Nasal and Sublabial Approaches to the Pituitary Workup
- Author: Howard S Kotler, MD; Chief Editor: Arlen D Meyers, MD, MBA more...
Imaging Studies
- The preoperative workup for patients undergoing transphenoidal resection of the pituitary includes a thorough history of sinus disease (eg, hyposmia, epistaxis, nasal polyps, nasal discharge, sinusitis) and past nasal and sinus surgical treatment. Active or untreated chronic sphenoid sinusitis is a contraindication to performing the transphenoidal approach to the pituitary.
- A CT scan is indispensable prior to performing any sinus surgery, and the transnasal-sublabial approach to the sphenoid sinus is no exception. Perform preoperative noncontrast-enhanced CT scanning in both the axial and the coronal planes. These positions allow the surgeon to visualize essential sinus anatomic relationships. The relationship of the perpendicular plate of the ethmoid bone to the sphenoid rostrum and the presence and location of any intersinus septae are important anatomic considerations. The CT scan also gives indication of any nasal or intrasinus pathology that may require surgical or medical treatment prior to transphenoidal hypophysectomy. Critical anatomic variations in the carotid artery or optic nerve can also be observed from the CT scan.
- MRI can help differentiate infectious etiology from mucocele formation in the sinus. MRI studies may also help differentiate a possible vascular mass from the projection of 1 or both carotid arteries into the sinus.
Coronal and median sagittal images are shown in the image below.
Coronal and median sagittal images of pituitary adenoma. Hirsch O. Eine neue methode der endonasalen operation von ypophysentumoren. Wien Med Wochenschr. 1909;59:636-638.
Halstead AE. Remarks on the operative treatment of tumors of the hypophysis: with a report of two cases operated on by an oro-nasal method. Surg Gynecol Obstet. 1910;10:494-502.
Cushing H. Surgical experiences with pituitary disorders. JAMA. 1914;63:1515-1525.
Guiot G. Indications for the trans-sphenoidal approach of the hypophyseal fossa. Rhinol. 1973;11:137-152.
Dott N, Bailey A. A consideration of the hypophysial adenomata. Br J Surg. 1925;13:314-366.
Hardy J. Transsphenoidal hypophysectomy. J Neurosurg. Apr 1971;34(4):582-94. [Medline].
Hamberger CA, Hammer G, Norlen G, Sjogren B. Transantrosphenoidal hypophysectomy. Arch Otolaryngol. Jul 1961;74:2-8. [Medline].
Congdon ED. The distribution and mode of origin of septa and walls of the sphenoid sinus. Anat Rec. 1930;18:97.
Lazaridis N, Natsis K, Koebke J, Themelis C. Nasal, sellar, and sphenoid sinus measurements in relation to pituitary surgery. Clin Anat. Sep 2010;23(6):629-36. [Medline].
Chole RA, Lim C, Dunham B, Chicoine MR, Dacey RG Jr. A novel transnasal transsphenoidal speculum: a design for both microscopic and endoscopic transsphenoidal pituitary surgery. J Neurosurg. May 2011;114(5):1380-5. [Medline].
Duz B, Harman F, Secer HI, Bolu E, Gonul E. Transsphenoidal approaches to the pituitary: a progression in experience in a single centre. Acta Neurochir (Wien). Nov 2008;150(11):1133-8; discussion 1138-9. [Medline].
Neal JG, Patel SJ, Kulbersh JS, Osguthorpe JD, Schlosser RJ. Comparison of techniques for transsphenoidal pituitary surgery. Am J Rhinol. Mar-Apr 2007;21(2):203-6. [Medline].
Er U, Gürses L, Saka C, Belen D, Yigitkanli K, Simsek S, et al. Sublabial transseptal approach to pituitary adenomas with special emphasis on rhinological complications. Turk Neurosurg. Oct 2008;18(4):425-30. [Medline].
Gammert C. Rhinosurgical experience with the transseptal-transsphenoidal hypophysectomy: technique and long-term results. Laryngoscope. Mar 1990;100(3):286-9. [Medline].
[Guideline] Cook DM, Ezzat S, Katznelson L, Kleinberg DL, Laws ER Jr, Nippoldt TB, et al. AACE Medical Guidelines for Clinical Practice for the diagnosis and treatment of acromegaly. Endocr Pract. May-Jun 2004;10(3):213-25. [Medline].
Cook DM, Ezzat S, Katznelson L, Kleinberg DL, Laws ER Jr, Nippoldt TB, et al. AACE Medical Guidelines for Clinical Practice for the diagnosis and treatment of acromegaly. Endocr Pract. May-Jun 2004;10(3):213-25. [Medline].
Cushing H. Partial hypophysectomy for acromegaly. Ann Surg. 1909;50:1002.
Dew LA, Haller JR, Major S. Transnasal transsphenoidal hypophysectomy: choice of approach for the otolaryngologist. Otolaryngol Head Neck Surg. Jun 1999;120(6):824-7. [Medline].
Hollinshead WH. Anatomy for Surgeons. 3rd ed. Philadelphia, Pa: Harper & Row;1982:255-259.
Koltai PJ, Goufman DB, Parnes SM, Steiniger JR. Transsphenoidal hypophysectomy through the external rhinoplasty approach. Otolaryngol Head Neck Surg. Sep 1994;111(3 Pt 1):197-200. [Medline].
Sawyer R. Nasal approach to the sphenoid sinus after prior septal surgery. Laryngoscope. Jan 1991;101(1 Pt 1):89-91. [Medline].
Schoem SR, Khan A, Wilson WR, Laws ER. Minimizing upper lip and incisor teeth paresthesias in approaches to transsphenoidal surgery. Otolaryngol Head Neck Surg. Jun 1997;116(6 Pt 1):656-61. [Medline].

