Thallium Toxicity Differential Diagnoses

  • Author: G Patrick Daubert, MD; Chief Editor: Asim Tarabar, MD   more...
 
Updated: Apr 11, 2011
 
 

Diagnostic Considerations

Acute intermittent porphyria

Diabetic polyneuritis

Thiamine deficiency

Poliomyelitis

Colchicine toxicity

Vinca alkaloids

Hydralazine toxicity

Selenium toxicity

Vasculitis

Botulism

Differential Diagnoses

Proceed to Workup
 
 
Contributor Information and Disclosures
Author

G Patrick Daubert, MD  Assistant Professor, Assistant Medical Director, Sacramento Division, California Poison Control System; Director of Clinical and Medical Toxicology Education, Department of Emergency Medicine, University of California, Davis Medical Center

G Patrick Daubert, MD is a member of the following medical societies: American College of Emergency Physicians, American College of Medical Toxicology, American Medical Association, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Specialty Editor Board

William K Chiang, MD  Associate Professor, Department of Emergency Medicine, New York University School of Medicine; Chief of Service, Department of Emergency Medicine, Bellevue Hospital Center

William K Chiang, MD is a member of the following medical societies: American Academy of Clinical Toxicology, American College of Medical Toxicology, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Senior Pharmacy Editor, eMedicine

Disclosure: eMedicine Salary Employment

John G Benitez, MD, MPH, FACMT, FAACT, FACPM, FAAEM,  Associate Professor, Department of Medicine, Medical Toxicology, Vanderbilt University Medical Center; Managing Director, Tennessee Poison Center

John G Benitez, MD, MPH, FACMT, FAACT, FACPM, FAAEM, is a member of the following medical societies: American Academy of Clinical Toxicology, American Academy of Emergency Medicine, American College of Medical Toxicology, American College of Preventive Medicine, Society for Academic Emergency Medicine, Undersea and Hyperbaric Medical Society, and Wilderness Medical Society

Disclosure: Nothing to disclose.

John D Halamka, MD, MS  Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center

John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Chief Editor

Asim Tarabar, MD  Assistant Professor, Director, Medical Toxicology, Department of Emergency Medicine, Yale University School of Medicine; Consulting Staff, Department of Emergency Medicine, Yale-New Haven Hospital

Disclosure: Nothing to disclose.

References
  1. Mercurio M, Hoffman RS. Thallium. In: Goldfrank's Toxicologic Emergencies. 6th ed. 1998:1349-57.

  2. Mulkey JP, Oehme FW. A review of thallium toxicity. Vet Hum Toxicol. Oct 1993;35(5):445-53. [Medline].

  3. Saddique A, Peterson CD. Thallium poisoning: a review. Vet Hum Toxicol. Feb 1983;25(1):16-22. [Medline].

  4. Rusyniak DE, Furbee RB, Kirk MA. Thallium and arsenic poisoning in a small midwestern town. Ann Emerg Med. Mar 2002;39(3):307-11. [Medline].

  5. LaDou J. Metals. In: Occupational and Environmental Medicine. 2nd ed. 1997:429-30.

  6. Galván-Arzate S, Santamaría A. Thallium toxicity. Toxicol Lett. Sep 30 1998;99(1):1-13. [Medline].

  7. Hasan M, Ali SF. Effects of thallium, nickel, and cobalt administration of the lipid peroxidation in different regions of the rat brain. Toxicol Appl Pharmacol. Jan 1981;57(1):8-13. [Medline].

  8. Hultin T, Näslund PH. Effects of thallium (I) on the structure and functions of mammalian ribosomes. Chem Biol Interact. May 1974;8(5):315-28. [Medline].

  9. Hazardous Substances Data Bank [Internet]. Bethesda (MD): National Library of Medicine (US); [Last Revision Date 2005 Jun 23; cited 2005 Nov 17]. Thallium, Elemental; Hazardous Substances Databank Number: 4496.

  10. Atsmon J, Taliansky E, Landau M, et al. Thallium poisoning in Israel. Am J Med Sci. Nov 2000;320(5):327-30. [Medline].

  11. Moore D, House I, Dixon A. Thallium poisoning. Diagnosis may be elusive but alopecia is the clue. BMJ. Jun 5 1993;306(6891):1527-9. [Medline].

  12. McMillan TM, Jacobson RR, Gross M. Neuropsychology of thallium poisoning. J Neurol Neurosurg Psychiatry. Aug 1997;63(2):247-50. [Medline].

  13. Tabandeh H, Thompson GM. Visual function in thallium toxicity. BMJ. Jul 31 1993;307(6899):324. [Medline].

  14. Tromme I, Van Neste D, Dobbelaere F, et al. Skin signs in the diagnosis of thallium poisoning. Br J Dermatol. Feb 1998;138(2):321-5. [Medline].

  15. Saha A, Sadhu HG, Karnik AB. Erosion of nails following thallium poisoning: a case report. Occup Environ Med. Jul 2004;61(7):640-2. [Medline].

  16. Lu CI, Huang CC, Chang YC, Tsai YT, Kuo HC, Chuang YH, et al. Short-term thallium intoxication: dermatological findings correlated with thallium concentration. Arch Dermatol. Jan 2007;143(1):93-8. [Medline].

  17. Shamshinova AM, Ivanina TA, Yakovlev AA, et al. Electroretinography in the diagnosis of thallium intoxication. J Hyg Epidemiol Microbiol Immunol. 1990;34(2):113-21. [Medline].

  18. Hoffman RS. Thallium toxicity and the role of Prussian blue in therapy. Toxicol Rev. 2003;22(1):29-40. [Medline].

  19. Yang Y, Brownell C, Sadrieh N, et al. Quantitative measurement of cyanide released from Prussian Blue. Clin Toxicol (Phila). Oct-Nov 2007;45(7):776-81. [Medline].

  20. Miller MA, Patel MM, Coon T. Prussian blue for treatment of thallium overdose in the US. Hosp Pharm. 2005;40:796-7.

  21. Misra UK, Kalita J, Yadav RK, et al. Thallium poisoning: emphasis on early diagnosis and response to haemodialysis. Postgrad Med J. Feb 2003;79(928):103-5. [Medline].

  22. Ammendola A, Ammendola E, Argenzio F, et al. Clinical and electrodiagnostic follow-up of an adolescent poisoned with thallium. Neurol Sci. Aug 2007;28(4):205-8. [Medline].

  23. Montes S, Soriano L, Ríos C, et al. Endogenous thiols enhance thallium toxicity. Arch Toxicol. Oct 2007;81(10):683-7. [Medline].

  24. Sharma AN, Nelson LS, Hoffman RS. Cerebrospinal fluid analysis in fatal thallium poisoning: evidence for delayed distribution into the central nervous system. Am J Forensic Med Pathol. Jun 2004;25(2):156-8. [Medline].

  25. Talas A, Wellhöner HH. Dose-dependency of Tl+ kinetics as studied in rabbits. Arch Toxicol. May 1983;53(1):9-16. [Medline].

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