Juvenile Systemic Sclerosis Differential Diagnoses

  • Author: Luke M Webb, MD; Chief Editor: Harumi Jyonouchi, MD   more...
 
Updated: Apr 17, 2012
 
 

Differential Diagnoses

Proceed to Workup
 
 
Contributor Information and Disclosures
Author

Luke M Webb, MD  Staff Physician, Department of Allergy and Immunology, Evans Army Community Hospital

Luke M Webb, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology and American College of Allergy, Asthma and Immunology

Disclosure: Nothing to disclose.

Coauthor(s)

David J Schwartz, MD  Fellow, Department of Allergy and Immunology, Walter Reed Army Medical Center

David J Schwartz, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, and American College of Allergy, Asthma and Immunology

Disclosure: Nothing to disclose.

Cecilia P Mikita, MD, MPH  Associate Program Director, Allergy-Immunology Fellowship, Associate Professor of Pediatrics and Medicine, Uniformed Services University of the Health Sciences; Staff Allergist/Immunologist, Walter Reed National Military Medical Center

Cecilia P Mikita, MD, MPH is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American College of Allergy, Asthma and Immunology, and Clinical Immunology Society

Disclosure: Nothing to disclose.

Donald Ames Person, MD  Expert Consultant in Pediatrics, Pediatric Rheumatology, Telemedicine, and Scientific Review, Tripler Army Medical Center; Professor of Pediatrics, F Edward Herbert School of Medicine, Uniformed Services University of the Health Sciences; Clinical Professor of Pediatrics and Public Health, University of Hawaii, John A Burns School of Medicine

Donald Ames Person, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Rheumatology, American Medical Association, American Pediatric Society, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Association of Military Surgeons of the US, Clinical Immunology Society, Federation of American Societies for Experimental Biology, Pediatric Infectious Diseases Society, Society for Experimental Biology and Medicine, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Specialty Editor Board

Ann O'Neill Shigeoka, MD †  Former Clinical Associate Professor, Department of Pediatrics, Division of Immunology-Rheumatology, University of Utah School of Medicine

Ann O'Neill Shigeoka, MD † is a member of the following medical societies: American Federation for Medical Research, Clinical Immunology Society, Pediatric Infectious Diseases Society, and Society for Pediatric Research

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

David J Valacer, MD  Consulting Staff, Hoffman La Roche Pharmaceuticals

David J Valacer, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American Association for the Advancement of Science, American Thoracic Society, and New York Academy of Sciences

Disclosure: Nothing to disclose.

David Pallares, MD  Clinical Assistant Professor, Department of Pediatrics, Division of Allergy and Immunology, University of Louisville School of Medicine

David Pallares, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology

Disclosure: Nothing to disclose.

Chief Editor

Harumi Jyonouchi, MD  Associate Professor, Division of Pulmonary, Allergy/Immunology, and Infectious Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Harumi Jyonouchi, MD is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American Academy of Pediatrics, American Association of Immunologists, American Medical Association, Clinical Immunology Society, New York Academy of Sciences, Society for Experimental Biology and Medicine, Society for Mucosal Immunology, and Society for Pediatric Research

Disclosure: Nothing to disclose.

References

  1. Behrman R, et al. Systemic Sclerosis. In: Nelson Textbook of Pediatrics. 17th ed. 2004:817-9.

  2. Johnson SR, Swiston JR, Swinton JR, Granton JT. Prognostic factors for survival in scleroderma associated pulmonary arterial hypertension. J Rheumatol. Aug 2008;35(8):1584-90. [Medline].

  3. Martini G, Foeldvari I, Russo R, Cuttica R, Eberhard A, Ravelli A. Systemic sclerosis in childhood: clinical and immunologic features of 153 patients in an international database. Arthritis Rheum. Dec 2006;54(12):3971-8. [Medline].

  4. [Guideline] Kowal-Bielecka O, Landewe R, Avouac J, Chwiesko S, Miniati I, Czirjak L. EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR). Ann Rheum Dis. May 2009;68(5):620-8. [Medline].

  5. [Best Evidence] Martini G, Vittadello F, Kasapcopur O, et al. Factors affecting survival in juvenile systemic sclerosis. Rheumatology (Oxford). Feb 2009;48(2):119-22. [Medline].

  6. Black CM, Denton CP. Therapy of Systemic Sclerosis. In: Van de Putte LBA, Furst DE, Williams HJ, van Riel PLCM, eds. Therapy of Systemic Rheumatic Disorders. 1998:495-545.

  7. Bottoni CR, Reinker KA, Gardner RD. Scleroderma in childhood: a 35-year history of cases and review of the literature. J Pediatr Orthop. Jul-Aug 2000;20(4):442-9. [Medline].

  8. Foeldvari I. Current developments in pediatric systemic sclerosis. Curr Rheumatol Rep. Apr 2009;11(2):97-102. [Medline].

  9. Foeldvari I. Scleroderma in children. Curr Opin Rheumatol. Nov 2002;14(6):699-703. [Medline].

  10. Foeldvari I. Systemic sclerosis in childhood. Rheumatology (Oxford). Oct 2006;45 Suppl 3:iii28-9. [Medline].

  11. Foti R, Leonardi R, Rondinone R, Di Gangi M, Leonetti C, Canova M. Scleroderma-like disorders. Autoimmun Rev. Feb 2008;7(4):331-9. [Medline].

  12. Hoeper MM. Pulmonary hypertension in collagen vascular disease. Eur Respir J. 2002;19: 571 - 576.

  13. Kaal SE, van Den Hoogen FH, de Jong EM. Systemic sclerosis: new insights in autoimmunity. Proc Soc Exp Biol Med. Oct 1999;222(1):1-8. [Medline].

  14. LeRoy EC. Pathogenesis of Systemic Sclerosis (scleroderma). In: Koopman WJ, ed. Arthritis and Allied Conditions. 1997:1481-90.

  15. Levy BD. Eicosanoids in scleroderma: lung disease hangs in the balance. Arthritis Rheum. Dec 2005;52(12):3693-7. [Medline].

  16. Nagaya N. Drug therapy of primary pulmonary hypertension. Am J Cardiovasc Drugs. 2004;4(2):75-85. [Medline].

  17. Poormoghim H, Lucas M, Fertig N. Systemic sclerosis sine scleroderma: demographic, clinical, and serologic features and survival in forty-eight patients. Arthritis Rheum. Feb 2000;43(2):444-51. [Medline].

  18. Rosenkranz ME, Agle LM, Efthimiou P, Lehman TJ. Systemic and localized scleroderma in children: current and future treatment options. Paediatr Drugs. 2006;8(2):85-97. [Medline].

  19. Russo RA, Katsicas MM. Clinical characteristics of children with Juvenile Systemic Sclerosis: follow-up of 23 patients in a single tertiary center. Pediatr Rheumatol Online J. May 1 2007;5:6. [Medline].

  20. Silver RM. Variant forms of scleroderma. In: Koopman WJ, ed. Arthritis and Allied Conditions. 1997:1465-80.

  21. Steen V. Advancements in diagnosis of pulmonary arterial hypertension in scleroderma. Arthritis Rheum. Dec 2005;52(12):3698-700. [Medline].

  22. Vancheeswaran R, Black CM, David J, et al. Childhood-onset scleroderma: is it different from adult-onset disease. Arthritis Rheum. Jun 1996;39(6):1041-9. [Medline].

  23. Zulian F. Systemic sclerosis and localized scleroderma in childhood. Rheum Dis Clin North Am. Feb 2008;34(1):239-55; ix. [Medline].

  24. Zulian F, Martini G. Childhood systemic sclerosis. Curr Opin Rheumatol. Nov 2007;19(6):592-7. [Medline].

  25. [Guideline] Zulian F, Woo P, Athreya BH, Laxer RM, Medsger TA Jr, Lehman TJ. The Pediatric Rheumatology European Society/American College of Rheumatology/European League against Rheumatism provisional classification criteria for juvenile systemic sclerosis. Arthritis Rheum. Mar 15 2007;57(2):203-12. [Medline].

 
Previous
Next
 
An 8-year-old girl with overlap syndrome with evolution to progressive systemic sclerosis (PSS).
Photo of hands revealing sclerodactyly. This demonstrates the progression of disease over 7 years.
Chest radiograph revealing diffuse, coarse interstitial marking with bilateral lower lobe bronchiectasis.
Axial CT scan of the chest of a 15-year-old female adolescent with progressive systemic sclerosis (PSS).
Esophagram revealing dysmotility.
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.