Mold Allergy Differential Diagnoses

  • Author: Shih-Wen Huang, MD; Chief Editor: Harumi Jyonouchi, MD   more...
 
Updated: Aug 22, 2011
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Shih-Wen Huang, MD  Professor Emeritus of Pulmonology and Allergy, Department of Pediatrics, University of Florida College of Medicine

Shih-Wen Huang, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology

Disclosure: Nothing to disclose.

Specialty Editor Board

C Lucy Park  MD, Head, Division of Allergy, Immunology, and Pulmonology, Associate Professor, Department of Pediatrics, University of Illinois at Chicago College of Medicine

C Lucy Park is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Medical Association, Chicago Medical Society, Clinical Immunology Society, and Illinois State Medical Society

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

David J Valacer, MD  Consulting Staff, Hoffman La Roche Pharmaceuticals

David J Valacer, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American Association for the Advancement of Science, American Thoracic Society, and New York Academy of Sciences

Disclosure: Nothing to disclose.

David Pallares, MD  Clinical Assistant Professor, Department of Pediatrics, Division of Allergy and Immunology, University of Louisville School of Medicine

David Pallares, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology

Disclosure: Nothing to disclose.

Chief Editor

Harumi Jyonouchi, MD  Associate Professor, Division of Pulmonary, Allergy/Immunology, and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Harumi Jyonouchi, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American Association of Immunologists, American Medical Association, Clinical Immunology Society, New York Academy of Sciences, Society for Experimental Biology and Medicine, Society for Mucosal Immunology, and Society for Pediatric Research

Disclosure: Nothing to disclose.

References

  1. Antova T, Pattenden S, Brunekreef B, et al. Exposure to indoor mould and children's respiratory health in the PATY study. J Epidemiol Community Health. Aug 2008;62(8):708-14. [Medline].

  2. Karvala K, Nordman H, Luukkonen R, et al. Occupational rhinitis in damp and moldy workplaces. Am J Rhinol. Sep-Oct 2008;22(5):457-62. [Medline].

  3. Soeria-Atmadja D, Onell A, Borga A. IgE sensitization to fungi mirrors fungal phylogenetic systematics. J Allergy Clin Immunol. Jun 2010;125(6):1379-1386.e1. [Medline].

  4. Holme J, Hagerhed-Engman L, Mattsson J, Sundell J, Bornehag CG. Culturable mold in indoor air and its association with moisture-related problems and asthma and allergy among Swedish children. Indoor Air. Aug 2010;20(4):329-40. [Medline].

  5. Deger L, Plante C, Goudreau S, et al. Home environmental factors associated with poor asthma control in Montreal children: a population-based study. J Asthma. Jun 2010;47(5):513-20. [Medline].

  6. Fairs A, Agbetile J, Hargadon B, Bourne M, Monteiro WR, Brightling CE, et al. IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med. Dec 1 2010;182(11):1362-8. [Medline].

  7. Vesper S, McKinstry C, Haugland R, et al. Development of an Environmental Relative Moldiness index for US homes. J Occup Environ Med. Aug 2007;49(8):829-33. [Medline].

  8. Crameri R, Zeller S, Glaser AG, Vilhelmsson M, Rhyner C. Cross-reactivity among fungal allergens: a clinically relevant phenomenon?. Mycoses. Mar 2009;52(2):99-106. [Medline].

  9. Huang SW, Kimbrough JW. Mold allergy is a risk factor for persistent cold-like symptoms in children. Clin Pediatr (Phila). Dec 1997;36(12):695-9. [Medline].

  10. Manning SC, Vuitch F, Weinberg AG, Brown OE. Allergic aspergillosis: a newly recognized form of sinusitis in the pediatric population. Laryngoscope. Jul 1989;99(7 Pt 1):681-5. [Medline].

  11. [Best Evidence] Cecchi L, D'Amato G, Ayres JG, Galan C, Forastiere F, Forsberg B, et al. Projections of the effects of climate change on allergic asthma: the contribution of aerobiology. Allergy. Sep 2010;65(9):1073-81. [Medline]. [Full Text].

  12. Hamilos DL. Allergic fungal rhinitis and rhinosinusitis. Proc Am Thorac Soc. May 2010;7(3):245-52. [Medline].

  13. Huang SW, Kimbrough JW. Effect of air cleaner on mold counts in the air and on symptoms of perennial allergic rhinitis. Pediatr Asthma, Allergy & Immunol. 1995;9:205-11.

  14. Gots RE, Layton NJ, Pirages SW. Indoor health: background levels of fungi. AIHA J (Fairfax, Va). Jul-Aug 2003;64(4):427-38. [Medline].

  15. Shah A, Kala J, Sahay S, Panjabi C. Frequency of familial occurrence in 164 patients with allergic bronchopulmonary aspergillosis. Ann Allergy Asthma Immunol. Oct 2008;101(4):363-9. [Medline].

  16. NAEPP. National Asthma Education and Prevention Program. Expert Panel Report 2: Guideline for the Diagnosis and Management of Asthma. NIH Publication No. 97-4051. Available at http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.pdf.

  17. Asturias JA, Ibarrola I, Ferrer A, et al. Diagnosis of Alternaria alternata sensitization with natural and recombinant Alt a 1 allergens. J Allergy Clin Immunol. Jun 2005;115(6):1210-7. [Medline].

  18. Klote M. Hypersensitive pneumonitis. Allergy and Asthma Proc. 2005;26:493-5.

  19. Stark PC, Celedon JC, Chew GL, et al. Fungal levels in the home and allergic rhinitis by 5 years of age. Environ Health Perspect. Oct 2005;113(10):1405-9. [Medline].

  20. Reponen T, Vesper S, Levin L, et al. High environmental relative moldiness index during infancy as a predictor of asthma at 7 years of age. Ann Allergy Asthma Immunol. Aug 2011;107(2):120-6. [Medline].

  21. van der Ent CK, Hoekstra H, Rijkers GT. Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody. Thorax. Mar 2007;62(3):276-7. [Medline].

  22. Fluticasone at different doses for chronic asthma in adults and children. [Best Evidence]. Cochrane Database Syst Rev. Oct 8 2008;(4):CD003534.

  23. Ricketti AJ, Greenberger PA, Patterson R. Serum IgE as an important aid in management of allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol. Jul 1984;74(1):68-71. [Medline].

  24. Greenberger PA. Allergic bronchopulmonary aspergillosis. In: Middleton E, Reed CE, Ellis EF, et al. Allergy: Principles and Practice. 4th ed. Mosby-Year Book; 1998:981-93.

  25. Barnes C, Tuck J, Simon S, Pacheco F, Hu F, Portnoy J. Allergenic materials in the house dust of allergy clinic patients. Ann Allergy Asthma Immunol. May 2001;86(5):517-23. [Medline].

  26. Buckland KF, O'Connor E, Murray LA, Hogaboam CM. Toll like receptor-2 modulates both innate and adaptive immune responses during chronic fungal asthma in mice. Inflamm Res. Aug 2008;57(8):379-87. [Medline].

  27. Bush RK, Portnoy JM, Saxon A, Terr AI, Wood RA. The medical effects of mold exposure. J Allergy Clin Immunol. Feb 2006;117(2):326-33. [Medline].

  28. Casey P, Garrett J, Eaton T. Allergic bronchopulmonary aspergillosis in a lung transplant patient successfully treated with nebulized amphotericin. J Heart Lung Transplant. Nov 2002;21(11):1237-41. [Medline].

  29. Committee on Environmental Health. Spectrum of noninfectious health effects from molds. www.pediatrics.org. Available at http://pediatrics.aappublications.org/content/118/6/2582.full. Accessed December, 2006.

  30. Denning DW, O'Driscoll BR, Powell G, et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med. Jan 1 2009;179(1):11-8. [Medline].

  31. Edmondson DA, Nordness ME, Zacharisen MC, Kurup VP, Fink JN. Allergy and "toxic mold syndrome". Ann Allergy Asthma Immunol. Feb 2005;94(2):234-9. [Medline].

  32. Gruchalla RS, Pongracic J, Plaut M, et al. Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity. J Allergy Clin Immunol. Mar 2005;115(3):478-85. [Medline].

  33. Hamilos DL. Chronic sinusitis. J Allergy Clin Immunol. Aug 2000;106(2):213-27. [Medline].

  34. Huang SW. The risk of sinusitis in children with allergic rhinitis. Allergy Asthma Proc. Mar-Apr 2000;21(2):85-8. [Medline].

  35. Huang SW. Treating pediatric perennial allergic rhinitis. Pract Allergy Immunol. 1995;10:193-8.

  36. Huang SW, Giannoni C. The risk of adenoid hypertrophy in children with allergic rhinitis. Ann Allergy Asthma Immunol. Oct 2001;87(4):350-5. [Medline].

  37. Jaakkola JJ, Hwang BF, Jaakkola N. Home dampness and molds, parental atopy, and asthma in childhood: a six-year population-based cohort study. Environ Health Perspect. Mar 2005;113(3):357-61. [Medline].

  38. Jacob B, Ritz B, Gehring U, et al. Indoor exposure to molds and allergic sensitization. Environ Health Perspect. Jul 2002;110(7):647-53. [Medline].

  39. Knutsen AP. When to suspect allergic bronchopulmonary aspergillosis. J Respir Dis. March 2006;27:123-34.

  40. Knutsen AP, Vijay HM, Kumar V, et al. Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ. Allergy. Nov 2010;65(11):1367-75. [Medline].

  41. Krieger JK, Takaro TK, Allen C, et al. The Seattle-King County healthy homes project: implementation of a comprehensive approach to improving indoor environmental quality for low-income children with asthma. Environ Health Perspect. Apr 2002;110 Suppl 2:311-22. [Medline].

  42. Meklin T, Potus T, Pekkanen J, Hyvarinen A, Hirvonen MR, Nevalainen A. Effects of moisture-damage repairs on microbial exposure and symptoms in schoolchildren. Indoor Air. 2005;15 Suppl 10:40-7. [Medline].

  43. Myatt TA, Minegishi T, Allen JG, Macintosh DL. Control of asthma triggers in indoor air with air cleaners: a modeling analysis. Environ Health. Aug 6 2008;7:43. [Medline].

  44. [Guideline] NHLBI. Guideline for the diagnosis and management of asthma-expert panel 11 report. NIH. 1997.

  45. Salvaggio JE, Hendrick DJ. Extrinsic allergic alveolitis. In: Allergy. 2nd ed. 2000:37-53.

  46. Santilli J, Rockwell W. Fungal contamination of elementary schools: a new environmental hazard. Ann Allergy Asthma Immunol. Feb 2003;90(2):203-8. [Medline].

  47. Schneider D, Freeman NC, McGarvey P. Asthma and respiratory dysfunction among urban, primarily Hispanic school children. Arch Environ Health. Jan 2004;59(1):4-13. [Medline].

  48. Selman M, Lacasse Y, Pardo A, Cormier Y. Hypersensitivity pneumonitis caused by fungi. Proc Am Thorac Soc. May 2010;7(3):229-36. [Medline].

  49. [Best Evidence] [Guideline] Selman M, Lacasse Y, Pardo A, et al. Hypersensitive pneumonitis caused by fungi. Proc Am Thorac Soc. May/2010;7:229-236. [Medline].

  50. Solomon WR. Pollen and fungi. Aerobiology and inhalant allergens. In: Middleton E, Reed CE, Ellis EF, et al. Allergy: Principles and Practice. 5th ed. Mosby-Year Book; 1998:367-93.

  51. Suzuki K, Iwata S, Iwata H. Allergic bronchopulmonary aspergillosis in a 9-year-old boy. Eur J Pediatr. Jul 2002;161(7):408-9. [Medline].

  52. Virant FS. Allergic rhinitis. Pediatr Rev. Sep 1992;13(9):323-8. [Medline].

  53. Wiszniewska M, Swierczynska-Machura D, Cezary P, Walusiak-Skorupa J. [Fungal allergy among art conservators: prevalence, risk factors and clinical symptoms]. Med Pr. 2010;61(2):133-41. [Medline].

 
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Aspergillus.
Alternaria alternata.
Bathrooms are favorite habitats for mold.
Moisture is trapped in the wall behind a vinyl wall covering.
Large amounts of moisture support fungal growth, as is the case with this dry wall covering.
Fungi collected from a spore sampler found in a cubic meter of air.
Glues can collect mold.
Soapy shower doors collect fungi.
Wet drywall collects mold.
Wall coverings can pucker because of mold.
Bipolaris.
Cladosporium (Hormodendrum).
Curvularia.
Dreschlera (Helminthosporium).
Epicoccum.
Penicillium.
Penicillium.
Stachybotrys.
Rhizopus.
 
 
 
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