eMedicine Specialties > Emergency Medicine > Toxicology

Toxicity, Methamphetamine: Follow-up

Author: Robert W Derlet, MD, Professor of Emergency Medicine, University of California at Davis School of Medicine; Chief Emeritus, Emergency Department, University of California at Davis Health System
Coauthor(s): Timothy E Albertson, MD, MPH, PhD, Professor of Pharmacology and Toxicology, Division Chief and Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Vice-Chair, Department of Internal Medicine, University of California, Davis, School of Medicine; Professor of Anesthesiology, Associate Dean, Academic Clinical Programs, University of California, Davis Health System; Professor of Emergency Medicine and Clinical Toxicology, Davis Medical Center; Chief of Pulmonary and Critical Care, Veterans Affairs, Northern California Health Care System; Medical Director of Poison Control System, University of California at San Francisco, School of Pharmacy.; John R Richards, MD, FAAEM, Professor of Emergency Medicine, University of California at Davis School of Medicine
Contributor Information and Disclosures

Updated: Dec 4, 2009

Follow-up

Further Inpatient Care

  • Critical care management may be needed for patients with persistent hypertension, severe rhabdomyolysis, seizures, stroke, coma, hyperthermia, CHF, or acute coronary ischemic syndrome.

Further Outpatient Care

  • Referral to drug treatment center and/or psychiatrist may be indicated

Deterrence/Prevention

  • Methamphetamine addiction is notoriously difficult to treat successfully, as it is difficult to remove the patient from the subculture involved in the production, distribution, and abuse of the drug.

Complications

Prognosis

  • Prognosis is generally good with rapid and appropriate treatment, assuming that the patient does not present with one of the above complications.

Patient Education

Miscellaneous

Medicolegal Pitfalls

  • Failure to diagnose and treat patients with methamphetamine toxicity if they have hyperthermia or rhabdomyolysis
  • Failure to obtain a head CT scan in patients with methamphetamine toxicity who present with mental status changes that do not normalize with pharmacologic treatment; thus, failing to diagnose an intracerebral hemorrhage
  • Failure to diagnose myocardial infarction or unstable angina in methamphetamine-intoxicated patients
  • Failure to consider other cause of altered mental status which may be concomitant with methamphetamine use

Special Concerns

  • Consider the possibility of methamphetamine or amphetamine toxicity in children who present with first-time seizures; several studies have noted amphetamine-positive drug screens in this patient population.53
  • Healthcare personnel should be aware regarding blood-borne exposure and risk of HIV, hepatitis B, and hepatitis C.
 


More on Toxicity, Methamphetamine

Overview: Toxicity, Methamphetamine
Differential Diagnoses & Workup: Toxicity, Methamphetamine
Treatment & Medication: Toxicity, Methamphetamine
Follow-up: Toxicity, Methamphetamine
References

References

  1. Das-Douglas M, Colfax G, Moss AR, Bangsberg DR, Hahn JA. Tripling of Methamphetamine/Amphetamine Use among Homeless and Marginally Housed Persons, 1996-2003. J Urban Health. Dec 27 2007;[Medline].

  2. Beebe DK, Walley E. Smokable methamphetamine ('ice'): an old drug in a different form. Am Fam Physician. Feb 1 1995;51(2):449-53. [Medline].

  3. Derlet RW, Heischober B. Methamphetamine. Stimulant of the 1990s?. West J Med. Dec 1990;153(6):625-8. [Medline].

  4. Richards JR. Amphetamine derivatives. In: Cole SM. New research on street drugs. New York: Nova; 2006:chap 5.

  5. Richards JR, Bretz SW, Johnson EB, Turnipseed SD, Brofeldt BT, Derlet RW. Methamphetamine abuse and emergency department utilization. West J Med. Apr 1999;170(4):198-202. [Medline].

  6. Hendrickson RG, Cloutier R, McConnell KJ. Methamphetamine-related emergency department utilization and cost. Acad Emerg Med. Jan 2008;15(1):23-31. [Medline].

  7. Callaghan RC, Brands B, Taylor L, Lentz T. The clinical characteristics of adolescents reporting methamphetamine as their primary drug of choice: an examination of youth admitted to inpatient substance-abuse treatment in northern British Columbia, Canada, 2001-2005. J Adolesc Health. Mar 2007;40(3):286-9. [Medline].

  8. Emonson DL, Vanderbeek RD. The use of amphetamines in U.S. Air Force tactical operations during Desert Shield and Storm. Aviat Space Environ Med. Mar 1995;66(3):260-3. [Medline].

  9. National Methamphetamine Threat Assessment 2009. Available at http://www.justice.gov/ndic/pubs32/32166/index.htm. Accessed November 22, 2009.

  10. MacKenzie RG, Heischober B. Methamphetamine. Pediatr Rev. Sep 1997;18(9):305-9. [Medline].

  11. Schepers RJ, Oyler JM, Joseph RE Jr, Cone EJ, Moolchan ET, Huestis MA. Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers. Clin Chem. Jan 2003;49(1):121-32. [Medline].

  12. Cruickshank CC, Dyer KR. A review of the clinical pharmacology of methamphetamine. Addiction. Jul 2009;104(7):1085-99. [Medline].

  13. Katsumata S, Sato K, Kashiwade H, et al. Sudden death due presumably to internal use of methamphetamine. Forensic Sci Int. Dec 1993;62(3):209-15. [Medline].

  14. Kashani J, Ruha AM. Methamphetamine toxicity secondary to intravaginal body stuffing. J Toxicol Clin Toxicol. 2004;42(7):987-9. [Medline].

  15. Hayase T, Yamamoto Y, Yamamoto K, Abiru H, Nishitani Y, Fukui Y. Effects of ethanol and/or cardiovascular drugs on cocaine- and methamphetamine-induced fatal toxicities in mice. Nihon Arukoru Yakubutsu Igakkai Zasshi. Oct 1999;34(5):475-90. [Medline].

  16. Zhang JX, Zhang da M, Han XG. Identification of impurities and statistical classification of methamphetamine hydrochloride drugs seized in China. Forensic Sci Int. Nov 20 2008;182(1-3):13-9. [Medline].

  17. US warns of 'global meth threat'. Available at http://news.bbc.co.uk/2/hi/americas/4757179.stm. Accessed November 22, 2009.

  18. Logan BK. Methamphetamine and driving impairment. J Forensic Sci. May 1996;41(3):457-64. [Medline].

  19. Schermer CR, Wisner DH. Methamphetamine use in trauma patients: a population-based study. J Am Coll Surg. Nov 1999;189(5):442-9. [Medline].

  20. Diercks DB, Kirk JD, Turnipseed SD, Amsterdam EA. Evaluation of patients with methamphetamine- and cocaine-related chest pain in a chest pain observation unit. Crit Pathw Cardiol. Dec 2007;6(4):161-4. [Medline].

  21. Bashour TT. Acute myocardial infarction resulting from amphetamine abuse: a spasm- thrombus interplay?. Am Heart J. Dec 1994;128(6 Pt 1):1237-9. [Medline].

  22. He SY, Matoba R, Fujitani N, et al. Cardiac muscle lesions associated with chronic administration of methamphetamine in rats. Am J Forensic Med Pathol. Jun 1996;17(2):155-62. [Medline].

  23. Turnipseed SD, Richards JR, Kirk JD. Frequency of acute coronary syndrome in patients presenting to the emergency department with chest pain after methamphetamine use. J Emerg Med. May 2003;24(4):369-73. [Medline].

  24. Watts DJ, McCollester L. Methamphetamine-induced myocardial infarction with elevated troponin I. Am J Emerg Med. Jan 2006;24(1):132-4. [Medline].

  25. Davis GG, Swalwell CI. Acute aortic dissections and ruptured berry aneurysms associated with methamphetamine abuse. J Forensic Sci. Nov 1994;39(6):1481-5. [Medline].

  26. Gold MS, Kobeissy FH, Wang KK, Merlo LJ, Bruijnzeel AW, Krasnova IN, et al. Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates. Biol Psychiatry. July 2009;66:118-27. [Medline].

  27. Rhee KJ, Albertson TE, Douglas JC. Choreoathetoid disorder associated with amphetamine-like drugs. Am J Emerg Med. Mar 1988;6(2):131-3. [Medline].

  28. Bowyer JF, Thomas M, Schmued LC, Ali SF. Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier. Ann N Y Acad Sci. Oct 2008;1139:127-39. [Medline].

  29. Albertson TE, Walby WF, Derlet RW. Stimulant-induced pulmonary toxicity. Chest. Oct 1995;108(4):1140-9. [Medline].

  30. Nestor TA, Tamamoto WI, Kam TH, Schultz T. Crystal methamphetamine-induced acute pulmonary edema: a case report. Hawaii Med J. Nov 1989;48(11):457-8, 460. [Medline].

  31. Thompson CA. Pulmonary arterial hypertension seen in methamphetamine abusers. Am J Health Syst Pharm. Jun 15 2008;65(12):1109-10. [Medline].

  32. Cohen AL, Shuler C, McAllister S, Fosheim GE, Brown MG, Abercrombie D, et al. Methamphetamine use and methicillin-resistant Staphylococcus aureus skin infections. Emerg Infect Dis. Nov 2007;13(11):1707-13. [Medline].

  33. Johnson TD, Berenson MM. Methamphetamine-induced ischemic colitis. J Clin Gastroenterol. Dec 1991;13(6):687-9. [Medline].

  34. Richards JR, Brofeldt BT. Patterns of tooth wear associated with methamphetamine use. J Periodontol. Aug 2000;71(8):1371-4. [Medline].

  35. Hamamoto DT, Rhodus NL. Methamphetamine abuse and dentistry. Oral Dis. Jan 2009;15(1):27-37. [Medline].

  36. Haning W, Goebert D. Electrocardiographic abnormalities in methamphetamine abusers. Addiction. Apr 2007;102 Suppl 1:70-5. [Medline].

  37. Smit AA, Wieling W, Voogel AJ, Koster RW, van Zwieten PA. Orthostatic hypotension due to suppression of vasomotor outflow after amphetamine intoxication. Mayo Clin Proc. Nov 1996;71(11):1067-70. [Medline].

  38. Yeo KK, Wijetunga M, Ito H, Efird JT, Tay K, Seto TB, et al. The association of methamphetamine use and cardiomyopathy in young patients. Am J Med. Feb 2007;120(2):165-71. [Medline].

  39. Richards JR, Derlet RW, Duncan DR. Methamphetamine toxicity: treatment with a benzodiazepine versus a butyrophenone. Eur J Emerg Med. Sep 1997;4(3):130-5. [Medline].

  40. Cherner M, Letendre S, Heaton RK. Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine. Neurology. 2005;64:1343-47. [Medline].

  41. Richards JR, Johnson EB, Stark RW, Derlet RW. Methamphetamine abuse and rhabdomyolysis in the ED: a 5-year study. Am J Emerg Med. Nov 1999;17(7):681-5. [Medline].

  42. Santos AP, Wilson AK, Hornung CA, Polk HC Jr, Rodriguez JL, Franklin GA. Methamphetamine laboratory explosions: a new and emerging burn injury. J Burn Care Rehabil. May-Jun 2005;26(3):228-32. [Medline].

  43. Stewart JL, Meeker JE. Fetal and infant deaths associated with maternal methamphetamine abuse. J Anal Toxicol. Oct 1997;21(6):515-7. [Medline].

  44. Catanzarite VA, Stein DA. 'Crystal' and pregnancy--methamphetamine-associated maternal deaths. West J Med. May 1995;162(5):454-7. [Medline].

  45. Ramamoorthy JD, Ramamoorthy S, Leibach FH, Ganapathy V. Human placental monoamine transporters as targets for amphetamines. Am J Obstet Gynecol. Dec 1995;173(6):1782-7. [Medline].

  46. Mother of baby killed by meth-contaminated breast milk gets 90 days. Available at http://www.sacbee.com/ourregion/story/1955191.html. Accessed November 22, 2009.

  47. New meth formula avoids anti-drug laws. Available at http://www.msnbc.msn.com/id/32542373/ns/us_news-crime_and_courts/. Accessed November 22, 2009.

  48. Burton BT. Heavy metal and organic contaminants associated with illicit methamphetamine production. NIDA Res Monogr. 1991;115:47-59. [Medline].

  49. Conn C, Dawson M, Baker AT, et al. Identification of n-acetylmethamphetamine in a sample of illicitly synthesized methamphetamine. J Forensic Sci. Jul 1996;41(4):645-7. [Medline].

  50. McKinney PE, Tomaszewski C, Phillips S, Brent J, Kulig K. Methamphetamine toxicity prevented by activated charcoal in a mouse model. Ann Emerg Med. Aug 1994;24(2):220-3. [Medline].

  51. Derlet RW, Albertson TE, Rice P. Protection against d-amphetamine toxicity. Am J Emerg Med. Mar 1990;8(2):105-8. [Medline].

  52. Derlet RW, Rice P, Horowitz BZ, Lord RV. Amphetamine toxicity: experience with 127 cases. J Emerg Med. Mar-Apr 1989;7(2):157-61. [Medline].

  53. Matteucci MJ, Auten JD, Crowley B, Combs D, Clark RF. Methamphetamine exposures in young children. Pediatr Emerg Care. Sep 2007;23(9):638-40. [Medline].

  54. Leelahanaj T, Kongsakon R, Netrakom P. A 4-week, double-blind comparison of olanzapine with haloperidol in the treatment of amphetamine psychosis. J Med Assoc Thai. Nov 2005;88 Suppl 3:S43-52. [Medline].

  55. Misra LK, Kofoed L, Oesterheld JR, Richards GA. Olanzapine treatment of methamphetamine psychosis. J Clin Psychopharmacol. Jun 2000;20(3):393-4. [Medline].

  56. Misra L, Kofoed L. Risperidone treatment of methamphetamine psychosis. Am J Psychiatry. Aug 1997;154(8):1170. [Medline].

Further Reading

Keywords

amphetamine, meth toxicity, methamphetamine abuse, signs of methamphetamine use, ice, crystal meth, meth overdose, methamphetamine poisoning, meth side effects, methamphetamine use, stimulant, euphoria, methamphetamine intoxication, speedballing

Contributor Information and Disclosures

Author

Robert W Derlet, MD, Professor of Emergency Medicine, University of California at Davis School of Medicine; Chief Emeritus, Emergency Department, University of California at Davis Health System
Robert W Derlet, MD is a member of the following medical societies: American Academy of Emergency Medicine, American Association for the Advancement of Science, Infectious Diseases Society of America, Society for Academic Emergency Medicine, and Wilderness Medical Society
Disclosure: Nothing to disclose.

Coauthor(s)

Timothy E Albertson, MD, MPH, PhD, Professor of Pharmacology and Toxicology, Division Chief and Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Vice-Chair, Department of Internal Medicine, University of California, Davis, School of Medicine; Professor of Anesthesiology, Associate Dean, Academic Clinical Programs, University of California, Davis Health System; Professor of Emergency Medicine and Clinical Toxicology, Davis Medical Center; Chief of Pulmonary and Critical Care, Veterans Affairs, Northern California Health Care System; Medical Director of Poison Control System, University of California at San Francisco, School of Pharmacy.
Timothy E Albertson, MD, MPH, PhD is a member of the following medical societies: American College of Chest Physicians and Sigma Xi
Disclosure: Nothing to disclose.

John R Richards, MD, FAAEM, Professor of Emergency Medicine, University of California at Davis School of Medicine
John R Richards, MD, FAAEM is a member of the following medical societies: American Academy of Emergency Medicine and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Medical Editor

Edward A Michelson, MD, Program Director, Associate Professor, Department of Emergency Medicine, University Hospital Health Systems in Cleveland
Edward A Michelson, MD is a member of the following medical societies: American College of Emergency Physicians, National Association of EMS Physicians, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Pharmacy Editor

John T VanDeVoort, PharmD, Regional Director of Pharmacy, Sacred Heart & St. Joseph's Hospitals
John T VanDeVoort, PharmD is a member of the following medical societies: American Society of Health-System Pharmacists
Disclosure: Nothing to disclose.

Managing Editor

Fred Harchelroad, MD, FACMT, FAAEM, FACEP, Chair, Department of Emergency Medicine, Director of Medical Toxicology - Allegheny General Hospital, Associate Professor, Department of Emergency Medicine, Drexel University College of Medicine
Disclosure: Nothing to disclose.

CME Editor

John D Halamka, MD, MS, Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center
John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Chief Editor

Asim Tarabar, MD, Assistant Professor, Director, Medical Toxicology, Department of Emergency Medicine, Yale University School of Medicine; Consulting Staff, Department of Emergency Medicine, Yale-New Haven Hospital
Disclosure: Nothing to disclose.

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.