Transient Hypogammaglobulinemia of Infancy Follow-up
- Author: Alan P Knutsen, MD; Chief Editor: Harumi Jyonouchi, MD more...
Further Outpatient Care
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- Confirm initial diagnosis by measuring serum immunoglobulin levels annually until levels normalize.
- As discussed above, treatment of infections and modalities to reduce infections should be instituted. Treatment of allergic disorders should also be instituted.
- With appropriate treatment, these children can be considered healthy. The prognosis for transient hypogammaglobulinemia of infancy (THI) is quite good. Most children outgrow this immune deficiency when aged 2-6 years. However, THI is a diagnosis that is made retrospectively when serum immunoglobulin levels normalize and all antibody responses are normal.
- The immune system is periodically evaluated, usually at yearly intervals.
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- Long-term prognosis for patients with THI is excellent; the immune system becomes normal in patients by age 2-6 years.
- Serious life-threatening infections in patients with THI are rare.
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- Inform parents that THI is an immunodeficiency that eventually self-corrects because it is a maturational immunodeficiency.
- Also inform parents that patients are unlikely to have serious life-threatening infections.
- In addition, many infants with THI have or develop concomitant allergic diseases.
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