Laboratory Studies
- In general, no laboratory studies are needed in patients with Gianotti-Crosti syndrome (GCS).
- Jaundice or hepatomegaly should prompt a search for the hepatitis B virus and elevated levels of liver enzymes. However, elevated levels of liver enzymes are most likely related to Epstein-Barr virus infection.
Procedures
- A skin biopsy may be performed to rule out other diseases in the differential diagnosis.
Histologic Findings
- Skin biopsy findings are nonspecific and are more helpful in ruling out other diseases.
- The epidermis shows focal spongiosis, parakeratosis, and mild acanthosis.
- The upper dermis has a moderately intense perivascular infiltrate of lymphocytes and histiocytes.
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