Pericardial Effusion, Malignant Differential Diagnoses
- Author: Poothirikovil Venugopalan, MBBS, MD, FRCP(Glasg), FRCPCH; Chief Editor: Stuart Berger, MD more...
Differential Diagnoses
- Bronchogenic Cyst
- Hemolytic-Uremic Syndrome
- Kawasaki Disease
- Pericarditis, Viral
- Postpericardiotomy Syndrome
Thomas-de-Montpreville V, Nottin R, Dulmet E, Serraf A. Heart tumors in children and adults: clinicopathological study of 59 patients from a surgical center. Cardiovasc Pathol. Jan-Feb 2007;16(1):22-8. [Medline].
Bien E, Stefanowicz J, Aleszewicz-Baranowska J, et al. [Cardio-vascular disorders at the time of diagnosis of malignant solid tumours in children--own experiences]. Med Wieku Rozwoj. Jul-Sep 2005;9(3 Pt 2):551-9. [Medline].
Ben-Horin S, Bank I, Guetta V, Livneh A. Large symptomatic pericardial effusion as the presentation of unrecognized cancer: a study in 173 consecutive patients undergoing pericardiocentesis. Medicine (Baltimore). Jan 2006;85(1):49-53. [Medline].
Medary I, Steinherz LJ, Aronson DC, La Quaglia MP. Cardiac tamponade in the pediatric oncology population: treatment by percutaneous catheter drainage. J Pediatr Surg. Jan 1996;31(1):197-9; discussion 199-200. [Medline].
Abadi MA, Zakowski MF. Cytologic features of sarcomas in fluids. Cancer. Apr 25 1998;84(2):71-6. [Medline].
Arya LS, Narain S, Thavaraj V, et al. Leukemic pericardial effusion causing cardiac tamponade. Med Pediatr Oncol. Apr 2002;38(4):282-4. [Medline].
Ascoli V, Taccogna S, Scalzo CC, Nardi F. Utility of cytokeratin 20 in identifying the origin of metastatic carcinomas in effusions. Diagn Cytopathol. Jun 1995;12(4):303-8. [Medline].
Bardales RH, Stanley MW, Schaefer RF, et al. Secondary pericardial malignancies: a critical appraisal of the role of cytology, pericardial biopsy, and DNA ploidy analysis. Am J Clin Pathol. Jul 1996;106(1):29-34. [Medline].
Bath LE, Walayat M, Mankad P, et al. Stage IV malignant intrapericardial germ cell tumor: a case report. Pediatr Hematol Oncol. Sep-Oct 1997;14(5):451-5. [Medline].
Batlle M, Ribera JM, Larrousse E, et al. Cardiac tamponade as the initial manifestation of acute leukemia: report of a case and review of the literature. Haematologica. Nov-Dec 1991;76(6):505-7. [Medline].
Benatar A, Vaughan J, Nicolini U, et al. Prenatal pericardiocentesis: its role in the management of intrapericardial teratoma. Obstet Gynecol. May 1992;79(5 ( Pt 2)):856-9. [Medline].
Braunschweig R, Guilleret I, Delacretaz F, et al. Pitfalls in TRAP assay in routine detection of malignancy in effusions. Diagn Cytopathol. Oct 2001;25(4):225-30. [Medline].
Cartagena AM, Levin TL, Issenberg H, Goldman HS. Pericardial effusion and cardiac hemangioma in the neonate. Pediatr Radiol. 1993;23(5):384-5. [Medline].
Ceresoli GL, Ferreri AJ, Bucci E, et al. Primary cardiac lymphoma in immunocompetent patients: diagnostic and therapeutic management. Cancer. Oct 15 1997;80(8):1497-506. [Medline].
Chan HS, Sonley MJ, Moes CA, et al. Primary and secondary tumors of childhood involving the heart, pericardium, and great vessels. A report of 75 cases and review of the literature. Cancer. Aug 15 1985;56(4):825-36. [Medline].
Chang JS, Young ML, Chuu WM, Lue HC. Infantile cardiac hemangioendothelioma. Pediatr Cardiol. Jan 1992;13(1):52-5. [Medline].
Cullinane CA, Paz IB, Smith D, et al. Prognostic factors in the surgical management of pericardial effusion in the patient with concurrent malignancy. Chest. Apr 2004;125(4):1328-34. [Medline].
Czader M, Ali SZ. Flow cytometry as an adjunct to cytomorphologic analysis of serous effusions. Diagn Cytopathol. Aug 2003;29(2):74-8. [Medline].
da Costa CM, de Camargo B, Gutierrez y Lamelas R, et al. Cardiac tamponade complicating hyperleukocytosis in a child with leukemia. Med Pediatr Oncol. Aug 1999;33(2):120-3; discussion 124. [Medline].
Daubeney PE, Ogilvie BC, Moore IE, Webber SA. Intrapericardial lymphangioma presenting as neonatal cardiac tamponade. Pediatr Cardiol. Mar-Apr 1996;17(2):129-31. [Medline].
Davidson B. Malignant effusions: from diagnosis to biology. Diagn Cytopathol. Oct 2004;31(4):246-54. [Medline].
Davidson B, Risberg B, Kristensen G, et al. Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies. Evaluation of five epithelial markers. Virchows Arch. Jul 1999;435(1):43-9. [Medline].
del Barrio LG, Morales JH, Delgado C, et al. Percutaneous balloon pericardial window for patients with symptomatic pericardial effusion. Cardiovasc Intervent Radiol. Sep-Oct 2002;25(5):360-4. [Medline].
Donadieu J, Canioni D, Cuenod B, et al. A familial T-cell lymphoma with gamma delta phenotype and an original location. Possible role of chronic Epstein-Barr virus infection. Cancer. Apr 15 1996;77(8):1571-7. [Medline].
Eyskens B, Lawrenson J, Moerman P, et al. Brief report. Sudden death following removal of pericardial fluid in a child presenting with mediastinal lymphoma. Med Pediatr Oncol. Dec 1998;31(6):547-8. [Medline].
Fang BR, Chiang CW, Hung JS, et al. Cardiac myxoma--clinical experience in 24 patients. Int J Cardiol. Dec 1990;29(3):335-41. [Medline].
Fernandes F, Ianni BM, Arteaga E, et al. Value of pericardial biopsy in the etiologic diagnosis of pericardial diseases [in Portuguese]. Arq Bras Cardiol. Jun 1998;70(6):393-5. [Medline].
Geissbuhler K, Leiser A, Fuhrer J, Ris HB. Video-assisted thoracoscopic pericardial fenestration for loculated or recurrent effusions. Eur J Cardiothorac Surg. Oct 1998;14(4):403-8. [Medline].
Georghiou GP, Stamler A, Sharoni E, et al. Video-assisted thoracoscopic pericardial window for diagnosis and management of pericardial effusions. Ann Thorac Surg. Aug 2005;80(2):607-10. [Medline].
Gerber TC, Safford RE. Intrapericardial Doppler flow signals in cardiac tamponade. Clin Cardiol. Mar 1999;22(3):231-2. [Medline].
Girardi LN, Ginsberg RJ, Burt ME. Pericardiocentesis and intrapericardial sclerosis: effective therapy for malignant pericardial effusions. Ann Thorac Surg. Nov 1997;64(5):1422-7; discussion 1427-8. [Medline].
Graham SJ, Duval-Arnould B, Mercado TC, Trepel JB, Cotelingam JD. Burkitt's lymphoma: a pericardial presentation. Cytopathology. 1990;1(4):239-42. [Medline].
Hallman JR, Geisinger KR. Cytology of fluids from pleural, peritoneal and pericardial cavities in children. A comprehensive survey. Acta Cytol. Mar-Apr 1994;38(2):209-17. [Medline].
Hoffmann U, Globits S, Schima W, et al. Usefulness of magnetic resonance imaging of cardiac and paracardiac masses. Am J Cardiol. Oct 1 2003;92(7):890-5. [Medline].
Hudnall SD, Melez K, Galindo A, Bryson Y. Massive pseudolymphomatous pericardial effusion in the posttransplant setting mimicking posttransplant lymphoproliferative disease. Transplantation. Jun 27 1996;61(12):1776-8. [Medline].
Karimi M, Eshghi P. Unusual lymphoblastic leukemia/lymphoma in Eastern Iran. Indian J Pediatr. Jul 2006;73(7):619-22. [Medline].
Kawakami K, Horigome H, Tsuchida M, et al. Right atrial hemangiopericytoma with hemopericardium during infancy. Pediatr Cardiol. Jan-Feb 1995;16(1):48-50. [Medline].
Kondo M, Kojima S, Horibe K, et al. Hemolytic uremic syndrome after allogeneic or autologous hematopoietic stem cell transplantation for childhood malignancies. Bone Marrow Transplant. Feb 1998;21(3):281-6. [Medline].
Krikorian JG, Hancock EW. Pericardiocentesis. Am J Med. Nov 1978;65(5):808-14. [Medline].
Kulthe SG, Nadkarni UB, Singh A, et al. Recurrent Cardiac tamponade: intrapericardial teratoma. Indian Pediatr. Jan 1995;32(1):88-91. [Medline].
Laga S, Gewillig MH, Van Schoubroeck D, Daenen W. Imminent fetal cardiac tamponade by right atrial hemangioma. Pediatr Cardiol. Sep-Oct 2006;27(5):633-5. [Medline].
Lazzarino M, Orlandi E, Paulli M, et al. Treatment outcome and prognostic factors for primary mediastinal (thymic) B-cell lymphoma: a multicenter study of 106 patients. J Clin Oncol. Apr 1997;15(4):1646-53. [Medline].
Lin YW, Kubota M, Matsumura M, et al. T cell leukemia with pericardial effusion at diagnosis. Pediatr Hematol Oncol. Oct-Dec 1993;10(4):379-80. [Medline].
Lindenberger M, Kjellberg M, Karlsson E, Wranne B. Pericardiocentesis guided by 2-D echocardiography: the method of choice for treatment of pericardial effusion. J Intern Med. Apr 2003;253(4):411-7. [Medline].
Loire R, Saint-Pierre A. Radiation-induced pericarditis. Long-term outcome. 45 cases with thoracotomy and biopsy [in French]. Presse Med. Dec 8 1990;19(42):1931-6. [Medline].
Luna A, Ribes R, Caro P, et al. Evaluation of cardiac tumors with magnetic resonance imaging. Eur Radiol. Jul 2005;15(7):1446-55. [Medline].
MacKenzie S, Loken S, Kalia N, et al. Intrapericardial teratoma in the perinatal period. Case report and review of the literature. J Pediatr Surg. Dec 2005;40(12):e13-8. [Medline].
Maisch B, Pankuweit S, Brilla C, et al. Intrapericardial treatment of inflammatory and neoplastic pericarditis guided by pericardioscopy and epicardial biopsy--results from a pilot study. Clin Cardiol. Jan 1999;22(1 Suppl 1):I17-22. [Medline].
Malamou-Mitsi VD, Zioga AP, Agnantis NJ. Diagnostic accuracy of pericardial fluid cytology: an analysis of 53 specimens from 44 consecutive patients. Diagn Cytopathol. Sep 1996;15(3):197-204. [Medline].
Manetti A, De Simone L, Pollini I, et al. Generalized lymphangiomatosis with chylopericardium [in Italian]. Pediatr Med Chir. Jan-Feb 1994;16(1):81-3. [Medline].
Marcy PY, Bondiau PY, Brunner P. Percutaneous treatment in patients presenting with malignant cardiac tamponade. Eur Radiol. Sep 2005;15(9):2000-9. [Medline].
Markiewicz W, Glatstein E, London EJ, Popp RL. Echocardiographic detection of pericardial effusion and pericardial thickening in malignant lymphoma. Radiology. Apr 1977;123(1):161-4. [Medline].
Markman M. Common complications and emergencies associated with cancer and its therapy. Cleve Clin J Med. Mar-Apr 1994;61(2):105-14; quiz 162. [Medline].
Martinez-Lopez JI. ECG of the month. The swinging heart. Electrical alternans. J La State Med Soc. Apr 1990;142(4):5-8. [Medline].
McClain JL, Clark MA, Sandusky GE. Undiagnosed, untreated acute lymphoblastic leukemia presenting as suspected child abuse. J Forensic Sci. May 1990;35(3):735-9. [Medline].
McDonald JM, Meyers BF, Guthrie TJ, et al. Comparison of open subxiphoid pericardial drainage with percutaneous catheter drainage for symptomatic pericardial effusion. Ann Thorac Surg. Sep 2003;76(3):811-5; discussion 816. [Medline].
Meyers DG, Meyers RE, Prendergast TW. The usefulness of diagnostic tests on pericardial fluid. Chest. May 1997;111(5):1213-21. [Medline].
Mihaescu A, Gebhard S, Chaubert P, et al. Application of molecular genetics to the diagnosis of lymphoid-rich effusions: study of 95 cases with concomitant immunophenotyping. Diagn Cytopathol. Aug 2002;27(2):90-5. [Medline].
Mishra OP, Yusuf S, Ali Z, Nath G. Lysozyme levels for the diagnosis of tuberculous effusions in children. J Trop Pediatr. Oct 2000;46(5):296-300. [Medline].
Moores DW, Allen KB, Faber LP, et al. Subxiphoid pericardial drainage for pericardial tamponade. J Thorac Cardiovasc Surg. Mar 1995;109(3):546-51; discussion 551-2. [Medline].
Mouallem M, Wolf I, Mindlin G, Farfel Z. Pericardial tamponade-associated hyponatremia. Am J Med Sci. Jan 2003;325(1):51-2. [Medline].
Mueller XM, Tevaearai HT, Hurni M, et al. Long-term results of surgical subxiphoid pericardial drainage. Thorac Cardiovasc Surg. Apr 1997;45(2):65-9. [Medline].
Mukai K, Shinkai T, Tominaga K, Shimosato Y. The incidence of secondary tumors of the heart and pericardium: a 10- year study. Jpn J Clin Oncol. Sep 1988;18(3):195-201. [Medline].
Nieh S, Chen SF, Fu E, et al. Detection of the human telomerase RNA component by in situ hybridization in cells from body fluids. Acta Cytol. Jan-Feb 2005;49(1):31-7. [Medline].
Ohnishi M, Niwayama H, Miyazawa Y, et al. Echocardiography in patients with malignant metastatic neoplasms of the heart and great vessels [in Japanese]. J Cardiol. 1990;20(2):377-84. [Medline].
Parwani AV, Ali TZ, Ali SZ. Pathologic quiz case: a 15-year-old adolescent girl with supraclavicular lymphadenopathy and pleural and pericardial effusions. Arch Pathol Lab Med. Jun 2003;127(6):e288-90. [Medline].
Perkkio M, Tikanoja T, Marin S. Leukemic coronary artery occlusion in a child with acute lymphoblastic leukemia. Pediatr Cardiol. Jan-Feb 1997;18(1):64-5. [Medline].
Politi E, Kandaraki C, Apostolopoulou C, et al. Immunocytochemical panel for distinguishing between carcinoma and reactive mesothelial cells in body cavity fluids. Diagn Cytopathol. Mar 2005;32(3):151-5. [Medline].
Pomjanski N, Motherby H, Buckstegge B, et al. Early diagnosis of mesothelioma in serous effusions using AgNOR analysis. Anal Quant Cytol Histol. Apr 2001;23(2):151-60. [Medline].
Posner MR, Cohen GI, Skarin AT. Pericardial disease in patients with cancer. The differentiation of malignant from idiopathic and radiation-induced pericarditis. Am J Med. Sep 1981;71(3):407-13. [Medline].
Puthanakit T, Pongprot Y, Borisuthipandit T, et al. A mediastinal mass resembling lymphoma: an unusual manifestation of probable case of invasive zygomycosis in an immunocompetent child. J Med Assoc Thai. Oct 2005;88(10):1430-3. [Medline].
Rienmuller R, Tiling R. Evaluation of paracardiac and intracardiac masses in children. Semin Ultrasound CT MR. Jun 1990;11(3):246-50. [Medline].
Rinkevich D, Borovik R, Bendett M, Markiewicz W. Malignant pericardial tamponade. Med Pediatr Oncol. 1990;18(4):287-91. [Medline].
Rosenkranz ER, Murphy DJ Jr. Diagnosis and neonatal resection of right atrial angiosarcoma. Ann Thorac Surg. Apr 1994;57(4):1014-5. [Medline].
Shimoyama Y, Kawada K, Imamura H. A functioning intrapericardial paraganglioma (pheochromocytoma). Br Heart J. Apr 1987;57(4):380-3. [Medline].
Sklansky M, Greenberg M, Lucas V, Gruslin-Giroux A. Intrapericardial teratoma in a twin fetus: diagnosis and management. Obstet Gynecol. May 1997;89(5 Pt 2):807-9. [Medline].
Spottswood SE, Goble MM, Massey GV, Ben-Ezra JM. Acute monoblastic leukemia presenting with pericardial effusion and cardiac tamponade. Pediatr Radiol. 1994;24(7):494-5. [Medline].
Szturmowicz M, Tomkowski W, Fijalkowska A, et al. Diagnostic utility of CYFRA 21-1 and CEA assays in pericardial fluid for the recognition of neoplastic pericarditis. Int J Biol Markers. Jan-Mar 2005;20(1):43-9. [Medline].
Toren A, Nagler A. Massive pericardial effusion complicating the course of chronic graft- versus-host disease (cGVHD) in a child with acute lymphoblastic leukemia following allogeneic bone marrow transplantation. Bone Marrow Transplant. Nov 1997;20(9):805-7. [Medline].
Vassilopoulos PP, Nikolaidis K, Filopoulos E, Griniatsos J, Efremidou A. Subxiphoidal pericardial 'window' in the management of malignant pericardial effusion. Eur J Surg Oncol. Oct 1995;21(5):545-7. [Medline].
Wilkes JD, Fidias P, Vaickus L, Perez RP. Malignancy-related pericardial effusion. 127 cases from the Roswell Park Cancer Institute. Cancer. Oct 15 1995;76(8):1377-87. [Medline].
Wong JW, Pitlik D, Abdul-Karim FW. Cytology of pleural, peritoneal and pericardial fluids in children. A 40-year summary. Acta Cytol. Mar-Apr 1997;41(2):467-73. [Medline].
Woods T, Vidarsson B, Mosher D, Stein JH. Transient effusive-constrictive pericarditis due to chemotherapy. Clin Cardiol. Apr 1999;22(4):316-8. [Medline].
Zendehrokh N, Dejmek A. Telomere repeat amplification protocol (TRAP) in situ reveals telomerase activity in three cell types in effusions: malignant cells, proliferative mesothelial cells, and lymphocytes. Mod Pathol. Feb 2005;18(2):189-96. [Medline].
.
Tsai MH, Yang CP, Chung HT, Shih LY. Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome. J Pediatr Hematol Oncol. Dec 2009;31(12):980-2. [Medline].
Devlieger R, Hindryckx A, Van Mieghem T, Debeer A, De Catte L, Gewillig M, et al. Therapy for foetal pericardial tumours: survival following in utero shunting, and literature review. Fetal Diagn Ther. 2009;25(4):407-12. [Medline].
Singh J, Rana SS, Kaur A, Srivastava V, Singh H, Sharma R. Intrapericardial teratoma presenting as recurrent pericardial tamponade: report of a case. Surg Today. 2009;39(8):700-4. [Medline].
Palma JH, Gaia DF, Guilhen JC, Branco JN, Buffolo E. Video-thoracoscopic pericardial drainage in the treatment of pericardial effusions. Rev Bras Cir Cardiovasc. Mar 2009;24(1):44-9. [Medline].
Walsh MA, Carcao M, Pope E, Lee KJ. Kaposiform hemangioendothelioma presenting antenatally with a pericardial effusion. J Pediatr Hematol Oncol. Oct 2008;30(10):761-3. [Medline].

