eMedicine Specialties > Otolaryngology and Facial Plastic Surgery > Head & Neck Surgery

Conservation Laryngeal Surgery, Supracricoid Laryngectomy

Stephen Y Lai, MD, PhD, Assistant Professor, Departments of Otolaryngology and Pharmacology, University of Pittsburgh Medical Center
Gregory S Weinstein, MD, FACS, Professor and Vice-Chairman, Department of Otorhinolaryngology-Head and Neck Surgery, Director of Division of Head and Neck Surgery, Director of Head and Oncology Fellowship, Director of Otorhinolaryngology-Head and Neck Clinic, Co-director of The Center for Head and Neck Surgery, University of Pennsylvania School of Medicine

Updated: Dec 18, 2009

Introduction

Total laryngectomy (TL) may be used either as an initial treatment or as a salvage option for many laryngeal cancers. TL has been used in particular for advanced laryngeal cancers. Although radiation (with or without chemotherapy) has been offered as an alternative to TL, in many cases risk of local failure remains significant.

In numerous European countries, the supracricoid partial laryngectomy (SCPL) was developed in the late 1950s as an alternative to TL. SCPL has the advantages of preservation of speech and swallowing function without a permanent stoma and a very high local control rate for selected glottic and supraglottic cancers.

Two types of SCPL are employed for distinctly different types of laryngeal cancers. The differences in the extent of resection achieved by these forms of SCPL require discrete reconstructions. The true and false cords, both paraglottic spaces, and the entire thyroid cartilage are resected in the SCPL that is used to treat selected glottic carcinomas. The reconstruction requires suturing the cricoid to the hyoid and the epiglottis, termed a cricohyoidoepiglottopexy (CHEP). The second form of the procedure, which is employed to ablate selected transglottic and supraglottic carcinomas, results in the resection of both true and false cords, both paraglottic spaces, the entire preepiglottic space, the epiglottis, and the entire thyroid cartilage. The reconstruction for this more extensive technique is accomplished by suturing the cricoid to the hyoid, termed a cricohyoidopexy (CHP).

Because no vocal or false cords are present in the postoperative view of the SCPL with CHEP, the normal V-shaped glottis is changed to a T shape in which the arytenoids abut each other and the epiglottis anteriorly. The postoperative anatomic configuration is different following SCPL with CHP because the epiglottis is also resected in this procedure. In this case, the neolarynx is T-shaped, with the arytenoids abutting each other in the midline and against the tongue base.

SCPL provides an effective alternative to the TL and offers better local control for selected lesions than an extended partial laryngectomy or nonsurgical therapy such as radiation with or without chemotherapy. Lesions that might typically require TL (eg, selected supraglottic carcinomas not amenable to SGL, selected T4 carcinomas, selected T3 glottic carcinomas, selected laryngeal carcinomas that have recurred following radiation therapy) may be treated effectively with SCPL-CHEP or SCPL-CHP. As with any technique, the key to successful oncologic outcome following SCPL is appropriate patient selection.

This article reviews the basics of SCPL, including the relevant surgical anatomy, indications, contraindications, and operative techniques.

An image depicting the larynx can be seen below.

Cartilages of the larynx, posterior view.

History of the Procedure

Although the supracricoid partial laryngectomy (SCPL) was first described in Europe in 1959, the technique was not reported in an American journal for another 30 years. Ultimately, these techniques were published in English journals from centers around the world. By the 1990s, numerous reports confirmed that SCPL had been performed around the world for decades. However, in 1990, when the first American cases of SCPL were presented in the United States, the technique was both largely unknown and hardly noticed.

A number of factors may have contributed to the delay in the recognition of SCPL in the United States. The focus of classic conservation surgery has traditionally been on vertical partial laryngectomy (VPL) and supraglottic partial laryngectomy (SGL). The SGL was imported from South America in the 1940s, and the VPL was first described in Europe in the 19th century. While the VPL and SGL were developed for and best suited to early laryngeal carcinoma, various extended partial laryngectomy approaches were later described in the literature. The reports of these extended techniques tended to include small numbers of patients without mention of functional outcome.

The plethora of reconstructions that accompanied these extended partial laryngectomies were typically difficult to reproduce by practicing clinicians. This lack of reproducibility with the extended VPL and extended SGL resulted in the avoidance of these procedures in favor of either TL or nonsurgical organ preservation approaches such as radiation and chemotherapy. In an atmosphere of distrust for extended conservation surgery techniques, extensive conservation laryngeal surgical techniques such as SCPL were not readily embraced.

During the years after its introduction, SCPL was popularized in France and other European centers. Both oncologic and functional successes with SCPL have been reported in large numbers in the world literature. A particular advantage of SCPL when compared to extended VPL or SGL is that the surgeon does not have to deal with a vast array of difficult-to-reproduce reconstructions. In contrast, outcomes for the extended VPL and/or SGL tend to be reported in small case series, and rarely has one type of reconstruction ever been reported in more than one series of patients treated with extended VPL and/or SGL.

Presentation

• Cardiac disease
• Arteritis
• Diabetes mellitus
• Gastroesophageal reflux (Irritation and edema of the arytenoid mucosa postoperatively affects wound healing.)
• Rheumatoid arthritis (decreased mobility of the arytenoid cartilage)

Important findings on physical examination include the following:

• Pain due to palpation at the level of the thyroid ala indicates thyroid cartilage invasion.
• Pain or mass at the level of the thyrohyoid membrane and vallecula indicate massive preepiglottic space invasion.
• Mirror examination provides initial information regarding the tumor epicenter, surface extent, airway impairment, and laryngeal mobility. Mirror examination provides binocular vision that is unavailable in indirect laryngoscopy.
• Perform careful palpation of the neck to detect nodal involvement.

SCPL alters the sphincteric function of the larynx, leading to a decreased quality of voice and a risk for aspiration, especially in the immediate postoperative period. Adequate pulmonary reserve is necessary to tolerate the increased postoperative aspiration with the concomitant risk for atelectasis and pneumonia. Patients with severe chronic obstructive pulmonary disease (COPD), impairment of the cough reflex, and impairment of pulmonary ciliary clearance are at higher risk. A clinical assessment is typically accurate. Chronic and inefficient cough, purulent sputum, and/or an inability to climb 2 flights of stairs without shortness of breath are strong contraindications against the use of SCPL-CHEP or SCPL-CHP.

Furthermore, a 2009 study by Joo et al determined that age (60 years or older) and cricohyoidopexy increase the risk of pulmonary complications following supracricoid partial laryngectomy.^{[1 ]}

Indications

Supracricoid partial laryngectomy-cricohyoidoepiglottopexy (SCPL-CHEP) and supracricoid partial laryngectomy-cricohyoidopexy (SCPL-CHP) provide useful and effective alternatives to total laryngectomy (TL). These organ preservation surgery techniques are useful for laryngeal lesions that have extended beyond the traditional indications for VPL and SGL. Unlike attempts to extend the resection margins of VPL and SGL, SCPL-CHEP and SCPL-CHP provide reliable oncologic outcomes and reproducible functional results from a fixed reconstruction technique.

A spectrum of procedures exists from smallest to largest, corresponding to a spectrum of lesions from smallest to largest. A spectrum exists for both supraglottic and glottic carcinoma. This spectrum is a useful tool for preoperative planning for organ preservation surgery. On the top of the spectrum, every other laryngeal schematic is blank. The clinician can then draw the lesion they are seeing into the appropriate point on the spectrum. The examples that are given in the spectrum are linked with the surgical procedures below. Some lesions are associated with 2 surgical procedures. This is because controversies remain in the literature concerning which is the most appropriate technique for a given lesion. Understanding these spectra helps the surgeon to see the role of the SCPLs relative to other useful organ preservation techniques.

Indications for SCPL-CHEP

• Bilateral vocal cord involvement with or without anterior commissure involvement (horseshoe lesion)
• Unilateral glottic carcinoma with anterior commissure involvement
• Impaired true vocal cord mobility
• T3 glottic lesion with fixation of the cord and either impaired or mobile arytenoid
• T4 glottic tumors with limited thyroid cartilage invasion

Indications for SCPL-CHP

• Supraglottic lesions not amenable to supraglottic laryngectomy because of ventricular invasion, extension to a vocal cord, or impaired vocal cord mobility
• T3 supraglottic and transglottic cancers with vocal cord fixation, preepiglottic space invasion, or both
• T4 lesions with limited thyroid cartilage invasion

Relevant Anatomy

Preoperative assessment of patients with laryngeal carcinoma requires a precise 3-dimensional understanding of the extent of disease within the complex anatomy of the larynx. The surgeon must predict the chances of being able to obtain negative margins within the larynx. Beyond the mucosal extent of the disease, understanding laryngeal anatomy provides insights into the behavior and spread of cancer within the larynx.

In 1986, a whole organ section study by Hirano et al demonstrated that 50-65% of the entire adult airway is posterior to the anterior aspect of the vocal processes of the arytenoids.^{[2 ]}The anterior glottis (vocal cords) serves as the phonatory larynx, and the posterior glottis (interarytenoid area) is the respiratory larynx. Thus, both vocal cords can be resected with little effect on respiration and swallowing. Functional reconstruction of the larynx requires the preservation of at least one arytenoid cartilage and the cricoid ring. Creation of the neoglottis from the remaining arytenoid cartilage and the tongue base or epiglottis remnant is sufficient to achieve lung-powered phonation and permits physiological speech and swallowing without a permanent tracheostomy.

Divisions and subsites of the larynx

The supraglottis is the area above the lateral angle of the ventricle. Its subsites include the epiglottis, preepiglottic space, aryepiglottic folds, ventricles, false vocal cords, hyoid bone, and arytenoid cartilages.

The glottis is the area from the lateral angle of the ventricle to 1 cm below this point. Its subsites include the true vocal cords, anterior commissure, and posterior commissure.

The subglottis occupies the area from below the glottis to the inferior portion of the cricoid cartilage.

Anatomic landmarks of the larynx as related to cancer spread include the following features.

• Skeletal framework
  • Cricoid cartilage: The cricoid cartilage is the only complete ring in the airway. The integrity of the circumference of the cricoid cartilage is necessary to perform organ preservation surgery (OPS) of the larynx and to decannulate the trachea postoperatively.
  • Epiglottis: Normal structures such as lymphatics, submucosal glands, blood vessels, and nerves cross through the multiple fenestrations present in the epiglottis. These perforations also serve as a route for the spread of supraglottic carcinoma from the surface mucosa into the preepiglottic space.
  • Hyoid: The hyoid bone is the most superior portion of the laryngeal skeleton and serves as the point of attachment for the strap muscles and suprahyoid musculature. The hypoglossal nerve and lingual artery run close laterally, requiring careful dissection in that area. The hyoid is rarely involved in laryngeal carcinoma.
  • Thyroid: The thyroid cartilage is shared between both the larynx and the pharynx. Although fenestrations are present in the laminae of the thyroid cartilage, they are not a route for the spread of laryngeal cancer.
  • Arytenoids: These cartilages rest upon the superior aspects of the posterior laminae of the cricoid cartilage. The cricoarytenoid unit includes an arytenoid cartilage, the adjacent cricoid cartilage, the ipsilateral superior and recurrent laryngeal nerve, the interarytenoid musculature, the ipsilateral lateral musculature, and the posterior cricoarytenoid musculature. This is the basic functional unit that allows for speech and swallow following organ preservation surgery of the larynx. Ossification of the cartilaginous framework is important to consider because cancer has an increased tendency to invade ossified structures rather than cartilage.
• Connective tissue barriers:Dye and radioisotope studies were initially used to delineate the location of barriers to the spread of cancer within the larynx. Whole organ section of the larynx demonstrated the intrinsic ligaments and broad sheaths of fibrous tissues that serve as barriers to cancer spread. Further studies demonstrated that while the intralaryngeal barriers may impede early cancer invasion, advanced lesions extend through the larynx without respecting these barriers.
  • Quadrangular membrane: This membrane sweeps down from the lateral borders of the epiglottis, forming a fibrous curtain of tissue within the mucosa of the aryepiglottic folds superiorly and the false cords inferiorly. At the inferior level of the false cord, a condensation of fibrous tissue extends from the thyroid cartilage to the arytenoid. This fibrous scaffold supports the aryepiglottic folds and false cords, separating the supraglottic endolaryngeal structures from the pyriform sinuses.
  • Conus elasticus: This membrane extends from the upper border of the cricoid cartilage to the vocal tendon, vocal process, and the inferior lateral portion of the arytenoid cartilage. The anterior condensation of the conus elasticus is the cricothyroid ligament, and the superior condensations bilaterally are the vocal ligaments.
  • Thyrohyoid membrane: The membrane extends from the hyoid to the thyroid cartilage. The superior laryngeal neurovascular pedicle passes through the lateral aspect of this membrane.
  • Anterior commissure tendon (Broyles ligament): The anterior condensation of the vocal tendons with the internal aspect of the thyroid cartilage meshes with the thyroepiglottic ligament. This area of the thyroid cartilage is devoid of perichondrium.
  • Hyoepiglottic ligament: This ligament extends from the epiglottis to the hyoid and serves as the roof of the paraglottic and preepiglottic spaces. The hypoepiglottic ligament serves as a formidable barrier to invasion from the supraglottis to the tongue base.
  • Cricothyroid ligament: This ligament is the anterior condensation of the conus elasticus connecting the cricoid and inferior border of the thyroid cartilage. Unlike the thyrohyoid membrane, the cricothyroid ligament is present only in the midline. Because the conus elasticus does not form a continuous layer between the thyroid and cricoid cartilages, no significant barrier exists to cancer extension beyond the larynx at that level.
• Laryngeal spaces
  • Preepiglottic space: This space is located in the supraglottis, anterior to the epiglottic cartilage, behind the thyrohyoid membrane superiorly, and between the supraglottic portions of the bilateral paraglottic spaces laterally. The space lies between the hyoid bone and the thyroid cartilage. Contents include fat, blood vessels, glands, and lymphatics.
  • Paraglottic space
    • This bilateral space extends from the upper border of the cricoid to the top of the aryepiglottic fold. In the supraglottis, the paraglottic space is bounded by the thyroid cartilage, the thyrohyoid membrane, and the quadrangular membrane. At the glottic level, this space is bounded by the conus elasticus, the thyroid cartilage, and the pyriform sinus mucosa. Inferolaterally, this space is continuous with a space between the thyroid cartilage and the cricoid cartilage. This point provides a route for extension of carcinoma beyond the larynx. Beyond this site, the cancer can invade the cricothyroid muscle and the ipsilateral thyroid lobe. Although the indentation of the ventricle and saccule shapes the paraglottic space in an hourglass fashion, no barrier prevents the spread of tumor. Cancer within this space has superior-inferior access to the larynx and to the thyroid cartilage.
    • Invasion of the paraglottic space is possible from any mucosal surface adjacent to the space. Fixation of the true cord from a glottic carcinoma indicates that the paraglottic space at the glottic level is involved by carcinoma. Additionally, supraglottic cancer causing a bulge in the ventricle and at the glottic level with decreased vocal cord mobility is evidence of extension to the cord level via the paraglottic space. Thus, clinical evaluation of vocal cord and arytenoid mobility separately is critical in the preoperative assessment of a laryngeal cancer.
    • The precise boundaries of the paraglottic and preepiglottic spaces are controversial. These spaces are not surrounded by specific anatomic boundaries and are continuous with one another at certain points. Additionally, depending upon the physician, the paraglottic space may include the intrinsic laryngeal musculature, the ventricle, the conus elasticus, and the quadrangular membrane or just the fat-filled space lateral to the laryngeal musculature and medial to the thyroid cartilage. Radiologists define the paraglottic space as only the lateral fat and not the musculature. In order to fully appreciate the spread of laryngeal carcinoma, the organ preservation surgeon needs to understand that the paraglottic space encompasses all of the above-mentioned structures.
  • Soft tissue adnexa
    • Laryngeal mucous glands: Carcinoma can spread along the seromucinous exocrine tubuloalveolar glands through the connective tissue barriers of the larynx. The glands serve as a conduit through the fenestrations of the epiglottis and into the preepiglottic space. Additionally, these glands also open beneath the anterior commissure, providing a route of carcinoma spread submucosally that may remain undetected.
    • Laryngeal microcirculation: Blood vessels may serve as a route of extension for carcinoma within the larynx.
    • Lymphatics: The lack of lymphatics at the level of the glottis may account for the lower incidence of lymph node metastases from glottic lesions. However, the supraglottis has a rich network of lymphatics and a correspondingly increased tendency to spread to cervical lymph nodes bilaterally. The subglottis is also rich in lymphatics and drains to the delphian (cricothyroid) and paratracheal nodes.

Ninety to 95% of primary malignant tumors of the larynx are squamous in origin. Connective tissue sheets and ligaments serve as relative barriers to the spread of early laryngeal lesions. Glottic cancer barriers include the vocal cords, conus elasticus, and the perichondrium of the thyroid cartilage. Transglottic and supraglottic cancer barriers include the thyrohyoid membranes, the hyoepiglottic ligament, and the hyoid bone. The hyoepiglottic ligament has been observed to be a resilient barrier for spread from supraglottis to tongue base as long as tumor has not already involved the suprahyoid epiglottis. The hyoid bone is rarely involved by laryngeal lesions and can be spared in resection of supraglottic carcinoma unless tumor is found at the level of the tongue or within the vallecula. Large advanced tumors invade the larynx without respecting any of these barriers.

Although supraglottic carcinoma was previously thought to not invade to the glottic level, more recent studies demonstrate that the ventricle acts more like a funnel than a true barrier to the spread of cancer. Twenty to 54% of all cases demonstrated spread of supraglottic carcinoma to the glottis. Clear margins cannot be achieved with SGL in cases with glottic extension, but oncologic resection is possible with SCPL-CHP.

Within the subglottis, no barriers to the spread of cancer exist. Extensive subglottic lesions grow circumferentially and extend submucosally to the undersurface of the vocal cords and the trachea. They may also invade the cricoid cartilage and may extend beyond the larynx at the level of the cricothyroid membrane to invade the thyroid gland.

Weak points for the spread of laryngeal cancer are as follows:

• The area of attachment of the anterior commissure tendon to the thyroid cartilage has no perichondrium, providing carcinoma direct access to the cartilage.
• The tubuloalveolar glands of the subglottis and the anterior floor of the ventricle serve as a route of cancer spread inferiorly beneath the mucosa and anteriorly to the thyroid cartilage.
• The Broyles tendon may be ruptured in patients with infrahyoid carcinoma, leading to early invasion of the preepiglottic space.
• Numerous fenestrations within the infrahyoid epiglottis provide a route for early invasion of the preepiglottic space via blood vessels and gland ducts.
• Areas of ossification at the anterior commissure and the posterior border of the thyroid ala of the thyroid cartilage provide a route for cancer spread.
• Points of attachment of the cricothyroid ligament and the anterior origin of the thyroarytenoid musculature provide a route for cancer spread.

Contraindications

The main contraindication for supracricoid partial laryngectomy-cricohyoidoepiglottopexy (SCPL-CHEP) and supracricoid partial laryngectomy-cricohyoidopexy (SCPL-CHP) is preoperative evidence of severe respiratory impairment. Patients with pulmonary disease do not have sufficient pulmonary reserve to tolerate the increased aspiration that occurs in the immediate postoperative period.

Oncologic contraindications for SCPL-CHEP

• Tumors originating (epicenter) in the anterior commissure or ventricle, which have a propensity for early invasion of the preepiglottic space (may be resected with SCPL-CHP)
• Tumors of the glottis with ipsilateral fixation of the arytenoid cartilage (high risk of involvement of the cricoid or cricoarytenoid joint)
• Tumors of the glottis with subglottic extent reaching the upper border of the cricoid cartilage or invading the cricoid cartilage
• Tumors of the glottis invading the posterior commissure
• Tumors of the glottis invading the outer perichondrium of the thyroid cartilage or manifesting with extralaryngeal spread of tumor

Oncologic contraindications for SCPL-CHP

• Arytenoid cartilage fixation
• Infraglottic extension of tumor more than 10 mm anteriorly (cricothyroid membrane), more than 5 mm posterolaterally, or reaching the superior border of the cricoid cartilage
• Major preepiglottic space invasion with clinical evidence of bulging beneath the vallecula mucosa and/or extension through the thyrohyoid membranes
• Tumor abutting the hyoid bone, requiring resection of this structure
• Cricoid cartilage invasion
• Involvement of the pharynx or interarytenoid fixation
• External thyroid cartilage perichondrial invasion and extralaryngeal spread of tumor

Workup

Imaging Studies

• Computerized tomography (CT) scanning and magnetic resonance imaging (MRI) provide confirmatory information regarding the status of the paraglottic and preepiglottic spaces. Also, these techniques provide information regarding metastatic involvement of the regional lymphatics of the neck, subglottic tumor extension, and potential invasion of the thyroid and cricoid cartilage.
• Endoscopic evaluation remains a superior method for evaluating superficial lesions and the mucosal extent of the cancer.

Diagnostic Procedures

• Direct laryngoscopy
  • Direct laryngoscopy under general anesthesia allows for thorough evaluation of the larynx and precise tumor mapping. Palpation of the lesion and surrounding structures allows for estimation of the depth of infiltration. The arytenoid cartilages are palpated to assess the status of the cricoarytenoid joint.
  • Points for assessment include the following:
    • Degree of alteration of mobility of the true vocal cord
    • Degree of alteration of mobility of the arytenoid cartilage
    • Involvement of the anterior commissure
    • Degree of invasion of the subglottis
    • Status of the mucosa surrounding the primary site
    • Degree of invasion of the preepiglottic space
    • Invasion of the thyroid cartilage
  • Mobility of the true vocal cords, arytenoid cartilages, and false vocal cords indicates the depth of cancer invasion. True fixation of the arytenoid cartilage is always associated with fixation of the true vocal cord, indicating infiltration of the cricoarytenoid joint and/or musculature. This posterolateral cricoid involvement is a major contraindication to any organ preservation surgery techniques. While true vocal cord immobility is a contraindication to SGL and VPL, fixation of the true vocal cord with some mobility of the arytenoid is not a contraindication to SCPL.
  • Impairment or fixation of the true vocal cord in glottic carcinoma indicates invasion of the thyroarytenoid muscle. The depth of invasion is directly related to the degree to which cord motion is impaired.
  • At the supraglottic level, the most common cause of cord fixation is deep arytenoid cartilage invasion. However, an important distinction exists between true vocal cord fixation and arytenoid cartilage fixation. Hypopharyngeal or epilaryngeal supraglottic carcinomas might appear to affect mobility of the arytenoid cartilages because of gross tumor characteristics but leave true vocal cord mobility unaffected or impaired rather than fixed. This pseudofixation is unlikely to represent malignant invasion of the cricoarytenoid joint and/or musculature, suggesting that laryngeal preservation techniques may be employed.

Treatment

Preoperative Details

Patients must be assessed for their willingness and motivation to undergo intensive speech and swallowing rehabilitation postoperatively. Because age impairs oropharyngeal motor control and laryngopharyngeal sensitivity and esophageal motility, elderly patients are at increased risk for postoperative swallowing impairment. A percutaneous endoscopic gastrostomy (at time of staging endoscopy) or an intraoperatively placed nasogastric feeding tube may be useful if rehabilitation of swallowing is expected to be difficult or longer than usual.

Precise evaluation of the extent of the laryngeal tumor depends upon findings on clinical examination (see Clinical), direct laryngoscopy (see Diagnostic Procedures), and imaging studies (see Imaging Studies). A precise understanding of the superficial and deep extent of the lesion is necessary to determine if surgical ablation of the lesion is possible.

Despite careful preoperative workup, the final decision concerning the suitability of a particular OPS procedure cannot be made until the time of surgery. Always obtain permission to perform a total laryngectomy with or without voice prosthesis insertion preoperatively in case tumor extent precludes organ preservation surgery.

Careful selection of patients should result in less postoperative morbidity and mortality and less need for a completion TL or permanent gastrostomy.

Intraoperative Details

The following section describes the SCPL-CHEP and SCPL-CHP techniques. The descriptions are meant to provide broad overviews. Details of the procedures are discussed elsewhere (see Bibliography).

In both SCPL-CHEP and SCPL-CHP, a subplatysmal apron flap is elevated in line with the planned position of the future tracheostomy site. The strap muscles are divided, and the constrictors are transected at the posterior aspect of the thyroid cartilage. The cricothyroid joints are disarticulated, with care taken to avoid damaging either the superior laryngeal nerve (SLN) or the recurrent laryngeal nerve (RLN). The internal thyroid perichondrium is elevated from the inner aspect of the thyroid cartilage. A transverse cricothyrotomy is performed at the superior level of the cricoid, and a flexible armored endotracheal tube is placed.

Supracricoid partial laryngectomy with cricohyoidoepiglottopexy reconstruction

The larynx is entered with scissors just above the thyroid notch. The entry above the false cords spares essentially the whole epiglottis and preepiglottic space. The arytenoid is preserved on the noninvolved side. With one scissor blade between the inner aspect of the thyroid cartilage and the internal thyroid perichondrium, the false cord is transected where it meets the arytenoid. The excision is extended posterior to the ventricle and through the vocal process of the true cord to the level of the cricoid.

The transection continues anteriorly through the cricothyroid musculature and along the top of the cricoid cartilage to the level of the previously made cricothyrotomy. The larynx is cracked open on itself like a book, and the resection on the involved side is performed along the cricoid, taking the involved arytenoid as necessary. The posterior arytenoid mucosa must be spared on the involved side. The remaining arytenoid and posterior arytenoid mucosa are sutured anteriorly to the level of the cricoid.

Closure is performed with 3 pexy sutures placed around the cricoid and passed through the epiglottis, preepiglottic space, around the hyoid, and deep into the tongue base. The sutures are initially placed and held tightly to approximate the cricoid and hyoid so that the tracheostomy can be performed in line with the original neck skin incision. The sutures are securely tied, and the strap muscles are closed over the reconstruction.

Supracricoid partial laryngectomy with cricohyoidopexy reconstruction

Scissors enter below the hyoid bone into the vallecula. Transection is performed along the lateral edges of the epiglottis almost to the level of the corniculate cartilages where the false cords come into view. The arytenoid is spared on the noninvolved side. With one scissor blade between the inner aspect of the thyroid cartilage and the internal thyroid perichondrium, the transection is made through the false cord where it meets the arytenoid and is continued just posterior to the ventricle and through the vocal process of the true cord to the level of the cricoid.

The transection is brought anteriorly through the cricothyroid musculature and along the top of the cricoid cartilage to the level of the previously made cricothyrotomy. The larynx is cracked open on itself like a book, and the resection of the involved side is performed along the cricoid, taking the involved arytenoid if necessary. The posterior arytenoid mucosa must be spared on the involved side. The remaining arytenoid and posterior arytenoid mucosa are sutured anteriorly to the level of the cricoid.

Closure is performed with 3 sutures placed around the cricoid, around the hyoid, and deep into the tongue base. The sutures are initially placed and held tightly to approximate the cricoid and hyoid so that the tracheostomy can be performed in line with the original neck skin incision. The sutures are securely tied and then the strap muscles are closed over the reconstruction.

Two points are worth particular attention. All of the vallecula mucosa should be resected and not utilized in the closure. This mucosa is not sufficiently vascularized and has a high risk of necrosis. Additionally, the entire ventricle must be resected to ensure that a postoperative laryngocele does not form and cause airway obstruction.

Management of neck disease

Bilateral modified neck dissection is the standard of care for all carcinoma invading the supraglottic larynx. Radical neck dissection may be required for all clinically palpable nodes that are larger than 2 cm.

• Elevate the superiorly based platysma flap to 2 cm above the hyoid bone to prevent tethering of the skin in the impaction during reconstruction.
• Incise the infrahyoid muscles at the superior border of the thyroid cartilage. Resection close to the hyoid bone precludes muscular reconstruction. The suprahyoid muscles must be spared because transection of these muscles threatens the blood supply of the hyoid bone.
• Blunt finger dissection along the anterior wall of the cervicomediastinal trachea reduces tension at the suture line at the time of closure and reduces risk of potential rupture of the pexy.
• Be careful to preserve an intact mobile cricoarytenoid unit on the noninvolved side of the larynx because this structure is the basis for laryngeal function postoperatively. Always take care to spare the cricoarytenoid joint.
• Spare the main trunks of both SLNs to ensure sensation of the remaining larynx postoperatively. Care must be taken when transecting the inferior constrictor muscles.
• A mobile arytenoid is necessary postoperatively for laryngeal closure during deglutition and for the best possible voice quality. Subperichondrial disarticulation of the cricothyroid joint always protects the RLN where the nerve enters the larynx.
• If the arytenoid is removed on the tumor-bearing side of the larynx, preserve the posterior arytenoid mucosa. This flap provides additional posterolateral mass that enhances recovery of swallowing function.
• Do not preserve the posterior third of the false and true vocal cords on the noninvolved side of the larynx. This additional tissue compromises the apposition of the arytenoid and the base of the tongue, compromising the functional efficiency of the neoglottis.
• Suturing the vocal process of the arytenoids anteriorly to the cricoid creates a narrow T-shaped larynx. This prevents the backward prolapse of the arytenoids cartilage and mucosa into the posterior pharynx. When only one arytenoid is preserved, the repositioning suture should be directed more anteriorly and towards the midline. The vertical portion of the T between the arytenoid cartilages and/or mucosa serves as the posterior respiratory glottis. The horizontal portion of the T between the arytenoid cartilage and the laryngeal surface of the epiglottis acts as the phonatory glottis.
• Pyriform repositioning improves swallowing function and reduces the risk of postoperative aspiration. Two sutures are placed through the transected interior constrictor muscles, which are positioned over the completed pexy (CHEP or CHP), bringing the pyriform sinuses into closer approximation than normal.
• Prior to impaction, a cricopharyngeal myotomy should be performed if palpation of the upper esophageal sphincter reveals hypertonia. However, a history of gastroesophageal reflux might be a contraindication.
• Only 3 pexy sutures are placed, and they should be precisely 1 cm apart. They should be placed deeply into the tongue base to allow for proper propulsion of the food bolus during swallowing and airway protection. Additional sutures only flatten the tongue, reducing swallowing efficiency.
• In SCPL-CHEP, the epiglottis is included in the impaction to avoid posterior dislocation of the epiglottic cartilage that would result in airway compromise postoperatively.
• Avoid rotation of the laryngeal skeletal structures at the time of impaction. The anterior border of the cricoid cartilage and the hyoid bone must be carefully aligned to reduce postoperative aspiration.
• Care must be taken when tying the pexy sutures to avoid fracture of the cricoid arch. If a fracture occurs, the pexy must be performed using the first 2 tracheal rings.
• The tracheostomy site is made in line with the neck incision to facilitate replacement of the tracheostomy tube if it becomes dislodged in the perioperative period. If the tracheostomy tube becomes dislodged, air could potentially track above the tracheostomy site, forming a dead space. Several steps are taken intraoperatively to prevent this occurrence. To obliterate the space anterior to the trachea above the tracheostomy site, the thyroid isthmus is resutured and a portion of the thyroid tissue is included within the vertical midline closure of the strap muscles. To separate the tracheostomy site from the remainder of the wound, a running 3-0 Vicryl suture is placed in a semicircular fashion above the tracheostomy site between the inferior portion of the upper skin flap and the strap muscles.

Postoperative Details

The goal is to discharge patients within the first postoperative week. The wound is cleaned with saline and treated with antibiotic ointment. In patients with no history of head and neck radiation therapy, staples or sutures are removed on postoperative day 6. Typically, a number 10 Jackson-Pratt drain is placed above the strap muscles and left on bulb suction. This drain is usually removed when output has decreased to less than 20 mL per 24 hours.

At present, tracheostomy management is based on late decannulation of the patient that permits early hospital discharge between day 3 and day 5 postoperatively. The tracheostomy cuff is deflated on postoperative day 1. The tracheostomy tube is changed to a cuffless tube on approximately postoperative day 3. Visualization of the airway by indirect laryngoscopy should not demonstrate any evidence of significant edema or granulation tissue. Either a 4 or 5 tracheostomy tube is put into place, and the patient is taught tracheostomy care. The tracheostomy is capped if the airway is sufficient, or a Passy-Muir valve is put into place instead. The date of hospital discharge is based on patients' ability to manage their tracheostomy and gastrostomy tube feeds.

Temporary postoperative dysphagia is to be expected, but long-term dysphagia is rare. Patients typically require swallowing therapy to facilitate adequate excursion of the neoglottis. If placed intraoperatively, the nasogastric tube is removed based upon the speed at which the patient recovers swallowing ability. The median time for removal of feeding tube in one study of SCPL-CHP was 16 days (range 9-40 d).

Finally, patients are able to communicate with lung-powered speech and engage in normal social interactions. The quality of the voice is breathy and permanently hoarse, as in chronic laryngitis. This improves somewhat as the mobility of the arytenoid improves. Speech and swallow rehabilitation should commence immediately to maximize postoperative laryngeal function.

Complications

A 1998 study of SCPL-CHEP in a series of 190 patients by Naudo et al reported a postoperative mortality rate of 1% and a morbidity rate of 11.7%.^{[3 ]}The postoperative mortality rate for SCPL-CHP is 2.6% in the literature, with a similar morbidity rate to that for SCPL-CHEP. These mortality and morbidity rates are similar to those reported for VPL and SGL.

Complications can include the following:

• Aspiration pneumonia (most common complication in a number of outcomes studies)
• Neck wound infection
• Hematoma
• Laryngocele, symptomatic
• Ruptured pexis
• Laryngeal chondronecrosis
• Laryngeal stenosis
• Local recurrence of carcinoma

Long-term functional complications (0.5-2.5% of all patients) can include the following:

• Completion laryngectomy
• Permanent gastrostomy
• Permanent tracheostomy

Intraoperative steps to prevent many of these complications were described earlier in this article (see Key surgical points).

Outcome and Prognosis

Oncologic rationale and results

Successful application of supracricoid partial laryngectomy-cricohyoidoepiglottopexy (SCPL-CHEP) and supracricoid partial laryngectomy-cricohyoidopexy (SCPL-CHP) to laryngeal carcinoma requires careful preoperative selection of patients and meticulous surgical technique. Local control rates for these procedures are comparable to those achieved with TL.

SCPL-CHEP is applied to selected glottic carcinomas that are invading the anterior commissure, ventricle, or thyroid cartilage or that manifest with impairment or fixation of the true vocal cord. Surgical resection involves the true and false vocal cords, the entire thyroid cartilage, both paraglottic spaces, the inferior portion of the epiglottis, and a maximum of one arytenoid. Local control rates are excellent. In a study in 1991 by Piquet and Chevalier, the local failure rate was 5% among 104 patients with glottic carcinoma.^{[4 ]}The 5-year actuarial local control was 94.4% with T2 glottic carcinoma.

SCPL-CHP is indicated for selected supraglottic and transglottic carcinomas, especially those lesions that are not amenable to SGL because of glottic involvement, invasion of the preepiglottic space, impaired cord mobility, or limited thyroid cartilage invasion. The resection is more extensive than in the SCPL-CHEP and involves removal of the entire epiglottis and preepiglottic space. Appropriate use of this technique also results in excellent local control. In one 1990 study in Laryngoscope by Laccouraeye, et al, no local failure occurred among 68 patients with at least 18 months of follow-up.^{[5,6 ]}Another study had a low 3.3% local failure rate.^{[7 ]}The 5-year survival rate is 75%, a rate that is comparable to survival following SGL.

Future and Controversies

The organ preservation surgery techniques of supracricoid partial laryngectomy-cricohyoidoepiglottopexy (SCPL-CHEP) and supracricoid partial laryngectomy-cricohyoidopexy (SCPL-CHP) are increasingly gaining acceptance around the world for the treatment of selected laryngeal cancers. Both SCPL-CHP and SCPL-CHEP achieve local control rates that are comparable to TL for selected laryngeal cancers. Furthermore, they achieve the functional goals of speech and swallowing without a permanent tracheostomy. These techniques also avoid the stigma of the permanent stoma that remains the primary detractor from quality of life for patients who have undergone a TL. Because both SCPL-CHP and SCPL-CHEP have standard resection boundaries and closure techniques, functional outcomes are predictable and reproducible.

Proper patient selection and preoperative evaluation remain the keys to successful functional and oncologic outcome. SCPL has become a valuable alternative to TL for surgical salvage of patients with residual or recurrent disease following other treatment modalities. Recent clinicopathological analysis has also demonstrated that SCPL is safe for the resection of glottic SCC with subglottic extension of up to 15 mm. Additional studies will be required to verify the effective use of SCPL in these clinical settings.

Multimedia

Media file 1: Cartilages of the larynx, posterior view.

References

1. Joo YH, Sun DI, Cho JH, Cho KJ, Kim MS. Factors that predict postoperative pulmonary complications after supracricoid partial laryngectomy. Arch Otolaryngol Head Neck Surg. Nov 2009;135(11):1154-7. [Medline].

2. Hirano M, Kurita S, Kiyokawa K, Sato K. Posterior glottis. Morphological study in excised human larynges. Ann Otol Rhinol Laryngol. Nov-Dec 1986;95(6 Pt 1):576-81. [Medline].

3. Naudo P, Laccourreye O, Weinstein G. Complications and functional outcome after supracricoid partial laryngectomy with cricohyoidoepiglottopexy. Otolaryngol Head Neck Surg. Jan 1998;118(1):124-9. [Medline].

4. Piquet JJ, Chevalier D. Subtotal laryngectomy with crico-hyoido-epiglotto-pexy for the treatment of extended glottic carcinomas. Am J Surg. Oct 1991;162(4):357-61. [Medline].

5. Laccourreye H, Laccourreye O, Weinstein G, et al. Supracricoid laryngectomy with cricohyoidoepiglottopexy: a partial laryngeal procedure for glottic carcinoma. Ann Otol Rhinol Laryngol. Jun 1990;99(6 Pt 1):421-6. [Medline].

6. Laccourreye H, Laccourreye O, Weinstein G, et al. Supracricoid laryngectomy with cricohyoidopexy: a partial laryngeal procedure for selected supraglottic and transglottic carcinomas. Laryngoscope. Jul 1990;100(7):735-41. [Medline].

7. Chevalier D, Piquet JJ. Subtotal laryngectomy with cricohyoidopexy for supraglottic carcinoma: review of 61 cases. Am J Surg. Nov 1994;168(5):472-3. [Medline].

8. Lai SY, Laccourreye O, Weinstein GS. Supracricoid partial laryngectomy with cricohyoidepiglottopexy. Oto HNS. (Mar) 2003;14:34-39.

9. Majer H, Reider W. Technique de laryngecomie permetant de conserver la permeabilite respiratoiré la cricohyoido-pexie. Ann Otolaryngol Chir Cervicofac. 1959;76:677-683.

10. Sewell DA. Supracricoid partial laryngectomy with cricohypodopexy. Oto HNSC. Mar 2003;1:27-33.

11. Sparano A, Chernock R, Feldman M, et al. Extending the inferior limits of supracricoid partial laryngectomy: a clinicopathological correlation. Laryngoscope. Feb 2005;115(2):297-300. [Medline].

12. Weinstein GS, Laccourreye O, Brasnu D, et al. Organ Preservation Surgery for Laryngeal Cancer. San Diego, Calif: Singular Publishing Group;2000.

13. Weinstein GS, Laccourreye O, Rassekh C. Conservation laryngeal surgery. In: Cummings C, et al, eds. Otolaryngology: Head and Neck Surgery. 3rd ed. St Louis, Mo: Mosby-Year Book;1998.

14. [Guideline] Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ, Ang KK, et al. American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol. Aug 1 2006;24(22):3693-704. [Medline].

Keywords

laryngectomy, laryngeal surgery, supracricoid partial laryngectomy, conservation laryngeal surgery, SCPL, SCPL with cricohyoidoepiglottopexy reconstruction, SCPL-CHEP, SCPL with cricohyoidopexy reconstruction, SCPL-CHP

Contributor Information and Disclosures

Author

Stephen Y Lai, MD, PhD, Assistant Professor, Departments of Otolaryngology and Pharmacology, University of Pittsburgh Medical Center
Stephen Y Lai, MD, PhD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American Association for Cancer Research, American Head and Neck Society, and Society of University Otolaryngologists-Head and Neck Surgeons
Disclosure: Nothing to disclose.

Coauthor(s)

Gregory S Weinstein, MD, FACS, Professor and Vice-Chairman, Department of Otorhinolaryngology-Head and Neck Surgery, Director of Division of Head and Neck Surgery, Director of Head and Oncology Fellowship, Director of Otorhinolaryngology-Head and Neck Clinic, Co-director of The Center for Head and Neck Surgery, University of Pennsylvania School of Medicine
Gregory S Weinstein, MD, FACS is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Laryngological Association, American Laryngological Rhinological and Otological Society, American Medical Association, American Radium Society, American Society for Head and Neck Surgery, Pennsylvania Medical Society, Philadelphia County Medical Society, and Society of University Otolaryngologists-Head and Neck Surgeons
Disclosure: Nothing to disclose.

Medical Editor

Daniel J Kelley, MD, Consulting Staff, Eastern Shore ENT and Allergy Associates and Peninsula Regional Medical Center
Daniel J Kelley, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Head and Neck Society, American Laryngological Rhinological and Otological Society, and Pennsylvania Medical Society
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Nader Sadeghi, MD, FRCS(C), Associate Professor of Surgery, Director of Head and Neck Surgery, Division of Otolaryngology, George Washington University
Nader Sadeghi, MD, FRCS(C) is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society, Federation of Medical Specialists in Quebec, and Royal College of Physicians and Surgeons of Canada
Disclosure: Nothing to disclose.

CME Editor

Christopher L Slack, MD, Otolaryngology-Facial Plastic Surgery, Private Practice, Associated Coastal ENT; Medical Director, Treasure Coast Sleep Disorders
Christopher L Slack, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Arlen D Meyers, MD, MBA, Professor, Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine
Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Head and Neck Society
Disclosure: Covidien Corp Consulting fee Consulting; US Tobacco Corporation unstricted gift unknown; Axis Three Corporation Ownership interest Consulting; Omni Biosciences Ownership interest Consulting; Sentegra Ownership interest Board membership; Syndicom Ownership interest Consulting; Oxlo  Consulting; Medvoy Ownership interest Management position

Clinical guidelines

American Society of Clinical Oncology, Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ, Ang KK, Clayman GL, Fisher SG, Forastiere AA, Harrison LB, Lefebvre JL, Leupold N, List MA, O'Malley BO, Patel S, Posner MR, Schwartz MA, Wolf GT. American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 2006 Aug 1;24(22):3693-704.^{[ 14 ]}

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