Tonsillitis and Peritonsillar Abscess
- Author: Udayan K Shah, MD; Chief Editor: Arlen D Meyers, MD, MBA more...
Background
In the first century AD, Celsus described tonsillectomy performed with sharp tools and followed by rinses with vinegar and other medicinals. Since that time, physicians have been documenting management of tonsillitis. Tonsillitis gained additional attention as a medical concern in the late 19th century. The consideration of quinsy in the differential diagnoses of George Washington's death and the discussion of tonsillitis in Kean's Domestic Medical Lectures, a home medical companion book published in the late 19th century, reflect the rise of tonsillitis as a medical concern.[1, 2]
Understanding the disease process and management of this common malady remain important today. This article summarizes the current management of tonsillitis and highlights recent advances in the pathophysiology and immunology of this condition and its variations: acute tonsillitis (shown below), recurrent tonsillitis, and chronic tonsillitis and peritonsillar abscess (PTA).
Acute bacterial tonsillitis is shown. The tonsils are enlarged and inflamed with exudates. The uvula is midline. Definitions
Tonsillitis is inflammation of the pharyngeal tonsils. The inflammation usually extends to the adenoid and the lingual tonsils; therefore, the term pharyngitis may be used interchangeably. Pharyngotonsillitis and adenotonsillitis are considered equivalent for the purposes of this article. Lingual tonsillitis refers to isolated inflammation of the lymphoid tissue at the tongue base.
A "carrier state" is defined by a positive pharyngeal culture of group A beta hemolytic Streptococcus pyogenes (GABHS), without evidence of an antistreptococcal immunologic response.
Pathophysiology
Viral or bacterial infections and immunologic factors lead to tonsillitis and its complications.
Epidemiology
Frequency
United States
Tonsillitis is a common illness. Nearly all children in the United States experience at least one episode of tonsillitis. Pharyngitis accompanies many upper respiratory tract infections.
Between 2.5% and 10.9% of children may be defined as carriers. The mean prevalence of carrier status of school children for group A Streptococcus, a cause of tonsillitis, was 15.9% in one study.[3, 4]
Children accounted for approximately one third of 45,000 peritonsillar abscess episodes estimated by Herzon et al to occur in the United States in 1995.[5]
International
Recurrent tonsillitis was reported in 11.7% of Norwegian children in one study and estimated in another study to affect 12.1% of Turkish children.[6]
A family history of atopy and of tonsillectomy may predict the occurrence of tonsillitis in their children.
Mortality/Morbidity
Because of improvements in medical and surgical treatments, complications associated with tonsillitis, including death, are rare.[7] Historically, scarlet fever was a major killer at the beginning of the 20th century, and rheumatic fever was a major cause of cardiac disease and mortality. Although the incidence of rheumatic fever has declined significantly, cases that occurred in the 1980s and early 1990s support concern over a resurgence of this condition.
Age
Tonsillitis most often occurs in children; however, the condition rarely occurs in children younger than 2 years. Tonsillitis caused by Streptococcus species typically occurs in children aged 5-15 years, while viral tonsillitis is more common in younger children.
Peritonsillar abscess (PTA) usually occurs in teens or young adults but may present earlier.
Morens DM. Death of a president. N Engl J Med. Dec 9 1999;341(24):1845-9. [Medline].
Kean J. Domestic Medical Lectures. Chicago, Ill: 1879.
Pichichero ME, Casey JR. Defining and dealing with carriers of group A Streptococci. Contemporary Pediatrics. 2003;1:46.
Wald ER. Commentary: Antibiotic treatment of pharyngitis. Pediatrics in Review. 2001;22 (8):255-256.
Herzon FS. Harris P. Mosher Award thesis. Peritonsillar abscess: incidence, current management practices, and a proposal for treatment guidelines. Laryngoscope. Aug 1995;105(8 Pt 3 Suppl 74):1-17. [Medline].
Kvestad E, Kvaerner KJ, Roysamb E, Tambs K, Harris JR, Magnus P. Heritability of recurrent tonsillitis. Arch Otolaryngol Head Neck Surg. May 2005;131(5):383-7. [Medline].
Schmidt RJ, Herzog A, Cook S, O'Reilly R, Deutsch E, Reilly J. Complications of tonsillectomy. Arch Otolaryngol Head and Neck Surg. 2007;133:925-928.
Woolford TJ, Hanif J, Washband S, Hari CK, Ganguli LA. The effect of previous antibiotic therapy on the bacteriology of the tonsils in children. Int J Clin Pract. Mar 1999;53(2):96-8. [Medline].
Bussi M, Carlevato MT, Panizzut B, Omede P, Cortesina G. Are recurrent and chronic tonsillitis different entities? An immunological study with specific markers of inflammatory stages. Acta Otolaryngol Suppl. 1996;523:112-4. [Medline].
Shah, Udayan K. Peritonsillar and Retropharyngeal Abscess. In: Shah, Samir S. Pediatric Pracice: Infectious Diseases. China: McGraw-Hill; 2009:Chapter 25, pp. 216-22.
Bisno AL, Gerber MA, Gwaltney JM Jr, Kaplan EL, Schwartz RH. Diagnosis and management of group A streptococcal pharyngitis: a practice guideline. Infectious Diseases Society of America. Clin Infect Dis. Sep 1997;25(3):574-83. [Medline].
[Guideline] Chiappini E, Regoli M, Bonsignori F, Sollai S, Parretti A, Galli L, et al. Analysis of different recommendations from international guidelines for the management of acute pharyngitis in adults and children. Clin Ther. Jan 2011;33(1):48-58. [Medline].
[Guideline] Baugh RF, Archer SM, Mitchell RB, et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg. Jan 2011;144(1 Suppl):S1-30. [Medline].
Sivaji N, Arshad FA, Karkos PD. A novel method of draining a peritonsillar abscess. Clin Otolaryngol. Apr 2011;36(2):189-90. [Medline].
Shah, Udayan K. Tonsillectomy & Adenoidectomy: Techniques and Technologies. Madison WI. 2008: Omnipress, Inc. ISBN 978-0-615-23355-0.; 2008.
Adam D, Scholz H, Helmerking M. Comparison of short-course (5 day) cefuroxime axetil with a standard 10 day oral penicillin V regimen in the treatment of tonsillopharyngitis. J Antimicrob Chemother. Feb 2000;45 Suppl:23-30. [Medline].
Agren K, Lindberg K, Samulesson A, Blomberg S, Forsgren J, Rynnel-Dagoo B. What is wrong in chronic adenoiditis/tonsillitis immunological factor. Int J Pediatr Otorhinolaryngol. Oct 5 1999;49 Suppl 1:S137-9. [Medline].
Berkovitch M, Vaida A, Zhovtis D, Bar-Yohai A, Earon Y, Boldur I. Group A streptococcal pharyngotonsillitis in children less than 2 years of age--more common than is thought. Clin Pediatr (Phila). Jun 1999;38(6):361-3. [Medline].
Bisno AL. Acute pharyngitis. N Engl J Med. Jan 18 2001;344(3):205-11. [Medline].
Brodsky L. Tonsillitis, tonsillectomy and adenoidectomy. In: Bailey B, Johnson JT, Kohut RI, Pillsbury HC, Tardy ME Jr, eds. Head and Neck surgery-Otolaryngology. Vol 1. Philadelphia, Pa: Lippincott Williams & Wilkins; 1993:833-47.
Brodsky L, Moore L, Stanievich J. The role of Haemophilus influenzae in the pathogenesis of tonsillar hypertrophy in children. Laryngoscope. Oct 1988;98(10):1055-60. [Medline].
Brook I. The role of anaerobic bacteria in tonsillitis. Int J Pediatr Otorhinolaryngol. Jan 2005;69(1):9-19. [Medline].
Brook I, Gober AE. Interference by aerobic and anaerobic bacteria in children with recurrent group A beta-hemolytic streptococcal tonsillitis. Arch Otolaryngol Head Neck Surg. May 1999;125(5):552-4. [Medline].
Brook I, Yocum P, Foote PA Jr. Changes in the core tonsillar bacteriology of recurrent tonsillitis: 1977-1993. Clin Infect Dis. Jul 1995;21(1):171-6. [Medline].
Cannon CR, Chambers A. Peritonsillar abscess (PTA) in children. J Miss State Med Assoc. Mar 1999;40(3):78-80. [Medline].
Casselbrant ML. What is wrong in chronic adenoiditis/tonsillitis anatomical considerations. Int J Pediatr Otorhinolaryngol. Oct 5 1999;49 Suppl 1:S133-5. [Medline].
Cohen JI. Epstein-Barr virus infection. N Engl J Med. Aug 17 2000;343(7):481-92. [Medline].
Curtin JM. The history of tonsil and adenoid surgery. Otolaryngol Clin North Am. May 1987;20(2):415-9. [Medline].
Dhawan B, Chaudhry R, Pandey A, Nisar N, Singh M. Anaerobic septicaemia by Fusobacterium necrophorum: Lemierre's syndrome. Indian J Pediatr. May-Jun 1998;65(3):469-72. [Medline].
Gerber MA. Streptococcal infections: Group A B-hemolytic streptococci. In: Rudolph AM, Hoffman JIE, Rudolph CD, eds. Rudolph's Pediatrics. 20th ed. Stamford, Conn: Appleton & Lange; 604-9.
Handler SD, Myer CM III. Atlas of Ear, Nose and Throat Disorders in Children. Hamilton, Ontario: BC Decker; 1998:91.
Krauss B, Green SM. Sedation and analgesia for procedures in children. N Engl J Med. Mar 30 2000;342(13):938-45. [Medline].
Kvestad E, Kvaerner KJ, Roysamb E, Tambs K, Harris JR, Magnus P. Heritability of recurrent tonsillitis. Arch Otolaryngol Head Neck Surg. May 2005;131(5):383-7. [Medline].
Lan AJ, Colford JM, Colford JM Jr. The impact of dosing frequency on the efficacy of 10-day penicillin or amoxicillin therapy for streptococcal tonsillopharyngitis: A meta-analysis. Pediatrics. Feb 2000;105(2):E19. [Medline].
Lascaratos J, Assimakopoulos D. Surgery on the larynx and pharynx in Byzantium (AD 324-1453): early scientific descriptions of these operations. Otolaryngol Head Neck Surg. Apr 2000;122(4):579-83. [Medline].
Licameli GR, Grillone GA. Inferior pole peritonsillar abscess. Otolaryngol Head Neck Surg. Jan 1998;118(1):95-9. [Medline].
Lilja M, Silvola J, Bye HM, Raisanen S, Stenfors LE. SIgA- and IgG-coated Streptococcus pyogenes on the tonsillar surfaces during acute tonsillitis. Acta Otolaryngol. 1999;119(6):718-23. [Medline].
Lomat L, Galburt G, Quastel MR, Polyakov S, Okeanov A, Rozin S. Incidence of childhood disease in Belarus associated with the Chernobyl accident. Environ Health Perspect. Dec 1997;105 Suppl 6:1529-32. [Medline].
Lopez-Gonzalez MA, Lucas M, Mata F, Delgado F. Microalbuminuria as renal marker in recurrent acute tonsillitis and tonsillar hypertrophy in children. Int J Pediatr Otorhinolaryngol. Oct 25 1999;50(2):119-24. [Medline].
Manecke GR Jr, Marghoob S, Finzel KC, Madoff DC, Quijano IH, Poppers PJ. Catastrophic caudad spread of a peritonsillar abscess: a case report. Anesthesiology. Dec 1999;91(6):1956-8. [Medline].
Martin JM, Green M, Barbadora KA, Wald ER. Group A streptococci among school-aged children: clinical characteristics and the carrier state. Pediatrics. Nov 2004;114(5):1212-9. [Medline].
Nord CE. The role of anaerobic bacteria in recurrent episodes of sinusitis and tonsillitis. Clin Infect Dis. Jun 1995;20(6):1512-24. [Medline].
Puchalski R, Shah UK. Plasma-mediated ablation for the management of obstructive sleep apnea. In: Anderson R, et al, eds. Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X. Proceedings of SPIE. Vol 3907. 2000:317-20.
Raut VV, Yung MW. Peritonsillar abscess: the rationale for interval tonsillectomy. Ear Nose Throat J. Mar 2000;79(3):206-9. [Medline].
Roberson DW, Kirse DJ. Infectious and inflammatory disorders of the neck. In: Wetmore RF, Muntz HR, McGill TJ. Pediatric Otolaryngology: Principles and Practical Pathways. New York, NY: Thieme; 2000:969-991.
Robinson AC, Hanif J, Dumbreck LA, Prichard AJ, Manners BT. Throat swabs in chronic tonsillitis: a time-honoured practice best forgotten. Br J Clin Pract. Apr-May 1997;51(3):138-9. [Medline].
Sancho LM, Minamoto H, Fernandez A, Sennes LU, Jatene FB. Descending necrotizing mediastinitis: a retrospective surgical experience. Eur J Cardiothorac Surg. Aug 1999;16(2):200-5. [Medline].
Shah UK, Tufano RP, Handler SD. Post-tonsillectomy observation and admission: Annual Meeting of the American Academy of Pediatrics. In: an American Society of Pediatric Otolaryngology (ASPO) member survey. Paper presented at: Washington, DC; 1999.
Skitarelic N, Mladina R, Matulic Z, Kovacic M. Necrotizing fasciitis after peritonsillar abscess in an immunocompetent patient. J Laryngol Otol. Aug 1999;113(8):759-61. [Medline].
Smitheringdale AJ. Acquired diseases of the oral cavity and pharynx. In: Wetmore RF, Muntz HR, McGill TJ. Pediatric Otolaryngology: Principles and Practical Pathways. New York, NY: Thieme; 2000:606-18.
Stjernquist-Desatnik A, Holst E. Tonsillar microbial flora: comparison of recurrent tonsillitis and normal tonsils. Acta Otolaryngol. Jan 1999;119(1):102-6. [Medline].
Suskind DL, Park J, Piccirillo JF, Lusk RP, Muntz HR. Conscious sedation: a new approach for peritonsillar abscess drainage in the pediatric population. Arch Otolaryngol Head Neck Surg. Nov 1999;125(11):1197-200. [Medline].
Suzuki M, Ueyama T, Mogi G. Immediate tonsillectomy for peritonsillar abscess. Auris Nasus Larynx. Jul 1999;26(3):299-304. [Medline].
Wolf M, Kronenberg J, Kessler A, Modan M, Leventon G. Peritonsillar abscess in children and its indication for tonsillectomy. Int J Pediatr Otorhinolaryngol. Nov 1988;16(2):113-7. [Medline].
Yoda K, Sata T, Kurata T, Aramaki H. Oropharyngotonsillitis associated with nonprimary Epstein-Barr virus infection. Arch Otolaryngol Head Neck Surg. Feb 2000;126(2):185-93. [Medline].

