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Iliotibial Band Syndrome Medication

  • Author: Jerold M Stirling, MD; Chief Editor: Craig C Young, MD  more...
 
Updated: Oct 21, 2015
 

Medication Summary

NSAIDs are often incorporated into the medical management of overuse injuries such as ITBS because of these agents' analgesic and anti-inflammatory effects. All NSAIDs share a common mechanism of action, inhibition of prostaglandins. Many types of NSAIDs are available for treatment of overuse injuries, but these drugs vary primarily in their onset of effectiveness and duration of action.

To some degree, all NSAIDs share a common side effect of irritation of the gastrointestinal (GI) tract. Patients who take NSAIDs may experience symptoms of flatulence, abdominal cramping, and diarrhea. The more serious GI side effects include esophageal reflux, gastritis, acid reflux, peptic disease, and ulcer formation. NSAIDs as a group may also produce renal side effects (interstitial nephritis, vasomotor nephropathy), dermatologic reactions (rashes), and central nervous system (CNS) symptoms (eg, headache, dizziness, mood change, confusion), but these are much less common than GI side effects.

The ideal NSAID for treatment of an overuse injury is one that combines several properties. The drug should act quickly, have good penetration into synovial tissues, and produce few or no side effects. Unfortunately, no NSAID exists that fulfills all these criteria. The following list indicates only a few of the NSAIDs that are commonly prescribed for overuse injuries.

See also Medscape Drugs & Diseases topics Overuse Injury and Nonsteroidal Anti-inflammatory Agent Toxicity.

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Nonsteroidal anti-inflammatory drugs

Class Summary

NSAIDs have analgesic, anti-inflammatory, and antipyretic activities. The mechanism of action of these agents is not known, but NSAIDs may inhibit cyclooxygenase activity and prostaglandin synthesis. Other mechanisms may exist as well, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell-membrane functions.

Naproxen (Naprelan, Naprosyn, Anaprox)

 

For relief of mild to moderate pain; inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis.

Ibuprofen (Motrin, Ibuprin)

 

DOC for patients with mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Diclofenac (Cataflam, Voltaren)

 

Designated chemically as 2-[(2,6-dichlorophenyl) amino] benzeneacetic acid, monosodium salt, with an empirical formula of C14 H10 Cl2 NO2 NA.

One of a series of phenylacetic acids that has demonstrated anti-inflammatory and analgesic properties in pharmacologic studies. Believed to inhibit the enzyme cyclooxygenase, which is essential in the biosynthesis of prostaglandins. Can cause hepatotoxicity; hence, liver enzymes should be monitored in the first 8 weeks of treatment.

Rapidly absorbed; metabolism occurs in the liver by demethylation, deacetylation, and glucuronide conjugation.

The delayed-release, enteric-coated form is diclofenac sodium, and the immediate-release form is diclofenac potassium. Has relatively low risk for bleeding GI ulcers. Available in extended-relief dosage of 75 mg or 100 mg (Voltaren SR) am or hs.

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Contributor Information and Disclosures
Author

Jerold M Stirling, MD Interim Chairman of Pediatrics, Associate Professor of Pediatrics and Orthopedics, Departments of Pediatrics and Orthopedic Surgery, Loyola University Medical Center

Jerold M Stirling, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Coauthor(s)

Pietro Tonino, MD Director of Sports Medicine, Associate Professor of Orthopaedic Surgery, Orthopaedic Surgery, Loyola University Medical Center

Pietro Tonino, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American College of Sports Medicine, American Medical Association, American Orthopaedic Society for Sports Medicine, Chicago Medical Society, Illinois State Medical Society, Mid-America Orthopaedic Association, American College of Occupational and Environmental Medicine

Disclosure: Nothing to disclose.

Timothy D Marsho, DO Pediatrician

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Chief Editor

Craig C Young, MD Professor, Departments of Orthopedic Surgery and Community and Family Medicine, Medical Director of Sports Medicine, Medical College of Wisconsin

Craig C Young, MD is a member of the following medical societies: American Academy of Family Physicians, American College of Sports Medicine, American Medical Society for Sports Medicine, Phi Beta Kappa

Disclosure: Nothing to disclose.

Additional Contributors

Leslie Milne, MD Assistant Clinical Instructor, Department of Emergency Medicine, Harvard University School of Medicine

Leslie Milne, MD is a member of the following medical societies: American College of Sports Medicine

Disclosure: Nothing to disclose.

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The Ober test.
This illustration demonstrates active stretching of the iliotibial band (ITB). The athlete stands a comfortable distance from a wall and, with the contralateral knee extended, leans the proximal shoulder against the wall to stretch the ipsilateral ITB.
This illustration demonstrates iliotibial band syndrome stretching that is performed in a side-lying position.
 
 
 
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