Hydrogen Sulfide Toxicity Medication
- Author: Sujal Mandavia, MD, FRCP(C), FACEP; Chief Editor: Asim Tarabar, MD more...
Medication Summary
Treatment of hydrogen sulfide (H2 S) poisoning is based on the creation of methemoglobinemia.
Nitrites
Class Summary
Nitrite administration leads to formation of methemoglobinemia. H2 S has a much greater affinity for methemoglobin than for cellular cytochromes, leading to lower metabolic toxicity.
Sodium nitrite
Initial DOC in hydrogen sulfide poisoning.
Bronchodilators
Class Summary
These agents are effective in reversing acute bronchospasm of allergic or irritant origin through combined alpha-adrenergic and beta-adrenergic agonist action.
An additional option in the management of persistent bronchospasm involves anticholinergics. These agents block action of acetylcholine at parasympathetic sites in bronchial smooth muscle, causing bronchodilation.
Albuterol (Ventolin, Proventil)
Beta agonist useful in treatment of bronchospasm refractory to epinephrine. Relaxes bronchial smooth muscle by acting on beta2 receptors with little effect on heart rate.
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