Pediatric Right Bundle Branch Block Differential Diagnoses

  • Author: Glenn T Wetzel, MD, PhD; Chief Editor: P Syamasundar Rao, MD  more...
 
Updated: Jul 24, 2015
 
 

Diagnostic ConsiderationsImportant considerationsOther problems to be considered

Although the risk of right bundle branch block (RBBB) progressing to complete heart block and sudden death is low, patients require workup and consultation with a pediatric cardiologist.

Failure to have the child properly evaluated could result in an unnecessary death and the legal ramifications resulting from such a tragedy.

In patients with suspected RBBB, also consider the following in the differential diagnosis:

  • Interventricular conduction delay
  • Right bundle branch aberrancy (premature atrial contractions, supraventricular tachycardia)
  • Premature ventricular contractions and other ventricular arrhythmia
  • Paced ventricular beat
  • Wolff-Parkinson-White syndrome (ventricular pre-excitation)
  • Brugada syndrome
  • Arrhythmogenic right ventricle cardiomyopathy (ARVC)
 
 
Contributor Information and Disclosures
Author

Glenn T Wetzel, MD, PhD Professor of Pediatrics, University of Tennessee College of Medicine; Director, Pediatric Arrhythmia Service, Le Bonheur Children's Hospital

Glenn T Wetzel, MD, PhD is a member of the following medical societies: American Academy of Pediatrics, Heart Rhythm Society

Disclosure: Nothing to disclose.

Coauthor(s)

Kenneth R Knecht, MD Assistant Professor of Cardiology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences College of Medicine

Kenneth R Knecht, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Alvin J Chin, MD Emeritus Professor of Pediatrics, University of Pennsylvania School of Medicine

Alvin J Chin, MD is a member of the following medical societies: American Association for the Advancement of Science, Society for Developmental Biology, American Heart Association

Disclosure: Nothing to disclose.

Chief Editor

P Syamasundar Rao, MD Professor of Pediatrics and Medicine, Division of Cardiology, Emeritus Chief of Pediatric Cardiology, University of Texas Medical School at Houston and Children's Memorial Hermann Hospital

P Syamasundar Rao, MD is a member of the following medical societies: American Academy of Pediatrics, American Pediatric Society, American College of Cardiology, American Heart Association, Society for Cardiovascular Angiography and Interventions, Society for Pediatric Research

Disclosure: Nothing to disclose.

Additional Contributors

Christopher Johnsrude, MD, MS Chief, Division of Pediatric Cardiology, University of Louisville School of Medicine; Director, Congenital Heart Center, Kosair Children's Hospital

Christopher Johnsrude, MD, MS is a member of the following medical societies: American Academy of Pediatrics, American College of Cardiology

Disclosure: Nothing to disclose.

Acknowledgements

The authors and editors of Medscape Drugs & Diseases gratefully acknowledge the contributions of previous authors Christopher Mart, MD; Kerry Rosen, MD; and Christopher Zachary, MD, to the development and writing of this article.

References
  1. Stein R, Nguyen P, Abella J, Olson H, Myers J, Froelicher V. Prevalence and prognostic significance of exercise-induced right bundle branch block. Am J Cardiol. 2010 Mar 1. 105(5):677-80. [Medline].

  2. Veeram Reddy SR, Du W, Zilberman MV. Left ventricular mechanical synchrony and global systolic function in pediatric patients late after ventricular septal defect patch closure: a three-dimensional echocardiographic study. Congenit Heart Dis. 2009 Nov-Dec. 4(6):454-8. [Medline].

  3. Hui W, Slorach C, Dragulescu A, Mertens L, Bijnens B, Friedberg MK. Mechanisms of Right Ventricular Electromechanical Dyssynchrony and Mechanical Inefficiency in Children After Repair of Tetralogy of Fallot. Circ Cardiovasc Imaging. 2014 May 1. [Medline].

  4. [Guideline] Finnish Medical Society Duodecim. Myocardial infarction. In: EBM Guidelines. Evidence-Based Medicine [Internet]. Helsinki, Finland: Wiley Interscience. John Wiley & Sons; 2008 Apr 2. [Full Text].

  5. Stephan E, Chedid R, Loiselet J, Bouvagnet P. Clinical and molecular genetics of familial bundle branch block related to chromosome 19 [in French]. Arch Mal Coeur Vaiss. 1998 Dec. 91(12):1465-74. [Medline].

  6. Deschenes I, Baroudi G, Berthet M, et al. Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes. Cardiovasc Res. 2000 Apr. 46(1):55-65. [Medline].

  7. Keller DI, Barrane FZ, Gouas L, et al. A novel nonsense mutation in the SCN5A gene leads to Brugada syndrome and a silent gene mutation carrier state. Can J Cardiol. 2005 Sep. 21(11):925-31. [Medline].

  8. Adams JC, Nelson MR, Chandrasekaran K, Jahangir A, Srivathsan K. Novel ECG criteria for right ventricular systolic dysfunction in patients with right bundle branch block. Int J Cardiol. 2012. [Full Text].

  9. Diogenes MS, Succi RC, Machado DM, et al. Cardiac longitudinal study of children perinatally exposed to human immunodeficiency virus type 1 [in Portuguese]. Arq Bras Cardiol. 2005 Oct. 85(4):233-40. [Medline].

  10. van Beynum I, Morava E, Taher M, Rodenburg RJ, Karteszi J, Toth K, et al. Cardiac arrest in kearns-sayre syndrome. JIMD Rep. 2012. 2:7-10. [Medline]. [Full Text].

  11. Chevallier S, Forclaz A, Tenkorang J, Ahmad Y, Faouzi M, Graf D, et al. New electrocardiographic criteria for discriminating between Brugada types 2 and 3 patterns and incomplete right bundle branch block. J Am Coll Cardiol. 2011 Nov 22. 58(22):2290-8. [Medline].

  12. Daga B, Minano A, de la Puerta I, et al. Electrocardiographic findings typical of Brugada syndrome unmasked by cocaine consumption [in Spanish]. Rev Esp Cardiol. 2005 Nov. 58(11):1355-7. [Medline].

  13. Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, et al. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria. Eur Heart J. 2010 Apr. 31(7):806-14. [Medline]. [Full Text].

  14. Jain R, Dalal D, Daly A, et al. Electrocardiographic features of arrhythmogenic right ventricular dysplasia. Circulation. 2009 Aug 11. 120(6):477-87. [Medline]. [Full Text].

  15. Becker AE, Anderson RH. Morphology of the human atrioventricular junctional area. Wellens JHH, Lie KI, Janse MJ eds. The Conduction System of the Heart. 1976. 263-71.

  16. Brugada J, Brugada R, Brugada P. Right bundle-branch block and ST-segment elevation in leads V1 through V3: a marker for sudden death in patients without demonstrable structural heart disease. Circulation. 1998 Feb 10. 97(5):457-60. [Medline].

  17. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol. 1992 Nov 15. 20(6):1391-6. [Medline].

  18. Brugada P, Brugada R, Brugada J. Sudden death in patients and relatives with the syndrome of right bundle branch block, ST segment elevation in the precordial leads V(1)to V(3)and sudden death. Eur Heart J. 2000 Feb. 21(4):321-6. [Medline].

  19. Colvin EV. Cardiac embryology. Garson A, Bricker JT, Fisher DJ, Neish SR, eds. The Science and Practice of Pediatric Cardiology. 2nd ed. Baltimore, MD: Williams & Wilkins; 1998. 91-123.

  20. Dubin D. Rapid Interpretation of EKGs. 3rd ed. Tampa, FL: Cover; 1984. 137-42.

  21. Esscher E, Hardell LI, Michaelsson M. Familial, isolated, complete right bundle-branch block. Br Heart J. 1975 Jul. 37(7):745-7. [Medline].

  22. Ewing L. Bundle-branch and fasicular blocks. Gillette PC, Garson A, eds. Pediatric Arrhythmias: Electrophysiology and Pacing. WB Saunders Co; 1990. 319-21.

  23. Garson A. Interventricular conduction disturbances. The Electrocardiogram in Infants and Children: A Systematic Approach. Philadelphia, PA: Lea & Febiger; 1983. 119-42.

  24. Garson A. Electrocardiography. Garson A, Bricker JT, Fisher DJ, Neish SR, eds. The Science and Practice of Pediatric Cardiology. 2nd ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 1998. 736.

  25. Horowitz LN, Alexander JA, Edmunds LH Jr. Postoperative right bundle branch block: identification of three levels of block. Circulation. 1980 Aug. 62(2):319-28. [Medline].

  26. Husson GS, Blackman MS, Rogers MC, et al. Familial congenital bundle branch system disease. Am J Cardiol. 1973 Sep 7. 32(3):365-9. [Medline].

  27. James TN. The connecting pathways between the sinus node and A-V node and between the right and the left atrium in the human heart. Am Heart J. 1963 Oct. 66:498-508. [Medline].

  28. Kehoe RF, Bauernfeind R, Tommaso C, et al. Cardiac conduction defects in polymyositis: electrophysiologic studies in four patients. Ann Intern Med. 1981 Jan. 94(1):41-3. [Medline].

  29. Komajda M, Frank R, Vedel J, et al. Intracardiac conduction defects in dystrophia myotonica. Electrophysiological study of 12 cases. Br Heart J. 1980 Mar. 43(3):315-20. [Medline].

  30. Krongrad E. Prognosis for patients with congenital heart disease and postoperative intraventricular conduction defects. Circulation. 1978 May. 57(5):867-70. [Medline].

  31. Li TC, Hu DY, Bian H, et al. Effects of transcatheter closure of perimembranous ventricular septal defects: intermediate and long-term follow-up of 68 cases [in Chinese]. Zhonghua Yi Xue Za Zhi. 2005 Oct 26. 85(40):2846-9. [Medline].

  32. Massing GK, James TN. Anatomical configuration of the His bundle and bundle branches in the human heart. Circulation. 1976 Apr. 53(4):609-21. [Medline].

  33. Nery PB, Ha AC, Keren A, Birnie DH. Cardiac resynchronization therapy in patients with left ventricular systolic dysfunction and right bundle branch block: a systematic review. Heart Rhythm. 2011 Jul. 8(7):1083-7. [Medline].

  34. Ogura Y, Kato J, Ogawa Y, et al. A case of alternating bundle branch block in combination with intra-Hisian block. Int Heart J. 2005 Jul. 46(4):737-44. [Medline].

  35. Pickhoff AS. Electrophysiology; development and function of the cardiac conduction system. Allen HD, Gutgesell HP, Clark EB, Driscoll DJ, eds. Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2000. 414-24.

  36. Priori SG, Napolitano C, Gasparini M, et al. Clinical and genetic heterogeneity of right bundle branch block and ST- segment elevation syndrome: A prospective evaluation of 52 families. Circulation. 2000 Nov 14. 102(20):2509-15. [Medline].

  37. Rossi L. Histopathology of Cardiac Arrhythmias. 2nd ed. Philadelphia, PA: Lea & Febiger; 1979. 1-75.

  38. Sanyal SK, Johnson WW. Cardiac conduction abnormalities in children with Duchenne''s progressive muscular dystrophy: electrocardiographic features and morphologic correlates. Circulation. 1982 Oct. 66(4):853-63. [Medline].

  39. Schaal SF, Seidensticker J, Goodman R, Wooley CF. Familial right bundle-branch block, left axis deviation, complete heart block, and early death. A heritable disorder of cardiac conduction. Ann Intern Med. 1973 Jul. 79(1):63-6. [Medline].

  40. Scheinman MM, Goldschlager NF, Peters RW. Bundle branch block. Cardiovasc Clin. 1980. 11(1):57-80. [Medline].

  41. Silka MJ. Bundle branch block. Garson A, Bricker JT, Fisher DJ, Neish SR, eds. The Science and Practice of Pediatric Cardiology. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998. 2033-6.

  42. Simonsen EE, Madsen EG. Four cases of right-sided bundle-branch block and one case of atrioventricular block in three generations of a family. Br Heart J. 1970 Jul. 32(4):501-4. [Medline].

  43. Stephan E. Hereditary bundle branch system defect. A new genetic entity?. Am Heart J. 1979 Jun. 97(6):708-18. [Medline].

  44. Stephan E. Hereditary bundle branch system defect: survey of a family with four affected generations. Am Heart J. 1978 Jan. 95(1):89-95. [Medline].

  45. Sun XJ, Gao W, Zhou AQ, et al. Risk factors for arrhythmia early after transcatheter closure of perimembranous ventricular septal defects [in Chinese]. Zhonghua Er Ke Za Zhi. 2005 Oct. 43(10):767-71. [Medline].

  46. Sung RJ, Tamer DM, Garcia OL, et al. Analysis of surgically-induced right bundle branch block pattern using intracardiac recording techniques. Circulation. 1976 Sep. 54(3):442-6. [Medline].

  47. Tawara S. Das Reizleitungssystem des Saugetierkerzens. Jena: Gustav Fisher; 1906.

  48. Udink ten Cate FE, van Heerde M, Rammeloo LA, Hruda J. Transientelectrocardiographic abnormalities following blunt chest trauma in a child. Eur J Pediatr. November 2008. 167(11):1331-3.

  49. Van Praagh R, Van Praagh S. Morphologic anatomy. Fyler DC, ed. Nadas' Pediatric Cardiology. Philadelphia, PA: Hanley & Belfus; 1992. 23.

  50. Waller BF, Schlant RC. Anatomy of the heart. O'Rourke RA, Schlant RC, Roberts R, et al, eds. Hurst's The Heart. 8th ed. New York, NY: McGraw-Hill Medical; 1994. 99-102.

  51. Walsh, EP. Electrocardiography and introduction to electrophysiologic techniques. Fyler, DC, ed. Nadas' Pediatric Cardiology. Philadelphia, PA: Hanley & Belfus; 1992. 134.

  52. Yasui H, Yoshitoshi M, Komori M, et al. Cardiodynamic effects of experimental right bundle branch block in canine hearts with normal and hypertrophied right ventricles. Am Heart J. 1985 Jan. 109(1):69-77. [Medline].

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ECGs demonstrate a normal sinus rhythm and a sinus rhythm with a right bundle branch block.
Anatomy of the penetrating portion of the atrioventricular (AV) bundle.
ECG depicts electrophysiologic events of right bundle branch block. AV = atrioventricular.
Pathophysiology of right bundle branch block. AV = atrioventricular; LV = left ventricular; RV = right ventricular.
ECG depicts electrophysiologic sequence of events that occur in normal cardiac conduction. AV = atrioventricular.
ECG demonstrates a wide S wave.
 
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