Contact Granulomas

Updated: Jan 10, 2016
  • Author: James D Garnett, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
  • Print
Overview

Background

Contact granulomas are benign lesions usually located on the posterior third of the vocal fold, which corresponds to the vocal process of the arytenoid cartilage. Contact granulomas may occur unilaterally or bilaterally.

Granulomas of the larynx can be classified into 2 general groups: specific granulomas and nonspecific granulomas. Specific granulomas are rare and include granulomas caused by tuberculosis [1] and syphilis. Nonspecific granulomas are benign and are unilaterally or bilaterally located on the vocal processes of the vocal folds. Histologically, they resemble pyogenic granulomas.

See the image below.

Left vocal process granuloma on initial presentati Left vocal process granuloma on initial presentation (scope view of 70°).

Contact ulcers (or granulomas) historically were thought to be the result of voice abuse or misuse, and the granulomas of intubation or gastroesophageal reflux were separate subsets of these conditions. However, for all purposes, the appearance, symptomatology, and treatment of these nonspecific granulomas are identical; therefore, both subsets of nonspecific granulomas can be considered a single entity.

Chevalier Jackson first identified contact ulcers in 1928. [2] He collected 127 case reports dating to 1888. In 1935, Jackson and Jackson suggested a mechanical cause related to the hammer and anvil effect of the vocal processes colliding against each other, leading to superficial mucosal ulceration (the contact ulcer) and focal granulation tissue response. [3]

Next:

Problem

A contact granuloma is a pale or sometimes red mass located on the medial aspect of the vocal process of the arytenoid cartilage. Histologically, contact granulomas resemble pyogenic granulomas, which consist of chronic inflammatory infiltration with neovascularization and fibrosis covered by squamous epithelium.

Classic contact ulcers are thought to be the result of vocal misuse and abuse. With this etiology, the lesion most commonly is identified in men. These lesions often are similar in appearance to those found in patients after intubation (intubation granulomas) and in patients with gastroesophageal reflux.

Occasionally, a vocal process granuloma is identified in a patient for whom none of these factors are apparent. de Lima Pontes et al label this group idiopathic. The literature contains much confusion about this entity; however, for practical purposes, these lesions may be conceptualized as a group.

Previous
Next:

Etiology

Primary causes of contact granulomas may coexist in the same patient and include the following:

  • Intubation (see video below)
    This patient was evaluated for hoarseness after prolonged intubation. The lesion resolved with observation and proton pump inhibitor therapy. Video courtesy of Vijay R Ramakrishnan, MD.
  • Voice abuse
  • Laryngopharyngeal reflux disease
  • Idiopathic

Factors that contribute to the development of contact granulomas include smoking, allergy, infections, postnasal drip, and chronic throat clearing. Psychosocial traits associated with development of contact granulomas include aggressive personality, introversion, depression, emotional tension, and/or cancerophobia.

Certain dietary factors may affect the laryngeal milieu, leading to a detrimental mucosal environment. These factors include consumption of caffeine, chocolate, alcohol, peppermint, spicy foods, and tomato products; high-fat diet; poor water intake; and use of tobacco products. However, a direct causal relationship in the formation of contact ulcers has not been established.

Differential diagnoses include carcinoma, granular cell tumor of the larynx, and sarcoid.

Previous
Next:

Pathophysiology

Contact granulomas are usually pale, pedunculated masses found on the medial or superior edge of the vocal process of the arytenoid cartilage; however, they may also be deep red, lobulated, and sessile. These lesions may be 2-lipped structures that fit the vocal process of the opposite side.

Contact ulcers occur when the thin mucosa overlying the firm cartilage of the vocal process is crushed repetitively against the opposite side, causing a breakdown of the mucosa. An ulcer forms, accompanied by granulation tissue formation. An object such as an endotracheal tube may cause the injury leading to granulomas, or granulomas may result secondary to chronic irritation (eg, persistent gastroesophageal reflux injury).

Previous
Next:

Presentation

Symptoms include the following:

  • Varying degrees of hoarseness and a low-pitched, pressed voice quality
  • Cough
  • Throat clearing
  • Pain, especially on pressed phonation or with cough or throat clearing
  • A rough foreign body sensation

The physician inquiry includes the following:

  • Intubation history, including nasogastric intubation
  • Reflux and associated high-risk habits (eg, dietary habits, caffeine intake)
  • Vocal use patterns (eg, glottal fry, hard glottal attack)
  • Pulmonary characteristics (eg, chronic cough, use of inhalers)
Previous
Next:

Indications

Even in relatively asymptomatic disease, treat the contact ulcer or vocal process granuloma to prevent growth and possible complications or sequelae of the inflammatory process, which include the following:

  • Airway obstruction
  • Bleeding (usually minor)
  • Vocal fold fixation
  • Posterior laryngeal stenosis

Surgical management of these lesions usually is frustrating because of a 37-50% recurrence rate. Surgical interventions are indicated for the following:

  • Fibroepithelial polyp
  • Airway compromise
  • Suspicion of carcinoma
Previous
Next:

Relevant Anatomy

Apices of the arytenoid cartilages are composed of elastic cartilage, and the rest of the arytenoid cartilage is hyaline cartilage. The arytenoid cartilages begin to ossify at approximately age 30 years. Ulcer or granuloma occurs on the vocal process of the arytenoid cartilage. The vocal process accounts for the posterior third of the vocal cord where the vocal ligament attaches.

The mucosa covering the vocal processes of the arytenoid cartilage is a thin layer of stratified squamous epithelium. This thin layer of mucosa is susceptible to being crushed between any unyielding object (eg, an endotracheal tube, the opposite arytenoid) and the firm cartilage beneath the mucosa.

Previous
Next:

Contraindications

Surgery is discouraged as the initial management for 2 reasons. Surgery is associated with a high recurrence rate of 37-50%, which often leads to multiple surgeries that may still be unsuccessful. Surgery may also cause the granuloma to migrate, following the wound edge.

Previous