Updated: Apr 23, 2009
Fractures of the hip are relatively common in adults and often lead to devastating consequences. Disability frequently results from persistent pain and limited physical mobility. Hip fractures are associated with substantial morbidity and mortality; approximately 15-20% of patients die within 1 year of fracture. Interestingly, morbidity and mortality in those older than 90 years sustaining a hip fracture were not found to be statistically higher than others in the same age group without such an injury.
Most hip fractures occur in elderly individuals as a result of minimal trauma, such as a fall from standing height. In young, healthy patients these fractures usually result from high-velocity injuries, such as motor vehicle collisions or falls from significant heights. Despite comparable fracture locations, the differences in low- and high-velocity injuries in older versus younger patients outweigh their similarities. High-velocity injuries are more difficult to treat and are associated with more complications than minor trauma injuries.
A recent study by Egan et al identified several risk factors associated with the risk of a hip fracture patient sustaining a second fall.[1 ] Increasing age, cognitive impairment, decreasing bone mass, decreasing depth perception, decreased mobility, dizziness, and a poor/fair self-perceived state of health were all linked to increasing likelihood of sustaining a second fall and thus a possible second hip fracture.
For more information, see Medscape's Fracture Resource Center.
The hip joint is a large multiaxial ball-and-socket synovial joint, enclosed by a thick articular capsule. The hip joint is designed for stability and a wide range of movement. Next to the shoulder, it is the most moveable of all joints. During standing, the entire weight of the upper body is transmitted to the heads and necks of the femurs. The round head of the femur articulates with the cuplike acetabulum. The depth of the acetabulum is increased by the reinforcing fibrocartilaginous labrum, which "grasps" the femoral head, covering more than half of it. Articular cartilage covers the entire head of the femur, except for the pit (fovea) for the ligament of the femoral head.
The strong, loose fibrous capsule permits free movement of the hip joint, attaching proximally to the acetabulum and transverse acetabular ligament. The fibrous capsule attaches distally to the neck of the femur only anteriorly at the intertrochanteric line and root of the greater trochanter. Posteriorly, the fibrous capsule crosses to the neck proximal to the intertrochanteric crest without attaching to it. The fibrous capsule thickens to form 3 ligaments of the hip joint: the Y-shaped iliofemoral ligament (of Bigelow), the pubofemoral ligament, and the ischiofemoral ligament.
The hip joint is further supported by the femur and the muscles that cross the joint; this bone and these muscles are the largest and most powerful in the human body. The anatomy of the femur is shown in Media file 1.
The vascular supply to the proximal femur is tenuous and provided largely by two sources.
Branches of the medial and lateral circumflex femoral arteries, usually branches of the deep femoral artery, ascend on the posterior aspect of the femoral neck in the retinacula (reflections of the capsule along the neck of the femur toward the head). The branches of the medial and lateral circumflex arteries perforate the bone just distal to the head of the femur where they anastomose with branches from the foveal artery and with medullary branches located within the shaft of the femur.
The ligament of the head of the femur usually contains the artery of the ligament of the head of the femur (foveal artery), a branch of the obturator artery. The foveal artery enters the head of the femur only when the center of the ossification has extended to the pit (fovea) for the ligament of the head, around age 11-13 years. This anastomosis persists even in advanced age but is never established in 20% of the population.
Femoral neck fractures often disrupt the blood supply to the head of the femur. The medial circumflex artery supplies most of the blood to the head and neck of the femur and is often torn in femoral neck fractures. In some cases, the blood supplied by the foveal artery may be the only blood received by the proximal fragment of the femoral head. If the blood vessels are ruptured, the fragment of bone may receive no blood and undergo avascular necrosis (AVN).
Hip fractures can be classified based on their relation to the hip capsule (intracapsular and extracapsular), geographic location (head, neck, trochanteric, intertrochanteric, and subtrochanteric), and degree of displacement. Higher-grade displacement implies worse prognosis. Fractures of the femoral head and neck are intracapsular, whereas those of the trochanteric, intertrochanteric, and subtrochanteric regions are extracapsular. The treatment as well as the prognosis for successful union and restoration of normal function varies considerably with fracture type.
Intracapsular hip fractures, like all other intracapsular fractures, frequently have complicated healing. The thick capsule that surrounds these fractures separates them from adjacent soft tissue and capillaries, leading to impaired callous formation. Thus, nonunion and AVN are added complications of these fractures.
Femoral head fractures
Isolated femoral head fractures are rare and are usually associated with hip dislocations. Superior femoral head fractures normally are associated with anterior dislocations, while inferior femoral head fractures are associated with posterior dislocations. They are usually best appreciated on postreduction radiographs for hip dislocations. Fractures of the femoral head are more common in younger patients as a result of major trauma, which is more likely to cause femoral neck fractures in older patients.
Femoral neck fractures
These are rare among younger patients but are commonly seen in older adults, most often secondary to osteoporosis or osteomalacia. These fractures usually result from minor trauma with falls accounting for 90%, or torsion. From proximal to distal, femoral neck fractures can be further delineated as subcapital, transcervical, and basicervical, all of which are intracapsular and associated with potential disruption of the vascular supply. The incidence of avascular necrosis (AVN) is up to 15% in nondisplaced fractures and increases to nearly 90% with untreated, completely displaced fractures.

Partially displaced femoral neck
fracture.

Completely displaced femoral neck
fracture.
Trochanteric fractures
Greater trochanteric fractures usually result from avulsion injuries at the insertion of the gluteus medius. Lesser trochanteric fractures may be caused by avulsion injuries of the iliopsoas secondary to forceful contraction. These are most common in children and young athletes (eg, dancers, gymnasts).
Intertrochanteric fractures
These extracapsular fractures occur in a line between the greater and lesser trochanters, generally in elderly patients and women secondary to osteoporosis.
Subtrochanteric fractures
These fractures have a bimodal age distribution and are seen most often in those aged 20-40 years in association with high-energy trauma and in patients older than 60 years secondary to falls on osteoporotic bones.
In the United States, hip fracture occurs in approximately 80 per 100,000 persons or approximately 250,000 persons each year. The rate of hip fracture increases with age, doubling each decade after age 50 years. Nearly half of all hip fractures occur in adults older than 80 years. Hip fracture at a young age is rare and is usually the result of a high-velocity injury or, rarely, secondary to bone pathology.
The US frequency of hip fracture, when age and sex are adjusted, ranks the highest in the world. Western Europe and New Zealand also have reported high rates, with the lowest rates occurring in the South African Bantu people and in East Asian countries, where the incidence of osteoporosis is low.
The incidence of hip fracture is 2-3 times greater in whites than in nonwhites, primarily because of the increased rate of osteoporosis in whites. This difference is not unique to females; African American and Asian men have been found to have significantly higher bone densities than their Caucasian and Latino counterparts.[3 ]
Rate of hip fracture is 2-3 times greater in women than in men. At least 75% of all hip fractures occur in women. The lifetime risk of hip fracture in white women and men is 15% and 5%, respectively. Femoral neck fractures are more common in women than in men by about 4:1, while intertrochanteric fractures are more common in women than in men by about 5:1.
Dislocations, Hip
Fractures, Pelvic
Orthopedic surgery; vascular surgery or neurology, if necessary
Parenteral analgesia is strongly recommended. A muscle relaxant also may be necessary. Administer antibiotics to cover skin flora (ie, cefazolin sodium) and tetanus immunization, as necessary, in open fractures.
Pain control is essential to quality patient care. It ensures patient comfort, promotes pulmonary toilet, and aids physical therapy regimens. Many analgesics have sedating properties that benefit patients who have sustained fractures.
DOC for narcotic analgesia due to its reliable and predictable effects, safety, and ease of reversibility with naloxone.
Morphine sulfate administered IV may be dosed in a number of ways and commonly is titrated until desired effect attained.
Starting dose: 0.1 mg/kg IV/IM/SC
Maintenance dose: 5-20 mg/70 kg IV/IM/SC q4h
Relatively hypovolemic patients: Start with 2 mg IV/IM/SC and reassess hemodynamic effects of dose
Neonates: 0.05-0.2 mg/kg IV/IM/SC prn
Children: 0.1-0.2 mg/kg IV/IM/SC q2-4h prn
Phenothiazines may antagonize analgesic effects; tricyclic antidepressants, MAOIs, and other CNS depressants may potentiate adverse effects
Documented hypersensitivity; hypotension; potentially compromised airway in which establishing rapid airway control would be difficult
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Avoid in hypotension, respiratory depression, nausea, emesis, constipation, and urinary retention; caution in atrial flutter and other supraventricular tachycardias; has vagolytic action and may increase ventricular response rate
More potent narcotic analgesic than morphine sulfate with much shorter half-life. DOC for conscious sedation analgesia. Ideal for analgesic action of short duration during anesthesia (premedication, induction, maintenance), and in immediate postoperative period.
With short duration (30-60 min) that is easy to titrate, excellent choice for pain management and sedation. Easily and quickly reversed by naloxone.
After initial dose, do not titrate subsequent doses more frequently than q3h or q6h. When using transdermal dosage form, pain is controlled in most patients with 72-h dosing intervals. However, a small number of patients require dosing intervals of 48 h.
0.5-1 mcg/kg/dose IV/IM q30-60min
Transdermal: Apply 25 mcg/h system q48-72h
<2 years: 2-3 mcg/kg/dose IV/IM q30-60min
2-12 years: 1-2 mcg/kg/dose IV/IM q60min
>12 years: Administer as in adults
Phenothiazines may antagonize analgesic effects; tricyclic antidepressants may potentiate adverse effects
Documented hypersensitivity; hypotension; potentially compromised airway in which establishing rapid airway control would be difficult
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Caution in hypotension, respiratory depression, constipation, nausea, emesis, and urinary retention; idiosyncratic reaction, known as chest wall rigidity syndrome, may require neuromuscular blockade to increase ventilation
Therapy must cover all likely pathogens in the context of the clinical setting.
First-generation, semisynthetic cephalosporin that acts by binding to 1 or more penicillin-binding proteins to arrest bacterial cell wall synthesis and inhibit bacterial replication. Primarily active against skin flora, including Staphylococcus aureus. Typically use alone for skin and skin-structure coverage.
Total daily dosages are same for IV/IM routes.
2 g IV/IM q6-12h; not to exceed 12 g/d
25-100 mg/kg/d IV/IM divided q6-8h; not to exceed 6 g/d
Probenecid prolongs effects; coadministration with aminoglycosides may increase renal toxicity; may yield false-positive urine dip test for glucose
Documented hypersensitivity
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Adjust dose in renal impairment; superinfections and promotion of nonsusceptible organisms may occur with prolonged use or repeated therapy
Aminoglycoside antibiotic used for gram-negative bacterial coverage. Commonly used in combination with both an agent against gram-positive organisms and one that covers anaerobes.
Used in conjunction with ampicillin or vancomycin for prophylaxis in patients with open fractures.
1.5 mg/kg IV; not to exceed 80 mg
2 mg/kg IV
Other aminoglycosides, cephalosporins, penicillins, and amphotericin B may increase nephrotoxicity; aminoglycosides enhance effects of neuromuscular blocking agents, thus prolonged respiratory depression may occur; loop diuretics may increase auditory toxicity of aminoglycosides—possible irreversible hearing loss of varying degrees may occur (monitor regularly)
Documented hypersensitivity; non–dialysis-dependent renal insufficiency
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Narrow therapeutic index (not intended for long-term therapy); caution in renal failure (not on dialysis), myasthenia gravis, hypocalcemia, and conditions that depress neuromuscular transmission; adjust dose in renal impairment
Used along with gentamicin for prophylaxis in patients with open fractures. Interferes with bacterial cell wall synthesis during active multiplication, causing bactericidal activity against susceptible organisms. Given in place of amoxicillin in patients unable to take medication orally.
2 g IV/IM
50 mg/kg IV/IM
Probenecid and disulfiram elevate levels; allopurinol decreases effects and has additive effects on ampicillin rash; may decrease effects of oral contraceptives
Documented hypersensitivity
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Adjust dose in renal failure; evaluate rash and differentiate from hypersensitivity reaction
Potent antibiotic directed against gram-positive organisms and active against Enterococcus species. Also useful in treatment of septicemia and skin-structure infections.
Used in conjunction with gentamicin for prophylaxis in penicillin-allergic patients with open fractures.
May need to adjust dose in patients with renal impairment.
1 g IV infused over 1 h
1.5 mg/kg IV infused over 1 h
Erythema, histaminelike flushing, and anaphylactic reactions may occur when administered with anesthetic agents; taken concurrently with aminoglycosides, risk of nephrotoxicity may increase above that with aminoglycoside monotherapy; effects in neuromuscular blockade may be enhanced when coadministered with nondepolarizing muscle relaxants
Documented hypersensitivity
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Caution in renal failure, neutropenia; red man syndrome caused by too rapid IV infusion (dose given over a few min) but rarely happens when dose given over 2 h or by PO or IP route; red man syndrome not an allergic reaction
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[Best Evidence] Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med. Mar 23 2009;169(6):551-61. [Medline].
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Steele MT, Ellison SR. Trauma to the pelvis, hip and femur. In: Tintinalli JE, et al, eds. Emergency Medicine: A Comprehensive Study Guide. The McGraw-Hill Companies Inc; 2004:1717-1726.
Van Balen R, Steyerberg EW, Polder JJ, et al. Hip fracture in elderly patients: outcomes for function, quality of life, and type of residence. Clin Orthop Relat Res. Sep 2001;232-43. [Medline].
van de Kerkhove MP, Antheunis PS, Luitse JS, Goslings JC. Hip fractures in nonagenarians: perioperative mortality and survival. Injury. Feb 2008;39(2):244-8. [Medline].
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hip fracture, fracture of the hip, femoral head fractures, femoral neck fractures, intertrochanteric fractures, trochanteric fractures, subtrochanteric fractures, hip joint, iliofemoral ligament, pubofemoral ligament, ischiofemoral ligament, avascular necrosis, intracapsular fracture, extracapsular fracture, anterior dislocation, posterior dislocation, single fragment fracture, comminuted fracture, stress fracture, incomplete fracture, impacted fracture, partially displaced fracture, completely displaced fracture, single fracture lines, multiple fracture lines, nondisplaced fracture
Moira Davenport, MD, Attending Physician, Departments of Emergency Medicine and Orthopedic Surgery, Allegheny General Hospital
Moira Davenport, MD is a member of the following medical societies: American College of Emergency Physicians and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.
Francis Counselman, MD, Program Director, Chair, Professor, Department of Emergency Medicine, Eastern Virginia Medical School
Francis Counselman, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Emergency Physicians, Norfolk Academy of Medicine, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.
Eric Legome, MD, Chair, Department of Emergency Medicine, St Vincent's Hospital, Manhattan
Eric Legome, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, American College of Emergency Physicians, Council of Emergency Medicine Residency Directors, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.
John D Halamka, MD, MS, Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center
John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.
Rick Kulkarni, MD, Medical Director, Assistant Professor of Surgery, Section of Emergency Medicine, Yale-New Haven Hospital
Rick Kulkarni, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
Disclosure: WebMD Salary Employment
The authors and editors of eMedicine gratefully acknowledge the contributions of previous authors, Gigi R Madore, MD, and Geoff Winkley, MD, to the development and writing of this article.
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