Legg-Calve-Perthes Disease in Emergency Medicine Medication
- Author: Jessica Hernandez, MD; Chief Editor: Trevor John Mills, MD, MPH more...
Medical treatment does not stop or reverse the bony changes. Recent experimental studies have demonstrated some success with antiresorptive and anabolic agents for the treatment of Legg-Calvé-Perthes disease. However, further studies are needed to assess the safety and effectiveness in humans.
In the emergency department setting, the focus should be on administering appropriate analgesic medication.
Nonsteroidal anti-inflammatory drugs (NSAIDs)
These drugs most commonly are used for the relief of mild to moderately severe pain. Although the effects of NSAIDs in the treatment of pain tend to be patient specific, ibuprofen is usually the drug of choice (DOC) for the initial therapy.
Ibuprofen is usually the DOC for the treatment of mild to moderately severe pain if there are no contraindications. It inhibits inflammatory reactions and pain, probably by decreasing the activity of enzyme cyclooxygenase, thus decreasing prostaglandin synthesis.
Acetaminophen is the DOC for the treatment of pain in patients with documented hypersensitivity to aspirin and NSAIDs, as well as those with upper GI disease or those who are taking oral anticoagulants.
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