eMedicine Specialties > Otolaryngology and Facial Plastic Surgery > Reconstructive Surgery

Implants, Soft Tissue, AlloDerm: Multimedia

Author: Nathan D Schwade, PhD, Adjunct Associate Professor of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center at Dallas, Deputy Associate Director (Acting) for Threat Reduction Directorate, Los Alamos National Laboratory
Contributor Information and Disclosures

Updated: Sep 25, 2008

Multimedia

A human biopsy sample 15 days postsurgery. Compar...Media file 1: A human biopsy sample 15 days postsurgery. Comparison of the control site (left) and the AlloDerm site (right) reveals minimal histologic differences. Analysis of the AlloDerm site reveals infiltration of host fibroblasts and evidence of neovascularization.
A human biopsy sample 15 days postsurgery. Compar...

A human biopsy sample 15 days postsurgery. Comparison of the control site (left) and the AlloDerm site (right) reveals minimal histologic differences. Analysis of the AlloDerm site reveals infiltration of host fibroblasts and evidence of neovascularization.

Schematic of AlloDerm processing.Media file 2: Schematic of AlloDerm processing.
Schematic of AlloDerm processing.

Schematic of AlloDerm processing.

Electron micrographs of allograft skin (left) and...Media file 3: Electron micrographs of allograft skin (left) and AlloDerm (right). The AlloDerm shows intact collagen fiber bundles (CF), elastin (E), and space previously occupied by a dermal fibroblast (arrows). The bars represent 5 micrometers.
Electron micrographs of allograft skin (left) and...

Electron micrographs of allograft skin (left) and AlloDerm (right). The AlloDerm shows intact collagen fiber bundles (CF), elastin (E), and space previously occupied by a dermal fibroblast (arrows). The bars represent 5 micrometers.

Rehydrated AlloDerm.Media file 4: Rehydrated AlloDerm.
Rehydrated AlloDerm.

Rehydrated AlloDerm.

More on Implants, Soft Tissue, AlloDerm

References

References

  1. Schulmann DM. The acellular dermal matrix: soft-tissue development for dental implants. Dent Implantol Update. Sep 2001;12(9):65-71. [Medline].

  2. Castor SA, To WC, Papay FA. Lip augmentation with AlloDerm acellular allogenic dermal graft and fat autograft: A comparison with autologous fat injection alone. Aesthetic Plast Surg. May-Jun 1999;23(3):218-23. [Medline].

  3. Griffey S, Schwade ND, Wright CG. Particulate dermal matrix as an injectable soft tissue replacement material. J Biomed Mater Res. 2001;58(1):10-5. [Medline].

  4. Jones FR, Schwartz BM, Silverstien P. Use of a non-immunogenic acellular dermal graft for soft tissue augmentation: a preliminary report. Aesthetic Surg J. 1996;16:196-201.

  5. Kreutz FP, Hyatt GW, Turner TC, et al. The preservation and clinical use of freeze dried bone. J Bone Joint Surg. 1951;33A:863.

  6. Kridel RW, Foda H, Lunde KC. Septal perforation repair with acellular human dermal allograft. Arch Otolaryngol Head Neck Surg. Jan 1998;124(1):73-8. [Medline].

  7. Lamke LO. The influence of different "skin grafts" on the evaporative water loss from burns. Scand J Plast Reconstr Surg. 1971;5(2):82-6. [Medline].

  8. Lavker RM, Dong G, Zheng PS, et al. Hairless micropig skin. A novel model for studies of cutaneous biology. Am J Pathol. Mar 1991;138(3):687-97. [Medline].

  9. Maloney BP. Cosmetic surgery of the lips. Facial Plast Surg. Jul 1996;12(3):265-78. [Medline].

  10. Papel ID, Mabrie DC. Deprojecting the nasal profile. Otolaryngol Clin North Am. Feb 1999;32(1):65-87. [Medline].

  11. Rigal C, Pieraggi MT, Serre G, et al. Optimization of a model of full-thickness epidermal burns in the pig and immunohistochemical study of epidermodermal junction regeneration during burn healing. Dermatology. 1992;184(2):103-10. [Medline].

  12. Rigal C, Pieraggi MT, Vincent C, et al. Healing of full-thickness cutaneous wounds in the pig. I. Immunohistochemical study of epidermo-dermal junction regeneration. J Invest Dermatol. May 1991;96(5):777-85. [Medline].

  13. Romo T 3rd, Sclafani AP, Falk AN, et al. A graduated approach to the repair of nasal septal perforations. Plast Reconstr Surg. Jan 1999;103(1):66-75. [Medline].

  14. Schwartz BM. Rhytid Revision: LifeCell Clinical Case Summary. Houston, TX: LifeCell; 1997.

  15. Sclafani AP, Romo T 3rd, Jacono AA, et al. Evaluation of acellular dermal graft in sheet (AlloDerm) and injectable (micronized AlloDerm) forms for soft tissue augmentation. Clinical observations and histological analysis. Arch Facial Plast Surg. Apr-Jun 2000;2(2):130-6. [Medline].

  16. Sedmak DD, Orosz CG. The role of vascular endothelial cells in transplantation. Arch Pathol Lab Med. Mar 1991;115(3):260-5. [Medline].

  17. Sheridan R, Choucair R, Donelan M, et al. Acellular allodermis in burns surgery: 1-year results of a pilot trial. J Burn Care Rehabil. Nov-Dec 1998;19(6):528-30. [Medline].

  18. Silverstein P. Depressed Scar Revision: LifeCell Clinical Case Summary. Houston, TX: LifeCell; 1997.

  19. Wainwright DJ. Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns. Burns. Jun 1995;21(4):243-8. [Medline].

Further Reading

Keywords

AlloDerm implants, implants, soft tissue implants, AlloDerm, acellular dermis, allograft skin, cross-linked porcine skin, allograft rejection, transplantation, cadaveric skin, cadaveric skin, acellular matrix, acellular human dermis

Contributor Information and Disclosures

Author

Nathan D Schwade, PhD, Adjunct Associate Professor of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center at Dallas, Deputy Associate Director (Acting) for Threat Reduction Directorate, Los Alamos National Laboratory
Nathan D Schwade, PhD is a member of the following medical societies: Association for Research in Vision and Ophthalmology
Disclosure: Nothing to disclose.

Medical Editor

Jennifer P Porter, MD, Assistant Professor, Department of Otorhinolaryngology, Division of Communicative Science, Chevy Chase Facial Plastic Surgery
Jennifer P Porter, MD is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and Texas Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Karen Hall Calhoun, MD, William E Davis Professor and Chair, Department of Otolaryngology-Head and Neck Surgery, University of Missouri
Karen Hall Calhoun, MD is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Head and Neck Society, American Medical Association, American Rhinologic Society, Association for Research in Otolaryngology, Society of University Otolaryngologists-Head and Neck Surgeons, Southern Medical Association, Texas Medical Association, and Texas Medical Association
Disclosure: Nothing to disclose.

CME Editor

Christopher L Slack, MD, Otolaryngology-Facial Plastic Surgery, Private Practice, Associated Coastal ENT; Medical Director, Treasure Coast Sleep Disorders
Christopher L Slack, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Arlen D Meyers, MD, MBA, Professor, Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine
Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, and American Head and Neck Society
Disclosure: Covidien Corp Consulting fee Consulting; US Tobacco Corporation unstricted gift unknown

 
 
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