eMedicine Specialties > Pediatrics: General Medicine > Allergy & Immunology

Common Variable Immunodeficiency: Follow-up

Author: C Lucy Park, MD, Head, Division of Allergy, Immunology, and Pulmonology, Associate Professor, Department of Pediatrics, University of Illinois at Chicago
Contributor Information and Disclosures

Updated: Nov 2, 2009

Follow-up

Further Inpatient Care

  • Inpatient care may be necessary for any serious clinical conditions associated with common variable immunodeficiency (CVID).

Complications

  • See History for a discussion of complications.

Prognosis

  • The prognosis for patients with common variable immunodeficiency is reasonably good unless severe autoimmune disease or malignancy develops and if intravenous immunoglobulin (IVIG) replacement therapy is started early before severe lung damage takes place (see Mortality/Morbidity).
  • The development of granulomatous-lymphocytic lung disease was associated with a worse prognosis and an increased prevalence of lymphoproliferative disease.6

Patient Education

The effort to educate patients and families regarding early signs of infection should be ongoing. The approach in identifying infectious agents and specific antimicrobial therapy needs to be aggressive.

The following may be helpful resources:

Miscellaneous

Medicolegal Pitfalls

  • Failure to measure ability to produce functional antibodies
  • Administration of live viral vaccine, such as oral polio or measles-mumps-rubella (MMR) vaccine, varicella vaccine, or live-attenuated influenza vaccine.
  • Failure to recognize and properly treat concurrent autoimmune process or malignancy

Special Concerns

  • Pregnant patients with common variable immunodeficiency (CVID) with chronic lung disease and compromised pulmonary function may experience further compromise in pulmonary function, especially in the third trimester. Newborn infants of patients with common variable immunodeficiency are usually born with a normal immunoglobulin (Ig)G level as long as the mother receives adequate intravenous immunoglobulin (IVIG) replacement therapy during pregnancy. IgG is actively transported across the placenta during the third trimester.
 


More on Common Variable Immunodeficiency

Overview: Common Variable Immunodeficiency
Differential Diagnoses & Workup: Common Variable Immunodeficiency
Treatment & Medication: Common Variable Immunodeficiency
Follow-up: Common Variable Immunodeficiency
References
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References

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Further Reading

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Keywords

common variable immunodeficiency, CVID, late-onset hypogammaglobulinemia, adult-onset hypogammaglobulinemia, acquired immunodeficiency, primary immunodeficiency disease, impaired antibody responses, immunologic disorder, treatment, diagnosis

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Contributor Information and Disclosures

Author

C Lucy Park, MD, Head, Division of Allergy, Immunology, and Pulmonology, Associate Professor, Department of Pediatrics, University of Illinois at Chicago
C Lucy Park, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Medical Association, Chicago Medical Society, Clinical Immunology Society, and Illinois State Medical Society
Disclosure: Nothing to disclose.

Medical Editor

Ann O'Neill Shigeoka, MD †, Former Clinical Associate Professor, Department of Pediatrics, Division of Immunology-Rheumatology, University of Utah School of Medicine
Ann O'Neill Shigeoka, MD † is a member of the following medical societies: American Federation for Medical Research, Clinical Immunology Society, Pediatric Infectious Diseases Society, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

John Wilson Georgitis, MD, Consulting Staff, Lafayette Allergy Services
John Wilson Georgitis, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American Association for the Advancement of Science, American College of Chest Physicians, American Lung Association, American Medical Writers Association, and American Thoracic Society
Disclosure: Nothing to disclose.

CME Editor

David Pallares, MD, Clinical Assistant Professor, Department of Pediatrics, Division of Allergy and Immunology, University of Louisville
David Pallares, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology
Disclosure: Nothing to disclose.

Chief Editor

Harumi Jyonouchi, MD, Associate Professor, Division of Pulmonary Allergy/Immunology and Infectious Diseases, Department of Pediatrics, UMDNJ-New Jersey Medical School
Harumi Jyonouchi, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American Association of Immunologists, American Medical Association, Clinical Immunology Society, New York Academy of Sciences, Society for Experimental Biology and Medicine, Society for Mucosal Immunology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

 
 
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