The Ross Procedure for Treatment of Pediatric Aortic Valve Disease Treatment & Management
- Author: Bahaaldin Alsoufi, MD; Chief Editor: Jonah Odim, MD, PhD, MBA more...
Echocardiography is used preoperatively to assess the aortic valve pathology, levels of left ventricular outflow tract obstruction and associated cardiac abnormalities. The pulmonary valve is assessed for clinically significant regurgitation or any other pathology. Echocardiography is also useful for assessing the sizes of the aorta and pulmonary annulus. A disparity in size of more than 2-3 mm is likely to require augmentation or reduction in the diameter of the aortic annulus.
All procedures are performed though midline sternotomy. Cardiopulmonary bypass is established via standard aortic and bicaval venous cannulation. The left ventricle is decompressed by venting through the right superior pulmonary vein. Mild hypothermia (32-34 º) is used with a combination of antegrade and retrograde cold blood cardioplegia. Antegrade cardioplegia is initially administered through the root and then by direct coronary artery cannulation at 20-minute intervals.
The aorta is transected 1.5 cm above the right coronary artery. The aortic valve is inspected and repaired, if possible. If the valve is not repairable, the leaflets are then completely excised and calcium is debrided if present. The main pulmonary artery is partially opened just proximal to the bifurcation, and the valve is inspected to ensure normal anatomy and function.
Once the decision is made to proceed with the Ross procedure, the coronary buttons are prepared. A generous rim of aorta is left around each ostium to allow for suturing to the pulmonary autograft later.
The pulmonary artery is separated from the aorta up to the bifurcation and is completely divided. The autograft is harvested by placing a right-angled clamp through the valve and by bringing the tip through the infundibulum approximately 1 cm below the base of the cusps. The right ventricular outflow tract is then opened circumferentially using scissors. Once the dissection proceeds laterally, the left anterior descending artery and its first septal branch are at risk if meticulous dissection is not performed. Following harvesting of the autograft, retrograde cardioplegia is administered and small venous branches are cauterized or ligated in the bed of the harvested autograft. See the images below.
The autograft and the right ventricular outflow tract are then sized with standard sizers to select an appropriate-sized pulmonary homograft to be prepared. The aortic root annulus is also sized to determine if any discrepancy needs to be addressed. An annular size difference of 2-3 mm is well tolerated. If the aortic annulus is too large, reduction is best achieved with an imbricating suture passed circumferentially at the level of the annulus and tied over a dilator the size of the pulmonary autograft. Alternatively, a series of mattress sutures can be used with care to avoid the region of the conduction system. If the aortic root annulus is too small, then an aortoventriculoplasty combined with the Ross procedure (commonly known as a Ross-Konno procedure) is appropriate. See the images below.
The autograft is sutured to the aortic valve annulus using either a running or interrupted 4-0 polypropylene suture. If no further growth is required, the sutures are tied around a circumferential strip of Teflon felt approximately 3 mm wide, as shown below. The graft should be orientated so that the commissures of the autograft line up with the commissures of the excised aortic valve. A small opening is made in the left coronary sinus of the autograft, and the left coronary artery is anastomosed using a running 6-0 polypropylene suture. The distal aortic anastomosis is then constructed with a continuous 4-0 polypropylene suture.
The aortic root is deaired and insufflated to test the suture lines and to allow proper placement of the right coronary artery once the autograft is distended. The anastomosis is constructed in a similar fashion as the left coronary button. Antegrade cardioplegia can now be administered, and bleeding in the bed of the harvested autograft site can be addressed.
A cryopreserved pulmonary homograft is then appropriately trimmed, and the distal anastomosis is performed using a continuous 4-0 polypropylene suture. The proximal anastomosis is then constructed with continuous 5-0 polypropylene. See the image below.
The patient is then placed in steep Trendelenburg position. While the aortic and left ventricular vents are aspirated, the cross-clamp can be removed. The remainder of the anterior portion of the homograft anastomosis can be completed with the heart beating.
The patient is then weaned from cardiopulmonary bypass; protamine is administered, and the patient is decannulated. Transesophageal echocardiography is used to assess the function of the autograft and the homograft once the procedure is complete, as shown below.
The autograft implantation technique described is the miniroot reimplantation technique. It is the preferred implantation strategy used at the authors' institution. Other implantation techniques are similar to those described for homografts, such as the subcoronary and the cylinder inclusion techniques, and are preferred by some surgeons. In the Ross registry database, 81% of autografts were implanted using the root technique, whereas 11% used the subcoronary technique, and 6% used the inclusion technique.
Standard postoperative cardiac management is administered. Patients can generally be weaned from ventilatory support in the early postoperative period, the exception is a neonate who was critically ill before surgery.
Patients are examined 4 weeks postoperatively to address any surgical issues. They should also continue to undergo biannual echocardiography to assess function of the right- and left-sided semilunar valves. After undergoing surgical repair of aortic valve disease, patients are given antibiotics to prevent endocarditis before they receive any procedures that may cause bacteremia. For more information, see Antibiotic Prophylactic Regimens for Endocarditis.
Outcome and Prognosis
The Ross procedure is a safe operation and can be performed with a low mortality.[5, 6, 7, 8, 9] Data from The International Registry for the Ross Procedure, which includes 6088 patients, reveals an early mortality of 3.3%. Perioperative complications are uncommon and include arrhythmias in 3% of patients, bleeding in 2% of patients, stroke in 1% of patients, and sepsis in 1% of patients.
Many groups have reported even more favorable results in children and young adults undergoing the Ross procedure, with an operative mortality rate approaching 0% in different series from experienced centers despite the complexity of the procedure.
In a study that included approximately 420 children and nearly 275 young adults who underwent the Ross procedure, Zebele et al determined that the patients’ 30-day and 1-year survival rates were 99.3% and 98.7%, respectively. Another study, by Luciani et al, of 305 children who underwent the Ross operation, found the 10- and 15-year survival rates to be 93% and 89%, respectively, with no reoperation needed during those same periods for 76% and 67% of patients, respectively.[10, 11]
Actuarial long-term survival for patients undergoing the Ross procedure in the Ross registry and multiple surgical series is 80-90% at 10 years and 70-80% at 20 years. Those favorable results reflect the selection bias as patients undergoing the Ross procedure are usually young with minimal comorbidities such as coronary artery disease.
Early autograft failure or dysfunction that requires replacement of the autograft at the time of operative insertion or reoperation within 6 months of the original Ross procedure is very rare at experienced centers, with an incidence rate of less than 1% in the Ross registry. This failure or dysfunction is usually due to technical problems, such as leaflet distortion and leaflet injury during the harvest or the implantation of the autograft.
Pulmonary autograft is a durable replacement for the aortic valve. Initial data collected by Ross demonstrated an autograft failure and replacement rate of 2.5% per patient year and an actuarial event-free survival rate of 48% at 19 years.
Several improvements in technique, including the use of the root replacement technique and procedures to limit potential autograft dilation, have resulted in improved outcomes for the Ross procedure.
In the most recent Ross registry, the rate of freedom from explantation of failing autografts at 10 years and 25 years is 89% and 82%, respectively. Valve durability is clearly superior to that of homografts or bioprosthetic valves because the latter 2 undergo calcific degeneration and require replacement, especially in younger patients with longer expected survival and accelerated early degeneration of biologic valve substitutes.
Moreover, the freedom from valve-related complications (eg, endocarditis, valve pannus, thrombosis) is very low following the Ross procedure, and valve explantation for these reasons is relatively uncommon compared with mechanical valves.
An increasing concern is dilatation of the neoaortic root following Ross procedure that leads to progression of aortic regurgitation, especially in the setting of geometric mismatch of aortic and pulmonary roots and bicuspid regurgitant aortic valve. These specific subsets of patients have been identified by several groups to have a higher risk of autograft dilatation and recurrence of regurgitation.
A study from Philadelphia examined serial echocardiograms following the Ross procedure in children and young adults. Evidence of progressive neoaortic root dilatation out of proportion to somatic growth was reported, along with progressive aortic insufficiency, especially in patients with prior ventricular septal defect repair or prior aortic valve replacement. Those results highlighted the need for continuous monitoring of those patients for the potential future development of autograft complications.
Dilatation of the sinuses of Valsalva results in root aneurysm, even without significant aortic regurgitation, whereas dilatation of the sinotubular junction causes recurrence of regurgitation, especially in patients who underwent the root implantation technique of the autograft. Dilatation of the sinotubular junction is probably the most common cause of failure of the pulmonary autograft. Although valve replacement may be required, several groups have reported valve sparing replacement of the aortic root and ascending aorta to eliminate the aneurysmal dilated wall and restore valve competency.
Several studies reported better performance of the autograft in younger children compared with older children and adults, with a higher rate of freedom from autograft dilatation and reoperations. These series may suggest the ability of the autograft of a young child to better adapt to systemic pressures. Nonetheless, the Ross procedure is undergoing reconsideration by many surgeons especially in the treatment of congenital and bicuspid aortic valve disease.
Finally, several groups have reported modifications of the valve implantation techniques, such as adjusting the diameter of the aortic annulus and/or the sinotubular junction of the aorta using Teflon strips, implanting the autografts into a Dacron graft, or wrapping the autograft with glutarylaldehyde-treated pericardium to prevent dilatation of the autograft. Further follow-up is needed to assess the use of these modifications.
Pulmonary homograft degeneration
The pulmonary homograft used for reconstruction of the right ventricular outflow tract is subject to calcific degeneration, which, in addition to its failure to grow with the child, likely requires reoperation and conduit replacement. Although the pulmonary homograft placed during the Ross procedure has greater longevity than the one used for reconstruction of the right ventricular outflow tract for repair of congenital heart disease (presumably due to the orthotopic position, normal pulmonary arteries, and pulmonary vascular resistance), recent data indicate that replacement is still necessary. Factors associated with homograft dysfunction include the use of aortic homograft, small homograft size, recipient age of less than 10 years, homograft storage time, blood-type disparity, and immune-mediated reaction.
The reported incidence of homograft dysfunction ranges from 6-20% at 10 years after the Ross procedure. The freedom from pulmonary homograft replacement at the Ross registry at 10 years and 25 years is 91% and 84%, respectively.
When re-replacement of the subpulmonary homograft is required, the operative results are associated with minimal mortality, therefore providing further support of the use of the Ross procedure for valve replacement in children and young adults.
Most importantly, experience with percutaneous pulmonary valve replacement has emerged in the past few years and has become a valid choice in many patients following the Ross procedure. Current exclusion criteria include unfavorable right ventricular outflow tract morphology (eg, narrowest right ventricular outflow tract diameter of >22 mm or conduits < 16 mm at time of surgical implantation), patient age less than 5 years, or weight less than 20 kg.
Comparison to mechanical valves in children
As no valve replacement substitute in children is ideal, studies compared outcomes between the Ross procedure and mechanical valve replacement in children.[13, 14] Evidence of improved short-term and long-term mortality was reported in children who underwent the Ross procedure. This survival advantage, although present in all children, was most evident in younger children who required smaller mechanical aortic valve prostheses. Moreover, in addition to early mortality, survival was stable for children undergoing the Ross procedure with minimal late mortality, whereas a constant attrition rate was noted in children who received mechanical valves (due to sudden death and thromboembolic complications).
Although autograft survival remains an issue, especially in those with underlying rheumatic activity and aortic regurgitation, autograft longevity was superior in patients with underlying congenital etiology.
Freedom from endocarditis was comparable between the 2 valve substitutes; however, freedom from anticoagulation-related morbidity was obviously superior in children who underwent the Ross procedure.
Patients undergoing the Ross procedure do not require anticoagulation. The patients have minimal restrictions on their lifestyle and do not require cardiac medications to maintain or preserve valve function. Despite development of mildly elevated gradients across the pulmonary homograft, patients undergoing the Ross procedure have near normal exercise endurance, and most are in New York Heath Association (NYHA) Class I.
An echocardiographic study that compared rest and exercise hemodynamics after the Ross procedure showed that hemodynamic characteristics and exercise performance in athletes after Ross procedure were similar to those in age-matched healthy athletes.
Future and Controversies
Although the Ross procedure for aortic valve replacement in the pediatric population is a more demanding procedure than straightforward valve replacement, it offers distinct advantages, including excellent hemodynamic flow characteristics, potential for growth, excellent patient survival, and minimal incidence of late embolic complications. Reoperations on the reconstructed right ventricular outflow tract are infrequent and are associated with low operative risk. A future role for percutaneous pulmonary valve replacement is noted. Surveillance for autograft dilatation is necessary because it may result in aneurysm formation and/or development of recurrent aortic regurgitation.
Reoperation on the autograft may be required; however, valve-sparing root replacement can be performed, preserving the autograft valve. The advantages of the Ross procedure, despite its limitations, make it the current preferred aortic valve replacement choice in children. Improvements in aortic valve repair technique and developments in valve-substitute technology may offer a better alternative choice for children with aortic valve disease in the future.
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