchitis. South Med J. Oct 2003;96(10):986-91. [Medline].
Saint S, Bent S, Vittinghoff E, Grady D. Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis. JAMA. Mar 22-29 1995;273(12):957-60. [Medline].
Schmidt GA, Hall JB. Acute or chronic respiratory failure. Assessment and management of patients with COPD in the emergency setting. JAMA. Jun 16 1989;261(23):3444-53. [Medline].
Sclar DA, Legg RF, Skaer TL, Robison LM, Nemic NL. Ipratropium bromide in the management of chronic obstructive pulmonary disease: effect on health service expenditures. Clin Ther. May-Jun 1994;16(3):595-601; discussion 594. [Medline].
Siedman JC. Chronic obstructive pulmonary disease. In: Tintinalli J, et al, eds. Emergency Medicine: A Comprehensive Study Guide. McGraw-Hill Co; 1992:298-302.
Skorodin MS. Pharmacotherapy for asthma and chronic obstructive pulmonary disease. Current thinking, practices, and controversies. Arch Intern Med. Apr 12 1993;153(7):814-28. [Medline].
Skorodin MS, Tenholder MF, Yetter B, Owen KA, Waller RF, Khandelwahl S, et al. Magnesium sulfate in exacerbations of chronic obstructive pulmonary disease. Arch Intern Med. Mar 13 1995;155(5):496-500. [Medline].
Sohy C, Pilette C, Niederman MS, Sibille Y. Acute exacerbation of chronic obstructive pulmonary disease and antibiotics: what studies are still needed?. Eur Respir J. May 2002;19(5):966-75. [Medline].
Stewart AG, Waterhouse JC, Billings CG, Baylis P, Howard P. Effects of angiotensin converting enzyme inhibition on sodium excretion in patients with hypoxaemic chronic obstructive pulmonary disease. Thorax. Oct 1994;49(10):995-8. [Medline].
US Department of Health and Human Services, National Institutes of Health, Third Expert Panel on the Diagnosis and Management of Asthma. National Heart, Lung and Blood Institute National Asthma Education and Prevention Program. 2007. Washington, DC: US Department of Health and Human Services; August 28, 2007. 1-404.
Varkey B. Obstructive, occupational, and environmental diseases. Curr Opin Pulm Med. Mar 2004;10(2):97. [Medline].
[Guideline] Whittle A. COPD guidelines. Thorax. Apr 1999;54(4):375-6. [Medline].
Zehner WJ Jr, Scott JM, Iannolo PM, Ungaro A, Terndrup TE. Terbutaline vs albuterol for out-of-hospital respiratory distress: randomized, double-blind trial. Acad Emerg Med. Aug 1995;2(8):686-91. [Medline].

