Complement Deficiency Medication
- Author: Ruchir Agrawal, MD; Chief Editor: Russell W Steele, MD more...
Active immunization increases resistance to infection. Vaccines consist of microorganisms or cellular components, which act as antigens. Administration of the vaccine stimulates the production of antibodies with specific protective properties. Meningococcal disease is common among patients with terminal common complement pathway (C3, C5-9) deficiencies. Prevention of meningococcal meningitis is recommended.
Isolated from groups A, C, Y, and W-135. Recommended for all individuals with known complement deficiency and those in close contact with the patient. The immunogenicity and clinical efficacy of serogroups A and C meningococcal vaccines have been well established. This vaccine does not confer any protection against serogroup B. The vaccine induces antibody response for serogroup A in individuals as young as 3 mo, but it is poorly immunogenic for serogroup C in recipients who are younger than 18-24 mo.
These agents may be used to prevent attacks associated with angioedema. Synthetic attenuated androgens taken prophylactically increase the serum concentration of C1NH.
Increases levels of C4 component of complement by increasing C1 esterase inhibitor, and thereby reduces attacks associated with angioedema.
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