Skull Base, Petrous Apex, Infection

Updated: Mar 15, 2016
  • Author: Andrea H Yeung, MD; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Overview

Background

The petrous portion of the temporal bone lies in a complicated anatomic position and has critical relationships to important neural and vascular structures. Consequently, infections arising within or spreading to the petrous apex can result in severe clinical sequelae.

Before the advent of antibiotics in the 1940s, infections of the petrous apex, termed petrous apicitis, commonly progressed to meningitis, brain abscess, cavernous sinus thrombosis, and death. Since the introduction of antibiotics, the prevalence of such serious complications has been drastically reduced. By the late 1950s, experienced clinicians already noted this decreasing prevalence; DeWeese cautioned physicians to remain vigilant of petrous apicitis, "Lest we forget that this condition still occurs." [1]

DeWeese's admonition is still valid. Patients still occasionally present with petrous apicitis, and the clinician needs to be wary of the condition's presenting features to prevent possible life-threatening complications.

An image depicting skull base anatomy can be seen below.

Internal anatomy of the skull base, lateral view, Internal anatomy of the skull base, lateral view, and base of the skull.
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History of the Procedure

Petrous apicitis, in combination with the clinical triad of headache, abducens nerve (cranial nerve [CN] VI) palsy, and otorrhea, is named after Giuseppe Gradenigo. In 1904, Gradenigo related his experience with this disorder in a manuscript entitled "Uber circumscripte Leptomeningitis mit spinalensymptomen und über Paralyse des N. Abducens otitischen Ursprungs," in the Archiv für Ohrenheilkunde. [2] In the paper, Gradenigo summed up the disease process through its 3 principal symptoms, which "... dearly and mutually cohere: acute inflammation of the middle ear, continuing pain in the temporal and parietal area, and paralysis the N Abducens, which is indicated usually by the patient himself."

Throughout the early 1900s, in the absence of antibiotics, various surgical procedures were developed to treat petrous apicitis. Procedures usually included a mastoidectomy with or without a labyrinthectomy. In 1930, Almour and Kopetsky describe following fistulous tracts into the petrous apex via a mastoidectomy with or without a labyrinthectomy. [3] Ramadier introduced the radical petrous apicectomy in 1933. [4]

In 1937, Lempert described the mastoidotympanoapicectomy, which is now the classic operation for exenteration of the anterior petrous apex. [5] This radical operation required glenoid fossa exposure and dissection along the carotid canal within the skull base. Because of the morbidity associated with the operation, many other surgeons rejected it during this period. In 1973, Hendershot and Wood advocated the extradural middle fossa approach. [6]

In the 1930s, Profant and Lindsay described the drainage pathways of the petrous apex through several air cell tracts along with the routes whereby infection may come to involve the petrous apex. [7, 8]

Between the 1940s and the 1960s, the incidence of petrous apicitis was dramatically reduced, which is evidenced by the paucity of clinical manuscripts on the topic. This reduction was primarily due to the introduction of antibiotics. Most reports since this time are based on single clinical cases or very small clinical series.

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Problem

Petrous apicitis is a rare infection of the petrous apex of the temporal bone that occurs as an extension of a middle ear or mastoid infection.

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Epidemiology

Frequency

Petrous apicitis was commonly encountered before the introduction of antibiotics. It now appears quite rarely. Most reports on petrous apicitis in the literature are single clinical cases, and determining its frequency is difficult.

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Etiology

Petrous apicitis is believed to result when organisms, typically pseudomonads, become trapped within the complex air cell system of the petrous apex. Blockage of this air cell system may result from acute or chronic inflammation or mechanical blockage from an obstructing lesion.

Direct extension of infection from the mastoid and middle ear through pneumatized air cell tracts into the petrous apex is thought to be the etiology of petrous apicitis, which can occur as a rare complication of acute or chronic otitis media. [9, 10] An undetected and poorly drained infected air cell of the petrous apex must trail through small air cell tracts into the middle ear and mastoid. These cell tracts consist of the infralabyrinthine air cell tract, the retrofacial tract, and the peritubal air cells superior to the eustachian tube.

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Pathophysiology

Because of the extensive pneumatization and presence of rich bone marrow within the petrous apex, it is susceptible to infection or inflammation, typically in combination with mastoiditis. The proximity of the venous sinuses to the petrous apex is the reason for the historically high incidence of venous sinus thrombosis associated with petrous apicitis. The inflammation may extend into the Dorello canal, which transmits CN VI and the gasserian ganglion (CN V). Inflammation of the canal produces the triad of symptoms recognized by Gradenigo: lateral rectus (CN VI) palsy, retroorbital pain, and otorrhea.

Pseudomonads are most often responsible for petrous apicitis. In rare cases, tuberculosis has been identified as the cause, primarily in individuals younger than 20 years. Rare cases of fungal petrous apicitis have also been described including aspergillosis and blastomycosis infections.

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Presentation

Petrous apicitis may follow an acute or a chronic course.

The acute form typically develops rapidly and is caused by sudden obstruction of a normally pneumatized petrous apex air cell system. This obstruction can be caused by mechanical blockage from a lesion within the mastoid or by acute mastoid inflammation.

Chronic apicitis has a more indolent course and typically follows months to years of otorrhea. Patients may not appear acutely ill compared with those patients with acute petrositis. Chronic apicitis may result from chronic mastoid inflammation, or it may occur after a mastoid operation has led to blockage of the air cell system.

The triad of retroorbital pain, lateral rectus (CN VI palsy), and otorrhea is pathognomic for petrous apicitis. However, the presence of this triad is uncommon, since antibiotics typically halt the disease process before it involves dural structures. The presence of both otorrhea and deep pain should lead the examining physician to suspect petrous apicitis.

The anatomic relationship at the petrous tip may explain some of the symptoms of petrous apicitis. If the bony cortex of the anterior petrous apex is involved by the extension of infection, the infection may cause an epidural abscess in the region or damage nearby cranial nerves. On the superior aspect of the petrous tip lies the trigeminal or gasserian ganglion. Damage or irritation to the ganglion may explain the deep facial pain in some patients with apicitis. The petroclinoid ligament extends from the tip of the petrous apex to the clinoid is the petroclinoid ligament. The abducens nerve travels below the petroclinoid ligament in a small canal called the Dorello canal. The inflammation may extend into the Dorello canal, which transmits CN VI and the gasserian ganglion (CN V). Inflammation of the canal produces the triad of symptoms recognized by Gradenigo: lateral rectus (CN VI) palsy, retroorbital pain, and otorrhea.

Symptoms of petrositis are usually subtle. Typically, a patient who has had previous mastoid surgery complains of persistent infection and deep facial pain. In the largest recent series of patients with petrous apicitis, Chole and Donald (1995) found that the most common presenting symptoms found in 22 patients from 1976-1995 were as follows:

  • Deep pain and headache – 13 patients (59%)
  • Otalgia – 16 patients (72%)
  • Otorrhea – 13 patients (59%)
  • Fever – 5 patients (22%)
  • Coma – 2 patients (9%)
  • Cranial nerve paralysis
    • Nerve V – 15 patients (68.2%)
    • Nerve VI – 4 patients (18.2%)
    • Nerve VII – 6 patients (27.3%)
    • Nerve VIII – 9 patients (40.9%)
    • Nerve IX – 1 patient (4.5%)
    • Nerve X – 1 patient (4.5%)
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Indications

Indications for surgical drainage of the petrous apex in patients with petrous apicitis include failure to respond to medical (antimicrobial) therapy, the development of CN deficits as a result of extension of the infection, development of a petrous apex, epidural or parenchymal brain abscess, and the development of another life-threatening complication as a result of the infection.

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Relevant Anatomy

Wedged between the occipital bone and the greater wing of the sphenoid, the petrous portion of the temporal bone is shaped like a 3-sided pyramid. The pyramid's base is the medial wall of the middle ear. Two of the sides of the pyramid constitute the anterior floor of the middle cranial fossa and the anterolateral wall of the posterior fossa. The jugular bulb and inferior petrosal sinus line the inferior aspect of the petrous bone.

Anterior and superior to the petrous apex lie CN V and the gasserian ganglion. CN VI traversing through the Dorello canal also lies in this region. At its apex lie the carotid artery and cavernous sinus.

Air cells within the petrous portion of the temporal bone communicate with the eustachian tube and nasopharynx via the middle ear, providing a route of pressure equalization and drainage. In 1931, Profant described 2 separate air cell tracts within the temporal bone, an epitympanic tract leading from the antrum and a hypotympanic tract traveling beneath the cochlea. [7]  A study by Lee et al suggested that pneumatization of the petrous apex may not be influenced by major temporal bone structures but may instead be primarily impacted by the anterior saccule of the saccus medius. [11]

The petrous apex is the most surgically inaccessible portion of the temporal bone. A coronal plane through the internal auditory canal may arbitrarily bisect the apex. This plane divides the apex into anterior and posterior portions. The anterior apex, which is pneumatized in 9% of patients, is a peritubal area anterior and medial to the cochlea. The carotid artery traverses the anterior petrous apex. The posterior petrous apex, which is pneumatized in 30% of patients, is a perilabyrinthine area just medial to the semicircular canals.

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Contraindications

If the patient is medically unstable and unable to tolerate general anesthesia, high-dose IV antibiotics may be attempted to eradicate the infection in place of surgery.

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