Pediatric Atrial Septal Defects Medication

  • Author: Michael R Carr, MD; Chief Editor: Steven R Neish, MD, SM   more...
 
Updated: May 2, 2012
 
 

Medication Summary

Medication is not currently a component of care for this condition. See Treatment.

Proceed to Follow-up
 
 
Contributor Information and Disclosures
Author

Michael R Carr, MD  Pediatric Cardiologist, Naval Medical Center Portsmouth

Michael R Carr, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American College of Cardiology, American Heart Association, and American Society of Echocardiography

Disclosure: Nothing to disclose.

Coauthor(s)

Brent R King  MD, MMM, Clive Nancy and Pierce Runnells Distinguished Professor of Emergency Medicine; Professor of Pediatrics, University of Texas Health Science Center at Houston; Chair, Department of Emergency Medicine, Chief of Emergency Services, Memorial Hermann Hospital and LBJ Hospital

Brent R King is a member of the following medical societies: American Academy of Emergency Medicine, American Academy of Pediatrics, American College of Emergency Physicians, American College of Physician Executives, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Specialty Editor Board

Paul M Seib, MD  Associate Professor of Pediatrics, University of Arkansas for Medical Sciences; Medical Director, Cardiac Catheterization Laboratory, Co-Medical Director, Cardiovascular Intensive Care Unit, Arkansas Children's Hospital

Paul M Seib, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology, American Heart Association, Arkansas Medical Society, International Society for Heart and Lung Transplantation, and Society for Cardiac Angiography and Interventions

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Alvin J Chin, MD  Professor of Pediatrics, University of Pennsylvania School of Medicine; Attending Physician, Cardiology Division, Children's Hospital of Philadelphia

Alvin J Chin, MD, is a member of the following medical societies: American Association for the Advancement of Science, American Heart Association, and Society for Developmental Biology

Disclosure: Nothing to disclose.

Gilbert Z Herzberg, MD  Assistant Professor, Department of Pediatrics, Section of Pediatric Cardiology, New York Medical College; Consulting Staff, Department of Pediatrics, Sound Shore Medical Center

Gilbert Z Herzberg, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Chief Editor

Steven R Neish, MD, SM  Director of Pediatric Cardiology Fellowship Program, Associate Professor, Department of Pediatrics, Baylor College of Medicine

Steven R Neish, MD, SM is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology, and American Heart Association

Disclosure: Nothing to disclose.

References

  1. Van Praagh R, Corsini I. Cor triatriatum: pathologic anatomy and a consideration of morphogenesis based on 13 postmortem cases and a study of normal development of the pulmonary vein and atrial septum in 83 human embryos. Am Heart J. Sep 1969;78(3):379-405. [Medline].

  2. Weinberg PM, Chin AJ, Murphy JD, et al. Postmortem echocardiography and tomographic anatomy of hypoplastic left heart syndrome after palliative surgery. Am J Cardiol. Dec 1 1986;58(13):1228-32. [Medline].

  3. Pierpont ME, Basson CT, Benson DW Jr, Gelb BD, Giglia TM, Goldmuntz E, et al. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation. Jun 12 2007;115(23):3015-38. [Medline].

  4. [Guideline] Jenkins KJ, Correa A, Feinstein JA, et al. Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation. Jun 12 2007;115(23):2995-3014. [Medline].

  5. Basson CT, Bachinsky DR, Lin RC, et al. Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet. Jan 1997;15(1):30-5. [Medline].

  6. Posch MG, Perrot A, Berger F, Ozcelik C. Molecular genetics of congenital atrial septal defects. Clin Res Cardiol. Mar 2010;99(3):137-47. [Medline].

  7. Hirayama-Yamada K, Kamisago M, Akimoto K, et al. Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect. Am J Med Genet A. 2005;135(1):47-52. [Medline].

  8. Posch MG, Waldmuller S, Müller M, Scheffold T, Fournier D, Andrade-Navarro MA, et al. Cardiac alpha-myosin (MYH6) is the predominant sarcomeric disease gene for familial atrial septal defects. PLoS One. 2011;6(12):e28872. [Medline]. [Full Text].

  9. Chin AJ, Weinberg PM, Barber G. Subcostal two-dimensional echocardiographic identification of anomalous attachment of septum primum in patients with left atrioventricular valve underdevelopment. J Am Coll Cardiol. Mar 1 1990;15(3):678-81. [Medline].

  10. Prompona M, Muehling O, Naebauer M, Schoenberg SO, Reiser M, Huber A. MRI for detection of anomalous pulmonary venous drainage in patients with sinus venosus atrial septal defects. Int J Cardiovasc Imaging. Mar 2011;27(3):403-12. [Medline].

  11. Hoey ET, Gopalan D, Ganesh V, Agrawal SK, Screaton NJ. Atrial septal defects: magnetic resonance and computed tomography appearances. J Med Imaging Radiat Oncol. Jun 2009;53(3):261-70. [Medline].

  12. Kilner PJ. The role of cardiovascular magnetic resonance in adults with congenital heart disease. Prog Cardiovasc Dis. Nov-Dec 2011;54(3):295-304. [Medline]. [Full Text].

  13. Johri AM, Rojas CA, El-Sherief A, Witzke CF, Chitty DW, Palacios IF, et al. Imaging of atrial septal defects: echocardiography and CT correlation. Heart. Sep 2011;97(17):1441-53. [Medline].

  14. Ko SF, Liang CD, Yip HK, Huang CC, Ng SH, Huang CF. Amplatzer septal occluder closure of atrial septal defect: evaluation of transthoracic echocardiography, cardiac CT, and transesophageal echocardiography. AJR Am J Roentgenol. Dec 2009;193(6):1522-9. [Medline].

  15. Vida VL, Padalino MA, Boccuzzo G, Veshti AA, Speggiorin S, Falasco G. Minimally invasive operation for congenital heart disease: a sex-differentiated approach. J Thorac Cardiovasc Surg. Oct 2009;138(4):933-6. [Medline].

  16. Kutty S, Hazeem AA, Brown K, Danford CJ, Worley SE, Delaney JW, et al. Long-term (5- to 20-year) outcomes after transcatheter or surgical treatment of hemodynamically significant isolated secundum atrial septal defect. Am J Cardiol. May 1 2012;109(9):1348-52. [Medline].

  17. Fukazawa M, Fukushige J, Ueda K. Atrial septal defects in neonates with reference to spontaneous closure. Am Heart J. Jul 1988;116(1 Pt 1):123-7. [Medline].

  18. Hanslik A, Pospisil U, Salzer-Muhar U, Greber-Platzer S, Male C. Predictors of spontaneous closure of isolated secundum atrial septal defect in children: a longitudinal study. Pediatrics. Oct 2006;118(4):1560-5. [Medline].

  19. Jonas RA. Atrial septal defect. In: Comprehensive Surgical Management of Congenital Heart Disease. 2004:225-41.

  20. Murphy JG, Gersh BJ, McGoon MD, et al. Long-term outcome after surgical repair of isolated atrial septal defect. Follow-up at 27 to 32 years. N Engl J Med. Dec 13 1990;323(24):1645-50. [Medline].

  21. Alexi-Meskishvili VV, Konstantinov IE. Surgery for atrial septal defect: from the first experiments to clinical practice. Ann Thorac Surg. Jul 2003;76(1):322-7. [Medline].

  22. Bierman FZ, Williams RG. Subxiphoid two-dimensional imaging of the interatrial septum in infants and neonates with congenital heart disease. Circulation. Jul 1979;60(1):80-90. [Medline].

  23. Bruneau BG. The developmental genetics of congenital heart disease. Nature. Febuary 2008;451(7178):943-8. [Medline].

  24. Butera G, Carminati M, Chessa M, et al. Percutaneous versus surgical closure of secundum atrial septal defect: comparison of early results and complications. Am Heart J. 2006;151(1):228-34. [Medline].

  25. Chin AJ, Murphy JD. Identification of coronary sinus septal defect (unroofed coronary sinus) by color Doppler echocardiography. Am Heart J. Dec 1992;124(6):1655-7. [Medline].

  26. Driscoll DJ. Left-to-right shunt lesions. Pediatr Clin North Am. Apr 1999;46(2):355-68, x. [Medline].

  27. Friedman WF. Congenital heart disease in infancy and childhood. In: Braunwald ed. Heart Disease: A Textbook of Cardiovascular Medicine. 5th ed. 1997:896-910.

  28. Helgason H, Jonsdottir G. Spontaneous closure of atrial septal defects. Pediatr Cardiol. 1999;20(3):195-9. [Medline].

  29. Mahoney LT, Truesdell SC, Krzmarzick TR, Lauer RM. Atrial septal defects that present in infancy. Am J Dis Child. Nov 1986;140(11):1115-8. [Medline].

  30. Mas MS, Bricker JT. Clinical physiology of left-to-right shunts. In: The Science and Practice of Pediatric Cardiology. Vol 2. 1990:999-1001.

  31. Patel HT, Hijazi ZM. Pediatric catheter interventions: a year in review 2004-2005. Curr Opin Pediatr. 2005;17(5):568-73. [Medline].

  32. Porter CJ, Feldt RH, Edwards WD, et al. Atrial septal defects. In: Heart Disease in Infants, Children, and Adolescents. Vol 1. 6th ed. 2001:603-17.

  33. Radzik D, Davignon A, van Doesburg N, et al. Predictive factors for spontaneous closure of atrial septal defects diagnosed in the first 3 months of life. J Am Coll Cardiol. Sep 1993;22(3):851-3. [Medline].

  34. Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. Oct 9 2007;116(15):1736-54. [Medline].

  35. Yeager SB, Chin AJ, Sanders SP. Subxiphoid two-dimensional echocardiographic diagnosis of coronary sinus septal defects. Am J Cardiol. Sep 1 1984;54(6):686-7. [Medline].

 
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Subcostal echocardiographic view of a child with a secundum atrial septal defect (ASD). Note the position of the defect in the atrial septum. RA = Right atrium; LA = Left atrium; SVC = Superior vena cava.
Subcostal long-axis view of the same child as in the previous image with a secundum atrial septal defect (ASD). RA = Right atrium; LA = Left atrium; RUPV = Right upper pulmonary vein.
Parasternal short axis view of a child with a secundum atrial septal defect (ASD). RA = Right atrium; LA = Left atrium; AO = Aorta.
Apical echocardiographic view of a primum atrial septal defect (ASD). Note the position of the defect when compared with a secundum ASD. RA = Right atrium; LA = Left atrium; RV = Right ventricle; LV = Left ventricle.
Apical echocardiographic view of a primum atrial septal defect (ASD). Note that the atrioventricular valves are at the same level (instead of mild apical displacement of the tricuspid valve), which is seen in the spectrum of atrioventricular canal defects. RA = Right atrium; LA = Left atrium; RV = Right ventricle; LV = Left ventricle.
Apical color Doppler echocardiographic view of a primum atrial septal defect (ASD). Note the flow across the defect from the left atrium to the right atrium (RA), and note the mitral regurgitation (MR) through a cleft in the anterior leaflet of the mitral valve. MV = Mitral valve; LV = Left ventricle.
Subcostal short-axis view of a child with a sinus venosus atrial septal defect (ASD). Note the position of the defect compared with that of a secundum or primum ASD. Also note the anomalous position of the right upper pulmonary vein (RUPV). RA = Right atrium; LA = Left atrium.
ECGs from a child with a secundum atrial septal defect (ASD). Note the right-axis deviation and rSR' pattern in lead V1.
ECG from a child with a primum atrial septal defect (ASD). Note the left-axis deviation with a counterclockwise vector of depolarization (small q waves in leads I and aVL) and right ventricular hypertrophy and/or volume overload (rSR' pattern and upright T wave in lead V1).
 
 
 
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