Septal Perforation - Surgical Aspects
- Author: Thomas Romo III, MD, FACS; Chief Editor: Arlen D Meyers, MD, MBA more...
Background
A nasal septal perforation is a through-and-through defect in any portion of the cartilaginous or bony septum with no overlying mucoperichondrium or mucoperiosteum on either side.
History of the Procedure
A myriad of techniques for repairing septal perforations have been described over the years, yet no standardized surgical protocol has been established. High failure rates can be attributed to two unfavorable factors: an inadequate blood supply and a scarred host bed. Failure rates range from 60% for procedures in early studies to 18% for the best of the modern 2-stage procedures. More than 90% of small perforations can be closed reliably, whereas 70-80% of large defects can be completely closed with the newer techniques.
The image below depicts the blood supply to the septum.
Surgical aspects of septal perforation. Blood supply to the nasal septum. Epidemiology
Frequency
The frequency of nasal septal perforations is correlated with the number of nasal procedures performed and history of cocaine use ingested by the nasal route. The incidence has no geographic correlation, and the condition is not clearly and directly associated with age, sex, diabetes, or smoking.
A broad examination of the Swedish population revealed a 0.9% prevalence of septal perforation.
Etiology
The etiology of nasal septal perforations can be classified into the following main categories:
traumatic, iatrogenic, inflammatory/malignant, infectious and inhalant related.
Different Etiologies of Nasal Septal Perforations Most traumatic or iatrogenic perforations result from mucosal lacerations on corresponding sides of the septum with exposure of the underlying cartilage or a fracture of the cartilaginous septum. Cartilage relies on the overlying mucoperichondrium for its blood supply and nutrients. Defects in the mucoperichondrium cause ischemia of the underlying cartilage, resulting in breakdown and subsequent perforation. Traumatic injuries may be self-induced from nose picking or may result from facial trauma.
Iatrogenic causes include nasal surgical procedures and nasal intubation or nasogastric tube placement; prior septal surgery is the most common cause of septal perforations. Septal hematoma, if not identified and treated early, may also result in perforation secondary to loss of cartilaginous structure, infection, and/or abscess formation.
Infectious and inflammatory etiologies, including tuberculosis, syphilis, Wegener granulomatosis, and sarcoidosis, should always be considered in the differential diagnosis.
Abuse of nasal inhalants is often implicated in septal perforation. Irritants including chromic or sulfuric acid fumes, glass dust, mercurials, and phosphorous have been associated. However, septal perforation is more commonly associated with cocaine abuse or, in a similar mechanism, use of vasoconstrictive nasal sprays. These patients often present with large and expanding perforations.
Primary mechanisms of injury from cocaine use are 2-fold: First, vasoconstrictive properties lead to ischemia and subsequent breakdown of the cartilage. Second, illicit cocaine contains adulterants that act as chemical irritants damaging the nasal mucosa. Chronic abuse leads to physiologic changes in the mucosa making these repairs particularly difficult with a higher rate of failure.
Pathophysiology
Nasal septal perforations result from trauma to the mucoperichondrium of the septum. Diminished blood supply can lead to cartilaginous and mucosal necrosis. After perforation occurs, the mucosal edges epithelialize, preventing closure of the defect. Symptoms arise from altered nasal laminar airflow and may be severely disturbing to the patient. Some patients may be completely asymptomatic.
Presentation
Symptoms tend to be related to the size and location of the perforation. Most symptomatic perforations are large and anterior. Posterior perforations tend to be less symptomatic than others because of humidification from the nasal mucosa and turbinates. A low-grade perichondritis may persist and require long-term antibiotic treatment.
Nasal obstruction, crusting, epistaxis, nasal discharge, parosmia, and neuralgia are commonly reported symptoms. Small perforations can cause a whistling sound with inspiration.[1] Larger perforations can lead to atrophic rhinitis. Long-standing large perforations may even result in a saddle-nose deformity from a lack of dorsal nasal support producing both an aesthetic and functional problem.
Indications
Surgical repair is an elective procedure reserved for patients who seek resolution of the aforementioned symptoms.
Relevant Anatomy
The nasal septum is composed of 2 major structural components: the anterior quadrangular cartilage and the posterior bony portion, predominately consisting of the vomer and perpendicular plate of the ethmoid bone. According to data from cadaveric studies, the cartilaginous septum accounts for approximately 34% of the nasal septum. The septum is inferiorly attached to the crest of the maxillary and palatine bones by dense fibrous tissue.
The arterial supply is a rich anastomosis of 4 major blood supplies (see the image below), which is important, especially when repair with various flaps is considered. The anterior and posterior ethmoid arteries supply the septum superiorly. Branches of the facial artery supply the septum anteriorly. The sphenopalatine artery supplies the septum posteriorly, and the greater palatine artery supplies the septum inferiorly.
Surgical aspects of septal perforation. Blood supply to the nasal septum. Contraindications
Current use of cocaine is an absolute contraindication for surgical repair. Postoperative cocaine abuse inevitably results in repeat perforation. If an obvious specific cause for perforation cannot be clearly identified or if the perforated edges do not appear well mucosalized, biopsy should be considered before repair is attempted. Further laboratory evaluation to rule out autoimmune or infectious etiologies may also be warranted.
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