Complement Deficiency: Multimedia

References

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Further Reading

Relevant clinical guidelines include the following:

• Practice parameter for the diagnosis and management of primary immunodeficiency
• Prevention and control of meningococcal disease: Recommendations for use of meningococcal vaccines in pediatric patients
• Recommended immunization schedules for persons aged 0 through 18 years: United States, 2009

Keywords

complement deficiency, complement system, mannose-binding lectin pathway, MBL pathway, classical pathway, alternative pathway, properdin, factor B, factor D, factor H, factor I, C3 component, late complement components, regulatory proteins, C1 inhibitor, C1INH, primary immunodeficiency, Streptococcus pneumoniae, Haemophilus influenzae, proteinuria, Fanconi syndrome, systemic lupus erythematosus, SLE, atherosclerosis, pneumococcal infection, MBL deficiency, schizophrenia, hemolytic-uremic syndrome, HUS, membranoproliferative glomerulonephritis, rheumatoid arthritis, Neisseria gonorrhoeae, Neisseria meningitidis, angioedema, collagen vascular disorders, cystic fibrosis, CF, treatment, diagnosis

Contributor Information and Disclosures

Author

Ruchir Agrawal, MD,, Chief, Allergy and Immunology, Aurora Sheboygan Clinic
Ruchir Agrawal, MD, is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American College of Allergy, Asthma and Immunology, and American Medical Association
Disclosure: Nothing to disclose.

Coauthor(s)

Vishweswar Chilumkurti, MBBS, MPH, Rehabilitation Consultant, Career Employment Australia
Disclosure: Nothing to disclose.

Harumi Jyonouchi, MD, Associate Professor, Division of Pulmonary Allergy/Immunology and Infectious Diseases, Department of Pediatrics, UMDNJ-New Jersey Medical School
Harumi Jyonouchi, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American Association of Immunologists, American Medical Association, Clinical Immunology Society, New York Academy of Sciences, Society for Experimental Biology and Medicine, Society for Mucosal Immunology, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Medical Editor

Ann O'Neill Shigeoka, MD †, Former Clinical Associate Professor, Department of Pediatrics, Division of Immunology-Rheumatology, University of Utah School of Medicine
Ann O'Neill Shigeoka, MD † is a member of the following medical societies: American Federation for Medical Research, Clinical Immunology Society, Pediatric Infectious Diseases Society, and Society for Pediatric Research
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

John Wilson Georgitis, MD, Consulting Staff, Lafayette Allergy Services
John Wilson Georgitis, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American Association for the Advancement of Science, American College of Chest Physicians, American Lung Association, American Medical Writers Association, and American Thoracic Society
Disclosure: Nothing to disclose.

CME Editor

David Pallares, MD, Clinical Assistant Professor, Department of Pediatrics, Division of Allergy and Immunology, University of Louisville
David Pallares, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology
Disclosure: Nothing to disclose.

Chief Editor

Russell W Steele, MD, Head, Division of Pediatric Infectious Diseases, Ochsner Children's Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine
Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association
Disclosure: None None None