Updated: May 30, 2006
Medial collateral ligament (MCL) injuries of the knee are very common sports-related injuries. The MCL is the most commonly injured knee ligament. Injuries to the MCL occur in almost all sports and in all age groups.
The incidence of MCL injuries is impossible to determine because of the wide spectrum of injury severity. Many MCL injuries are minor and may never be evaluated by a physician.
The medial aspect of the knee has been divided into 3 distinct layers based on cadaver dissection. The first layer is the deep fascia, which consists of the sartorius fascia anteriorly and a thin fascial layer posteriorly. The thin posterior fascia covers the popliteal fossa and the heads of the gastrocnemius muscle. The second layer includes the superficial MCL, also known as the tibial collateral ligament. This ligament attaches proximally to the medial femoral epicondyle and to the tibia distally, approximately 4-5 cm distal to the joint line. The parapatellar retinaculum and patellofemoral ligament are within this layer.
The third layer is the knee joint capsule, which attaches proximally and distally at the articular margins. The capsule is divided into thirds from anterior to posterior. The anterior third of the capsule is the thinnest portion. It is attached to the anterior horn of the medial meniscus and is reinforced by the medial retinaculum. The middle third of the capsule consists of the deep medial collateral ligament. It is firmly attached to the mid body of the medial meniscus. Proximal to the meniscal attachment, it is termed the meniscofemoral ligament. Distal to its meniscal attachment, it is termed the meniscotibial ligament. The posterior third of the capsule includes the posterior oblique ligament (POL) and the oblique popliteal ligament. The POL has 3 arms, the superficial, tibial, and capsular.
The superficial MCL has been shown through serial cutting studies to provide the primary restraint to valgus loads at all degrees of flexion. It is also an important restraint to anterior tibial translation when the anterior cruciate ligament is injured. The superficial MCL acts as a primary restraint to external rotation of the tibia.
Stability of the medial side of the knee is provided by dynamic and static restraints. The static restraints are the superficial MCL and the joint capsule, including the deep MCL and the POL. The semimembranosus muscle, the pes anserine muscles, and the vastus medialis muscle provide dynamic stability. The muscles of the pes include the sartorius, gracilis, and semitendinosus. These muscles flex and internally rotate the tibia. The semimembranosus has 4 attachments: direct, tibial, inferior, and capsular.
A thorough history should be obtained prior to performing the physical examination. The following questions should be answered:
A complete physical examination of the knee should be performed after a thorough history is obtained. Attention should be directed toward localizing the MCL injury and identifying any associated injuries.
Contact, noncontact, and overuse mechanisms are involved in causing MCL injuries.
Femur Injuries and Fractures
Medial meniscal tears
Patella subluxation
Patella dislocation
Tibial plateau fracture
Medial soft tissue contusion
Osteochondral fracture
Osteochondritis desiccans
Tibial plateau fracture
Medial hamstring strain
Pes bursitis
Medial retinacular strain and capsular tears
The initial treatment of all sprains is similar and follows the RICE protocol with rest, ice, compression, and elevation. Protective weightbearing is instituted with crutches. This is continued until a normal gait is obtained. The severity of the injury dictates further treatment.
Grade 1 and 2 sprains are routinely treated nonoperatively. They may be braced with a knee sleeve or a double-upright hinged knee orthosis, individualized to the patient's discomfort. Crutches are only necessary for a few days. These injuries represent incomplete tears and allow for a rapid return to activities.
Historically, grade 3 tears were treated operatively but currently are routinely treated nonoperatively. In the past, nonoperative treatment meant a long leg cast. Currently, bracing with a hinged knee orthosis is common. Some authors recommend immediate braced increase in range of motion (ROM), while others prefer waiting up to 6 weeks with the knee at 30° of flexion. Crutches are usually necessary for 1-2 weeks.
The goals of therapy are to decrease pain, restore ROM, and regain strength. Crutches are used until weightbearing is comfortable. ROM exercises are performed in a cold whirlpool. Quadriceps strengthening is started with quad sets and progressed to closed-chain exercises as tolerated. Running is allowed when weightbearing is comfortable and is progressed to more narrow S-shaped patterns, until pivoting is comfortable. At this point, sport-specific exercises and drills are added and advanced until the athlete is ready to return to the sport. Return to play is allowed when sport-specific agility testing is performed comfortably. People with grade 1 and 2 injuries usually return to play within 2-3 weeks. People with grade 3 injuries frequently require 6 or more weeks before a return to play.
After sufficient healing of the ligament has occurred, the initial focus of rehabilitation is to restore full ROM. After acceptable knee ROM is restored, the therapist is to concentrate on controlled strengthening. Often in the knee, the functional strength of the quadriceps muscle, especially the medial VMO muscle, is weak and atrophied. After restoration of sufficient strength, the athlete needs to go through sport-specific or function-based training. Upon achieving full strength and pain-free ROM in the lower extremity, the athlete can be cleared to return to their sport, most often without any brace or external support.
Persistent instability and laxity may require surgical treatment.
The consensus is that isolated MCL tears rarely require operative repair, while treatment of severe combined ruptures of the MCL and ACL or PCL would require reconstruction. A recent study found that nonoperative and operative treatments of medial collateral ligament injuries lead to equally good results. Another indication for surgical intervention would be persistent instability and consist of tissue repair and imbrication. Often, reinforcement with an allograft is necessary.
Long-term outcome studies have shown that almost all patients with grade 1 and 2 injuries have returned to full preinjury activities by 3 months. Isolated grade 3 injuries still allow excellent return to preactivity levels by 6-9 months.
The goals of pharmacotherapy are to reduce morbidity and to prevent complications.
Have analgesic, anti-inflammatory, and antipyretic activities. Their mechanism of action is not known, but they may inhibit cyclooxygenase activity and prostaglandin synthesis. Other mechanisms may exist as well, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell membrane functions.
DOC for patients with mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.
200-400 mg PO q4-6h while symptoms persist; not to exceed 3.2 g/d
<6 years: Not established
6 months to 12 years: 4-10 mg/kg/dose PO tid/qid
>12 years: Administer as in adults
Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effect of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
Documented hypersensitivity; peptic ulcer disease; recent GI bleeding or perforation; renal insufficiency; high risk of bleeding
B - Usually safe but benefits must outweigh the risks.
Category D in third trimester of pregnancy; caution in congestive heart failure, hypertension, and decreased renal and hepatic function; caution in coagulation abnormalities or during anticoagulant therapy
For relief of mild to moderate pain; inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis.
500 mg PO followed by 250 mg q6-8h; not to exceed 1.25 g/d
<2 years: Not established
>2 years: 2.5 mg/kg/dose PO; not to exceed 10 mg/kg/d
Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effect of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
Documented hypersensitivity; peptic ulcer disease; recent GI bleeding or perforation; renal insufficiency
B - Usually safe but benefits must outweigh the risks.
Category D in third trimester of pregnancy; acute renal insufficiency, interstitial nephritis, hyperkalemia, hyponatremia, and renal papillary necrosis may occur; patients with preexisting renal disease or compromised renal perfusion risk acute renal failure; leukopenia occurs rarely, is transient, and usually returns to normal during therapy; persistent leukopenia, granulocytopenia, or thrombocytopenia warrants further evaluation and may require discontinuation of drug
For relief of mild to moderate pain and inflammation.
Small dosages are initially indicated in small and elderly patients and in those with renal or liver disease.
Doses >75 mg do not increase therapeutic effects. Administer high doses with caution and closely observe patient for response.
25-50 mg PO q6-8h prn; not to exceed 300 mg/d
<3 months: Not established
3 months to 12 years: 0.1-1 mg/kg PO q6-8h
>12 years: Administer as in adults
Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effect of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
Documented hypersensitivity
B - Usually safe but benefits must outweigh the risks.
Category D in third trimester of pregnancy; caution in congestive heart failure, hypertension, and decreased renal and hepatic function; caution in coagulation abnormalities or during anticoagulant therapy
Decreases activity of cyclooxygenase and in turn inhibits prostaglandin synthesis. Results in a decreased formation of inflammatory mediators.
150-200 mg PO bid or 300-400 qd; not to exceed 400 mg/d
Not established
Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effect of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
Documented hypersensitivity; aspirin-, iodide-, or other NSAID-induced hypersensitivity; GI bleeding; renal insufficiency
C - Safety for use during pregnancy has not been established.
Category D in third trimester of pregnancy; acute renal insufficiency, hyperkalemia, hyponatremia, interstitial nephritis, and renal papillary necrosis may occur; increases risk of acute renal failure in preexisting renal disease or compromised renal perfusion; low white blood cell counts occur rarely and usually return to reference range in ongoing therapy; discontinuation of therapy may be necessary if persistent leukopenia, granulocytopenia, or thrombocytopenia occurs; caution in anticoagulation defects or in persons who are receiving anticoagulant therapy
Pain control is essential to quality patient care. Analgesics ensure patient comfort, promote pulmonary toilet, and have sedating properties, which are beneficial for patients who have sustained trauma or have sustained injuries.
Drug combination indicated for mild to moderate pain.
1-2 tab PO q4h prn; not to exceed 600 mg/d
Not established
May increase serum concentrations of MAOIs, tricyclic antidepressants, carbamazepine, phenobarbital, and warfarin
Documented hypersensitivity
C - Safety for use during pregnancy has not been established.
Caution in patients dependent on opiates, substitution may result in acute opiate withdrawal symptoms; caution in severe renal or hepatic dysfunction
DOC for pain in patients with documented hypersensitivity to aspirin or NSAIDs, with upper GI disease, or who are taking PO anticoagulants.
325-650 mg PO q4-6h or 1000 mg tid/qid; not to exceed 4 g/d
<12 years: 10-15 mg/kg/dose PO q4-6h prn; not to exceed 2.6 g/d
>12 years: 325-650 mg PO q4h; not to exceed 5 doses in 24 h
Rifampin can reduce analgesic effects of acetaminophen; coadministration with barbiturates, carbamazepine, hydantoins, and isoniazid may increase hepatotoxicity
Documented hypersensitivity; known G-6-PD deficiency
B - Usually safe but benefits must outweigh the risks.
Hepatotoxicity possible in people with long-term alcoholism following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; APAP is contained in many OTC products and combined use with these products may result in cumulative APAP doses exceeding recommended maximum dose
Indicated for the treatment of mild to moderate pain.
30-60 mg/dose based on codeine content PO q4-6h or 1-2 tab q4h; not to exceed 4 g/d of acetaminophen
0.5-1 mg/kg/dose based on codeine PO q4-6h; 10-15 mg/kg/dose based on acetaminophen content; not to exceed 2.6 g/d of acetaminophen
Toxicity of codeine increases with CNS depressants, tricyclic antidepressants, MAOIs, neuromuscular blockers, CNS depressants, phenothiazines, and narcotic analgesics
Rifampin can reduce analgesic effects of acetaminophen; coadministration with barbiturates, carbamazepine, hydantoins, and isoniazid may increase hepatotoxicity of acetaminophen
Documented hypersensitivity
C - Safety for use during pregnancy has not been established.
Caution in patients dependent on opiates because this substitution may result in acute opiate withdrawal symptoms; caution in severe renal or hepatic dysfunction
Hepatotoxicity with acetaminophen possible in people with long-term alcoholism following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; acetaminophen is contained in many OTC products, and combined use with these products may result in cumulative acetaminophen doses that exceed recommended maximum dose
Drug combination indicated for moderate to severe pain.
1-2 tab or cap PO q4-6h prn
<12 years: 10-15 mg/kg/dose acetaminophen PO q4-6h prn; not to exceed 2.6 g/d acetaminophen
>12 years: 750 mg acetaminophen PO q4h; not to exceed 10 mg hydrocodone bitartrate per dose or 5 doses/24 h
Coadministration with phenothiazines may decrease analgesic effects; toxicity increases with CNS depressants or tricyclic antidepressants
Documented hypersensitivity; high altitude cerebral edema (HACE); elevated intracranial pressure (ICP)
C - Safety for use during pregnancy has not been established.
Tabs contain metabisulfite, which may cause hypersensitivity; caution in patients dependent on opiates because this substitution may result in acute opiate withdrawal symptoms; caution in severe renal or hepatic dysfunction
Drug combination indicated for short-term (<10 d) relief of moderate to severe acute pain.
1-2 tab PO q4-6h prn pain; not to exceed 5 tab/d
Not established
Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effect of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; monitor PT closely (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
Documented hypersensitivity; third trimester of pregnancy
C - Safety for use during pregnancy has not been established.
Caution in impaired renal function, peptic ulcer disease, impaired thyroid function, asthma, hypertension, edema, heart failure, increased intracranial pressure, and erosive gastritis; duration of action may increase in elderly patients
Drug combination indicated for the relief of moderate to severe pain.
1-2 tab or cap PO q4-6h prn
0.05-0.15 mg/kg/dose oxycodone PO q4-6h prn; not to exceed 5 mg/dose of oxycodone
Phenothiazines may decrease analgesic effects of this medication; toxicity increases with coadministration of either CNS depressants or tricyclic antidepressants
Documented hypersensitivity
C - Safety for use during pregnancy has not been established.
Duration of action may increase in elderly patients; be aware of total daily dose of acetaminophen patient is receiving; do not exceed 4,000 mg/24h of acetaminophen; higher doses may cause liver toxicity
Return to play is allowed when sport-specific agility testing is completed comfortably. Usually this requires 90% return of strength compared to the contralateral knee.
Grade 1 and 2 sprains often allow return to play within 1-2 weeks. Grade 3 injuries usually require at least 6 weeks for return to play, although some authors have reported 3-4 weeks.
Late instability can occur, requiring operative intervention.
Prophylactic bracing is controversial, although many athletes wear braces. Some studies recommend bracing after showing a decrease in injury rate. Older studies did not show a decrease in injuries, and some actually demonstrated a slightly increased rate of injuries.
Patients with grade 1 and 2 injuries consistently recover well, and athletes return to play early. Patients with isolated grade 3 injuries also consistently return to full preinjury level, but recovery takes longer.
For excellent patient education resources, visit eMedicine's Breaks, Fractures, and Dislocations Center and Sports Injury Center. Also, see eMedicine's patient education article Knee Injury.
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Fanelli GC, Edson CJ, Orcutt DR, et al. Treatment of combined anterior cruciate-posterior cruciate ligament-medial-lateral side knee injuries. J Knee Surg. Jul 2005;18(3):240-8. [Medline].
Halinen J, Lindahl J, Hirvensalo E, Santavirta S. Operative and Nonoperative Treatments of Medial Collateral Ligament Rupture With Early Anterior Cruciate Ligament Reconstruction: A Prospective Randomized Study. Am J Sports Med. Feb 1 2006;[Medline].
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Reider B, Sathy MR, Talkington J, et al. Treatment of isolated medial collateral ligament injuries in athletes with early functional rehabilitation. A five-year follow-up study. Am J Sports Med. Jul-Aug 1994;22(4):470-7. [Medline].
Warren LF, Marshall JL. The supporting structures and layers on the medial side of the knee: an anatomical analysis. J Bone Joint Surg Am. Jan 1979;61(1):56-62. [Medline].
MCL injury, tibial collateral knee ligament injury, TCL injury, torn ligament, knee injury
Thomas M DeBerardino, MD, Director, John A Feagin Jr West Point Sports Medicine Fellowship, Orthopedic Surgery Service, Clinical Instructor in Surgery, Keller Army Community Hospital at West Point
Thomas M DeBerardino, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Medical Association, American Orthopaedic Association, and American Orthopaedic Society for Sports Medicine
Disclosure: Nothing to disclose.
Jeffrey C Gundel, MD, Consulting Surgeon, Department of Orthopedic Surgery, North Country Sports Medicine
Jeffrey C Gundel, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Sports Medicine, American Orthopaedic Society for Sports Medicine, Arthroscopy Association of North America, and Medical Society of the State of New York
Disclosure: Nothing to disclose.
Andrew L Sherman, MD, Associate Professor, Departments of Neurological Surgery, Orthopedics, and Rehabilitation, University of Miami Miller School of Medicine
Andrew L Sherman, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, American Association of Neuromuscular and Electrodiagnostic Medicine, American College of Sports Medicine, and American Medical Association
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.
Russell D White, MD, Professor of Medicine, Department of Community and Family Medicine, University of Missouri-Kansas City School of Medicine, Truman Medical Center Lakewood
Disclosure: Nothing to disclose.
Jon Whitehurst, MD, Consulting Staff, Rockford Orthopedic Associates
Disclosure: Nothing to disclose.
Wylie D Lowery, Jr, MD, Department of Orthopedic Surgery, Associate Professor, George Washington University
Wylie D Lowery, Jr, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Medical Association, Medical Society of Virginia, and Phi Beta Kappa
Disclosure: Nothing to disclose.
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