eMedicine Specialties > Otolaryngology and Facial Plastic Surgery > Reconstructive Surgery

Hypertrophic Scarring and Keloids: Multimedia

Author: Mimi S Kokoska, MD, Associate Professor, Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences; Chief, Department of Otolaryngology-Head and Neck Surgery, Central Arkansas Veterans Healthcare System
Coauthor(s): Stephen Prendiville, MD, Otolaryngology, Facial Plastic Surgery, Ft. Myers Centre for Facial Plastic and Laser Surgery
Contributor Information and Disclosures

Updated: Dec 7, 2007

Multimedia

Hypertrophic scarring and keloids. Keloid scar s...Media file 1: Hypertrophic scarring and keloids. Keloid scar showing overgrowth of scar margins.
Hypertrophic scarring and keloids. Keloid scar s...

Hypertrophic scarring and keloids. Keloid scar showing overgrowth of scar margins.

Hypertrophic scarring and keloids. Keloid scar s...Media file 2: Hypertrophic scarring and keloids. Keloid scar showing overgrowth of scar margins.
Hypertrophic scarring and keloids. Keloid scar s...

Hypertrophic scarring and keloids. Keloid scar showing overgrowth of scar margins.

Hypertrophic scarring and keloids. Light microgr...Media file 3: Hypertrophic scarring and keloids. Light micrograph of keloid scar (200X) shows haphazard arrangement of fairly acellular collagen, with decreased myofibroblasts. Light micrograph courtesy of T. Brent Ponder, MD, St Louis University Anatomic Pathology.
Hypertrophic scarring and keloids. Light microgr...

Hypertrophic scarring and keloids. Light micrograph of keloid scar (200X) shows haphazard arrangement of fairly acellular collagen, with decreased myofibroblasts. Light micrograph courtesy of T. Brent Ponder, MD, St Louis University Anatomic Pathology.

Hypertrophic scarring and keloids. Hypertrophic ...Media file 4: Hypertrophic scarring and keloids. Hypertrophic scars on neck with raised features within scar margins.
Hypertrophic scarring and keloids. Hypertrophic ...

Hypertrophic scarring and keloids. Hypertrophic scars on neck with raised features within scar margins.

Hypertrophic scarring and keloids. Hypertrophic ...Media file 5: Hypertrophic scarring and keloids. Hypertrophic scars on neck with raised features within scar margins.
Hypertrophic scarring and keloids. Hypertrophic ...

Hypertrophic scarring and keloids. Hypertrophic scars on neck with raised features within scar margins.

Hypertrophic scarring and keloids. Light microgr...Media file 6: Hypertrophic scarring and keloids. Light micrograph of hypertrophic scar (200X) with collagen that is oriented parallel to skin surface and has numerous myofibroblasts. Light micrograph courtesy of T. Brent Ponder, MD, St Louis University Anatomic Pathology.
Hypertrophic scarring and keloids. Light microgr...

Hypertrophic scarring and keloids. Light micrograph of hypertrophic scar (200X) with collagen that is oriented parallel to skin surface and has numerous myofibroblasts. Light micrograph courtesy of T. Brent Ponder, MD, St Louis University Anatomic Pathology.

More on Hypertrophic Scarring and Keloids

References

References

  1. De Felice B, Ciarmiello LF, Mondola P, Damiano S, Seru R, Argenziano C, et al. Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts. DNA Cell Biol. Aug 2007;26(8):541-7. [Medline][Full Text].

  2. Zouboulis CC, Blume U, Buttner P, et al. Outcomes of cryosurgery in keloids and hypertrophic scars. A prospective consecutive trial of case series. Arch Dermatol. Sep 1993;129(9):1146-51. [Medline].

  3. Addison T. On the Keloid in Alibert and on True Keloid. Medicochie Trans. 1854;37:27.

  4. Berman B, Flores F. The treatment of hypertrophic scars and keloids. Eur J Dermatol. Dec 1998;8(8):591-5. [Medline].

  5. Clavere P, Bedane C, Bonnetblanc JM, et al. Postoperative interstitial radiotherapy of keloids by iridium 192: a retrospective study of 46 treated scars. Dermatology. 1997;195(4):349-52. [Medline].

  6. Darzi MA, Chowdri NA, Kaul SK, et al. Evaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up study. Br J Plast Surg. Jul 1992;45(5):374-9. [Medline].

  7. Durani P, Bayat A. Levels of evidence for the treatment of keloid disease. J Plast Reconstr Aesthet Surg. Jul 2007;e-pub ahead of print:[Medline][Full Text].

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  9. Granstein RD, Rook A, Flotte TJ. A controlled trial of intralesional recombinant interferon-gamma in the treatment of keloidal scarring. Clinical and histologic findings. Arch Dermatol. Oct 1990;126(10):1295-302. [Medline].

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  14. Larrabee WF Jr. Keloid excision and recurrence prophylaxis via interdermal interferon- gamma injections [letter; comment]. Laryngoscope. Sep 1997;107(9):1284. [Medline].

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  17. Ohtsuru A, Yoshimoto H, Ishihara H, et al. Insulin-like growth factor-I (IGF-I)/IGF-I receptor axis and increased invasion activity of fibroblasts in keloid. Endocr J. Mar 2000;47 Suppl:S41-4. [Medline].

  18. Oliver N, Babu M, Diegelmann R. Fibronectin gene transcription is enhanced in abnormal wound healing. J Invest Dermatol. Nov 1992;99(5):579-86. [Medline].

  19. Sclafani AP, Gordon L, Chadha M, et al. Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature. Dermatol Surg. Jun 1996;22(6):569-74. [Medline].

  20. Smith CJ, Smith JC, Finn MC. The possible role of mast cells (allergy) in the production of keloid and hypertrophic scarring. J Burn Care Rehabil. Mar-Apr 1987;8(2):126-31. [Medline].

  21. Stucker FJ, Shaw GY. Keloids and Hypertrophic Scars. In: Papel ID, Nachlas NE, eds. Facial Plastic and Reconstructive Surgery. St. Louis, Mo: Mosby Year Book;1992:53-55.

  22. Urioste SS, Arndt KA, Dover JS. Keloids and hypertrophic scars: review and treatment strategies. Semin Cutan Med Surg. Jun 1999;18(2):159-71. [Medline].

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Further Reading

Keywords

hypertropic scarring and keloids, cheloids, hypertrophic scars, wound healing, abnormal scar, trauma wounds, treatment of keloids, keloid formation, scarring

Contributor Information and Disclosures

Author

Mimi S Kokoska, MD, Associate Professor, Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences; Chief, Department of Otolaryngology-Head and Neck Surgery, Central Arkansas Veterans Healthcare System
Mimi S Kokoska, MD is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American College of Physician Executives, American College of Surgeons, American Head and Neck Society, and Arkansas Medical Society
Disclosure: Nothing to disclose.

Coauthor(s)

Stephen Prendiville, MD, Otolaryngology, Facial Plastic Surgery, Ft. Myers Centre for Facial Plastic and Laser Surgery
Stephen Prendiville, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngic Allergy, and American Academy of Otolaryngology-Head and Neck Surgery
Disclosure: Nothing to disclose.

Medical Editor

Mark K Wax, MD, Professor and Program Director, Department of Otolaryngology-Head and Neck Surgery, Oregon Health Sciences University; Service Chief, Department of Surgery, Section of Otolaryngology, Veterans Affairs Medical Center
Mark K Wax, MD is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Bronchoesophagological Association, American College of Surgeons, American Rhinologic Society, American Society for Head and Neck Surgery, American Society for Laser Medicine and Surgery, Canadian Academy of Facial Plastic and Reconstructive Surgery, North American Skull Base Society, and Royal College of Physicians and Surgeons of Canada
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Robert M Kellman, MD, Professor and Chair, Department of Otolaryngology and Communication Sciences, State University of New York Upstate Medical University
Robert M Kellman, MD is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American College of Physician Executives, American College of Surgeons, American Medical Association, American Society for Head and Neck Surgery, and Medical Society of the State of New York
Disclosure: Nothing to disclose.

CME Editor

Christopher L Slack, MD, Otolaryngology-Facial Plastic Surgery, Private Practice, Associated Coastal ENT; Medical Director, Treasure Coast Sleep Disorders
Christopher L Slack, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Arlen D Meyers, MD, MBA, Professor, Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine
Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Head and Neck Society
Disclosure: UST Grant/research funds Consulting

 
 
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