Pediatric Status Asthmaticus Differential Diagnoses

  • Author: Adam J Schwarz, MD; Chief Editor: Michael R Bye, MD   more...
 
Updated: Oct 26, 2011
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Adam J Schwarz, MD  Consulting Staff, Critical Care Division, Pediatric Subspecialty Faculty, Children's Hospital of Orange County

Adam J Schwarz, MD is a member of the following medical societies: American Academy of Pediatrics and Phi Beta Kappa

Disclosure: Nothing to disclose.

Specialty Editor Board

G Patricia Cantwell, MD, FCCM  Professor of Clinical Pediatrics, Chief, Division of Pediatric Critical Care Medicine, University of Miami, Leonard M Miller School of Medicine; Medical Director, Palliative Care Team, Director, Pediatric Critical Care Transport, Holtz Children's Hospital, Jackson Memorial Medical Center; Medical Manager, FEMA, Urban Search and Rescue, South Florida, Task Force 2; Pediatric Medical Director, Tilli Kids – Pediatric Initiative, Division of Hospice Care Southeast Florida, Inc

G Patricia Cantwell, MD, FCCM is a member of the following medical societies: American Academy of Hospice and Palliative Medicine, American Academy of Pediatrics, American Heart Association, American Trauma Society, National Association of EMS Physicians, Society of Critical Care Medicine, and Wilderness Medical Society

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Barry J Evans, MD  Assistant Professor of Pediatrics, Temple University Medical School; Director of Pediatric Critical Care and Pulmonology, Associate Chair for Pediatric Education, Temple University Children's Medical Center

Barry J Evans, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Chest Physicians, American Thoracic Society, and Society of Critical Care Medicine

Disclosure: Nothing to disclose.

Mary E Cataletto, MD  Director of Children's Sleep Services, Winthrop Sleep Disorders Center, Mineola, NY; Professor of Clinical Pediatrics, State University of New York at Stony Brook, Stony Brook, NY

Mary E Cataletto, MD is a member of the following medical societies: American Academy of Pediatrics and American College of Chest Physicians

Disclosure: Shering Plough Pharmaceuticals Honoraria Consulting

Chief Editor

Michael R Bye, MD  Professor of Clinical Pediatrics, Division of Pulmonary Medicine, Columbia University College of Physicians and Surgeons; Attending Physician, Pediatric Pulmonary Medicine, Morgan Stanley Children's Hospital of New York Presbyterian, Columbia University Medical Center

Michael R Bye, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Chest Physicians, and American Thoracic Society

Disclosure: Nothing to disclose.

References

  1. Gorelick M, Scribano PV, Stevens MW, Schultz T, Shults J. Predicting need for hospitalization in acute pediatric asthma. Pediatr Emerg Care. Nov 2008;24(11):735-44. [Medline].

  2. National Asthma Education and Prevention Program (NAEPP) Expert Panel. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. 2007. National Heart, Lung, and Blood Institute; August 28, 2007. [Full Text].

  3. [Best Evidence] Andrews T, McGintee E, Mittal MK, et al. High-dose continuous nebulized levalbuterol for pediatric status asthmaticus: a randomized trial. J Pediatr. Aug 2009;155(2):205-10.e1. [Medline].

  4. [Best Evidence] Castro-Rodriguez JA, Rodrigo GJ. Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis. Pediatrics. Mar 2009;123(3):e519-25. [Medline].

  5. Ciarallo L, Brousseau D, Reinert S. Higher-dose intravenous magnesium therapy for children with moderate to severeacute asthma. Arch Pediatr Adolesc Med. Oct 2000;154(10):979-83. [Medline].

  6. Stephanopoulos DE, Monge R, Schell KH, et al. Continuous intravenous terbutaline for pediatric status asthmaticus. Crit Care Med. Oct 1998;26(10):1744-8. [Medline].

  7. Chiang VW, Burns JP, Rifai N, Lipshultz SE, Adams MJ, Weiner DL. Cardiac toxicity of intravenous terbutaline for the treatment of severe asthma in children: a prospective assessment. J Pediatr. Jul 2000;137(1):73-7. [Medline].

  8. Kalyanaraman M, Bhalala U, Leoncio M. Serial cardiac troponin concentrations as marker of cardiac toxicity in children with status asthmaticus treated with intravenous terbutaline. Pediatr Emerg Care. Oct 2011;27(10):933-6. [Medline].

  9. Ream RS, Loftis LL, Albers GM, et al. Efficacy of IV theophylline in children with severe status asthmaticus. Chest. May 2001;119(5):1480-8. [Medline]. [Full Text].

  10. Wheeler DS, Jacobs BR, Kenreigh CA, et al. Theophylline versus terbutaline in treating critically ill children with statusasthmaticus: a prospective, randomized, controlled trial. Pediatr Crit Care Med. Mar 2005;6(2):142-7. [Medline].

  11. [Best Evidence] Kim IK, Phrampus E, Venkataraman S, Pitetti R, Saville A, Corcoran T. Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial. Pediatrics. Nov 2005;116(5):1127-33. [Medline].

  12. Kudukis TM, Manthous CA, Schmidt GA, Hall JB, Wylam ME. Inhaled helium-oxygen revisited: effect of inhaled helium-oxygen during the treatment of status asthmaticus in children. J Pediatr. Feb 1997;130(2):217-24. [Medline].

  13. Anderson M, Svartengren M, Bylin G, Philipson K, Camner P. Deposition in asthmatics of particles inhaled in air or in helium-oxygen. Am Rev Respir Dis. Mar 1993;147(3):524-8. [Medline].

  14. Hebbar KB, Petrillo-Albarano T, Coto-Puckett W, et al. Experience with use of extracorporeal life support for severe refractory status asthmaticus in children. Crit Care. Mar 2 2009;13(2):R29. [Medline].

  15. Elias JA, Zhu Z, Chupp G, Homer RJ. Airway remodeling in asthma. J Clin Invest. Oct 1999;104(8):1001-6. [Medline]. [Full Text].

  16. Pearlman DS. Pathophysiology of the inflammatory response. J Allergy Clin Immunol. Oct 1999;104(4 Pt 1):S132-7. [Medline].

  17. Asthma. In: Fuhrman B, Zimmerman J, eds. Pediatric Critical Care. 2nd ed. St. Louis, MO: Mosby; 1998:473-5.

  18. Scarfone RJ, Loiselle JM, Joffe MD, et al. A randomized trial of magnesium in the emergency department treatment of childrenwith asthma. Ann Emerg Med. Dec 2000;36(6):572-8. [Medline].

  19. Schuh S, Johnson DW, Callahan S, et al. Efficacy of frequent nebulized ipratropium bromide added to frequent high-dosealbuterol therapy in severe childhood asthma. J Pediatr. Apr 1995;126(4):639-45. [Medline].

  20. Schwarz AJ, Lubinsky PS. Acute severe asthma. In: Levin DL, Morriss FC, eds. Essentials of Pediatric Intensive Care. Vol 1. 2nd ed. 1997:143-56.

  21. Werner HA. Status asthmaticus in children: a review. Chest. Jun 2001;119(6):1913-29. [Medline]. [Full Text].

  22. Yung M, South M. Randomised controlled trial of aminophylline for severe acute asthma. Arch Dis Child. Nov 1998;79(5):405-10. [Medline]. [Full Text].

  23. Zorc JJ, Pusic MV, Ogborn CJ, et al. Ipratropium bromide added to asthma treatment in the pediatric emergency department. Pediatrics. Apr 1999;103(4 Pt 1):748-52. [Medline]. [Full Text].

 
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Figure depicting antigen presentation by the dendritic cell with the lymphocyte and cytokine response leading to airway inflammation and asthma symptoms.
 
 
 
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