eMedicine Specialties > Emergency Medicine > Warfare - Chemical, Biological, Radiological, Nuclear and Explosives
CBRNE - Ricin: Differential Diagnoses & Workup
Updated: Feb 14, 2008
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
- Multimedia
Differential Diagnoses
| CBRNE - Anthrax Infection | Tick-Borne Diseases, Q Fever |
| CBRNE - Lung-Damaging Agents, Phosgene | Tick-Borne Diseases, Tularemia |
| CBRNE - Q Fever | |
| CBRNE - Staphylococcal Enterotoxin B | |
| Cellulitis |
Other Problems to Be Considered
Pneumonic plague
Salmonella
Shigella
Cholera
Necrotizing fasciitis
Workup
Laboratory Studies
- Obtain baseline laboratory information. Useful testing includes a complete blood count (which may reveal leukocytosis), electrolytes, BUN, creatinine, glucose, prothrombin time, activated partial thromboplastin time, international normalized ratio, type and screen, fibrinogen, liver enzymes, amylase, and lipase. An arterial blood gas may reveal hypoxemia.
- Specific enzyme-linked immunosorbent assay (ELISA) testing on serum and immunohistochemical techniques for direct tissue analysis are under development.
- Collect acute and convalescent serum to determine measurements of antibody response.
Imaging Studies
- Chest radiography
- A chest radiograph may reveal infiltrates or an acute respiratory distress syndrome (ARDS) picture.
- Radiography may also be useful in parenteral exposures to evaluate for retained foreign body.
Procedures
- Bronchoscopy: If performed, bronchial aspirate may be rich in protein compared to plasma, as observed in any condition causing high-permeability pulmonary edema.
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Differential Diagnoses & Workup: CBRNE - Ricin |
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References
CDC and Public Health Training Network. Recognition, Management and Surveillance of Ricin-Associated Illness [Web cast script]. December 30, 2003. [Full Text].
CNN.com. Timeline: UK ricin terror probe. January 23, 2003. [Full Text].
Balint GA. Ricin: the toxic protein of castor oil seeds. Toxicology. Mar 1974;2(1):77-102. [Medline].
Challoner KR, McCarron MM. Castor bean intoxication. Ann Emerg Med. Oct 1990;19(10):1177-83. [Medline].
Ellenhorn MJ, Barceloux DG. Ornamental beans. In: Medical Toxicology Diagnosis and Treatment of Human Poisoning. 1988:1225-27.
FBI. Federal Bureau of Investigations Web Page. Available at www.fbi.gov. Accessed 2000.
Franz D, USAMRIID. Defense against toxic weapons. In: US Army Medical Research Material Command. 1997.
Kopferschmitt J, Flesch F, Lugnier A, et al. Acute voluntary intoxication by ricin. Hum Toxicol. Apr 1983;2(2):239-42. [Medline].
Kortepeter MG, Parker GW. Potential biological weapons threats. Emerg Infect Dis. Jul-Aug 1999;5(4):523-7. [Medline].
Meselson M, Guillemin J, Hugh-Jones M, et al. The Sverdlovsk anthrax outbreak of 1979. Science. Nov 18 1994;266(5188):1202-8. [Medline].
Shih RD, Goldfrank LR. Plants. In: Goldfrank's Toxicologic Emergencies. 6th ed. 1998:1254-55.
US Medical Research Institute of Infectious Diseases. Medical Management of Biocasualities Handbook. 1998.
Zilinskas RA. Iraq's biological weapons. The past as future?. JAMA. Aug 6 1997;278(5):418-24. [Medline].
Further Reading
Keywords
Ricinus communis, toxin, agent of biological warfare, weapon of mass destruction, WMD, beans of castor plant, castor beans, food contaminant, water contaminant, hematemesis, bloody diarrhea, melena, food poisoning, hypoxia, cyanosis, labored breathing, tachypnea, tachycardia, progressive respiratory failure, ricin, biological warfare agent, terrorism
Differential Diagnoses & Workup: CBRNE - Ricin