Pediatric Hypokalemia Medication
- Author: Michael J Verive, MD; Chief Editor: Timothy E Corden, MD more...
Medication Summary
Medical therapy is aimed at potassium supplementation by the enteral (ie, oral or through feeding tubes) or parenteral route. Transient, asymptomatic, or mild hypokalemia may resolve spontaneously, or it may be treated using enteral potassium supplements. Symptomatic or severe hypokalemia should be corrected with intravenous potassium preparations.
Potassium supplements
Class Summary
These agents are used to restore body potassium storage. Electrolytes are used to correct disturbances in fluid and electrolyte homoeostasis or acid-base balance and to reestablish osmotic equilibrium of specific ions.
Potassium chloride (also citrate, acetate, bicarbonate, gluconate)
Potassium chloride is the preferred salt for patients with preexisting alkalosis. First choice for IV therapy. Essential for transmission of nerve impulses; contraction of cardiac muscle; and maintenance of intracellular tonicity, skeletal and smooth muscles, and normal renal function. Gradual potassium depletion occurs via renal excretion, through GI loss, or because of low intake. Depletion may result from diuretic therapy, primary or secondary hyperaldosteronism, diabetic ketoacidosis, severe diarrhea, vomiting, or inadequate replacement during prolonged parenteral nutrition.
Bevacqua JE. Diabetic ketoacidosis in the pediatric ICU. Crit Care Nurs Clin North Am. Dec 2005;17(4):341-7, x. [Medline].
Kumar PS, Deenadayalan M, Janakiraman L, Vijayakumar M. Neonatal Bartter syndrome. Indian Pediatr. Aug 2006;43(8):735-7. [Medline].
Johns C. Glycyrrhizic acid toxicity caused by consumption of licorice candy cigars. CJEM. Jan 2009;11(1):94-6. [Medline].
Gürakan F, Baysoy G, Wedenoja S, Uslu N, Ozen H, Ozaltin F, et al. Three cases of a rare disease, congenital chloride diarrhea, summons up the variation in the clinical course and significance of early diagnosis and adequate treatment in the prevention of intellectual disability. Turk J Pediatr. Mar-Apr 2011;53(2):194-8. [Medline].
Patra S, Nadri G, Chowdhary H, Pemde HK, Singh V, Chandra J. Nephrogenic diabetes insipidus with idiopathic Fanconi's syndrome in a child who presented as vitamin D resistant rickets. Indian J Endocrinol Metab. Oct 2011;15(4):331-3. [Medline]. [Full Text].
Lumpaopong A, Kaewplang P, Watanaveeradej V, Thirakhupt P, Chamnanvanakij S, Srisuwan K, et al. Electrolyte disturbances and abnormal urine analysis in children with dengue infection. Southeast Asian J Trop Med Public Health. Jan 2010;41(1):72-6. [Medline].
Bouthoorn SH, van der Ploeg T, van Erkel NE, van der Lely N. Alcohol intoxication among Dutch adolescents: acute medical complications in the years 2000-2010. Clin Pediatr (Phila). Mar 2011;50(3):244-51. [Medline].
Bhattacharya M, Kapoor S. Quadriplegia due to Celiac Crisis with Hypokalemia As Initial Presentation of Celiac Disease: A Case Report. J Trop Pediatr. Apr 27 2011;[Medline].
Emiroglu M. Micafungin use in children. Expert Rev Anti Infect Ther. Sep 2011;9(9):821-34. [Medline].
Zaki SA, Lad V. Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis. Indian J Pharmacol. Sep 2011;43(5):609-10. [Medline]. [Full Text].
[Guideline] Drew BJ, Califf RM, Funk M, et al. Practice standards for electrocardiographic monitoring in hospital settings: an American Heart Association scientific statement from the Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the Young: endorsed by the International Society of Computerized Electrocardiology and the American Association of Critical-Care Nurses. Circulation. Oct 26 2004;110(17):2721-46. [Medline].
Clayton JA, Rodgers S, Blakey J, Avery A, Hall IP. Thiazide diuretic prescription and electrolyte abnormalities in primary care. Br J Clin Pharmacol. Jan 2006;61(1):87-95. [Medline].
Dinleyici EC, Dogruel N, Acikalin MF, Tokar B, Oztelcan B, Ilhan H. An additional child case of an aldosterone-producing adenoma with an atypical presentation of peripheral paralysis due to hypokalemia. J Endocrinol Invest. Nov 2007;30(10):870-2. [Medline].
Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol. Dec 2006;46(3):167-92. [Medline].
Jospe N, Forbes G. Fluids and electrolytes--clinical aspects. Pediatr Rev. Nov 1996;17(11):395-403; quiz 404. [Medline].
Landau D. Potassium handling in health and disease: lessons from inherited tubulopathies. Pediatr Endocrinol Rev. Dec 2004;2(2):203-8. [Medline].
Lucas da Silva PS, Iglesias SB, Waisberg J. Hypokalemic rhabdomyolysis in a child due to amphotericin B therapy. Eur J Pediatr. 2007;166:169-71. [Medline].
Lumpaopong A, Thirakhupt P, Srisuwan K, Chulamokha Y. Rare F311L CFTR gene mutation in a child presented with recurrent electrolyte abnormalities and metabolic alkalosis: case report. J Med Assoc Thai. May 2009;92(5):694-8. [Medline].
Mueller PL, Jaimovich DG. Endocrine and metabolic emergencies. In: Handbook of Pediatric and Neonatal Transport Medicine. 1996:265-92, 492.
Parr JR, Salama A, Sebire P. A survey of consultant practice: intravenous salbutamol or aminophylline for acute severe childhood asthma and awareness of potential hypokalaemia. Eur J Pediatr. May 2006;165(5):323-5. [Medline].
Rodriguez-Soriano J. Bartter and related syndromes: the puzzle is almost solved. Pediatr Nephrol. May 1998;12(4):315-27. [Medline].
Rose BD. Introduction to disorders of potassium balance. In: Clinical Physiology of Acid-Base and Electrolyte Disorders. 1989:715-56.
Wiseman K. Index of suspicion. Case 3. Familial periodic paralysis. Pediatr Rev. Oct 1997;18(10):357, 359-60. [Medline].
Wood EG, Lynch RE. Fluid and Electrolyte Balance. 1998:703-22.

