Updated: Nov 11, 2008
Barotrauma of the paranasal sinuses is a risk factor for anyone exposed to ambient pressure changes. These pressure changes most often result from travel through mountainous regions, flying, or diving. Barosinusitis is characterized by inflammation of one or more of the paranasal sinuses. Inflammation is caused by a pressure gradient, almost always negative, between the sinus cavity and the surrounding ambient environment.
The paranasal sinuses have rigid walls with relatively small ostia for gas exchange and mucus transport. Physical gas laws, particularly Boyle's Law, apply to this space. Boyle's Law states that at constant temperature, the volume of a gas is inversely proportional to the pressure placed upon it.
To show how Boyle's Law affects the sinuses, consider the case of an individual with normal sinuses exposed to pressure changes while flying in an unpressurized aircraft. As the individual transitions to higher altitude, the ambient pressure surrounding the sinus cavity decreases, and the air in the sinuses expands and equalizes through the natural ostium. Upon descent, ambient air pressure increases, the air in the sinuses contracts, and air moves into the sinus cavity, preventing a pressure gradient from developing.
Now consider the same flight in someone who has an upper respiratory tract infection (URTI) with tissue edema and secretions blocking the natural sinus ostia. In this individual, tissue edema and debris will not allow free pressure equalization. Again, as the individual moves up in altitude, the ambient pressure decreases, and volume in the sinus cavity increases. A positive pressure develops in the sinus. With this positive pressure, tissue edema gradually decreases enough to allow debris and air to escape the natural ostium. Air pressure then equalizes. When the individual descends, the ambient pressure increases. Pressure cannot equalize across the nasal cavity to the sinus because of blockage at the ostium. Air volume decreases in the sinus cavity, creating a negative pressure.
At this point, a condition exists in which the volume of the sinus must be filled if the pressure gradient is to be eliminated. In mild-to-moderate cases, vascular engorgement and generalized submucosal edema occur. Over time, transudate and mucus fill the volume, reducing negative pressure and decreasing symptoms. In severe cases, especially with rapid onset, the sinus mucosa is stripped from the subjacent bone, resulting in severe pain and hematoma formation.
Prevalence is approximately 3-4 episodes per 100,000 exposures in a generally healthy population.
Race predilection is not widely reported.
Sex predilection is not widely reported.
Barosinusitis is not typically reported in children. Frontal sinuses are most frequently affected, and these do not fully develop until late adolescence. In addition, children do not routinely participate in activities that lend themselves to rapid pressure changes.
Differentiate sinus barotrauma from other causes of facial pain and headache. The history is particularly important in shortening the differential. In sinus barotrauma, a condition of barometric pressure change always exists either during or shortly after onset of symptoms.
Physical findings may be relatively sparse in mild cases of barosinusitis. In severe cases, the patient may have marked pain in the forehead, face, and upper teeth. This pain is typically unilateral. Erythema, edema, congested mucous membranes, epistaxis, and tenderness to palpation of the face may occur.
The following activities and conditions place individuals at particular risk for barosinusitis:
| Allergic Rhinitis | Sinusitis, Frontal, Acute, Surgical
Treatment |
| Malignant Tumors of the Nasal Cavity | Sinusitis, Fungal |
| Malignant Tumors of the Sinuses | Sinusitis, Maxillary, Acute, Surgical
Treatment |
| Nasal Polyps, Nonsurgical Treatment | Sinusitis, Maxillary, Chronic, Surgical
Treatment |
| Nasal Polyps, Surgical Treatment | Sinusitis, Sphenoid, Acute, Surgical
Treatment |
| Sinusitis, Acute, Medical Treatment | Turbinate Dysfunction |
| Sinusitis, Chronic, Medical Treatment | |
| Sinusitis, Ethmoid, Acute, Surgical
Treatment |
Seasonal or perineal allergic rhinitis
Mucosal irritation from smoke or other environmental agents
Nasal polyposis
Nasal septal deviation
Concha bullosa
Infraorbital ethmoid cells
Benign or malignant sinus or nasal cavity tumors
Begin treatment at the first sign of barotrauma. Treatment is accomplished most simply by returning to the altitude at which symptoms occurred, or, in the case of diving, returning to the surface. Decongest the nose with liberally applied topical agents, and then gradually descend to ground level. Unfortunately, immediate treatment is not always possible, and treatment often begins after the fact.
Medical therapy is generally directed toward pain control, establishing ventilation, and preventing infection.
Surgical therapy is designed to restore sinus ventilation. Conventional therapy with septoplasty, turbinectomy, antral windows, Caldwell-Luc operation, external or transantral ethmoidectomy, nasal polypectomy, and frontal sinus trephination has had variable efficacy. Endoscopic sinus surgery has substantially increased the chance of returning the patient to full activities.
Depending upon the extent of surgery, most patients can return to full activity within 1-3 weeks following surgery.
Commercial airline travel is generally permitted within 2-3 days, as is swimming on the water surface.
The goal of pharmacotherapy is to reduce morbidity and prevent complications.
Decongestants establish ventilation of the sinuses and relieve pressure, pain, and edema. Combine topical and oral decongestants in most cases, especially for acute symptoms. Topical agents are frequently useful when oral agents are contraindicated.
First-line therapy for topical decongestion. Applied directly to mucous membranes, stimulating alpha-adrenergic receptors and causing vasoconstriction. Decongestion occurs without drastic changes in blood pressure, vascular redistribution, or cardiac stimulation.
3-4 sprays each nostril q12h; caution with >3-5 d of continual use
Not established
Hypotensive action of guanethidine may be reversed; concurrent administration with methyldopa may result in an increased vasopressor response; concurrent use of MAOIs and ephedrine may result in hypertensive crisis; pressor sensitivity to mixed-acting agents such as ephedrine may be increased; guanethidine potentiates effects of epinephrine and inhibits effects of ephedrine; phenothiazines may reverse action of nasal decongestants such as oxymetazoline; tricyclic antidepressants potentiate vasopressor response and may result in dysrhythmias
Documented hypersensitivity; MAOI therapy
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Caution in hyperthyroidism, coronary artery and ischemic heart disease, diabetes mellitus, increased intraocular pressure, or prostatic hypertrophy; because of increase in vasoconstriction, patients with hypertension may experience change in blood pressure; do not use topical decongestants for >3-5 d
First-line topical decongestant if a shorter-acting agent is preferred. Strong postsynaptic alpha-receptor stimulant with little beta-adrenergic activity that produces vasoconstriction of arterioles in the body.
3-4 sprays each nostril q3-4h; caution with >3-5 d of continual use
Not established
Bretylium may potentiate action of vasopressors on adrenergic receptors, possibly resulting in arrhythmias; MAOIs may significantly enhance adrenergic effects of phenylephrine, and pressor response may be increased by a 2- to 3-fold factor; guanethidine may increase pressor response of direct-acting vasopressors, possibly resulting in severe hypertension
Documented hypersensitivity; severe hypertension or ventricular tachycardia
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis; in hypovolemia, use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore these when loss occurs)
Recalled from US market. First-line oral decongestant. Epinephrine stores are released under phenylpropanolamine stimulation and produce alpha- and beta-adrenergic stimulation. These effects may increase outlet resistance.
25-50 mg PO q4h
75 mg PO q12h sustained release
Not established
May decrease hypotensive effects of guanethidine; hypertensive episode may occur if taken concurrently with indomethacin; phenylpropanolamine may increase pressor effect of beta-blockers
Documented hypersensitivity; kidney disease, hyperthyroidism, cardiovascular disease, and diabetes; MAOIs within last 14 d; women who are breastfeeding
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Contraindicated in women who are breastfeeding; caution in patients with hypertension; may cause nervousness, dizziness, anxiety, headache, irritability, nausea, vomiting, palpitations, and tachycardia
First-line oral decongestant. Stimulates vasoconstriction by directly activating alpha-adrenergic receptors of the respiratory mucosa. Induces bronchial relaxation and increases heart rate and contractility by stimulating beta-adrenergic receptors.
60 mg PO q4-6h
120 mg PO q12h sustained release
2-5 years: 15 mg/dose PO q4-6h; not to exceed 60 mg/d
6-12 years: 30 mg/dose PO q4-6h; not to exceed 120 mg/d
>12 years: Administer as in adults
Propranolol, MAOIs, and sympathomimetic agents may increase toxicity; methyldopa and reserpine may reduce effects
Documented hypersensitivity; severe anemia, postural hypertension or hypotension, closed-angle glaucoma, head trauma, or cerebral hemorrhage
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Not indicated in women who are breastfeeding; caution in patients with hypertension; may cause nervousness, dizziness, anxiety, headache, irritability, nausea, vomiting, palpitations, and tachycardia
Antibiotics control infection either as an inciting factor in the barosinusitis or as a sequela of the barosinusitis.
Drug combination treats bacteria resistant to beta-lactam antibiotics. First-line therapy for persons not allergic.
500-875 mg PO bid
45 mg/kg/d PO divided bid
Coadministration with warfarin or heparin increases risk of bleeding
Documented hypersensitivity to any penicillins; beware of anaphylactic reaction
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Common adverse effects include diarrhea, nausea, indigestion, skin rash, pruritus, and urticaria; safety in women who are breastfeeding is unknown
First-line therapy in patients allergic to penicillin, although adverse effect profile may make other agents more desirable.
1 tab PO bid (double strength)
1 tab PO bid (single strength)
May increase PT when used with warfarin (perform coagulation tests and adjust dose accordingly); coadministration with dapsone may increase blood levels of both drugs; coadministration of diuretics increases frequency of thrombocytopenia purpura in elderly patients; phenytoin levels may increase with coadministration; may potentiate effects of methotrexate in bone marrow depression; hypoglycemic response to sulfonylureas may increase with coadministration; may increase levels of zidovudine
Documented hypersensitivity; megaloblastic anemia due to folate deficiency; women who are breastfeeding
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Do not use if breastfeeding; may prolong bleeding time in those on warfarin; may increase anticonvulsant levels; severe reactions (eg, Stevens-Johnson syndrome, hepatic necrosis, aplastic anemia, epidermolysis) may occur; causes photosensitivity
Second-line therapy, but may be first-line therapy in patients who are allergic to penicillin.
250-500 mg PO qd or divided bid
15 mg/kg/dose PO bid
Disulfiramlike reactions may occur when alcohol is consumed within 72 h after taking cefuroxime; may increase hypoprothrombinemic effects of anticoagulants; may increase nephrotoxicity in patient receiving potent diuretics such as loop diuretics; coadministration with aminoglycosides increase nephrotoxic potential
Documented hypersensitivity
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Generally well tolerated; safety during breastfeeding unknown; most common adverse effects include nausea and diarrhea
Interferes with synthesis of cell wall mucopeptides during active multiplication resulting in bactericidal activity against susceptible bacteria.
500 mg PO q8h; not to exceed 3 g/d
Not established
Reduces efficacy of oral contraceptives
Documented hypersensitivity
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Adjust dose in renal impairment.
Acetaminophen, with or without codeine, is useful for pain control.
First-line analgesic for severe pain. Fixed combination Tylenol #3 is 300-mg acetaminophen with 30-mg codeine.
1-2 tab PO q4h
Not established
Toxicity increases with CNS depressants or tricyclic antidepressants
Documented hypersensitivity
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
May result in acute opiate withdrawal symptoms in patients dependent on opiates; caution in severe renal or hepatic dysfunction.
DOC for pain in patients with documented hypersensitivity to aspirin, NSAIDs, upper GI disease, or on oral anticoagulants.
650-1000 mg PO q4-6h
15 mg/kg/dose PO q4h
Rifampin can reduce analgesic effects of acetaminophen; coadministration with barbiturates, carbamazepine, hydantoins, and isoniazid may increase hepatotoxicity.
Documented hypersensitivity
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Various dose levels of acetaminophen can induce hepatotoxicity in persons with chronic alcoholism
Parsons DS, Chambers DW, Boyd EM. Long-term follow-up of aviators after functional endoscopic sinus surgery for sinus barotrauma. Aviat Space Environ Med. Nov 1997;68(11):1029-34. [Medline].
Vaughan WC. Review of balloon sinuplasty. Curr Opin Otolaryngol Head Neck Surg. Feb 2008;16(1):2-9. [Medline].
Hanna HH, Tarington CT. Otolaryngology in aerospace medicine. In: DeHart RL, ed. Fundamentals of Aerospace Medicine. Philadelphia: Lippincott Williams & Wilkins; 1985:520-530.
Jones JS, Sheffield W, White LJ, et al. A double-blind comparison between oral pseudoephedrine and topical oxymetazoline in the prevention of barotrauma during air travel. Am J Emerg Med. May 1998;16(3):262-4. [Medline].
Setliff RC 3rd. Minimally invasive sinus surgery: the rationale and the technique. Otolaryngol Clin North Am. Feb 1996;29(1):115-24. [Medline].
barosinusitis, sinusitis, sinus, sinus barotrauma, sinus squeeze, sinus inflammation, paranasal sinus barotrauma, barotrauma
J Kim Thiringer, DO, Otolaryngologist, Ear, Nose, and Throat Associates
J Kim Thiringer, DO is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery
Disclosure: Nothing to disclose.
Lanny Garth Close, MD, Chair, Professor, Department of Otolaryngology-Head and Neck Surgery, Columbia University College of Physicians and Surgeons
Lanny Garth Close, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American College of Physicians, American Laryngological Association, American Society for Head and Neck Surgery, and New York Academy of Medicine
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.
Stephen G Batuello, MD, Consulting Staff, Colorado ENT Specialists
Stephen G Batuello, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Physician Executives, American Medical Association, and Colorado Medical Society
Disclosure: Nothing to disclose.
Christopher L Slack, MD, Otolaryngology-Facial Plastic Surgery, Private Practice, Associated Coastal ENT; Medical Director, Treasure Coast Sleep Disorders
Christopher L Slack, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Medical Association
Disclosure: Nothing to disclose.
Arlen D Meyers, MD, MBA, Professor, Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine
Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Head and Neck Society
Disclosure: Covidien Corp Consulting fee Consulting; US Tobacco Corporation unstricted gift unknown
© 1994-
by Medscape.
All Rights Reserved
(http://www.medscape.com/public/copyright)