eMedicine Specialties > Otolaryngology and Facial Plastic Surgery > Head & Neck Surgery

Malignant Tumors of the Sinuses: Follow-up

Author: Christopher Klem, MD, Consulting Staff, Department of Otolaryngology-Head and Neck Surgery, Tripler Army Medical Center
Coauthor(s): Jared M Theler, MD, Resident Physician in Otolaryngology-Head and Neck Surgery, Department of Surgery, Tripler Army Medical Center
Contributor Information and Disclosures

Updated: Mar 3, 2009

Outcome and Prognosis

Survival rates for patients with maxillary sinus cancer average about 40% over 5 years. Early-stage tumors have a cure rate of up to 80%. Patients with unresectable tumors treated with radiation have a survival rate of less than 20%. Survival rates for ethmoid tumors have improved slightly because of advances in skull-base surgery.

Future and Controversies

Although intra-arterial chemotherapy was used in the past, it was only recently shown to be consistently effective. With the advent of thiosulfate, a neutralizer of cisplatin, physicians can now deliver large doses of intra-arterial chemotherapy more safely than before. High-dose cisplatin is administered by means of the arterial blood supply of the tumor. A simultaneous infusion of thiosulfate prevents the systemic effects of cisplatin.

Intra-arterial chemotherapy is used with radiation and had promising results in preserving organs and in managing bulky nodal disease.

Given the anatomy of the paranasal sinuses and their blood supply, intra-arterial chemotherapy may be an effective method of treating sinus malignancies.

 


More on Malignant Tumors of the Sinuses

Overview: Malignant Tumors of the Sinuses
Workup: Malignant Tumors of the Sinuses
Treatment: Malignant Tumors of the Sinuses
Follow-up: Malignant Tumors of the Sinuses
References
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Further Reading

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Keywords

malignant tumors of the sinuses, sinus tumors, malignant sinus tumors, paranasal sinus malignancy, carcinoma of the sinus, sphenoid sinus, ethmoid sinus, ethmoid air cells, frontal sinus, maxillary sinus, sphenoid sinus, nasal cavity cancer, sinus carcinoma, sinus cancer, paranasal sinus cancer, sinus cancer, sinonasal malignancies

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Contributor Information and Disclosures

Author

Christopher Klem, MD, Consulting Staff, Department of Otolaryngology-Head and Neck Surgery, Tripler Army Medical Center
Christopher Klem, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Head and Neck Society, American Medical Association, and American Society for Reconstructive Microsurgery
Disclosure: Nothing to disclose.

Coauthor(s)

Jared M Theler, MD, Resident Physician in Otolaryngology-Head and Neck Surgery, Department of Surgery, Tripler Army Medical Center
Jared M Theler, MD is a member of the following medical societies: American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American Medical Association, and Association of Military Surgeons of the US
Disclosure: Nothing to disclose.

Medical Editor

William M Lydiatt, MD, Professor and Division Director, Head and Neck Surgical Oncology, Department of Otolaryngology-Head and Neck Surgery, University of Nebraska Medical Center
William M Lydiatt, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Head and Neck Society, and Nebraska Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Karen Hall Calhoun, MD, Professor, Department of Otolaryngology-Head and Neck Surgery, The Ohio State University
Karen Hall Calhoun, MD is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Head and Neck Society, American Medical Association, American Rhinologic Society, Association for Research in Otolaryngology, Society of University Otolaryngologists-Head and Neck Surgeons, Southern Medical Association, Texas Medical Association, and Texas Medical Association
Disclosure: Nothing to disclose.

CME Editor

Christopher L Slack, MD, Otolaryngology-Facial Plastic Surgery, Private Practice, Associated Coastal ENT; Medical Director, Treasure Coast Sleep Disorders
Christopher L Slack, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Arlen D Meyers, MD, MBA, Professor, Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine
Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Head and Neck Society
Disclosure: Covidien Corp Consulting fee Consulting; US Tobacco Corporation unstricted gift unknown; Axis Three Corporation Ownership interest Consulting; Omni Biosciences Ownership interest Consulting; Sentegra Ownership interest Board membership; Syndicom Ownership interest Consulting; Oxlo  Consulting; Medvoy Ownership interest Management position

 
 
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