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Toxicity, Phosgene: Multimedia
Updated: Jul 10, 2008
Multimedia
![]() | Media file 1: British machine-gunners in anti-phosgene masks, Somme, 1915. (Photograph courtesy of the Imperial War Museum, London) |
![]() | Media file 2: Phosgene structure. |
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References
Balmes J. Phosgene. In: Olson KR, ed. Poisoning and Drug Overdose. 2nd ed. Appleton & Lange; 1994:256.
Bardana EJ. 8. Occupational asthma and allergies. J Allergy Clin Immunol. Feb 2003;111(2 Suppl):S530-9. [Medline].
Borak J, Diller WF. Phosgene exposure: mechanisms of injury and treatment strategies. J Occup Environ Med. Feb 2001;43(2):110-9. [Medline].
British War Office. Medical Manual of Chemical Warfare. London: 1941:31-38.
Dombi A, Fekete ZA, Kiricsi I. In Situ Photocatalytic Reactor with FT-IR Analysis for Heterogeneous Catalytic Studies. Applied Catalysis. 2000;193:L5-L8.
Ellenhorn MJ. Chemical warfare. In: Ellenhorn's Medical Toxicology. 2nd ed. Lippincott Williams & Wilkins; 1997:1301-2.
Kennedy TP, Michael JR, Hoidal JR, et al. Dibutyryl cAMP, aminophylline, and beta-adrenergic agonists protect against pulmonary edema caused by phosgene. J Appl Physiol. Dec 1989;67(6):2542-52. [Medline].
Nelson LS. Simple asphyxiants and pulmonary irritants. In: Goldfrank L, ed. Goldfrank's Toxicologic Emergencies. 6th ed. New York: McGraw-Hill; 1998:1530.
Ng TP, Tsin TW, O'Kelly FJ. An outbreak of illness after occupational exposure to ozone and acid chlorides. Br J Ind Med. Oct 1985;42(10):686-90. [Medline].
Noort D, Hulst AG, Fidder A, et al. In vitro adduct formation of phosgene with albumin and hemoglobin in human blood. Chem Res Toxicol. Aug 2000;13(8):719-26. [Medline].
Parkhouse DA, Brown RF, Jugg BJ, Harban FM, Platt J, Kenward CE. Protective ventilation strategies in the management of phosgene-induced acute lung injury. Mil Med. Mar 2007;172(3):295-300. [Medline].
Parrish JS, Bradshaw DA. Toxic inhalational injury: gas, vapor and vesicant exposure. Respir Care Clin N Am. Mar 2004;10(1):43-58. [Medline].
Phosgene Medical Experts Group. Phosgene: Information on Options for First Aid and Medical Treatment. American Chemistry Council: Phosgene Panel. Available at http://www.americanchemistry.com/s_acc/bin.asp?CID=1175&DID=4396&DOC=FILE.PDF. Accessed 3/3/2008.
Schelble DT. Phosgene and phosphine. In: Haddad LM, Shannon MW, Winchester J, eds. Clinical Management of Poisoning and Drug Overdose. 3rd ed. Philadelphia: WB Saunders; 1998:960-3.
Sciuto AM. Assessment of early acute lung injury in rodents exposed to phosgene. Arch Toxicol. Apr 1998;72(5):283-8. [Medline].
Sciuto AM, Stotts RR. Posttreatment with eicosatetraynoic acid decreases lung edema in guinea pigs exposed to phosgene: the role of leukotrienes. Exp Lung Res. May-Jun 1998;24(3):273-92. [Medline].
Sciuto AM, Stotts RR, Hurt HH. Efficacy of ibuprofen and pentoxifylline in the treatment of phosgene- induced acute lung injury. J Appl Toxicol. Sep-Oct 1996;16(5):381-4. [Medline].
Sciuto AM, Strickland PT, Kennedy TP, et al. Intratracheal administration of DBcAMP attenuates edema formation in phosgene-induced acute lung injury. J Appl Physiol. Jan 1996;80(1):149-57. [Medline].
Sciuto AM, Strickland PT, Kennedy TP, Gurtner GH. Postexposure treatment with aminophylline protects against phosgene- induced acute lung injury. Exp Lung Res. Jul-Aug 1997;23(4):317-32. [Medline].
Sciuto AM, Strickland PT, Kennedy TP, Gurtner GH. Protective effects of N-acetylcysteine treatment after phosgene exposure in rabbits. Am J Respir Crit Care Med. Mar 1995;151(3 Pt 1):768-72. [Medline].
Selden A, Sundell L. Chlorinated solvents, welding and pulmonary edema. Chest. Jan 1991;99(1):263. [Medline].
Sidell FR, Takafuji ET, Franz DR. Toxic inhalation injury. In: Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare. Walter Reed Army Medical Center; 1997:257-60.
Sjogren B, Plato N, Alexandersson R, et al. Pulmonary reactions caused by welding-induced decomposed trichloroethylene. Chest. Jan 1991;99(1):237-8. [Medline].
Snyder RW, Mishel HS, Christensen GC 3d. Pulmonary toxicity following exposure to methylene chloride and its combustion product, phosgene. Chest. Mar 1992;101(3):860-1. [Medline].
Warden CR. Respiratory agents: irritant gases, riot control agents, incapacitants, and caustics. Crit Care Clin. Oct 2005;21(4):719-37, vi. [Medline].
Weiss SJ, Lesser SH. Hazards associated with metalworking by artists. South Med J. Jul 1997;90(7):665-71. [Medline].
Further Reading
Keywords
phosgene toxicity, phosgene exposure, phosgene poisoning, COCl2, carbonic dichloride, carbon oxychloride, carbonyl dichloride, chloroformyl chloride, d-stoff, green cross, CG, pulmonary irritant






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