Clonidine Toxicity Medication
- Author: David Riley, MD, MSc; Chief Editor: Asim Tarabar, MD more...
In general, treat with supportive care. Administer activated charcoal to all patients at risk for aspiration after intubation. Temporary support for symptomatic cardiovascular effects of clonidine also may be necessary.
Used to elevate blood pressure and heart rate in patients who already have been adequately volume resuscitated and remain in shock.
DOC in patients with clonidine toxicity who remain hypotensive after IVF. Stimulates adrenergic and dopaminergic receptors. Hemodynamic effect is dependent on dose. Lower doses predominantly stimulate dopaminergic receptors that, in turn, produce renal and mesenteric vasodilation. Higher doses produce cardiac stimulation and renal vasodilation.
Vagolytic for patients with bradycardia (eg, SA or AV nodal block).
Doses < 0.5 mg can produce a paradoxical reaction.
May improve level of consciousness.
Absolute benefits are unproven and rates of success vary. Consider a drip if significant improvement results.
Empirically used to minimize systemic absorption of the toxin. Most effective if administered within 4 h of ingestion.
Emergency treatment in poisoning caused by drugs and chemicals. Network of pores present in activated charcoal adsorbs 100-1000 mg of drug per gram of charcoal. Does not dissolve in water.
For maximum effect, administer within 30 min of ingesting poison.
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