Pediatric Hypereosinophilic Syndrome Treatment & Management
- Author: Bruce M Rothschild, MD; Chief Editor: Harumi Jyonouchi, MD more...
Medical Care
No therapy is indicated in hypereosinophilic syndrome with absence of organ damage. Angioedema and urticaria suggest a benign course (see the image below).
Urticarial and erythematous rash. Mucosal ulcers do not respond to corticosteroids. Rapid intervention for cardiac disease is essential.
Reducing the eosinophil load is the major goal of treatment.[9] Although seemingly important, aggressive control of eosinophilia is hypothetical because all reports about treatment approaches are essentially anecdotal for this rare disorder. In the absence of organ disease, however, any indication for treatment is unclear, except with respect to thrombosis risk.
Therapy to prevent the risk of thrombosis may be reasonable for all patients.[10]
Surgical Care
Cardiac surgery is indicated for annuloplasty, valve replacement, thrombectomy, and aortic prostheses. Because patients with mechanical valve replacements are especially prone to thrombosis, bioprostheses are recommended. Splenectomy may ameliorate platelet sequestration and is indicated for splenic infarction and pain due to splenic distention.
Consultations
Obtaining subspecialty input from a rheumatologist and hematologist is essential.
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