IgA and IgG Subclass Deficiencies Treatment & Management
- Author: Terry W Chin, MD, PhD; Chief Editor: Harumi Jyonouchi, MD more...
Medical Care
As noted in Medication, even if the patient cannot produce specific antibodies, the decision to treat with intravenous immunoglobulin (IVIg) is controversial. Aggressive use of antibiotics is required for recurrent respiratory tract infections, such as sinusitis, asthma, and bronchitis.
The use of prophylactic antibiotics (eg, during the winter months) has not been well studied but can be considered. Cohort studies indicate that this approach can be successful.[29] If conventional initial intervention with antibiotics is not successful, a trial of IVIg at 400-600 mg/kg for 6 months may be considered. For partial deficiencies (ie, specific antibody deficiency), IVIg can be stopped if no clinical response is observed.
In IgG subclass deficiency, most clinicians reserve IVIg for patients unable to make antibodies to both protein and polysaccharide antigens. Although reports mention a possible beneficial effect of decreased duration of bacterial infection in patients with IgG subclass deficiency,[30] an unpublished, blinded, and randomized trial of IVIg in IgG subclass deficiency showed that IVIg was not effective. However, cohort studies indicate a benefit, especially in those patients with fewer responses to pneumococcal polysaccharide challenge.[17]
Some advocate using IVIg if a patient aged 3 years or older does not respond to the unconjugated vaccine, especially if the titer or quantity to any 1 serotype (eg, type 3 polysaccharide, the most immunogenic) does not increase 2-fold.
Patients with a decreased ability to make antipolysaccharide antibodies should be immunized with polysaccharide-protein conjugate vaccines, such as H influenzae type b (HIB) with diphtheria-tetanus. The conjugated protein allows anti-HIB antibodies to develop, though 2 or 3 doses are usually required.
A conjugated pneumococcal vaccine is now licensed for use in the United States. Conjugated meningococcal vaccine (Menactra) is also now yet available in the United States. Sorensen et al (1998) showed that a significant percentage of children with specific antibody deficiency develop protective antibody levels to the conjugated pneumococcal vaccine (Prevnar) with a subsequently decreased rate of infections.[31] Patients with isolated IgG3 subclass deficiency have a similar dilemma as to whether IVIg is helpful.[32]
Aggressive treatment of underlying allergies and/or asthma may help reduce the frequency and/or severity of recurrent respiratory tract infections, such as sinusitis and bronchitis.
Conventionally treat associated autoimmune diseases. Nothing indicates that patients with a concomitant specific IgA deficiency do worse than those without any immunodeficiency.
Surgical Care
A few patients with chronic upper or lower respiratory infections and subsequent structural changes may need strategic, long-term, broad-spectrum antibiotics, in addition to chest physiotherapy and sinus surgery.
Although many patients benefit from the placement of tympanostomy tubes to manage recurrent otitis media and/or they might undergo endoscopic sinus surgery for chronic sinusitis, the importance of aggressive medical therapy for the underlying immunodeficiency and its accompanied allergic condition cannot be overemphasized.
Consultations
Consultation with a surgeon may be needed for patients with chronic infections of the upper or lower respiratory tracts. Chronic sinusitis may require various ear, nose, and throat (ENT) procedures to promote drainage.
A rheumatologist, allergist/immunologist, or both may be required because of the various autoimmune and allergic diseases present with increased frequency in B-cell disorders.
Diet
Gluten-free and other restricted diets have been tried but are ineffective in these disorders when chronic diarrhea is present.
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| Brand(Manufacturer) | Manufacturing Process | pH | Additives (IVIg products containing sucrose are most often associated with renal dysfunction, acute renal failure, and osmotic nephrosis, particularly with preexisting risk factors [eg, history of renal insufficiency, diabetes mellitus, age >65 y, dehydration, sepsis, paraproteinemia, nephrotoxic drugs]) | Parenteral Form and Final Concentrations | IgA Content mcg/mL |
| Carimune NF (CSL Behring) | Kistler-Nitschmann fractionation; pH 4, nanofiltration | 6.4-6.8 | 6% solution: 10% sucrose, < 20 mg NaCl/g protein | Lyophilized powder 3%, 6%, 9%, 12% | Trace |
| Flebogamma (Grifols USA) | Cohn-Oncley fractionation, PEG precipitation, ion-exchange chromatography, pasteurization | 5.1-6 | Sucrose free, contains 5% D-sorbitol | Liquid 5% | < 50 |
| Gammagard Liquid 10% (Baxter Bioscience) | Cohn-Oncley cold ethanol fractionation, cation and anion exchange chromatography, solvent detergent treated, nanofiltration, low pH incubation | 4.6-5.1 | 0.25M glycine | Ready-for-use Liquid 10% | 37 |
| Gamunex (Talecris Biotherapeutics) | Cohn-Oncley fractionation, caprylate-chromatography purification, cloth and depth filtration, low pH incubation | 4-4.5 | Does not catain carbohydrate stabilizers (eg, sucrose, maltose), contains glycine | Liquid 10% | 46 |
| Gammaplex (Bio Products) | Solvent/detergent treatment targeted to enveloped viruses; virus filtration using Pall Ultipor to remove small viruses including nonenveloped viruses; low pH incubation | 4.8-5.1 | Contains sorbitol (40 mg/mL); do not administer if fructose intolerant | Ready-for-use solution 5% | < 10 |
| Iveegam EN (Baxter Bioscience) | Cohn-Oncley fraction II/III; ultrafiltration; pasteurization | 6.4-7.2 | 5% solution: 5% glucose, 0.3% NaCl | Lyophilized powder 5% | < 10 |
| Polygam S/D Gammagard S/D (Baxter Bioscience for the American Red Cross) | Cohn-Oncley cold ethanol fractionation, followed by ultracentrafiltration and ion exchange chromatography; solvent detergent treated | 6.4-7.2 | 5% solution: 0.3% albumin, 2.25% glycine, 2% glucose | Lyophilized powder 5%, 10% | < 1.6 (5% solution) |
| Octagam (Octapharma USA) 9/24/10: Withdrawn from market because of unexplained reports of thromboembolic events | Cohn-Oncley fraction II/III; ultrafiltration; low pH incubation; S/D treatment pasteurization | 5.1-6 | 10% maltose | Liquid 5% | 200 |
| Panglobulin (Swiss Red Cross for the American Red Cross) | Kistler-Nitschmann fractionation; pH 4 incubation, trace pepsin, nanofiltration | 6.6 | Per gram of IgG: 1.67 g sucrose, < 20 mg NaCl | Lyophilized powder 3%, 6%, 9%, 12% | 720 |
| Privigen Liquid 10% (CSL Behring) | Cold ethanol fractionation, octanoic acid fractionation, and anion exchange chromatography; pH 4 incubation and depth filtration | 4.6-5 | L-proline (approximately 250 mmol/L) as stabilizer; trace sodium; does not contain carbohydrate stabilizers (eg, sucrose, maltose) | Ready-for use liquid 10% | < 25 |
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