eMedicine Specialties > Otolaryngology and Facial Plastic Surgery > Nasal & Sinus Diseases

CSF Rhinorrhea: Follow-up

Author: Kevin C Welch, MD, Assistant Professor, Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center
Coauthor(s): James Stankiewicz, MD, Professor, Chair, Program Director, Department of Otolaryngology-Head and Neck Surgery, Loyola University Chicago School of Medicine
Contributor Information and Disclosures

Updated: Sep 28, 2009

Outcome and Prognosis

See individual surgical techniques in Surgical therapy.

Future and Controversies

CSF rhinorrhea can occur as a result of craniofacial injury, iatrogenic surgical trauma, or spontaneous causes. Several diagnostic tools are available to aid in diagnosis. In the case of early-onset traumatic fistula, a conservative approach can be used. Other causes require a more aggressive intervention. Endoscopic and external techniques have replaced invasive craniotomy. Because of these techniques, the otolaryngologist plays a key role in diagnosing and managing this problem.

With the growing popularity of computer-assisted, image-guided surgical techniques, the ability to precisely locate areas of CSF leakage is enhanced. This advance may improve the accuracy and precision of closing the defects, with a resulting increase in success rates. In addition, the use of synthetic graft material to repair these defects is another option that has recently become available.

 
Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous authors Joseph Scianna, MD, and Srinivas Mukkamala, MD, to the development and writing of this article.



More on CSF Rhinorrhea

Overview: CSF Rhinorrhea
Workup: CSF Rhinorrhea
Treatment: CSF Rhinorrhea
Follow-up: CSF Rhinorrhea
Multimedia: CSF Rhinorrhea
References

References

  1. Lindstrom DR, Toohill RJ, Loehrl TA, Smith TL. Management of cerebrospinal fluid rhinorrhea: the Medical College of Wisconsin experience. Laryngoscope. Jun 2004;114(6):969-74. [Medline].

  2. Liu HS, Chen YT, Wang D, Liang H, Wang Y, Wang SJ, et al. The use of topical intranasal fluorescein in endoscopic endonasal repair of cerebrospinal fluid rhinorrhea. Surg Neurol. Oct 2009;72(4):341-5; discussion 346. [Medline].

  3. Bolger WE, Kennedy DW. Nasal endoscopy in the outpatient clinic. Otolaryngol Clin North Am. Aug 1992;25(4):791-802. [Medline].

  4. Byrne JV, Ingram CE, MacVicar D, et al. Digital subtraction cisternography: a new approach to fistula localisation in cerebrospinal fluid rhinorrhoea. J Neurol Neurosurg Psychiatry. Dec 1990;53(12):1072-5. [Medline].

  5. Cappabianca P, Cavallo LM, Esposito F, et al. Sellar repair in endoscopic endonasal transsphenoidal surgery: results of 170 cases. Neurosurgery. Dec 2002;51(6):1365-71; discussion 1371-2. [Medline].

  6. Carrau RL, Snyderman CH, Kassam AB. The management of cerebrospinal fluid leaks in patients at risk for high-pressure hydrocephalus. Laryngoscope. Feb 2005;115(2):205-12. [Medline].

  7. Carrion E, Hertzog JH, Medlock MD, et al. Use of acetazolamide to decrease cerebrospinal fluid production in chronically ventilated patients with ventriculopleural shunts. Arch Dis Child. Jan 2001;84(1):68-71. [Medline].

  8. Chow JM, Goodman D, Mafee MF. Evaluation of CSF rhinorrhea by computerized tomography with metrizamide. Otolaryngol Head Neck Surg. Feb 1989;100(2):99-105. [Medline].

  9. Dodson EE, Gross CW, Swerdloff JL, et al. Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea and skull base defects: a review of twenty-nine cases. Otolaryngol Head Neck Surg. Nov 1994;111(5):600-5. [Medline].

  10. Dula DJ, Fales W. The 'ring sign': is it a reliable indicator for cerebral spinal fluid?. Ann Emerg Med. Apr 1993;22(4):718-20. [Medline].

  11. Eljamel MS, Foy PM. Post-traumatic CSF fistulae, the case for surgical repair. Br J Neurosurg. 1990;4(6):479-83. [Medline].

  12. Eljamel MS, Pidgeon CN, Toland J, et al. MRI cisternography, and the localization of CSF fistulae. Br J Neurosurg. 1994;8(4):433-7. [Medline].

  13. Hegazy HM, Carrau RL, Snyderman CH, et al. Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea: a meta-analysis. Laryngoscope. Jul 2000;110(7):1166-72. [Medline].

  14. Hubbard JL, McDonald TJ, Pearson BW, et al. Spontaneous cerebrospinal fluid rhinorrhea: evolving concepts in diagnosis and surgical management based on the Mayo Clinic experience from 1970 through 1981. Neurosurgery. Mar 1985;16(3):314-21. [Medline].

  15. Jones DT, McGill TJ, Healy GB. Cerebrospinal fistulas in children. Laryngoscope. Apr 1992;102(4):443-6. [Medline].

  16. Lee TJ, Huang CC, Chuang CC, et al. Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea and skull base defect: ten-year experience. Laryngoscope. Aug 2004;114(8):1475-81. [Medline].

  17. Lopatin AS, Kapitanov DN, Potapov AA. Endonasal endoscopic repair of spontaneous cerebrospinal fluid leaks. Arch Otolaryngol Head Neck Surg. Aug 2003;129(8):859-63. [Medline].

  18. Marshall AH, Jones NS, Robertson IJ. CSF rhinorrhoea: the place of endoscopic sinus surgery. Br J Neurosurg. Feb 2001;15(1):8-12. [Medline].

  19. Mattox DE, Kennedy DW. Endoscopic management of cerebrospinal fluid leaks and cephaloceles. Laryngoscope. Aug 1990;100(8):857-62. [Medline].

  20. McMains KC, Gross CW, Kountakis SE. Endoscopic management of cerebrospinal fluid rhinorrhea. Laryngoscope. Oct 2004;114(10):1833-7. [Medline].

  21. Naidich TP, Moran CJ. Precise anatomic localization of atraumatic sphenoethmoidal cerebrospinal fluid rhinorrhea by metrizamide CT cisternography. J Neurosurg. Aug 1980;53(2):222-8. [Medline].

  22. Nuss D, Constantino P. Diagnosis and management of cerebrospinal fluid leaks. In: Otolaryngology Head and Neck Surgery. St Louis, Mo: Mosby-Year Book; 1996:79-95.

  23. Ommaya AK, Di Chiro G, Baldwin M, et al. Non-traumatic cerebrospinal fluid rhinorrhoea. J Neurol Neurosurg Psychiatry. Jun 1968;31(3):214-25. [Medline].

  24. Persky MS, Rothstein SG, Breda SD, et al. Extracranial repair of cerebrospinal fluid otorhinorrhea. Laryngoscope. Feb 1991;101(2):134-6. [Medline].

  25. Porter MJ, Brookes GB, Zeman AZ, et al. Use of protein electrophoresis in the diagnosis of cerebrospinal fluid rhinorrhoea. J Laryngol Otol. Jun 1992;106(6):504-6. [Medline].

  26. Ray BS, Bergland RM. Cerebrospinal fluid fistula: clinical aspects, techniques of localization, and methods of closure. J Neurosurg. Apr 1969;30(4):399-405. [Medline].

  27. Rontal M, Rontal E. Studying whole-mounted sections of the paranasal sinuses to understand the complications of endoscopic sinus surgery. Laryngoscope. Apr 1991;101(4 Pt 1):361-6. [Medline].

  28. Ryall RG, Peacock MK, Simpson DA. Usefulness of beta 2-transferrin assay in the detection of cerebrospinal fluid leaks following head injury. J Neurosurg. Nov 1992;77(5):737-9. [Medline].

  29. Schlosser RJ, Bolger WE. Nasal cerebrospinal fluid leaks: critical review and surgical considerations. Laryngoscope. Feb 2004;114(2):255-65. [Medline].

  30. Stankiewicz JA. Cerebrospinal fluid fistula and endoscopic sinus surgery. Laryngoscope. Mar 1991;101(3):250-6. [Medline].

  31. Stankiewicz JA. Complications in endoscopic intranasal ethmoidectomy: an update. Laryngoscope. Jul 1989;99(7 Pt 1):686-90. [Medline].

  32. Stone JA, Castillo M, Neelon B, et al. Evaluation of CSF leaks: high-resolution CT compared with contrast-enhanced CT and radionuclide cisternography. AJNR Am J Neuroradiol. Apr 1999;20(4):706-12. [Medline].

  33. Tolley NS. A clinical study of spontaneous CSF rhinorrhoea. Rhinology. Sep 1991;29(3):223-30. [Medline].

  34. Tolley NS, Lloyd GA, Williams HO. Radiological study of primary spontaneous CSF rhinorrhoea. J Laryngol Otol. Apr 1991;105(4):274-7. [Medline].

  35. Wakhloo AK, van Velthoven V, Schumacher M, et al. Evaluation of MR imaging, digital subtraction cisternography, and CT cisternography in diagnosing CSF fistula. Acta Neurochir (Wien). 1991;111(3-4):119-27. [Medline].

  36. Woodworth BA, Schlosser RJ, Faust RA, et al. Evolutions in the management of congenital intranasal skull base defects. Arch Otolaryngol Head Neck Surg. Nov 2004;130(11):1283-8. [Medline].

  37. Yerkes SA, Thompson DH, Fisher WS 3d. Spontaneous cerebrospinal fluid rhinorrhea. Ear Nose Throat J. Jul 1992;71(7):318-20. [Medline].

  38. Yessenow RS, McCabe BF. The osteo-mucoperiosteal flap in repair of cerebrospinal fluid rhinorrhea: a 20-year experience. Otolaryngol Head Neck Surg. Nov 1989;101(5):555-8. [Medline].

  39. Zlab MK, Moore GF, Daly DT, et al. Cerebrospinal fluid rhinorrhea: a review of the literature. Ear Nose Throat J. Jul 1992;71(7):314-7. [Medline].

Further Reading

Keywords

CSF, rhinorrhea, CSF rhinorrhea, cerebrospinal fluid, cerebrospinal fluid rhinorrhea, CSF leak, cerebrospinal fluid leak, traumatic CSF leak, nontraumatic CSF leak, primary nontraumatic CSF leak, secondary nontraumatic CSF leak, secondary nontraumatic CSF rhinorrhea, spontaneous CSF rhinorrhea, paradoxical rhinorrhea, reservoir sign, Queckenstedt-Stookey test, ring sign, double-ring sign, halo sign, CSF rhinorrhea

Contributor Information and Disclosures

Author

Kevin C Welch, MD, Assistant Professor, Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center
Kevin C Welch, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery and American Rhinologic Society
Disclosure: Nothing to disclose.

Coauthor(s)

James Stankiewicz, MD, Professor, Chair, Program Director, Department of Otolaryngology-Head and Neck Surgery, Loyola University Chicago School of Medicine
James Stankiewicz, MD is a member of the following medical societies: American College of Surgeons
Disclosure: Nothing to disclose.

Medical Editor

Lanny Garth Close, MD, Chair, Professor, Department of Otolaryngology-Head and Neck Surgery, Columbia University College of Physicians and Surgeons
Lanny Garth Close, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American College of Physicians, American Laryngological Association, American Society for Head and Neck Surgery, and New York Academy of Medicine
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Stephen G Batuello, MD, Consulting Staff, Colorado ENT Specialists
Stephen G Batuello, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Physician Executives, American Medical Association, and Colorado Medical Society
Disclosure: Nothing to disclose.

CME Editor

Christopher L Slack, MD, Otolaryngology-Facial Plastic Surgery, Private Practice, Associated Coastal ENT; Medical Director, Treasure Coast Sleep Disorders
Christopher L Slack, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Arlen D Meyers, MD, MBA, Professor, Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine
Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Head and Neck Society
Disclosure: Covidien Corp Consulting fee Consulting; US Tobacco Corporation unstricted gift unknown; Axis Three Corporation Ownership interest Consulting; Omni Biosciences Ownership interest Consulting; Sentegra Ownership interest Board membership; Syndicom Ownership interest Consulting; Oxlo  Consulting; Medvoy Ownership interest Management position

 
 
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