eMedicine Specialties > Otolaryngology and Facial Plastic Surgery > Head & Neck Surgery

Combined Modality Molecular Targeted Therapy, Head/Neck Squamous Cell Carcinoma: Multimedia

Author: Pankaj Chaturvedi, MBBS, MS, Associate Professor, Head and Neck Surgery, Department of Surgical Oncology, Tata Memorial Hospital, India
Coauthor(s): Bhavin Chandrakant Shah, MD, MS, MRCS, MIS, Advanced Laparoscopic Research Fellow, Department of Surgery, University of Nebraska Medical Center
Contributor Information and Disclosures

Updated: May 8, 2009

Multimedia

The epidermal growth factor receptor (HER) family...Media file 1: The epidermal growth factor receptor (HER) family consists of 4 closely related transmembrane receptors: HER-1/EGFR, HER-2, HER-3, and HER-4. Each receptor has an extracellular ligand-binding domain, a transmembrane region that anchors the receptor to the cell, and an intracellular cytoplasmic domain that contains a tyrosine kinase region and a carboxy terminal tail.
The epidermal growth factor receptor (HER) family...

The epidermal growth factor receptor (HER) family consists of 4 closely related transmembrane receptors: HER-1/EGFR, HER-2, HER-3, and HER-4. Each receptor has an extracellular ligand-binding domain, a transmembrane region that anchors the receptor to the cell, and an intracellular cytoplasmic domain that contains a tyrosine kinase region and a carboxy terminal tail.

Normal cells and cancer cells rely on epidermal g...Media file 2: Normal cells and cancer cells rely on epidermal growth factor receptor (EGFR) signals, but the signal is not correctly regulated in cancer cells.
Normal cells and cancer cells rely on epidermal g...

Normal cells and cancer cells rely on epidermal growth factor receptor (EGFR) signals, but the signal is not correctly regulated in cancer cells.

More on Combined Modality Molecular Targeted Therapy, Head/Neck Squamous Cell Carcinoma

References

References

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Further Reading

Keywords

squamous cell carcinoma of the head and neck, neck cancer, head cancer, neck malignancy, head malignancy, HNSCC, epidermal growth factor receptor, EGFR, human epidermal growth factor receptor, EGF, HER, HER1, HER2, HER2/neu, Her-1, Her-2, Her-2/neu, molecular medicine, molecular therapy, trastuzumab, STI-571, ERBB2, EGFR overexpression, EGFR tyrosine kinase, EGFR inhibitors, non–small-cell lung cancer, NSCLC, anticancer therapy, antitumor therapy, Pertuzumab 2C4, cetuximab, erlotinib, gefitinib, angiogenesis, interleukin-13 receptors, IL-13R, gene therapy, cyclooxygenase-2, COX-2 inhibitors, chemoprevention, carcinoembryonic antigen, CEA

Contributor Information and Disclosures

Author

Pankaj Chaturvedi, MBBS, MS, Associate Professor, Head and Neck Surgery, Department of Surgical Oncology, Tata Memorial Hospital, India
Pankaj Chaturvedi, MBBS, MS is a member of the following medical societies: American Association for the Advancement of Science and Association of Surgeons of India
Disclosure: Nothing to disclose.

Coauthor(s)

Bhavin Chandrakant Shah, MD, MS, MRCS, MIS, Advanced Laparoscopic Research Fellow, Department of Surgery, University of Nebraska Medical Center
Bhavin Chandrakant Shah, MD, MS, MRCS, MIS is a member of the following medical societies: Royal College of Surgeons of Edinburgh
Disclosure: Nothing to disclose.

Medical Editor

Benoit J Gosselin, MD, FRCSC, Associate Professor of Surgery, Dartmouth Medical School; Director, Comprehensive Head and Neck Oncology Program, Norris Cotton Cancer Center; Staff Otolaryngologist, Division of Otolaryngology-Head and Neck Surgery, Dartmouth-Hitchcock Medical Center
Benoit J Gosselin, MD, FRCSC is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society, American Medical Association, American Rhinologic Society, Canadian Medical Association, Canadian Society of Otolaryngology-Head & Neck Surgery, College of Physicians and Surgeons of Ontario, New Hampshire Medical Society, North American Skull Base Society, and Ontario Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Karen Hall Calhoun, MD, Professor, Department of Otolaryngology-Head and Neck Surgery, The Ohio State University
Karen Hall Calhoun, MD is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Head and Neck Society, American Medical Association, American Rhinologic Society, Association for Research in Otolaryngology, Society of University Otolaryngologists-Head and Neck Surgeons, Southern Medical Association, Texas Medical Association, and Texas Medical Association
Disclosure: Nothing to disclose.

CME Editor

Christopher L Slack, MD, Otolaryngology-Facial Plastic Surgery, Private Practice, Associated Coastal ENT; Medical Director, Treasure Coast Sleep Disorders
Christopher L Slack, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Arlen D Meyers, MD, MBA, Professor, Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine
Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Head and Neck Society
Disclosure: Covidien Corp Consulting fee Consulting; US Tobacco Corporation unstricted gift unknown

 
 
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