Otitis Media With Effusion Differential Diagnoses
- Author: Richard D Thrasher III, MD; Chief Editor: Arlen D Meyers, MD, MBA more...
Diagnostic Considerations
In adults, recognizing unilateral otitis media (OME) with effusion is crucial. This entity must be considered a nasopharyngeal mass until definitively proven otherwise. Note that the single greatest pitfall in otitis media with effusion is the failure to fully evaluate a potential nasopharyngeal mass in an adult patient who has recurrent unilateral otitis media with effusion. At minimum, indirect mirror examination or flexible nasopharyngoscopy should be performed. Imaging studies and possibly even biopsies may be indicated.
Other pitfalls include the failure to note hearing loss and the failure to recognize a potential delay in language development in children; these failures could have a lasting effect in the patient.
The following are conditions that should be considered when evaluating patients with suspected otitis media with effusion:
- Benign nasopharyngeal masses
- Nasopharyngeal carcinoma
- Acute otitis media (AOM)
- Adenoid hypertrophy
- Congenital defects affecting the eustachian tube and its egress
- Ciliary dyskinesia
- Immunoglobulin G (IgG) subclass deficiencies
Differential Diagnoses
- Cleft Palate
- Eustachian Tube Function
- Malignant Tumors of the Nasal Cavity
- Malignant Tumors of the Temporal Bone
- Middle Ear Function
- Middle Ear, Eustachian Tube, Inflammation/Infection
- Middle Ear, Tympanic Membrane, Infections
- Patulous Eustachian Tube
- Sinonasal Manifestations of Cystic Fibrosis
Bluestone CD, Beery QC, Andrus WS. Mechanics of the eustachian tube as it influences susceptibility to and persistence of middle ear effusions in children. Ann Otol Rhinol Laryngol. Mar-Apr 1974;83:Suppl 11:27-34. [Medline].
Crapko M, Kerschner JE, Syring M, Johnston N. Role of extra-esophageal reflux in chronic otitis media with effusion. Laryngoscope. Jun 20 2007;[Medline].
Yilmaz T, Koçan EG, Besler HT, Yilmaz G, Gürsel B. The role of oxidants and antioxidants in otitis media with effusion in children. Otolaryngol Head Neck Surg. Dec 2004;131(6):797-803. [Medline].
Kubba H, Pearson JP, Birchall JP. The aetiology of otitis media with effusion: a review. Clin Otolaryngol. Jun 2000;25(3):181-94. [Medline].
[Guideline] Rosenfeld RM, Culpepper L, Doyle KJ, Grundfast KM, Hoberman A, Kenna MA. Clinical practice guideline: Otitis media with effusion. Otolaryngol Head Neck Surg. May 2004;130(5 Suppl):S95-118. [Medline].
Pichichero ME, Poole MD. Assessing diagnostic accuracy and tympanocentesis skills in the management of otitis media. Arch Pediatr Adolesc Med. Oct 2001;155(10):1137-42. [Medline].
Kaleida PH. Evidence assessment of the accuracy of methods of diagnosing middle ear effusion in children with otitis media with effusion. J Pediatr. Jul 2004;145(1):138. [Medline].
Kouwen HB, Dejonckere PH. Prevalence of OME is reduced in young children using chewing gum. Ear Hear. Aug 2007;28(4):451-5. [Medline].
Williams RL, Chalmers TC, Stange KC, et al. Use of antibiotics in preventing recurrent acute otitis media and in treating otitis media with effusion. A meta-analytic attempt to resolve the brouhaha. JAMA. Sep 15 1993;270(11):1344-51. [Medline].
Tracy JM, Demain JG, Hoffman KM, Goetz DW. Intranasal beclomethasone as an adjunct to treatment of chronic middle ear effusion. Ann Allergy Asthma Immunol. Feb 1998;80(2):198-206. [Medline].
Simpson SA, Lewis R, van der Voort J, Butler CC. Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev. May 11 2011;CD001935. [Medline].
Simpson SA, Lewis R, van der Voort J, Butler CC. Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev. May 11 2011;5:CD001935. [Medline].
[Best Evidence] Williamson I, Benge S, Barton S, et al. A double-blind randomised placebo-controlled trial of topical intranasal corticosteroids in 4- to 11-year-old children with persistent bilateral otitis media with effusion in primary care. Health Technol Assess. Aug 2009;13(37):1-144. [Medline].
Cantekin EI, Mandel EM, Bluestone CD, et al. Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial. N Engl J Med. Feb 10 1983;308(6):297-301. [Medline].
Griffin G, Flynn CA. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev. Sep 7 2011;9:CD003423. [Medline].
Maw R, Bawden R. Spontaneous resolution of severe chronic glue ear in children and the effect of adenoidectomy, tonsillectomy, and insertion of ventilation tubes (grommets). BMJ. Mar 20 1993;306(6880):756-60. [Medline].
Boston M, McCook J, Burke B, Derkay C. Incidence of and risk factors for additional tympanostomy tube insertion in children. Arch Otolaryngol Head Neck Surg. Mar 2003;129(3):293-6. [Medline].
Burton MJ, Rosenfeld RM. Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children. Otolaryngol Head Neck Surg. Oct 2006;135(4):507-10. [Medline].
Pichichero ME, Reiner SA, Brook I, et al. Controversies in the medical management of persistent and recurrent acute otitis media. Recommendations of a clinical advisory committee. Ann Otol Rhinol Laryngol Suppl. Aug 2000;183:1-12. [Medline].
[Guideline] Rosenfeld RM, Culpepper L, Doyle KJ. Clinical practice guideline: Otitis media with effusion. Am Fam Physician. Jun 15 2004;69(12):2776, 2778-9. [Medline]. [Full Text].
Gates GA. Acute otitis media and otitis media with effusion. In: Cummings CW, ed. Otolaryngology Head and Neck Surgery. Pediatric Otolaryngology. Vol 5. 3rd ed. St Louis, Mo: Mosby; 1998:461-77.

